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The protein encoded by this gene is a guanine nucleotide exchange factor that activates the oncogenes HRAS and RAP1A. Defects in this gene have been associated with systemic lupus erythematosus and several cancers. [provided by RefSeq, Mar 2017] See more...
Aliases for RASGRP3 Gene
Aliases for RASGRP3 Gene
External Ids for RASGRP3 Gene
- HGNC: 14545
- NCBI Entrez Gene: 25780
- Ensembl: ENSG00000152689
- OMIM®: 609531
- UniProtKB/Swiss-Prot: Q8IV61
Previous GeneCards Identifiers for RASGRP3 Gene
- GC02P033619
- GC02P033635
- GC02P033573
- GC02P033514
- GC02P033395
- GC02P033661
Summaries for RASGRP3 Gene
-
The protein encoded by this gene is a guanine nucleotide exchange factor that activates the oncogenes HRAS and RAP1A. Defects in this gene have been associated with systemic lupus erythematosus and several cancers. [provided by RefSeq, Mar 2017]
GeneCards Summary for RASGRP3 Gene
RASGRP3 (RAS Guanyl Releasing Protein 3) is a Protein Coding gene. Diseases associated with RASGRP3 include Bleeding Disorder, Platelet-Type, 18 and Systemic Lupus Erythematosus. Among its related pathways are RET signaling and G-protein signaling M-RAS regulation pathway. Gene Ontology (GO) annotations related to this gene include calcium ion binding and GTPase activator activity. An important paralog of this gene is RASGRP1.
UniProtKB/Swiss-Prot Summary for RASGRP3 Gene
-
Guanine nucleotide exchange factor (GEF) for Ras and Rap1.
Additional gene information for RASGRP3 Gene
- HGNC (14545)
- NCBI Entrez Gene (25780)
- Ensembl (ENSG00000152689)
- OMIM® (609531)
- UniProtKB/Swiss-Prot (Q8IV61)
- Open Targets Platform(ENSG00000152689)
- Monarch Initiative
- Alliance of Genome Resources
- Search for RASGRP3 at DataMed
- Search for RASGRP3 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RASGRP3 Gene
Genomics for RASGRP3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for RASGRP3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around RASGRP3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RASGRP3
- Top Transcription factor binding sites by QIAGEN in the RASGRP3 gene promoter:
-
- aMEF-2
- CUTL1
- MEF-2A
- NF-kappaB
- NF-kappaB1
- Sox5
- SRF
- SRF (504 AA)
- SRY
- STAT5A
Genomic Locations for RASGRP3 Gene
Latest Assembly
- chr2:33,436,324-33,564,750
- (GRCh38/hg38)
- Size:
- 128,427 bases
- Orientation:
- Plus strand
Previous Assembly
- chr2:33,661,415-33,789,798
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 128,384 bases
- Orientation:
- Plus strand
Genomic View for RASGRP3 Gene
Genes around RASGRP3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2p22.3 by HGNC
- 2p22.3 by Entrez Gene
- 2p22.3 by Ensembl
RASGRP3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RASGRP3 Gene
Proteins for RASGRP3 Gene
-
Protein details for RASGRP3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8IV61-GRP3_HUMAN
- Recommended name:
- Ras guanyl-releasing protein 3
- Protein Accession:
- Q8IV61
- D6W583
- O94931
- Q53SD7
Protein attributes for RASGRP3 Gene
- Size:
- 690 amino acids
- Molecular mass:
- 78332 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAA74869.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
Protein Expression for RASGRP3 Gene
Post-translational modifications for RASGRP3 Gene
Other Protein References for RASGRP3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- G Biosciences Immunotagā¢ GRP3 Polyclonal Antibody and Immunotagā¢ RASGRP3 Antibody
- Novus Biologicals Antibodies for RASGRP3
-
Abcam antibodies for RASGRP3
- Invitrogen Antibodies for RASGRP3 (AFLGC-Rasgrp3)
-
Custom Antibody ServicesProSci Antibodies for RASGRP3
-
Santa Cruz Biotechnology (SCBT) Antibodies for RASGRP3
Protein products for research
-
OriGene Purified Proteins for RASGRP3
- Search Origene for MassSpec and Protein Over-expression Lysates for RASGRP3
- Origene Custom Protein Services for RASGRP3
- antibodies-online: Show 6 available RASGRP3 Proteins ranked by validation data
- Compare Top RASGRP3 Proteins
-
Quality Products:
-
Abcam proteins for RASGRP3
Assay products for research
No data available for DME Specific Peptides for RASGRP3 Gene
Domains & Families for RASGRP3 Gene
Gene Families for RASGRP3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for RASGRP3 Gene
- InterPro:
- Blocks:
-
- Guanine-nucleotide dissociation stimulator CDC25
Suggested Antigen Peptide Sequences for RASGRP3 Gene
- GenScript: Design optimal peptide antigens:
-
- Guanine nucleotide exchange factor for Rap1 (GRP3_HUMAN)
- RAS guanyl releasing protein 3 (Calcium and DAG-regulated), isoform CRA_b (Q53SD7_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q8IV61- Family:
-
- Belongs to the RASGRP family.
Function for RASGRP3 Gene
Molecular function for RASGRP3 Gene
- UniProtKB/Swiss-Prot Function:
- Guanine nucleotide exchange factor (GEF) for Ras and Rap1.
Phenotypes From GWAS Catalog for RASGRP3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005085 | guanyl-nucleotide exchange factor activity | IEA,TAS | -- |
| GO:0005096 | GTPase activator activity | IEA,IDA | 10934204 |
| GO:0005509 | calcium ion binding | IEA,NAS | 10934204 |
| GO:0005515 | protein binding | IPI | 25416956 |
| GO:0019900 | kinase binding | IEA | -- |
Phenotypes for RASGRP3 Gene
- MGI mutant phenotypes for RASGRP3:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for RASGRP3:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased viability after Maraba virus infection
- Resistant to vaccinia virus (VACV-A4L) infection
- Decreased ionizing radiation sensitivity
- Decreased viability
- No cells
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Synthetic lethal with vaccinia virus (VACV) infection
- Two nuclei (binuclear)
Animal Models for RASGRP3 Gene
- MGI Knock Outs for RASGRP3:
-
- Rasgrp3 Rasgrp3<tm1Jstn>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for RASGRP3 - Starting at $85 >
- * RASGRP3 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for RASGRP3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RASGRP3
-
Santa Cruz Biotechnology (SCBT) CRISPR for RASGRP3
miRNA for RASGRP3 Gene
- miRTarBase miRNAs that target RASGRP3
-
- mmu-miR-124-3p (MIRT015811)
- hsa-miR-21-5p (MIRT030769)
- hsa-miR-30a-5p (MIRT159242)
- hsa-miR-30c-5p (MIRT159243)
- hsa-miR-30d-5p (MIRT159244)
- hsa-miR-30b-5p (MIRT159246)
- hsa-miR-30e-5p (MIRT159250)
- hsa-miR-26a-5p (MIRT159273)
- hsa-miR-26b-5p (MIRT159274)
- hsa-miR-6824-5p (MIRT482998)
- hsa-miR-7106-5p (MIRT482999)
- hsa-miR-6825-5p (MIRT483000)
- hsa-miR-765 (MIRT483001)
- hsa-miR-766-5p (MIRT483002)
- hsa-miR-6782-5p (MIRT483003)
- hsa-miR-6783-5p (MIRT483004)
- hsa-miR-708-3p (MIRT483005)
- mmu-miR-883b-3p (MIRT602992)
- mmu-miR-883a-3p (MIRT602993)
- mmu-miR-883a-5p (MIRT602994)
- mmu-miR-3473c (MIRT602995)
- mmu-miR-1960 (MIRT606227)
- hsa-miR-335-3p (MIRT654430)
- hsa-miR-30e-3p (MIRT654431)
- hsa-miR-30d-3p (MIRT654432)
- hsa-miR-30a-3p (MIRT654433)
- hsa-miR-7977 (MIRT654434)
- hsa-miR-24-3p (MIRT654435)
- hsa-miR-4264 (MIRT654436)
- hsa-miR-138-2-3p (MIRT654437)
- hsa-miR-4267 (MIRT654438)
- hsa-miR-1910-5p (MIRT654439)
- hsa-miR-455-3p (MIRT654440)
- hsa-miR-5588-3p (MIRT654441)
- hsa-miR-484 (MIRT662168)
- hsa-miR-3155b (MIRT662169)
- hsa-miR-3155a (MIRT662170)
- hsa-miR-4438 (MIRT662171)
- hsa-miR-409-3p (MIRT732813)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RASGRP3
- Browse OriGene Inhibitory RNA Products For RASGRP3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RASGRP3
Clone products for research
- Applied Biological Materials (abm): Clones for RASGRP3 - Starting at $45 >
- * RASGRP3 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG210071
- MG214823
- MR210071
- MR210071L3
- MR210071L4
- MR214823
- MR214823L3
- MR214823L4
- RC206487
- RC206487L1
- RC206487L2
- RC206487L3
- RC206487L4
- RC227703
- RC227703L1
- RC227703L2
- RC227703L3
- RC227703L4
- RC228997
- RC228997L3
- RC228997L4
- RG206487
- RG227703
- RG228997
- RR201858
- RR201858L3
- RR201858L4
- MR210071L3V
- MR210071L4V
- MR214823L3V
- MR214823L4V
- RC206487L1V
- RC206487L2V
- RC206487L3V
- RC206487L4V
- RC227703L1V
- RC227703L2V
- RC227703L3V
- RC227703L4V
- RC228997L3V
- RC228997L4V
- RR201858L3V
- RR201858L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for RASGRP3
- Addgene plasmids for RASGRP3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RASGRP3
Cell Lines for research
-
Horizon Cell Lines for RASGRP3
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RASGRP3 Gene
Localization for RASGRP3 Gene
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytosol | 3 |
| mitochondrion | 2 |
| nucleus | 2 |
| extracellular | 1 |
| cytoskeleton | 1 |
| endoplasmic reticulum | 1 |
| golgi apparatus | 1 |
- Golgi apparatus (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | NAS | 10934204 |
| GO:0032045 | guanyl-nucleotide exchange factor complex | IEA | -- |
| GO:0048471 | perinuclear region of cytoplasm | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for RASGRP3 Gene
Pathways & Interactions for RASGRP3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | Downstream signaling events of B Cell Receptor (BCR) | ||
| 3 | B cell receptor signaling pathway (KEGG) | ||
| 4 | Ras signaling pathway | ||
| 5 | Developmental Biology |
.51
|
|
Pathways by source for RASGRP3 Gene
2 BioSystems pathways for RASGRP3 Gene
50 Reactome pathways for RASGRP3 Gene
5 KEGG pathways for RASGRP3 Gene
4 GeneGo (Thomson Reuters) pathways for RASGRP3 Gene
- G-protein signaling M-RAS regulation pathway
- G-protein signaling TC21 regulation pathway
- G-protein signaling_H-RAS regulation pathway
- G-protein signaling_Rap1A regulation pathway
1 Qiagen pathway for RASGRP3 Gene
- ITK and TCR Signaling
2 Cell Signaling Technology pathways for RASGRP3 Gene
Interacting Proteins for RASGRP3 Gene
Selected Interacting proteins:
Q8IV61-GRP3_HUMAN
ENSP00000384192
for RASGRP3 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for RASGRP3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | NAS,TAS | -- |
| GO:0007264 | small GTPase mediated signal transduction | IEA,TAS | 10934204 |
| GO:0007265 | Ras protein signal transduction | IEA | -- |
| GO:0035556 | intracellular signal transduction | IEA | -- |
| GO:0043087 | regulation of GTPase activity | IEA | -- |
Drugs & Compounds for RASGRP3 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| DG(16:0/24:0/0:0) |
|
|
||||
| Diglycerides Group B |
|
257891-89-7 |
|
|||
| Diglycerides Group C |
|
91125-76-7, 29541-66-0, 51621-26-2 |
|
|||
| Diglycerides Group D |
|
|
Transcripts for RASGRP3 Gene
mRNA/cDNA for RASGRP3 Gene
- 10 REFSEQ mRNAs :
- 11 NCBI additional mRNA sequence :
- 18 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000402538 4738 nts (view in UCSC)
- ENST00000403687 4386 nts (view in UCSC)
- ENST00000407811 4210 nts (view in UCSC)
- ENST00000419772 548 nts (view in UCSC)
- ENST00000423159 557 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for RASGRP3 - Starting at $85 >
- * RASGRP3 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for RASGRP3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RASGRP3
-
Santa Cruz Biotechnology (SCBT) CRISPR for RASGRP3
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RASGRP3
- Browse OriGene Inhibitory RNA Products For RASGRP3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RASGRP3
Clone products for research
- Applied Biological Materials (abm): Clones for RASGRP3 - Starting at $45 >
- * RASGRP3 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG210071
- MG214823
- MR210071
- MR210071L3
- MR210071L4
- MR214823
- MR214823L3
- MR214823L4
- RC206487
- RC206487L1
- RC206487L2
- RC206487L3
- RC206487L4
- RC227703
- RC227703L1
- RC227703L2
- RC227703L3
- RC227703L4
- RC228997
- RC228997L3
- RC228997L4
- RG206487
- RG227703
- RG228997
- RR201858
- RR201858L3
- RR201858L4
- MR210071L3V
- MR210071L4V
- MR214823L3V
- MR214823L4V
- RC206487L1V
- RC206487L2V
- RC206487L3V
- RC206487L4V
- RC227703L1V
- RC227703L2V
- RC227703L3V
- RC227703L4V
- RC228997L3V
- RC228997L4V
- RR201858L3V
- RR201858L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for RASGRP3
- Addgene plasmids for RASGRP3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RASGRP3
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c | · | 11d | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ | 19a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: |
| ExUns: | 19b | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25a | · | 25b | · | 25c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||
| SP2: | - | ||||||||||||||||
| SP3: | - | ||||||||||||||||
| SP4: | |||||||||||||||||
| SP5: | |||||||||||||||||
| SP6: | |||||||||||||||||
| SP7: | |||||||||||||||||
| SP8: | |||||||||||||||||
| SP9: | |||||||||||||||||
| SP10: |
Relevant External Links for RASGRP3 Gene
- GeneLoc Exon Structure for
- RASGRP3
Expression for RASGRP3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Myelinating Oligodendrocyte Cells Forebrain White Matter
-
Glial Cells
- Myelinating Oligodendrocyte Cells Forebrain White Matter
-
Blood (Hematopoietic System)
- Mature B-Cells Peripheral Blood
- Bone (Muscoskeletal System)
- NULL (Uncategorized)
-
Dermis (Integumentary System)
mRNA differential expression in normal tissues according to GTEx for RASGRP3 Gene
This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x7.7).
This gene is overexpressed in Heart (37.4) and Liver (31.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RASGRP3 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RASGRP3
SOURCE GeneReport for Unigene cluster for RASGRP3 Gene:
Hs.143674Evidence on tissue expression from TISSUES for RASGRP3 Gene
- Nervous system(4.3)
- Heart(2.3)
- Lymph node(2.2)
Primer products for research
-
OriGene qPCR primer pairs for RASGRP3
Gene Expression Assays for research
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RASGRP3 Gene
Orthologs for RASGRP3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | RASGRP3 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | RASGRP3 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | RASGRP3 29 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Rasgrp3 29 16 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | RASGRP3 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | RASGRP3 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Rasgrp3 29 |
|
||
| Chicken (Gallus gallus) |
Aves | RASGRP3 29 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | RASGRP3 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | rasgrp3 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | rasgrp3 29 30 |
|
OneToOne | |
| Worm (Caenorhabditis elegans) |
Secernentea | rgef-1 29 30 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 30 |
|
OneToMany |
- Species where no ortholog for RASGRP3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for RASGRP3 Gene
- ENSEMBL:
- Gene Tree for RASGRP3 (if available)
- TreeFam:
- Gene Tree for RASGRP3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for RASGRP3: view image
- Alliance of Genome Resources:
- Additional Orthologs for RASGRP3
Paralogs for RASGRP3 Gene
Paralogs for RASGRP3 Gene
(5) SIMAP similar genes for RASGRP3 Gene using alignment to 7 proteins:
- GRP3_HUMAN
- C9IYA5_HUMAN
- C9J9C9_HUMAN
- C9JSS2_HUMAN
- C9JWP0_HUMAN
- C9K0P4_HUMAN
- H7C352_HUMAN
Variants for RASGRP3 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RASGRP3 Gene
| SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1574485216 | Likely Benign: not provided | 33,549,712(+) |
C/T NM_001139488.2(RASGRP3):c.1503C>T (p.Thr501=) |
SYNONYMOUS | |
| rs189837410 | Benign: not provided | 33,522,003(+) |
C/T NM_001139488.2(RASGRP3):c.417C>T (p.Ser139=) |
SYNONYMOUS | |
| rs2124437 | Association: Lip and oral cavity carcinoma | 33,457,670(+) |
G/T NM_170672.3(RASGRP3):c.-261+9727G>T |
INTRON | |
| rs781152306 | Likely Benign: not provided | 33,520,009(+) |
C/T NM_001139488.2(RASGRP3):c.231C>T (p.Phe77=) |
SYNONYMOUS | |
| rs13388394 | -- |
p.Thr393Ala |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
36.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.84;
67.16% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RASGRP3 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASGRP3 Gene
Disorders for RASGRP3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| bleeding disorder, platelet-type, 18 |
|
|
| systemic lupus erythematosus |
|
|
Search RASGRP3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for RASGRP3
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for RASGRP3 Gene
Publications for RASGRP3 Gene
- Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction. (PMID: 10934204) Rebhun JF ā¦ Quilliam LA (The Journal of biological chemistry 2000) 2 3 4 22
- Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T ā¦ Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE ā¦ Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 40
- TNIP1, SLC15A4, ETS1, RasGRP3 and IKZF1 are associated with clinical features of systemic lupus erythematosus in a Chinese Han population. (PMID: 20516000) He CF ā¦ Yang S (Lupus 2010) 3 40
- Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. (PMID: 19838193) Han JW ā¦ Zhang XJ (Nature genetics 2009) 3 40
ExternalLinks
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Sources for RASGRP3 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
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- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
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- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
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- (56) Novus Biologicals
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- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73)