Aliases for RASIP1 Gene
External Ids for RASIP1 Gene
Previous GeneCards Identifiers for RASIP1 Gene
GeneCards Summary for RASIP1 Gene
RASIP1 (Ras Interacting Protein 1) is a Protein Coding gene. Diseases associated with RASIP1 include Peroxisomal Acyl-Coa Oxidase Deficiency and Cerebral Cavernous Malformations. An important paralog of this gene is RADIL.
UniProtKB/Swiss-Prot Summary for RASIP1 Gene
Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells (By similarity). May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS-mediated transformation. Negative regulator of amino acid starvation-induced autophagy.