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Aliases for RASL10A Gene

Aliases for RASL10A Gene

  • RAS Like Family 10 Member A 2 3 5
  • Ras-Related Protein On Chromosome 22 3 4
  • Ras-Like Protein RRP22 3 4
  • RRP22 3 4
  • Ras-Like Protein Family Member 10A 3
  • RAS-Like, Family 10, Member A 2
  • RAS-Like Family 10 Member A 2

External Ids for RASL10A Gene

Previous GeneCards Identifiers for RASL10A Gene

  • GC22M028038
  • GC22M029708
  • GC22M012673

Summaries for RASL10A Gene

GeneCards Summary for RASL10A Gene

RASL10A (RAS Like Family 10 Member A) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RASL10B.

UniProtKB/Swiss-Prot for RASL10A Gene

  • Potent inhibitor of cellular proliferation.

Additional gene information for RASL10A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASL10A Gene

Genomics for RASL10A Gene

GeneHancer (GH) Regulatory Elements for RASL10A Gene

Promoters and enhancers for RASL10A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22I029312 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 550.8 +4.8 4796 4.3 ZNF76 SIN3A RAD21 ZNF335 GLIS2 ZNF366 ZNF143 EGR2 USF2 ZNF398 RASL10A GAS2L1 EWSR1 ENSG00000237015 RHBDD3 CCDC117 ENSG00000273216
GH22I029381 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 20.1 -65.7 -65725 8.1 PKNOX1 SMAD1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 SLC30A9 AP1B1 RASL10A SNORD125 ZNRF3 GAS2L1 RHBDD3 LOC102723305 MIR3653
GH22I029265 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 16.3 +51.1 51109 6.6 HDGF PKNOX1 CLOCK FOXA2 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 EWSR1 RHBDD3 GAS2L1 RASL10A
GH22I029341 Enhancer 1.1 ENCODE dbSUPER 20.7 -23.7 -23743 3.4 PKNOX1 FOXA2 NEUROD1 SIN3A FOS RXRA TSHZ1 ZNF518A ZSCAN16 GLIS1 RASL10A GAS2L1 ENSG00000237015 RHBDD3 MIR3653 LOC102723305 AP1B1
GH22I029479 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE 10.4 -161.0 -161017 4.5 ATF1 SIN3A ZNF766 GLIS2 ZNF143 ATF7 SP3 NCOA1 MIER2 REST NEFH ENSG00000282816 THOC5 RFPL1 RNF215 RASL10A EWSR1 NIPSNAP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RASL10A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RASL10A gene promoter:

Genomic Locations for RASL10A Gene

Genomic Locations for RASL10A Gene
chr22:29,312,933-29,319,679
(GRCh38/hg38)
Size:
6,747 bases
Orientation:
Minus strand
chr22:29,708,922-29,715,668
(GRCh37/hg19)

Genomic View for RASL10A Gene

Genes around RASL10A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RASL10A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RASL10A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASL10A Gene

Proteins for RASL10A Gene

  • Protein details for RASL10A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92737-RSLAA_HUMAN
    Recommended name:
    Ras-like protein family member 10A
    Protein Accession:
    Q92737
    Secondary Accessions:
    • Q49AU5
    • Q6PI03

    Protein attributes for RASL10A Gene

    Size:
    203 amino acids
    Molecular mass:
    22541 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RASL10A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RASL10A Gene

Post-translational modifications for RASL10A Gene

  • Isoprenylation is essential for nucleolar localization, and the proliferation-inhibiting activity of RASL10A.

Other Protein References for RASL10A Gene

No data available for DME Specific Peptides for RASL10A Gene

Domains & Families for RASL10A Gene

Gene Families for RASL10A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RASL10A Gene

Suggested Antigen Peptide Sequences for RASL10A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92737

UniProtKB/Swiss-Prot:

RSLAA_HUMAN :
  • Belongs to the small GTPase superfamily. Ras family.
Family:
  • Belongs to the small GTPase superfamily. Ras family.
genes like me logo Genes that share domains with RASL10A: view

Function for RASL10A Gene

Molecular function for RASL10A Gene

UniProtKB/Swiss-Prot Function:
Potent inhibitor of cellular proliferation.

Phenotypes From GWAS Catalog for RASL10A Gene

Gene Ontology (GO) - Molecular Function for RASL10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA,TAS --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RASL10A: view
genes like me logo Genes that share phenotypes with RASL10A: view

Animal Model Products

miRNA for RASL10A Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RASL10A Gene

Localization for RASL10A Gene

Subcellular locations from UniProtKB/Swiss-Prot for RASL10A Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Nucleus, nucleolus. Note=May cycle in and out of the nucleolus in a GTP-dependent manner.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RASL10A gene
Compartment Confidence
nucleus 4
plasma membrane 3
extracellular 1
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for RASL10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with RASL10A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RASL10A Gene

Pathways & Interactions for RASL10A Gene

SuperPathways for RASL10A Gene

No Data Available

Gene Ontology (GO) - Biological Process for RASL10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007264 small GTPase mediated signal transduction TAS 8975699
genes like me logo Genes that share ontologies with RASL10A: view

No data available for Pathways by source and SIGNOR curated interactions for RASL10A Gene

Drugs & Compounds for RASL10A Gene

No Compound Related Data Available

Transcripts for RASL10A Gene

Unigene Clusters for RASL10A Gene

RAS-like, family 10, member A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RASL10A Gene

ExUns: 1a · 1b ^ 2 ^ 3
SP1:
SP2:

Relevant External Links for RASL10A Gene

GeneLoc Exon Structure for
RASL10A
ECgene alternative splicing isoforms for
RASL10A

Expression for RASL10A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RASL10A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RASL10A Gene

This gene is overexpressed in Brain - Amygdala (x6.9), Brain - Cortex (x5.9), Brain - Anterior cingulate cortex (BA24) (x5.5), Brain - Hippocampus (x5.0), and Brain - Frontal Cortex (BA9) (x4.8).

NURSA nuclear receptor signaling pathways regulating expression of RASL10A Gene:

RASL10A

SOURCE GeneReport for Unigene cluster for RASL10A Gene:

Hs.73088

mRNA Expression by UniProt/SwissProt for RASL10A Gene:

Q92737-RSLAA_HUMAN
Tissue specificity: Expression appears to be strictly limited to the central nervous system.

Evidence on tissue expression from TISSUES for RASL10A Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with RASL10A: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RASL10A Gene

Orthologs for RASL10A Gene

This gene was present in the common ancestor of animals.

Orthologs for RASL10A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RASL10A 33 34
  • 100 (n)
dog
(Canis familiaris)
Mammalia RASL10A 33 34
  • 93.1 (n)
cow
(Bos Taurus)
Mammalia RASL10A 33 34
  • 92.45 (n)
mouse
(Mus musculus)
Mammalia Rasl10a 33 16 34
  • 86.7 (n)
oppossum
(Monodelphis domestica)
Mammalia RASL10A 34
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RASL10A 34
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 31 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia rasl10a 33
  • 56.18 (n)
zebrafish
(Danio rerio)
Actinopterygii rasl10a 34
  • 53 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG14669 34
  • 22 (a)
OneToMany
Species where no ortholog for RASL10A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RASL10A Gene

ENSEMBL:
Gene Tree for RASL10A (if available)
TreeFam:
Gene Tree for RASL10A (if available)

Paralogs for RASL10A Gene

(5) SIMAP similar genes for RASL10A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RASL10A: view

Variants for RASL10A Gene

Sequence variations from dbSNP and Humsavar for RASL10A Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000001882 -- 29,318,208(-) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000142819 -- 29,315,986(-) C/T coding_sequence_variant, genic_upstream_transcript_variant, intron_variant, missense_variant, upstream_transcript_variant
rs1000520114 -- 29,318,002(-) A/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000865897 -- 29,316,166(-) A/G 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001123125 -- 29,316,680(-) T/C 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RASL10A Gene

Variant ID Type Subtype PubMed ID
nsv829154 CNV gain 20364138
nsv829155 CNV loss 20364138
nsv834171 CNV loss 17160897

Variation tolerance for RASL10A Gene

Gene Damage Index Score: 0.13; 3.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RASL10A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RASL10A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASL10A Gene

Disorders for RASL10A Gene

Additional Disease Information for RASL10A

No disorders were found for RASL10A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RASL10A Gene

Publications for RASL10A Gene

  1. RRP22 is a farnesylated, nucleolar, Ras-related protein with tumor suppressor potential. (PMID: 15833841) Elam C … Clark GJ (Cancer research 2005) 3 4 22 58
  2. Identification of new members of the Gas2 and Ras families in the 22q12 chromosome region. (PMID: 8975699) Zucman-Rossi J … Thomas G (Genomics 1996) 2 3 4 58
  3. The Ras superfamily at a glance. (PMID: 15731001) Wennerberg K … Der CJ (Journal of cell science 2005) 2 3 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for RASL10A Gene

Sources for RASL10A Gene

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