Aliases for RASGRP1 Gene
- RAS Guanyl Releasing Protein 1 2 3 5
- RASGRP 2 3 4
- Calcium- And Diacylglycerol-Regulated Guanine Nucleotide Exchange Factor II 2 3
- Calcium And DAG-Regulated Guanine Nucleotide Exchange Factor II 3 4
- RAS Guanyl Releasing Protein 1 (Calcium And DAG-Regulated) 2 3
- RAS Guanyl-Releasing Protein 1 3 4
- CalDAG-GEFII 2 4
External Ids for RASGRP1 Gene
Previous GeneCards Identifiers for RASGRP1 Gene
This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008]
GeneCards Summary for RASGRP1 Gene
RASGRP1 (RAS Guanyl Releasing Protein 1) is a Protein Coding gene. Diseases associated with RASGRP1 include Immunodeficiency 64 and Autoimmune Lymphoproliferative Syndrome. Among its related pathways are RET signaling and G-protein signaling M-RAS regulation pathway. Gene Ontology (GO) annotations related to this gene include calcium ion binding and lipid binding. An important paralog of this gene is RASGRP3.
UniProtKB/Swiss-Prot Summary for RASGRP1 Gene
Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP (PubMed:15899849, PubMed:23908768, PubMed:27776107, PubMed:29155103). Activates the Erk/MAP kinase cascade (PubMed:15899849). Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras (PubMed:10807788, PubMed:12839994, PubMed:27776107, PubMed:29155103). Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways (PubMed:19933860). Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses. May also function in differentiation of other cell types (PubMed:12845332).