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RASIP1 Gene(Protein Coding)

Ras Interacting Protein 1

GCID:
GC19M048720
GIFtS:
42
Genes Participants
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Aliases for RASIP1 Gene

Aliases for RASIP1 Gene

  • Ras Interacting Protein 1 2 3 5
  • Ras-Interacting Protein 1 3 4
  • RAIN 3
  • Rain 4

External Ids for RASIP1 Gene

Previous GeneCards Identifiers for RASIP1 Gene

  • GC19M053916
  • GC19M053917
  • GC19M049223
  • GC19M045604

Summaries for RASIP1 Gene

GeneCards Summary for RASIP1 Gene

RASIP1 (Ras Interacting Protein 1) is a Protein Coding gene. Diseases associated with RASIP1 include Enamel Erosion and Tooth Erosion. An important paralog of this gene is RADIL.

UniProtKB/Swiss-Prot for RASIP1 Gene

  • Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells (By similarity). May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS-mediated transformation. Negative regulator of amino acid starvation-induced autophagy.

Additional gene information for RASIP1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASIP1 Gene

Genomics for RASIP1 Gene

GeneHancer (GH) Regulatory Elements for RASIP1 Gene

Promoters and enhancers for RASIP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH19J048736 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 600.7 +1.3 1257 5.5 SP1 ZFX CTCF POLR2A MLLT1 ZNF121 GTF2F1 ZNF687 KLF14 PRDM1 RASIP1 FUT2 IZUMO1 SNRNP70 PRR12 CYTH2 ENSG00000268093 PRMT1 LIG1 SEC1P
GH19J048750 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 22 -11.6 -11606 4.1 ZFX SP1 CBFA2T2 MLLT1 ZNF121 CSDE1 NFIB ZSCAN21 MAFK MYC FUT1 GC19P048754 PRR12 FUT2 GRWD1 SNRNP70 RASIP1 SNORD35A ADM5 IZUMO1
GH19J047741 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 18.9 +996.7 996709 5.4 SP1 ZFX CTCF ELF3 MNT SIX5 ZNF148 NKRF POLR2A MLLT1 NOP53 ZC3H4 BICRA SELENOW GRWD1 RASIP1 CA11 ENSG00000268093 ZSWIM9 NOP53-AS1
GH19J048712 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 17.7 +23.5 23512 9 HDGF SP1 CC2D1A ZFX ELF3 MNT SIX5 ZNF148 POLR2A ZNF121 MAMSTR FUT2 IZUMO1 RASIP1 GRWD1 NOP53-AS1 SNRNP70 NOSIP RUVBL2 DKKL1
GH19J049442 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 18.9 -701.9 -701914 3.5 SP1 CC2D1A CTCF SIX5 CBFA2T2 ZNF148 NKRF GTF2F1 MYC ZBTB7A GC19M049443 SLC17A7 ALDH16A1 PRR12 GRWD1 SNORD35A SNORD35B SNRNP70 POLD1 PIH1D1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RASIP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RASIP1 gene promoter:
  • ATF
  • MyoD
  • p300
  • STAT3

Genomic Locations for RASIP1 Gene

Genomic Locations for RASIP1 Gene
chr19:48,720,585-48,740,813
(GRCh38/hg38)
Size:
20,229 bases
Orientation:
Minus strand
chr19:49,223,842-49,243,978
(GRCh37/hg19)
Size:
20,137 bases
Orientation:
Minus strand

Genomic View for RASIP1 Gene

Genes around RASIP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RASIP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RASIP1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for RASIP1 Gene

Proteins for RASIP1 Gene

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  • Protein details for RASIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5U651-RAIN_HUMAN
    Recommended name:
    Ras-interacting protein 1
    Protein Accession:
    Q5U651
    Secondary Accessions:
    • Q6U676

    Protein attributes for RASIP1 Gene

    Size:
    963 amino acids
    Molecular mass:
    103457 Da
    Quaternary structure:
    • Interacts with Ras family members that have been activated by GTP binding. Interacts with HRAS, RAP1A, RAP2, RRAS, RAF1 and RRAS2. Interacts with MYH9 and ARHGAP29 (By similarity).

    Three dimensional structures from OCA and Proteopedia for RASIP1 Gene

neXtProt entry for RASIP1 Gene

Protein Expression for RASIP1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for RASIP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RASIP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RASIP1 Gene

Domains & Families for RASIP1 Gene

Gene Families for RASIP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RASIP1 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RASIP1 Gene

GenScript: Design optimal peptide antigens:
  • RASIP1 protein (Q7L251_HUMAN)
  • RASIP1 protein (Q8IUR2_HUMAN)
  • Ras-interacting protein 1 (RAIN_HUMAN)

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RASIP1: view

No data available for UniProtKB/Swiss-Prot for RASIP1 Gene

Function for RASIP1 Gene

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  1. Animal Model
  2. CRISPR
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  4. Inhibitory RNA
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Molecular function for RASIP1 Gene

UniProtKB/Swiss-Prot Function:
Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells (By similarity). May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS-mediated transformation. Negative regulator of amino acid starvation-induced autophagy.

Phenotypes From GWAS Catalog for RASIP1 Gene

Gene Ontology (GO) - Molecular Function for RASIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 26780829
GO:0042803 protein homodimerization activity IDA 26780829
GO:0051020 GTPase binding IPI 26780829
genes like me logo Genes that share ontologies with RASIP1: view
genes like me logo Genes that share phenotypes with RASIP1: view

Animal Models for RASIP1 Gene

MGI Knock Outs for RASIP1:

Animal Model Products

CRISPR Products

miRNA for RASIP1 Gene

miRTarBase miRNAs that target RASIP1

Clone Products

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  • * RASIP1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RASIP1 Gene

Localization for RASIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RASIP1 Gene

Cytoplasm, perinuclear region. Golgi apparatus, Golgi stack. Note=Associated with perinuclear vesicles. Is recruited to Golgi stacks by activated HRAS.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RASIP1 gene
Compartment Confidence
golgi apparatus 3
nucleus 2
cytoskeleton 1
cytosol 1

Gene Ontology (GO) - Cellular Components for RASIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005795 Golgi stack IEA --
GO:0005911 cell-cell junction IMP 26780829
GO:0032991 protein-containing complex IDA 26780829
genes like me logo Genes that share ontologies with RASIP1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RASIP1 Gene

Pathways & Interactions for RASIP1 Gene

GeneAnalytics - gene set analysis. Cells, Diseases, Pathways, Function and Compounds, relevant to your gene set. Powered by GeneCards
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SuperPathways for RASIP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RASIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis ISS --
GO:0001570 vasculogenesis ISS,IEA --
GO:0007165 signal transduction IEA --
GO:0010507 negative regulation of autophagy IMP 22354037
GO:0033625 positive regulation of integrin activation IMP 26780829
genes like me logo Genes that share ontologies with RASIP1: view

No data available for Pathways by source and SIGNOR curated interactions for RASIP1 Gene

Drugs & Compounds for RASIP1 Gene

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  1. Drug
GeneAnalytics - gene set analysis. Cells, Diseases, Pathways, Function and Compounds, relevant to your gene set. Powered by GeneCards

(1) Drugs for RASIP1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RASIP1: view

Transcripts for RASIP1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for RASIP1 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(68) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for RASIP1 Gene

Ras interacting protein 1:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for RASIP1 - Now 50% OFF >
  • * RASIP1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * RASIP1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for RASIP1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: - -
SP2:
SP3: -
SP4: - - - - - -
SP5:

Relevant External Links for RASIP1 Gene

GeneLoc Exon Structure for
RASIP1
ECgene alternative splicing isoforms for
RASIP1

Expression for RASIP1 Gene

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  1. Primer
  2. Gene Expression Assay
GeneAnalytics - gene set analysis. Cells, Diseases, Pathways, Function and Compounds, relevant to your gene set. Powered by GeneCards

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RASIP1 Gene

mRNA expression in normal human tissues for RASIP1 Gene
mRNA expression by BioGPS for RASIP1 GenemRNA expression by GTEx for RASIP1 Gene

Protein differential expression in normal tissues from HIPED for RASIP1 Gene

This gene is overexpressed in Lung (12.4), Brain (8.8), Heart (6.7), Placenta (6.4), and Platelet (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RASIP1 Gene



NURSA nuclear receptor signaling pathways regulating expression of RASIP1 Gene:

RASIP1

SOURCE GeneReport for Unigene cluster for RASIP1 Gene:

Hs.233955

mRNA Expression by UniProt/SwissProt for RASIP1 Gene:

Q5U651-RAIN_HUMAN
Tissue specificity: Highly expressed in heart. Detected at lower levels in placenta and pancreas.

Evidence on tissue expression from TISSUES for RASIP1 Gene

  • Liver(4.2)
  • Muscle(4.1)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with RASIP1: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RASIP1 Gene

Orthologs for RASIP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RASIP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia RASIP1 35
  • 97 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia RASIP1 35 34
  • 91.35 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia RASIP1 35 34
  • 90.69 (n)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Rasip1 34
  • 86.61 (n)
mouse
(Mus musculus)
 Mammalia Rasip1 17 35 34
  • 85.41 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia RASIP1 35
  • 62 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia RASIP1 35
  • 50 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia RASIP1 35
  • 54 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia rasip1 34
  • 58.65 (n)
zebrafish
(Danio rerio)
 Actinopterygii LOC100151130 34
  • 52.7 (n)
rasip1 35
  • 41 (a)
 OneToOne
sea squirt
(Ciona savignyi)
 Ascidiacea -- 35
  • 24 (a)
 OneToMany
Species where no ortholog for RASIP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RASIP1 Gene

ENSEMBL:
Gene Tree for RASIP1 (if available)
TreeFam:
Gene Tree for RASIP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RASIP1: view image

Paralogs for RASIP1 Gene

Paralogs for RASIP1 Gene

(1) SIMAP similar genes for RASIP1 Gene using alignment to 4 proteins:

  • RAIN_HUMAN
  • M0R148_HUMAN
  • Q7L251_HUMAN
  • Q8IUR2_HUMAN
genes like me logo Genes that share paralogs with RASIP1: view

Variants for RASIP1 Gene

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VarElect - NGS phenotyper. Rapid prioritization of variants from NGS data powered by 100+ GeneCards sources

Sequence variations from dbSNP and Humsavar for RASIP1 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000154500 -- 48,742,383(-) T/G upstream_transcript_variant
rs1000228340 -- 48,724,400(-) C/T coding_sequence_variant, non_coding_transcript_variant, synonymous_variant
rs1000274117 -- 48,723,975(-) T/C intron_variant
rs1000580411 -- 48,724,643(-) T/C intron_variant
rs1000659642 -- 48,722,657(-) C/G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RASIP1 Gene

Variant ID Type Subtype PubMed ID
nsv1144878 CNV deletion 24896259
nsv471822 CNV novel sequence insertion 20440878
nsv9739 CNV gain+loss 18304495

Variation tolerance for RASIP1 Gene

Residual Variation Intolerance Score: 29.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.38; 81.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RASIP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RASIP1
Human Gene Mutation Database (HGMD)
RASIP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASIP1 Gene

Disorders for RASIP1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for RASIP1 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
enamel erosion
tooth erosion
  • generalized erosion
sotos syndrome 1
  • sotos1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for RASIP1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with RASIP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RASIP1 Gene

Publications for RASIP1 Gene

  1. Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization. (PMID: 15031288) Mitin NY … Taparowsky EJ (The Journal of biological chemistry 2004) 2 3 4 23 58
  2. Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC. (PMID: 22354037) McKnight NC … Tooze SA (The EMBO journal 2012) 3 4 58
  3. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. (PMID: 21926972) Psychiatric GWAS Consortium Bipolar Disorder Working Group (Nature genetics 2011) 3 45 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 58
  5. Four novel Loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo. (PMID: 21060863) Ikram MK … Wong TY (PLoS genetics 2010) 3 45 58

ExternalLinks

View latest publications for RASIP1 gene in Mastermind

Products for RASIP1 Gene

Sources for RASIP1 Gene

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