RASGRP3 Gene (Protein Coding)

RAS Guanyl Releasing Protein 3

GC02P033436
GIFtS:
42
The protein encoded by this gene is a guanine nucleotide exchange factor that activates the oncogenes HRAS and RAP1A. Defects in this gene have been associated with systemic lupus erythematosus and several cancers. [provided by RefSeq, Mar 2017] See more...

Aliases for RASGRP3 Gene

Aliases for RASGRP3 Gene

  • RAS Guanyl Releasing Protein 3 2 3 5
  • Calcium- And Diacylglycerol-Regulated Guanine Nucleotide Exchange Factor III 2 3
  • Calcium And DAG-Regulated Guanine Nucleotide Exchange Factor III 3 4
  • RAS Guanyl Releasing Protein 3 (Calcium And DAG-Regulated) 2 3
  • Guanine Nucleotide Exchange Factor For Rap1 3 4
  • Ras Guanyl-Releasing Protein 3 3 4
  • GRP3 3 4
  • CalDAG-GEFIII 3
  • KIAA0846 4

External Ids for RASGRP3 Gene

Previous GeneCards Identifiers for RASGRP3 Gene

  • GC02P033619
  • GC02P033635
  • GC02P033573
  • GC02P033514
  • GC02P033395
  • GC02P033661

Summaries for RASGRP3 Gene

Entrez Gene Summary for RASGRP3 Gene

  • The protein encoded by this gene is a guanine nucleotide exchange factor that activates the oncogenes HRAS and RAP1A. Defects in this gene have been associated with systemic lupus erythematosus and several cancers. [provided by RefSeq, Mar 2017]

GeneCards Summary for RASGRP3 Gene

RASGRP3 (RAS Guanyl Releasing Protein 3) is a Protein Coding gene. Diseases associated with RASGRP3 include Systemic Lupus Erythematosus. Among its related pathways are RET signaling and Downstream signaling events of B Cell Receptor (BCR). Gene Ontology (GO) annotations related to this gene include calcium ion binding and GTPase activator activity. An important paralog of this gene is RASGRP1.

UniProtKB/Swiss-Prot Summary for RASGRP3 Gene

Gene Wiki entry for RASGRP3 Gene

Additional gene information for RASGRP3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RASGRP3 Gene

Genomics for RASGRP3 Gene

GeneHancer (GH) Regulatory Elements for RASGRP3 Gene

Promoters and enhancers for RASGRP3 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH02J033474 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 525.1 +41.5 41502 6.1 CTCF SIN3A GTF2E2 ZNF10 ZIC2 POLR2A RELA MYC CTBP1 RAD21 RASGRP3 lnc-LTBP1-1 HSALNG0014116
GH02J033437 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 500.7 +1.1 1076 2.4 JUND FOS REST RUNX1 NCOR1 TRIM24 PBX2 NFE2 FOSL1 EZH2 RASGRP3 lnc-LTBP1-1 HSALNG0014116
GH02J033405 Promoter/Enhancer 0.6 EPDnew Ensembl 511.7 -30.5 -30523 0.8 USF1 RASGRP3 MIR4430 piR-61101-378
GH02J033529 Enhancer 1.1 Ensembl ENCODE dbSUPER 25 +94.2 94205 5.9 JUND FOS EP300 RELA MEF2C RBM25 CTCF ZNF384 POLR2A YY1 HSALNG0014116 RASGRP3 lnc-LTBP1-1
GH02J033597 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 9.4 +162.6 162576 3.8 ZBTB40 ZNF217 EP300 SIN3A NRF1 POLR2G PHF8 PHB2 ZIC2 REST FAM98A ENSG00000286415 LOC105374455 TTC27 RASGRP3 lnc-RASGRP3-8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RASGRP3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RASGRP3

Top Transcription factor binding sites by QIAGEN in the RASGRP3 gene promoter:
  • aMEF-2
  • CUTL1
  • MEF-2A
  • NF-kappaB
  • NF-kappaB1
  • Sox5
  • SRF
  • SRF (504 AA)
  • SRY
  • STAT5A

Genomic Locations for RASGRP3 Gene

Genomic Locations for RASGRP3 Gene
chr2:33,436,324-33,564,750
(GRCh38/hg38)
Size:
128,427 bases
Orientation:
Plus strand
chr2:33,661,391-33,789,817
(GRCh37/hg19)
Size:
128,427 bases
Orientation:
Plus strand

Genomic View for RASGRP3 Gene

Genes around RASGRP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RASGRP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RASGRP3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for RASGRP3 Gene

Proteins for RASGRP3 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for RASGRP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IV61-GRP3_HUMAN
    Recommended name:
    Ras guanyl-releasing protein 3
    Protein Accession:
    Q8IV61
    Secondary Accessions:
    • D6W583
    • O94931
    • Q53SD7

    Protein attributes for RASGRP3 Gene

    Size:
    690 amino acids
    Molecular mass:
    78332 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA74869.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for RASGRP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RASGRP3 Gene

Protein Expression for RASGRP3 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for RASGRP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RASGRP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for RASGRP3

No data available for DME Specific Peptides for RASGRP3 Gene

Domains & Families for RASGRP3 Gene

Gene Families for RASGRP3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RASGRP3 Gene

Blocks:
  • Guanine-nucleotide dissociation stimulator CDC25
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RASGRP3 Gene

GenScript: Design optimal peptide antigens:
  • Guanine nucleotide exchange factor for Rap1 (GRP3_HUMAN)
  • RAS guanyl releasing protein 3 (Calcium and DAG-regulated), isoform CRA_b (Q53SD7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IV61

UniProtKB/Swiss-Prot:

GRP3_HUMAN :
  • Belongs to the RASGRP family.
Family:
  • Belongs to the RASGRP family.
genes like me logo Genes that share domains with RASGRP3: view

Function for RASGRP3 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for RASGRP3 Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide exchange factor (GEF) for Ras and Rap1.

Phenotypes From GWAS Catalog for RASGRP3 Gene

Gene Ontology (GO) - Molecular Function for RASGRP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity IEA,TAS --
GO:0005088 Ras guanyl-nucleotide exchange factor activity IEA --
GO:0005096 GTPase activator activity IDA,IEA 10934204
GO:0005509 calcium ion binding IEA,NAS 10934204
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with RASGRP3: view
genes like me logo Genes that share phenotypes with RASGRP3: view

Animal Models for RASGRP3 Gene

MGI Knock Outs for RASGRP3:

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RASGRP3 Gene

Localization for RASGRP3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RASGRP3 gene
Compartment Confidence
plasma membrane 5
mitochondrion 2
nucleus 2
cytosol 2
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RASGRP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS 10934204
GO:0032045 guanyl-nucleotide exchange factor complex IEA --
genes like me logo Genes that share ontologies with RASGRP3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RASGRP3 Gene

Pathways & Interactions for RASGRP3 Gene

PathCards logo

SuperPathways for RASGRP3 Gene

SuperPathway Contained pathways
1 RET signaling
Frs2-mediated activation
.95
GRB2 events in EGFR signaling
.95
MAPK1/MAPK3 signaling
.95
Prolonged ERK activation events
.95
RAF/MAP kinase cascade
.95
SHC1 events in EGFR signaling
.95
Signaling by Leptin
.95
SOS-mediated signalling
.95
VEGFR2 mediated cell proliferation
.95
ARMS-mediated activation
.95
Signalling to ERKs
.95
Signalling to p38 via RIT and RIN
.95
Signalling to RAS
.95
Interleukin receptor SHC signaling
.95
Interleukin-3, 5 and GM-CSF signaling
.94
Interleukin-2 signaling
.94
Downstream signal transduction
.94
Signaling by PDGF
.94
DAP12 signaling
.92
RET signaling
.92
Insulin receptor signalling cascade
.92
Signaling by Insulin receptor
.92
IRS-mediated signalling
.91
Signaling by EGFR
.90
FCERI mediated MAPK activation
.90
IGF1R signaling cascade
.90
IRS-related events triggered by IGF1R
.90
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
.90
DAP12 interactions
.89
NCAM signaling for neurite out-growth
.89
NGF signalling via TRKA from the plasma membrane
.87
MAPK family signaling cascades
.87
Signaling by SCF-KIT
.85
Signalling by NGF
.81
Fc epsilon receptor (FCERI) signaling
.79
VEGFA-VEGFR2 Pathway
.78
Signaling by VEGF
.76
Gastrin-CREB signalling pathway via PKC and MAPK
.55
2 Downstream signaling events of B Cell Receptor (BCR)
Downstream signaling events of B Cell Receptor (BCR)
.84
Signaling by the B Cell Receptor (BCR)
.84
Activation of RAS in B cells
.01
3 B cell receptor signaling pathway (KEGG)
B cell receptor signaling pathway
.38
B Cell Receptor Signaling Pathway
.32
4 Ras signaling pathway
Rap1 signaling pathway
.34
Ras signaling pathway
.34
5 Developmental Biology
Axon guidance
.51
Developmental Biology
.51
genes like me logo Genes that share pathways with RASGRP3: view

Pathways by source for RASGRP3 Gene

4 GeneGo (Thomson Reuters) pathways for RASGRP3 Gene
  • G-protein signaling M-RAS regulation pathway
  • G-protein signaling TC21 regulation pathway
  • G-protein signaling_H-RAS regulation pathway
  • G-protein signaling_Rap1A regulation pathway
1 Qiagen pathway for RASGRP3 Gene
  • ITK and TCR Signaling
2 Cell Signaling Technology pathways for RASGRP3 Gene

SIGNOR curated interactions for RASGRP3 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for RASGRP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0007264 small GTPase mediated signal transduction IEA,TAS 10934204
GO:0007265 Ras protein signal transduction IEA --
GO:0035556 intracellular signal transduction IEA --
GO:0043087 regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with RASGRP3: view

Drugs & Compounds for RASGRP3 Gene

Products:

  1. Drug

(3) Drugs for RASGRP3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(3) Additional Compounds for RASGRP3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Diglycerides Group B
  • 1-Myristoyl-2-eicosadienoyl-sn-glycerol
  • DAG(14:0/20:2)
  • DAG(14:0/20:2N6)
  • DAG(14:0/20:2W6)
  • DAG(34:2)
Diglycerides Group C
  • 1-Stearoyl-2-palmitoyl-sn-glycerol
  • DAG(18:0/16:0)
  • DAG(34:0)
  • DG(18:0/16:0)
  • DG(34:0)
Diglycerides Group D
  • 1,2-Di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol
  • 1,2-Didocosahexaenoyl-sn-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6N3/22:6N3)
  • DAG(22:6OMEGA3/22:6OMEGA3)
genes like me logo Genes that share compounds with RASGRP3: view

Transcripts for RASGRP3 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for RASGRP3 Gene

10 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
18 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RASGRP3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a ·
SP1: - - - - - - - - -
SP2: - - - - -
SP3: - -
SP4: - - - - - - - -
SP5: - - - - -
SP6: - -
SP7: - - - - - - -
SP8: - - -
SP9: -
SP10:

ExUns: 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b · 25c
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for RASGRP3 Gene

GeneLoc Exon Structure for
RASGRP3

Expression for RASGRP3 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RASGRP3 Gene

mRNA expression in normal human tissues for RASGRP3 Gene
mRNA expression by BioGPS for RASGRP3 GenemRNA expression by GTEx for RASGRP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RASGRP3 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x7.7).

Protein differential expression in normal tissues from HIPED for RASGRP3 Gene

This gene is overexpressed in Heart (37.4) and Liver (31.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RASGRP3 Gene



Protein tissue co-expression partners for RASGRP3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RASGRP3

SOURCE GeneReport for Unigene cluster for RASGRP3 Gene:

Hs.143674

Evidence on tissue expression from TISSUES for RASGRP3 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with RASGRP3: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RASGRP3 Gene

Orthologs for RASGRP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for RASGRP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia RASGRP3 31 30
  • 99.71 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia RASGRP3 31 30
  • 93.81 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia RASGRP3 31 30
  • 93.47 (n)
 OneToOne
mouse
(Mus musculus)
 Mammalia Rasgrp3 17 31 30
  • 89.28 (n)
oppossum
(Monodelphis domestica)
 Mammalia RASGRP3 31
  • 89 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia RASGRP3 31
  • 88 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Rasgrp3 30
  • 87.87 (n)
chicken
(Gallus gallus)
 Aves RASGRP3 31 30
  • 80.49 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia RASGRP3 31
  • 86 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia rasgrp3 30
  • 75 (n)
zebrafish
(Danio rerio)
 Actinopterygii rasgrp3 31 30
  • 70.5 (n)
 OneToOne
worm
(Caenorhabditis elegans)
 Secernentea rgef-1 31 30
  • 50.19 (n)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 42 (a)
 OneToMany
Species where no ortholog for RASGRP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RASGRP3 Gene

ENSEMBL:
Gene Tree for RASGRP3 (if available)
TreeFam:
Gene Tree for RASGRP3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RASGRP3: view image

Paralogs for RASGRP3 Gene

Paralogs for RASGRP3 Gene

(5) SIMAP similar genes for RASGRP3 Gene using alignment to 7 proteins:

  • GRP3_HUMAN
  • C9IYA5_HUMAN
  • C9J9C9_HUMAN
  • C9JSS2_HUMAN
  • C9JWP0_HUMAN
  • C9K0P4_HUMAN
  • H7C352_HUMAN
genes like me logo Genes that share paralogs with RASGRP3: view

Variants for RASGRP3 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RASGRP3 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs2124437 Association: Lip and oral cavity carcinoma 33,457,670(+) G/T INTRON_VARIANT
rs13388394 - p.Thr393Ala

Additional dbSNP identifiers (rs#s) for RASGRP3 Gene

Structural Variations from Database of Genomic Variants (DGV) for RASGRP3 Gene

Variant ID Type Subtype PubMed ID
dgv1885n106 CNV deletion 24896259
dgv444n27 CNV loss 19166990
dgv6755n54 CNV loss 21841781
dgv6756n54 CNV loss 21841781
dgv684e214 CNV loss 21293372
esv2199255 CNV deletion 18987734
esv2462414 CNV deletion 19546169
esv2661374 CNV deletion 23128226
esv2719890 CNV deletion 23290073
esv2762447 CNV gain 21179565
esv28690 CNV gain+loss 19812545
esv3554711 CNV deletion 23714750
esv3583713 CNV loss 25503493
esv3590286 CNV loss 21293372
esv3590288 CNV loss 21293372
esv3590289 CNV loss 21293372
esv3590291 CNV gain 21293372
esv3590295 CNV loss 21293372
esv3891725 CNV gain 25118596
esv4426 CNV loss 18987735
nsv1072406 CNV deletion 25765185
nsv1120122 OTHER inversion 24896259
nsv1123309 CNV deletion 24896259
nsv1127719 CNV deletion 24896259
nsv433177 CNV loss 18776910
nsv435723 CNV deletion 17901297
nsv516338 CNV loss 19592680
nsv517737 CNV loss 19592680
nsv581310 CNV loss 21841781
nsv819369 CNV gain 19587683
nsv820684 CNV deletion 20802225
nsv828775 CNV loss 20364138
nsv955027 CNV deletion 24416366

Variation tolerance for RASGRP3 Gene

Residual Variation Intolerance Score: 36.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.84; 67.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RASGRP3 Gene

Human Gene Mutation Database (HGMD)
RASGRP3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RASGRP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASGRP3 Gene

Disorders for RASGRP3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RASGRP3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
systemic lupus erythematosus
  • sle
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for RASGRP3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with RASGRP3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RASGRP3 Gene

Publications for RASGRP3 Gene

  1. Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction. (PMID: 10934204) Rebhun JF … Quilliam LA (The Journal of biological chemistry 2000) 2 3 4 23 54
  2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 54
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  4. TNIP1, SLC15A4, ETS1, RasGRP3 and IKZF1 are associated with clinical features of systemic lupus erythematosus in a Chinese Han population. (PMID: 20516000) He CF … Yang S (Lupus 2010) 3 41 54
  5. Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. (PMID: 19838193) Han JW … Zhang XJ (Nature genetics 2009) 3 41 54

ExternalLinks

View latest publications for RASGRP3 gene in Mastermind

Products for RASGRP3 Gene