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RASGEF1A (RasGEF Domain Family Member 1A) is a Protein Coding gene. Diseases associated with RASGEF1A include Intrahepatic Cholangiocarcinoma and Cholangiocarcinoma. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include guanyl-nucleotide exchange factor activity and Ras guanyl-nucleotide exchange factor activity. An important paralog of this gene is RASGEF1B.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005085 | guanyl-nucleotide exchange factor activity | IEA | -- |
GO:0005088 | Ras guanyl-nucleotide exchange factor activity | IDA | 17121879 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005829 | cytosol | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | RET signaling |
.92
|
.92
|
2 | Developmental Biology |
.51
|
|
3 | Cytokine Signaling in Immune system | ||
4 | Innate Immune System |
.61
|
|
5 | Signaling by GPCR |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000165 | MAPK cascade | TAS | -- |
GO:0007264 | small GTPase mediated signal transduction | IEA | -- |
GO:0016477 | cell migration | IDA | 17121879 |
GO:0046579 | positive regulation of Ras protein signal transduction | IDA | 17121879 |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | |||||||||||||||||||||||||||||||||||
SP5: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | RASGEF1A 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | RASGEF1A 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | RASGEF1A 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Rasgef1a 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Rasgef1a 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | RASGEF1A 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | RASGEF1A 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | RASGEF1A 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | RASGEF1A 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | rasgef1a 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.24425 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG7369 31 |
|
ManyToMany | |
CG4853 31 |
|
ManyToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | R05G6.10 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv434n106 | CNV | deletion | 24896259 |
dgv728n100 | CNV | gain | 25217958 |
esv2656730 | CNV | deletion | 23128226 |
esv2669702 | CNV | deletion | 23128226 |
esv3546222 | CNV | deletion | 23714750 |
esv3623039 | CNV | loss | 21293372 |
nsv1068302 | CNV | deletion | 25765185 |
nsv1068303 | CNV | deletion | 25765185 |
nsv1068689 | CNV | deletion | 25765185 |
nsv1119806 | CNV | deletion | 24896259 |
nsv466881 | CNV | loss | 19166990 |
nsv550696 | CNV | loss | 21841781 |
nsv550697 | CNV | gain | 21841781 |
nsv825351 | CNV | gain | 20364138 |
nsv825352 | CNV | gain | 20364138 |
nsv951566 | CNV | deletion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
intrahepatic cholangiocarcinoma |
|
|
cholangiocarcinoma |
|
|
hirschsprung disease 1 |
|
|