Aliases for RASGRP3 Gene
External Ids for RASGRP3 Gene
Previous GeneCards Identifiers for RASGRP3 Gene
The protein encoded by this gene is a guanine nucleotide exchange factor that activates the oncogenes HRAS and RAP1A. Defects in this gene have been associated with systemic lupus erythematosus and several cancers. [provided by RefSeq, Mar 2017]
GeneCards Summary for RASGRP3 Gene
RASGRP3 (RAS Guanyl Releasing Protein 3) is a Protein Coding gene. Diseases associated with RASGRP3 include Bleeding Disorder, Platelet-Type, 18 and Systemic Lupus Erythematosus. Among its related pathways are RET signaling and G-protein signaling M-RAS regulation pathway. Gene Ontology (GO) annotations related to this gene include calcium ion binding and GTPase activator activity. An important paralog of this gene is RASGRP1.
UniProtKB/Swiss-Prot Summary for RASGRP3 Gene
Guanine nucleotide exchange factor (GEF) for Ras and Rap1.