Aliases for RASGRP3 Gene
Aliases for RASGRP3 Gene
- RAS Guanyl Releasing Protein 3 2 3 5
- Calcium- And Diacylglycerol-Regulated Guanine Nucleotide Exchange Factor III 2 3
- Calcium And DAG-Regulated Guanine Nucleotide Exchange Factor III 3 4
- RAS Guanyl Releasing Protein 3 (Calcium And DAG-Regulated) 2 3
- Guanine Nucleotide Exchange Factor For Rap1 3 4
- GRP3 3 4
- Ras Guanyl-Releasing Protein 3 3
- CalDAG-GEFIII 3
- KIAA0846 4
External Ids for RASGRP3 Gene
- HGNC: 14545
- Entrez Gene: 25780
- Ensembl: ENSG00000152689
- OMIM: 609531
- UniProtKB: Q8IV61
Previous GeneCards Identifiers for RASGRP3 Gene
- GC02P033619
- GC02P033635
- GC02P033573
- GC02P033514
- GC02P033395
- GC02P033661
Summaries for RASGRP3 Gene
-
The protein encoded by this gene is a guanine nucleotide exchange factor that activates the oncogenes HRAS and RAP1A. Defects in this gene have been associated with systemic lupus erythematosus and several cancers. [provided by RefSeq, Mar 2017]
GeneCards Summary for RASGRP3 Gene
RASGRP3 (RAS Guanyl Releasing Protein 3) is a Protein Coding gene. Among its related pathways are Integrated Breast Cancer Pathway and RET signaling. Gene Ontology (GO) annotations related to this gene include calcium ion binding and GTPase activator activity. An important paralog of this gene is RASGRP1.
UniProtKB/Swiss-Prot for RASGRP3 Gene
-
Guanine nucleotide exchange factor (GEF) for Ras and Rap1.
Additional gene information for RASGRP3 Gene
- Monarch Initiative
- Search for RASGRP3 at DataMed
- Search for RASGRP3 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASGRP3 Gene
Genomics for RASGRP3 Gene
GeneHancer (GH) Regulatory Elements for RASGRP3 Gene
Promoters and enhancers for RASGRP3 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH02J033474 | Promoter/Enhancer | 2.5 | EPDnew FANTOM5 Ensembl ENCODE dbSUPER | 675.1 | +41.5 | 41502 | 6.1 | PKNOX1 FOXA2 SMAD1 SIN3A FEZF1 IRF4 YY1 ZNF143 JUNB REST | RASGRP3 TTC27 LOC105374454 | |
| GH02J033436 | Enhancer | 0.9 | Ensembl ENCODE | 650.7 | +1.3 | 1266 | 1.5 | HDAC1 MEIS2 ATF1 LEF1 PKNOX1 TEAD4 TAL1 CHAMP1 FOSL1 TCF12 | RASGRP3 LOC105374454 | |
| GH02J033437 | Promoter | 0.7 | EPDnew | 650.7 | -0.1 | -71 | 0.1 | POLR2A TAF1 | RASGRP3 MIR4430 | |
| GH02J033438 | Promoter | 0.7 | EPDnew | 650.7 | +0.0 | 30 | 0.1 | POLR2A TAF1 | RASGRP3 LOC105374454 | |
| GH02J033405 | Promoter | 0.5 | EPDnew | 661.7 | -30.7 | -30667 | 0.1 | RASGRP3 MIR4430 PIR50335 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around RASGRP3 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the RASGRP3 gene promoter:
-
- NF-kappaB
- CUTL1
- NF-kappaB1
- MEF-2A
- aMEF-2
- STAT5A
- SRY
- Sox5
- SRF
- SRF (504 AA)
Regulatory Element Products
Genomic Locations for RASGRP3 Gene
Genomic Locations for RASGRP3 Gene
- chr2:33,436,324-33,564,750
- (GRCh38/hg38)
- Size:
- 128,427 bases
- Orientation:
- Plus strand
- chr2:33,661,391-33,789,817
- (GRCh37/hg19)
- Size:
- 128,427 bases
- Orientation:
- Plus strand
Genomic View for RASGRP3 Gene
Genes around RASGRP3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2p22.3 by Entrez Gene
- 2p22.3 by HGNC
- 2p22.3 by Ensembl
RASGRP3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RASGRP3 Gene
Proteins for RASGRP3 Gene
-
Protein details for RASGRP3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8IV61-GRP3_HUMAN
- Recommended name:
- Ras guanyl-releasing protein 3
- Protein Accession:
- Q8IV61
- D6W583
- O94931
- Q53SD7
Protein attributes for RASGRP3 Gene
- Size:
- 690 amino acids
- Molecular mass:
- 78332 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAA74869.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for RASGRP3 Gene
Post-translational modifications for RASGRP3 Gene
Other Protein References for RASGRP3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for RASGRP3
-
Abcam antibodies for RASGRP3
- Invitrogen Antibodies for RASGRP3
- GeneTex RASGRP3 Antibody for RASGRP3
-
Santa Cruz Biotechnology (SCBT) Antibodies for RASGRP3
Protein Products
-
OriGene Purified Proteins for RASGRP3
- Search Origene for MassSpec and Protein Over-expression Lysates for RASGRP3
- Origene Custom Protein Services for RASGRP3
- antibodies-online: Search results for 6 available RASGRP3 Proteins ranked by validation data
- Compare Top RASGRP3 Proteins
-
Quality Products:
- Search GeneTex for Proteins for RASGRP3
-
Abcam proteins for RASGRP3
Assay Products
No data available for DME Specific Peptides for RASGRP3 Gene
Domains & Families for RASGRP3 Gene
Gene Families for RASGRP3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for RASGRP3 Gene
Suggested Antigen Peptide Sequences for RASGRP3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8IV61- Family:
-
- Belongs to the RASGRP family.
Function for RASGRP3 Gene
Molecular function for RASGRP3 Gene
- UniProtKB/Swiss-Prot Function:
- Guanine nucleotide exchange factor (GEF) for Ras and Rap1.
Phenotypes From GWAS Catalog for RASGRP3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004871 | obsolete signal transducer activity | TAS | -- |
| GO:0005085 | guanyl-nucleotide exchange factor activity | IEA,TAS | -- |
| GO:0005088 | Ras guanyl-nucleotide exchange factor activity | TAS | -- |
| GO:0005096 | GTPase activator activity | IDA,IEA | 10934204 |
| GO:0005509 | calcium ion binding | NAS | 10934204 |
Phenotypes for RASGRP3 Gene
- MGI mutant phenotypes for RASGRP3:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for RASGRP3:
-
- Increased shRNA abundance (Z-score > 2)
- Dynamic nuclei (hole, folded or small irregular)
- Decreased ionizing radiation sensitivity
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Resistant to vaccinia virus (VACV-A4L) infection
- Decreased shRNA abundance (Z-score < -2)
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased viability after Maraba virus infection
- Synthetic lethal with vaccinia virus (VACV) infection
Animal Models for RASGRP3 Gene
- MGI Knock Outs for RASGRP3:
-
- Rasgrp3 Rasgrp3<tm1Jstn>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for RASGRP3
-
CRISPR Products
-
OriGene CRISPR knockouts for RASGRP3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RASGRP3
- genomics-online: gRNA clones - Search results for 105 available RASGRP3 gene related products
- Overview of 105 available RASGRP3 gene related products
- Applied Biological Materials CRISPR for RASGRP3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for RASGRP3
- GenScript: Design CRISPR guide RNA sequences for RASGRP3
miRNA for RASGRP3 Gene
- miRTarBase miRNAs that target RASGRP3
-
- hsa-mir-21-5p (MIRT030769)
- hsa-mir-30a-5p (MIRT159242)
- hsa-mir-30c-5p (MIRT159243)
- hsa-mir-30d-5p (MIRT159244)
- hsa-mir-30b-5p (MIRT159246)
- hsa-mir-30e-5p (MIRT159250)
- hsa-mir-26a-5p (MIRT159273)
- hsa-mir-26b-5p (MIRT159274)
- hsa-mir-6824-5p (MIRT482998)
- hsa-mir-7106-5p (MIRT482999)
- hsa-mir-6825-5p (MIRT483000)
- hsa-mir-765 (MIRT483001)
- hsa-mir-766-5p (MIRT483002)
- hsa-mir-6782-5p (MIRT483003)
- hsa-mir-6783-5p (MIRT483004)
- hsa-mir-708-3p (MIRT483005)
- hsa-mir-335-3p (MIRT654430)
- hsa-mir-30e-3p (MIRT654431)
- hsa-mir-30d-3p (MIRT654432)
- hsa-mir-30a-3p (MIRT654433)
- hsa-mir-7977 (MIRT654434)
- hsa-mir-24-3p (MIRT654435)
- hsa-mir-4264 (MIRT654436)
- hsa-mir-138-2-3p (MIRT654437)
- hsa-mir-4267 (MIRT654438)
- hsa-mir-1910-5p (MIRT654439)
- hsa-mir-455-3p (MIRT654440)
- hsa-mir-5588-3p (MIRT654441)
- hsa-mir-484 (MIRT662168)
- hsa-mir-3155b (MIRT662169)
- hsa-mir-3155a (MIRT662170)
- hsa-mir-4438 (MIRT662171)
- hsa-mir-409-3p (MIRT732813)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RASGRP3
- Browse OriGene Inhibitory RNA Products For RASGRP3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RASGRP3
- genomics-online: shRNA clones - Search results for 105 available RASGRP3 gene related products
- Overview of 105 available RASGRP3 gene related products
Clone Products
-
OriGene ORF clones in human for RASGRP3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for RASGRP3
- VectorBuilder custom plasmid, inducible vectors for RASGRP3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RASGRP3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for RASGRP3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RASGRP3
- Applied Biological Materials Clones for RASGRP3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for RASGRP3
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RASGRP3 Gene
Localization for RASGRP3 Gene
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytosol | 2 |
| mitochondrion | 1 |
| nucleus | 1 |
| golgi apparatus | 1 |
- Golgi apparatus (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005622 | intracellular | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | NAS | 10934204 |
| GO:0032045 | guanyl-nucleotide exchange factor complex | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for RASGRP3 Gene
Pathways & Interactions for RASGRP3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | Downstream signaling events of B Cell Receptor (BCR) | ||
| 3 | B cell receptor signaling pathway (KEGG) | ||
| 4 | Ras signaling pathway | ||
| 5 | Developmental Biology |
.51
|
|
Pathways by source for RASGRP3 Gene
2 BioSystems pathways for RASGRP3 Gene
50 Reactome pathways for RASGRP3 Gene
5 KEGG pathways for RASGRP3 Gene
4 GeneGo (Thomson Reuters) pathways for RASGRP3 Gene
1 Qiagen pathway for RASGRP3 Gene
2 Cell Signaling Technology pathways for RASGRP3 Gene
Interacting Proteins for RASGRP3 Gene
Selected Interacting proteins:
ENSP00000384192
Q8IV61-GRP3_HUMAN
for RASGRP3 Gene via
STRING
IID
UniProtKB
GPS-Prot Interaction Network for RASGRP3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0007264 | small GTPase mediated signal transduction | TAS,IEA | 10934204 |
| GO:0007265 | Ras protein signal transduction | IEA | -- |
| GO:0035556 | intracellular signal transduction | IEA | -- |
| GO:0043087 | regulation of GTPase activity | IEA | -- |
Drugs & Compounds for RASGRP3 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Diglycerides Group A |
|
|
||||
| Diglycerides Group B |
|
|
||||
| Diglycerides Group D |
|
|
Transcripts for RASGRP3 Gene
mRNA/cDNA for RASGRP3 Gene
- (14) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (124) Selected AceView cDNA sequences:
- (18) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000402538 4738 bps (uc002rox.4)
- ENST00000484909 2144 bps (uc002row.2)
- ENST00000497723 558 bps (uc061hzh.1)
- ENST00000479528 631 bps (uc061hzi.1)
- ENST00000437184 861 bps (uc061hzj.1)
Unigene Clusters for RASGRP3 Gene
- RAS guanyl releasing protein 3 (calcium and DAG-regulated):
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for RASGRP3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RASGRP3
- genomics-online: gRNA clones - Search results for 105 available RASGRP3 gene related products
- Overview of 105 available RASGRP3 gene related products
- Applied Biological Materials CRISPR for RASGRP3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for RASGRP3
- GenScript: Design CRISPR guide RNA sequences for RASGRP3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RASGRP3
- Browse OriGene Inhibitory RNA Products For RASGRP3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RASGRP3
- genomics-online: shRNA clones - Search results for 105 available RASGRP3 gene related products
- Overview of 105 available RASGRP3 gene related products
Clone Products
-
OriGene ORF clones in human for RASGRP3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for RASGRP3
- VectorBuilder custom plasmid, inducible vectors for RASGRP3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RASGRP3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for RASGRP3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RASGRP3
- Applied Biological Materials Clones for RASGRP3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c | · | 11d | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ | 19a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: |
| ExUns: | 19b | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25a | · | 25b | · | 25c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||
| SP2: | - | ||||||||||||||||
| SP3: | - | ||||||||||||||||
| SP4: | |||||||||||||||||
| SP5: | |||||||||||||||||
| SP6: | |||||||||||||||||
| SP7: | |||||||||||||||||
| SP8: | |||||||||||||||||
| SP9: | |||||||||||||||||
| SP10: |
Expression for RASGRP3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Myelinating Oligodendrocyte Cells Forebrain White Matter
-
Glial Cells
- Myelinating Oligodendrocyte Cells Forebrain White Matter
-
Blood (Hematopoietic System)
- Mature B-Cells Peripheral Blood
- Bone (Muscoskeletal System)
- NULL (Uncategorized)
-
Dermis (Integumentary System)
mRNA differential expression in normal tissues according to GTEx for RASGRP3 Gene
This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x7.7).
This gene is overexpressed in Heart (37.4) and Liver (31.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RASGRP3 Gene
NURSA nuclear receptor signaling pathways regulating expression of RASGRP3 Gene:
RASGRP3SOURCE GeneReport for Unigene cluster for RASGRP3 Gene:
Hs.143674Evidence on tissue expression from TISSUES for RASGRP3 Gene
- Nervous system(4)
Primer Products
-
OriGene qPCR primer pairs for RASGRP3
- genomics-online: primer clones - Search results for 105 available RASGRP3 gene related products
- Overview of 105 available RASGRP3 gene related products
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RASGRP3 Gene
Orthologs for RASGRP3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | RASGRP3 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | RASGRP3 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | RASGRP3 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Rasgrp3 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | RASGRP3 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | RASGRP3 34 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Rasgrp3 33 |
|
||
| chicken (Gallus gallus) |
Aves | RASGRP3 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | RASGRP3 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | rasgrp3 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | rasgrp3 34 33 |
|
OneToOne | |
| worm (Caenorhabditis elegans) |
Secernentea | rgef-1 34 33 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for RASGRP3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for RASGRP3 Gene
- ENSEMBL:
- Gene Tree for RASGRP3 (if available)
- TreeFam:
- Gene Tree for RASGRP3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for RASGRP3: view image
Paralogs for RASGRP3 Gene
Paralogs for RASGRP3 Gene
(5) SIMAP similar genes for RASGRP3 Gene using alignment to 7 proteins:
- GRP3_HUMAN
- C9IYA5_HUMAN
- C9J9C9_HUMAN
- C9JSS2_HUMAN
- C9JWP0_HUMAN
- C9K0P4_HUMAN
- H7C352_HUMAN
Variants for RASGRP3 Gene
| SNP ID | Clin | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs2124437 | association, Lip and oral cavity carcinoma | 33,457,670(+) | G/T | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000023781 | -- | 33,505,946(+) | C/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000047483 | -- | 33,541,544(+) | T/C | genic_downstream_transcript_variant, intron_variant | |
| rs1000053257 | -- | 33,506,283(+) | A/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000101726 | -- | 33,439,712(+) | G/A | genic_upstream_transcript_variant, intron_variant |
Residual Variation Intolerance Score:
36.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.84;
67.16% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RASGRP3 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASGRP3 Gene
Disorders for RASGRP3 Gene
Additional Disease Information for RASGRP3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for RASGRP3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RASGRP3 Gene
Publications for RASGRP3 Gene
- Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction. (PMID: 10934204) Rebhun JF … Quilliam LA (The Journal of biological chemistry 2000) 2 3 4 22 58
- Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
- TNIP1, SLC15A4, ETS1, RasGRP3 and IKZF1 are associated with clinical features of systemic lupus erythematosus in a Chinese Han population. (PMID: 20516000) He CF … Yang S (Lupus 2010) 3 44 58
- Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. (PMID: 19838193) Han JW … Zhang XJ (Nature genetics 2009) 3 44 58
Products for RASGRP3 Gene
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- Custom Antibody ServicesOriGene Antibodies for RASGRP3
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- Custom Assay Services
- OriGene Purified Proteins for RASGRP3
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- GenScript: Next-day shipping of latest version cDNA ORF clones for RASGRP3 in any vector
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- Novus Biologicals Tissue Microarrays
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- Cyagen custom Knockout/knockin (KOKI) mouse models for RASGRP3
- VectorBuilder custom plasmid, inducible vectors for RASGRP3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RASGRP3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for RASGRP3
- antibodies-online: Search results for 42 available RASGRP3 Antibodies ranked by validation data
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- antibodies-online: Search results for available RASGRP3 related products ranked by validation data
- antibodies-online: Search results for 6 available RASGRP3 Proteins ranked by validation data
- Compare Top RASGRP3 Proteins
- Quality Products:
- GeneTex RASGRP3 Antibody for RASGRP3
- Search GeneTex for Proteins for RASGRP3
- Santa Cruz Biotechnology (SCBT) Antibodies for RASGRP3
- Search Santa Cruz Biotechnology (SCBT) for RASGRP3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for RASGRP3
- Horizon Cell Lines for RASGRP3
- genomics-online: cdna clones - Search results for 105 available RASGRP3 gene related products
- Overview of 105 available RASGRP3 gene related products
- orf clones - Search results for 105 available RASGRP3 gene related products
- Overview of 105 available RASGRP3 gene related products
- genomics-online: gRNA clones - Search results for 105 available RASGRP3 gene related products
- Overview of 105 available RASGRP3 gene related products
- genomics-online: primer clones - Search results for 105 available RASGRP3 gene related products
- Overview of 105 available RASGRP3 gene related products
- genomics-online: shRNA clones - Search results for 105 available RASGRP3 gene related products
- Overview of 105 available RASGRP3 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RASGRP3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RASGRP3
- GeneCopoeia miRNA 3'UTR Target clone products for RASGRP3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RASGRP3
Sources for RASGRP3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index