Aliases for RASGRF1 Gene
External Ids for RASGRF1 Gene
Previous HGNC Symbols for RASGRF1 Gene
Previous GeneCards Identifiers for RASGRF1 Gene
The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Mar 2009]
GeneCards Summary for RASGRF1 Gene
RASGRF1 (Ras Protein Specific Guanine Nucleotide Releasing Factor 1) is a Protein Coding gene. Diseases associated with RASGRF1 include Refractive Error and Degenerative Myopia. Among its related pathways are RET signaling and G-protein signaling M-RAS regulation pathway. Gene Ontology (GO) annotations related to this gene include guanyl-nucleotide exchange factor activity and Ras guanyl-nucleotide exchange factor activity. An important paralog of this gene is RASGRF2.
UniProtKB/Swiss-Prot Summary for RASGRF1 Gene
Promotes the exchange of Ras-bound GDP by GTP.