Aliases for RASL10A Gene

Aliases for RASL10A Gene

  • RAS Like Family 10 Member A 2 3 5
  • RRP22 2 3 4
  • Ras-Related Protein On Chromosome 22 3 4
  • Ras-Like Protein Family Member 10A 3 4
  • Ras-Like Protein RRP22 3 4
  • RAS-Like, Family 10, Member A 2
  • RAS-Like Family 10 Member A 2
  • EC 4
  • RASL10A 5

External Ids for RASL10A Gene

Previous GeneCards Identifiers for RASL10A Gene

  • GC22M028038
  • GC22M029708
  • GC22M012673

Summaries for RASL10A Gene

GeneCards Summary for RASL10A Gene

RASL10A (RAS Like Family 10 Member A) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RASL10B.

UniProtKB/Swiss-Prot Summary for RASL10A Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RASL10A Gene

Genomics for RASL10A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RASL10A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RASL10A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RASL10A

Top Transcription factor binding sites by QIAGEN in the RASL10A gene promoter:
  • GR
  • GR-alpha
  • MAZR
  • Pax-2
  • Pax-2a
  • Pax-5
  • PPAR-alpha
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for RASL10A Gene

Latest Assembly
6,747 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
2,765 bases
Minus strand

(GRCh37/hg19 by Ensembl)
6,747 bases
Minus strand

Genomic View for RASL10A Gene

Genes around RASL10A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RASL10A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RASL10A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASL10A Gene

Proteins for RASL10A Gene

  • Protein details for RASL10A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras-like protein family member 10A
    Protein Accession:
    Secondary Accessions:
    • Q49AU5
    • Q6PI03

    Protein attributes for RASL10A Gene

    203 amino acids
    Molecular mass:
    22541 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RASL10A Gene


neXtProt entry for RASL10A Gene

Post-translational modifications for RASL10A Gene

  • Isoprenylation is essential for nucleolar localization, and the proliferation-inhibiting activity of RASL10A.

Other Protein References for RASL10A Gene

No data available for DME Specific Peptides for RASL10A Gene

Domains & Families for RASL10A Gene

Gene Families for RASL10A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RASL10A Gene

  • Transforming protein P21 RAS signature
  • Miro-like

Suggested Antigen Peptide Sequences for RASL10A Gene

GenScript: Design optimal peptide antigens:
  • Ras-related protein on chromosome 22 (RSLAA_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Ras family.
  • Belongs to the small GTPase superfamily. Ras family.
genes like me logo Genes that share domains with RASL10A: view

Function for RASL10A Gene

Molecular function for RASL10A Gene

UniProtKB/Swiss-Prot Function:
Potent inhibitor of cellular proliferation.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=; Evidence={ECO:0000250|UniProtKB:P01116};.

Enzyme Numbers (IUBMB) for RASL10A Gene

Phenotypes From GWAS Catalog for RASL10A Gene

Gene Ontology (GO) - Molecular Function for RASL10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003924 GTPase activity TAS,IEA --
GO:0005525 GTP binding IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with RASL10A: view
genes like me logo Genes that share phenotypes with RASL10A: view

miRNA for RASL10A Gene

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RASL10A

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RASL10A Gene

Localization for RASL10A Gene

Subcellular locations from UniProtKB/Swiss-Prot for RASL10A Gene

Cell membrane. Lipid-anchor. Cytoplasmic side. Nucleus, nucleolus. Note=May cycle in and out of the nucleolus in a GTP-dependent manner.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RASL10A gene
Compartment Confidence
nucleus 4
plasma membrane 3
extracellular 1
cytoskeleton 1
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for RASL10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with RASL10A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RASL10A Gene

Pathways & Interactions for RASL10A Gene

PathCards logo

SuperPathways for RASL10A Gene

No Data Available

Gene Ontology (GO) - Biological Process for RASL10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007264 small GTPase mediated signal transduction TAS 8975699
genes like me logo Genes that share ontologies with RASL10A: view

No data available for Pathways by source and SIGNOR curated interactions for RASL10A Gene

Drugs & Compounds for RASL10A Gene

No Compound Related Data Available

Transcripts for RASL10A Gene

mRNA/cDNA for RASL10A Gene

7 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RASL10A

Alternative Splicing Database (ASD) splice patterns (SP) for RASL10A Gene

ExUns: 1a · 1b ^ 2 ^ 3

Relevant External Links for RASL10A Gene

GeneLoc Exon Structure for

Expression for RASL10A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RASL10A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RASL10A Gene

This gene is overexpressed in Brain - Amygdala (x6.9), Brain - Cortex (x5.9), Brain - Anterior cingulate cortex (BA24) (x5.5), Brain - Hippocampus (x5.0), and Brain - Frontal Cortex (BA9) (x4.8).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RASL10A

SOURCE GeneReport for Unigene cluster for RASL10A Gene:


mRNA Expression by UniProt/SwissProt for RASL10A Gene:

Tissue specificity: Expression appears to be strictly limited to the central nervous system.

Evidence on tissue expression from TISSUES for RASL10A Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with RASL10A: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RASL10A Gene

Orthologs for RASL10A Gene

This gene was present in the common ancestor of animals.

Orthologs for RASL10A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RASL10A 30 31
  • 100 (n)
(Canis familiaris)
Mammalia RASL10A 30 31
  • 93.1 (n)
(Bos Taurus)
Mammalia RASL10A 30 31
  • 92.45 (n)
(Mus musculus)
Mammalia Rasl10a 30 17 31
  • 86.7 (n)
(Monodelphis domestica)
Mammalia RASL10A 31
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia RASL10A 31
  • 67 (a)
(Anolis carolinensis)
Reptilia -- 31
  • 31 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia rasl10a 30
  • 56.18 (n)
(Danio rerio)
Actinopterygii rasl10a 31
  • 53 (a)
Fruit Fly
(Drosophila melanogaster)
Insecta CG14669 31
  • 22 (a)
Species where no ortholog for RASL10A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for RASL10A Gene

Gene Tree for RASL10A (if available)
Gene Tree for RASL10A (if available)
Evolutionary constrained regions (ECRs) for RASL10A: view image

Paralogs for RASL10A Gene

(5) SIMAP similar genes for RASL10A Gene using alignment to 2 proteins:

  • L8E9A0_HUMAN
genes like me logo Genes that share paralogs with RASL10A: view

Variants for RASL10A Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for RASL10A Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for RASL10A Gene

Variant ID Type Subtype PubMed ID
nsv829154 CNV gain 20364138
nsv829155 CNV loss 20364138
nsv834171 CNV loss 17160897

Variation tolerance for RASL10A Gene

Gene Damage Index Score: 0.13; 3.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RASL10A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RASL10A Gene

Disorders for RASL10A Gene

Additional Disease Information for RASL10A

No disorders were found for RASL10A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RASL10A Gene

Publications for RASL10A Gene

  1. RRP22 is a farnesylated, nucleolar, Ras-related protein with tumor suppressor potential. (PMID: 15833841) Elam C … Clark GJ (Cancer research 2005) 3 4 23
  2. Identification of new members of the Gas2 and Ras families in the 22q12 chromosome region. (PMID: 8975699) Zucman-Rossi J … Thomas G (Genomics 1996) 2 3 4
  3. The Ras superfamily at a glance. (PMID: 15731001) Wennerberg K … Der CJ (Journal of cell science 2005) 2 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for RASL10A Gene

Sources for RASL10A Gene