RASIP1 Gene (Protein Coding)

Ras Interacting Protein 1

GC19M048720
GIFtS:
36
See more...

Aliases for RASIP1 Gene

Aliases for RASIP1 Gene

  • Ras Interacting Protein 1 2 3 5
  • Ras-Interacting Protein 1 3 4
  • RAIN 2 3
  • FLJ20401 2
  • RASIP1 5
  • Rain 4

External Ids for RASIP1 Gene

Previous GeneCards Identifiers for RASIP1 Gene

  • GC19M053916
  • GC19M053917
  • GC19M049223
  • GC19M045604

Summaries for RASIP1 Gene

GeneCards Summary for RASIP1 Gene

RASIP1 (Ras Interacting Protein 1) is a Protein Coding gene. Diseases associated with RASIP1 include Peroxisomal Acyl-Coa Oxidase Deficiency and Cerebral Cavernous Malformations. An important paralog of this gene is RADIL.

UniProtKB/Swiss-Prot Summary for RASIP1 Gene

  • Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells (By similarity). May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS-mediated transformation. Negative regulator of amino acid starvation-induced autophagy.

Additional gene information for RASIP1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RASIP1 Gene

Genomics for RASIP1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for RASIP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RASIP1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RASIP1

Top Transcription factor binding sites by QIAGEN in the RASIP1 gene promoter:
  • ATF
  • MyoD
  • p300
  • STAT3

Genomic Locations for RASIP1 Gene

Genomic Locations for RASIP1 Gene
chr19:48,720,585-48,740,610
(GRCh38/hg38)
Size:
20,026 bases
Orientation:
Minus strand
chr19:49,223,842-49,243,978
(GRCh37/hg19)
Size:
20,137 bases
Orientation:
Minus strand

Genomic View for RASIP1 Gene

Genes around RASIP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RASIP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RASIP1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for RASIP1 Gene

Proteins for RASIP1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for RASIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5U651-RAIN_HUMAN
    Recommended name:
    Ras-interacting protein 1
    Protein Accession:
    Q5U651
    Secondary Accessions:
    • Q6U676

    Protein attributes for RASIP1 Gene

    Size:
    963 amino acids
    Molecular mass:
    103457 Da
    Quaternary structure:
    • Interacts with Ras family members that have been activated by GTP binding. Interacts with HRAS, RAP1A, RAP2, RRAS, RAF1 and RRAS2. Interacts with MYH9 and ARHGAP29 (By similarity).

    Three dimensional structures from OCA and Proteopedia for RASIP1 Gene

neXtProt entry for RASIP1 Gene

Protein Expression for RASIP1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for RASIP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RASIP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RASIP1 Gene

Domains & Families for RASIP1 Gene

Gene Families for RASIP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RASIP1 Gene

InterPro:
Blocks:
  • RA domain
ProtoNet:

Suggested Antigen Peptide Sequences for RASIP1 Gene

GenScript: Design optimal peptide antigens:
  • RASIP1 protein (Q7L251_HUMAN)
  • RASIP1 protein (Q8IUR2_HUMAN)
  • Ras-interacting protein 1 (RAIN_HUMAN)
genes like me logo Genes that share domains with RASIP1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for RASIP1 Gene

Function for RASIP1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for RASIP1 Gene

UniProtKB/Swiss-Prot Function:
Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells (By similarity). May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS-mediated transformation. Negative regulator of amino acid starvation-induced autophagy.

Phenotypes From GWAS Catalog for RASIP1 Gene

Gene Ontology (GO) - Molecular Function for RASIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 26780829
GO:0042803 protein homodimerization activity IDA 26780829
GO:0051020 GTPase binding IPI 26780829
genes like me logo Genes that share ontologies with RASIP1: view
genes like me logo Genes that share phenotypes with RASIP1: view

Animal Models for RASIP1 Gene

MGI Knock Outs for RASIP1:

Animal Model Products

CRISPR Products

miRNA for RASIP1 Gene

miRTarBase miRNAs that target RASIP1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RASIP1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RASIP1 Gene

Localization for RASIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RASIP1 Gene

Cytoplasm, perinuclear region. Golgi apparatus, Golgi stack. Note=Associated with perinuclear vesicles. Is recruited to Golgi stacks by activated HRAS.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RASIP1 gene
Compartment Confidence
nucleus 3
golgi apparatus 3
cytoskeleton 2
cytosol 2
plasma membrane 1
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1

Gene Ontology (GO) - Cellular Components for RASIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005795 Golgi stack IEA --
GO:0005911 cell-cell junction IMP 26780829
GO:0032991 protein-containing complex IDA 26780829
genes like me logo Genes that share ontologies with RASIP1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RASIP1 Gene

Pathways & Interactions for RASIP1 Gene

PathCards logo

SuperPathways for RASIP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RASIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis ISS --
GO:0001570 vasculogenesis IEA,ISS --
GO:0007165 signal transduction IEA --
GO:0010507 negative regulation of autophagy IMP 22354037
GO:0033625 positive regulation of integrin activation IMP 26780829
genes like me logo Genes that share ontologies with RASIP1: view

No data available for Pathways by source and SIGNOR curated interactions for RASIP1 Gene

Drugs & Compounds for RASIP1 Gene

Products:

  1. Drug

(1) Drugs for RASIP1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RASIP1: view

Transcripts for RASIP1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for RASIP1 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RASIP1

Alternative Splicing Database (ASD) splice patterns (SP) for RASIP1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: - -
SP2:
SP3: -
SP4: - - - - - -
SP5:

Relevant External Links for RASIP1 Gene

GeneLoc Exon Structure for
RASIP1

Expression for RASIP1 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RASIP1 Gene

mRNA expression in normal human tissues for RASIP1 Gene
mRNA expression by BioGPS for RASIP1 GenemRNA expression by GTEx for RASIP1 Gene

Protein differential expression in normal tissues from HIPED for RASIP1 Gene

This gene is overexpressed in Lung (12.4), Brain (8.8), Heart (6.7), Placenta (6.4), and Platelet (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RASIP1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RASIP1

SOURCE GeneReport for Unigene cluster for RASIP1 Gene:

Hs.233955

mRNA Expression by UniProt/SwissProt for RASIP1 Gene:

Q5U651-RAIN_HUMAN
Tissue specificity: Highly expressed in heart. Detected at lower levels in placenta and pancreas.

Evidence on tissue expression from TISSUES for RASIP1 Gene

  • Liver(4.3)
  • Muscle(4.3)
  • Nervous system(4.3)
  • Heart(2.3)
genes like me logo Genes that share expression patterns with RASIP1: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RASIP1 Gene

Orthologs for RASIP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RASIP1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia RASIP1 31
  • 97 (a)
 OneToOne
Dog
(Canis familiaris)
 Mammalia RASIP1 30 31
  • 91.35 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia RASIP1 30 31
  • 90.69 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Rasip1 30
  • 86.61 (n)
Mouse
(Mus musculus)
 Mammalia Rasip1 30 17 31
  • 85.41 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia RASIP1 31
  • 62 (a)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia RASIP1 31
  • 50 (a)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia RASIP1 31
  • 54 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia rasip1 30
  • 58.65 (n)
Zebrafish
(Danio rerio)
 Actinopterygii LOC100151130 30
  • 52.7 (n)
rasip1 31
  • 41 (a)
 OneToOne
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 24 (a)
 OneToMany
Species where no ortholog for RASIP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for RASIP1 Gene

ENSEMBL:
Gene Tree for RASIP1 (if available)
TreeFam:
Gene Tree for RASIP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RASIP1: view image

Paralogs for RASIP1 Gene

Paralogs for RASIP1 Gene

(1) SIMAP similar genes for RASIP1 Gene using alignment to 4 proteins:

  • RAIN_HUMAN
  • M0R148_HUMAN
  • Q7L251_HUMAN
  • Q8IUR2_HUMAN
genes like me logo Genes that share paralogs with RASIP1: view

Variants for RASIP1 Gene

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  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RASIP1 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs2287922 - p.Arg601Cys

Additional dbSNP identifiers (rs#s) for RASIP1 Gene

Structural Variations from Database of Genomic Variants (DGV) for RASIP1 Gene

Variant ID Type Subtype PubMed ID
nsv1144878 CNV deletion 24896259
nsv471822 CNV novel sequence insertion 20440878
nsv9739 CNV gain+loss 18304495

Variation tolerance for RASIP1 Gene

Residual Variation Intolerance Score: 29.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.38; 81.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RASIP1 Gene

Human Gene Mutation Database (HGMD)
RASIP1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RASIP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASIP1 Gene

Disorders for RASIP1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for RASIP1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
peroxisomal acyl-coa oxidase deficiency
  • straight-chain acyl-coa oxidase deficiency
cerebral cavernous malformations
  • cam
sotos syndrome 1
  • sotos1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for RASIP1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with RASIP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RASIP1 Gene

Publications for RASIP1 Gene

  1. Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization. (PMID: 15031288) Mitin NY … Taparowsky EJ (The Journal of biological chemistry 2004) 2 3 4 23
  2. Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC. (PMID: 22354037) McKnight NC … Tooze SA (The EMBO journal 2012) 3 4
  3. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. (PMID: 21926972) Psychiatric GWAS Consortium Bipolar Disorder Working Group (Nature genetics 2011) 3 41
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  5. Four novel Loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo. (PMID: 21060863) Ikram MK … Wong TY (PLoS genetics 2010) 3 41

ExternalLinks

View latest publications for RASIP1 gene in Mastermind

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