Aliases for RASGRP2 Gene
External Ids for RASGRP2 Gene
Previous GeneCards Identifiers for RASGRP2 Gene
The protein encoded by this gene is a brain-enriched nucleotide exchanged factor that contains an N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. This protein can activate small GTPases, including RAS and RAP1/RAS3. The nucleotide exchange activity of this protein can be stimulated by calcium and diacylglycerol. Four alternatively spliced transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
GeneCards Summary for RASGRP2 Gene
RASGRP2 (RAS Guanyl Releasing Protein 2) is a Protein Coding gene. Diseases associated with RASGRP2 include Bleeding Disorder, Platelet-Type, 18 and Leukocyte Adhesion Deficiency, Type Iii. Among its related pathways are TCR signaling in naive CD4+ T cells and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include calcium ion binding and guanyl-nucleotide exchange factor activity. An important paralog of this gene is RASGRP3.
UniProtKB/Swiss-Prot Summary for RASGRP2 Gene
Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activates other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway.