This gene encodes a member of the Ras superfamily of small GTPases and is induced by dexamethasone. The encoded protein is an activator of G-protein signaling and acts as a direct nucleotide exchange factor for Gi-Go proteins. This protein interacts with the neuronal nitric oxide adaptor protein CAPON, and a nuclear adaptor protein FE65, which interacts with the Alzheimer's dis... See more...

Aliases for RASD1 Gene

Aliases for RASD1 Gene

  • Ras Related Dexamethasone Induced 1 2 3 5
  • Dexamethasone-Induced Ras-Related Protein 1 2 3 4
  • Activator Of G-Protein Signaling 1 3 4
  • RAS, Dexamethasone-Induced 1 2 3
  • Ras-Related Protein 2 3
  • DEXRAS1 3 4
  • AGS1 3 4
  • Activator Of G Protein Signaling 2
  • MGC:26290 3

External Ids for RASD1 Gene

Previous GeneCards Identifiers for RASD1 Gene

  • GC17M017712
  • GC17M018770
  • GC17M017340
  • GC17M017598
  • GC17M017341
  • GC17M017397
  • GC17M017150

Summaries for RASD1 Gene

Entrez Gene Summary for RASD1 Gene

  • This gene encodes a member of the Ras superfamily of small GTPases and is induced by dexamethasone. The encoded protein is an activator of G-protein signaling and acts as a direct nucleotide exchange factor for Gi-Go proteins. This protein interacts with the neuronal nitric oxide adaptor protein CAPON, and a nuclear adaptor protein FE65, which interacts with the Alzheimer's disease amyloid precursor protein. This gene may play a role in dexamethasone-induced alterations in cell morphology, growth and cell-extracellular matrix interactions. Epigenetic inactivation of this gene is closely correlated with resistance to dexamethasone in multiple myeloma cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2011]

GeneCards Summary for RASD1 Gene

RASD1 (Ras Related Dexamethasone Induced 1) is a Protein Coding gene. Diseases associated with RASD1 include Malt Worker's Lung and Prostate Leiomyosarcoma. Among its related pathways are MAP Kinase Signaling and Circadian entrainment. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RASD2.

UniProtKB/Swiss-Prot Summary for RASD1 Gene

  • Small GTPase. Negatively regulates the transcription regulation activity of the APBB1/FE65-APP complex via its interaction with APBB1/FE65 (By similarity).

Gene Wiki entry for RASD1 Gene

Additional gene information for RASD1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RASD1 Gene

Genomics for RASD1 Gene

GeneHancer (GH) Regulatory Elements for RASD1 Gene

Promoters and enhancers for RASD1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J017493 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 500.7 +1.1 1088 4.5 HNRNPK EP300 CTCF TCF12 POLR2G PHF8 ZIC2 POLR2A ZBTB11 GABPA RASD1 DRG2 SMCR8 LOC100419436 RPL13P12 RAI1 TOP3A LOC644422 MPRIP FLII
GH17J017522 Enhancer 1.2 Ensembl ENCODE CraniofacialAtlas dbSUPER 13 -26.8 -26806 2 ZIC2 ZNF423 ZNF341 CTCF OSR2 ZNF263 ZFHX2 FEZF1 GLIS1 ZNF398 PEMT RASD1 MED9 KRT16P6 piR-55851 ENSG00000265511 lnc-RASD1-4
GH17J017525 Enhancer 1 Ensembl ENCODE dbSUPER 13 -31.0 -31006 4.8 ZIC2 FOXA2 USF1 ZBTB33 MXD4 NR2F2 JUND MAX RAD21 RXRA piR-55851 PEMT RASD1 MED9 ATPAF2 KRT16P6 ENSG00000265511 lnc-RASD1-4
GH17J017461 Enhancer 1 Ensembl ENCODE 11.4 +34.1 34089 1.2 KDM6A TCF7 ZBTB26 FOXA2 TFDP1 SAP130 ZNF205 CREM FOXP1 DRAP1 ENSG00000201741 RF00951-051 RASD1 PEMT
GH17J017467 Enhancer 0.8 Ensembl ENCODE dbSUPER 12.3 +28.5 28547 1.5 ZBTB17 POLR2A GLIS1 SMARCA4 MAZ ZNF140 RASD1 PEMT RF00951-051 MED9
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RASD1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RASD1

Top Transcription factor binding sites by QIAGEN in the RASD1 gene promoter:
  • Arnt
  • C/EBPalpha
  • CREB
  • deltaCREB
  • p53

Genomic Locations for RASD1 Gene

Genomic Locations for RASD1 Gene
chr17:17,494,437-17,496,395
(GRCh38/hg38)
Size:
1,959 bases
Orientation:
Minus strand
chr17:17,397,751-17,399,709
(GRCh37/hg19)
Size:
1,959 bases
Orientation:
Minus strand

Genomic View for RASD1 Gene

Genes around RASD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RASD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RASD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASD1 Gene

Proteins for RASD1 Gene

  • Protein details for RASD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y272-RASD1_HUMAN
    Recommended name:
    Dexamethasone-induced Ras-related protein 1
    Protein Accession:
    Q9Y272
    Secondary Accessions:
    • B2R709
    • B4DFF4
    • Q9NYB4

    Protein attributes for RASD1 Gene

    Size:
    281 amino acids
    Molecular mass:
    31642 Da
    Quaternary structure:
    • Forms a ternary complex with CAPON and NOS1. Component of a complex, at least composed of APBB1, RASD1/DEXRAS1 and APP. Interacts with APBB1/FE65 (By similarity).

    Alternative splice isoforms for RASD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RASD1 Gene

Post-translational modifications for RASD1 Gene

  • S-nitrosylation stimulates guanine-nucleotide exchange activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RASD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RASD1 Gene

Domains & Families for RASD1 Gene

Gene Families for RASD1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RASD1 Gene

Blocks:
  • Ras small GTPase, Ras type
  • Transforming protein P21 RAS signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RASD1 Gene

GenScript: Design optimal peptide antigens:
  • Activator of G-protein signaling 1 (RASD1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y272

UniProtKB/Swiss-Prot:

RASD1_HUMAN :
  • Belongs to the small GTPase superfamily. RasD family.
Family:
  • Belongs to the small GTPase superfamily. RasD family.
genes like me logo Genes that share domains with RASD1: view

Function for RASD1 Gene

Molecular function for RASD1 Gene

UniProtKB/Swiss-Prot Function:
Small GTPase. Negatively regulates the transcription regulation activity of the APBB1/FE65-APP complex via its interaction with APBB1/FE65 (By similarity).
UniProtKB/Swiss-Prot Induction:
By dexamethasone.

Phenotypes From GWAS Catalog for RASD1 Gene

Gene Ontology (GO) - Molecular Function for RASD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA,TAS --
GO:0005515 protein binding IPI 25416956
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RASD1: view
genes like me logo Genes that share phenotypes with RASD1: view

Animal Models for RASD1 Gene

MGI Knock Outs for RASD1:

Animal Model Products

  • Taconic Biosciences Mouse Models for RASD1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RASD1 Gene

Localization for RASD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RASD1 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, perinuclear region. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RASD1 gene
Compartment Confidence
plasma membrane 4
nucleus 4
endoplasmic reticulum 3
cytosol 3
extracellular 2
cytoskeleton 2
mitochondrion 2
endosome 2
lysosome 2
golgi apparatus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RASD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016529 sarcoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with RASD1: view

Pathways & Interactions for RASD1 Gene

PathCards logo

SuperPathways for RASD1 Gene

genes like me logo Genes that share pathways with RASD1: view

Pathways by source for RASD1 Gene

2 KEGG pathways for RASD1 Gene
1 Qiagen pathway for RASD1 Gene
  • nNOS Signaling at Neuronal Synapses
2 Cell Signaling Technology pathways for RASD1 Gene

Gene Ontology (GO) - Biological Process for RASD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 10471929
GO:0007186 G protein-coupled receptor signaling pathway TAS 10840027
GO:0007263 nitric oxide mediated signal transduction IEA --
GO:0045892 negative regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with RASD1: view

No data available for SIGNOR curated interactions for RASD1 Gene

Drugs & Compounds for RASD1 Gene

(1) Drugs for RASD1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for RASD1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RASD1: view

Transcripts for RASD1 Gene

mRNA/cDNA for RASD1 Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RASD1 Gene

No ASD Table

Relevant External Links for RASD1 Gene

GeneLoc Exon Structure for
RASD1

Expression for RASD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RASD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RASD1 Gene

This gene is overexpressed in Liver (x5.7) and Adipose - Visceral (Omentum) (x4.5).

Protein differential expression in normal tissues from HIPED for RASD1 Gene

This gene is overexpressed in Frontal cortex (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RASD1 Gene



Protein tissue co-expression partners for RASD1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RASD1

SOURCE GeneReport for Unigene cluster for RASD1 Gene:

Hs.25829

mRNA Expression by UniProt/SwissProt for RASD1 Gene:

Q9Y272-RASD1_HUMAN
Tissue specificity: Expressed in a variety of tissues including heart, cardiovascular tissues, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, gastrointestinal and reproductive tissues.

Evidence on tissue expression from TISSUES for RASD1 Gene

  • Nervous system(4.8)
  • Liver(4.3)
  • Kidney(2.6)
  • Muscle(2.5)
  • Heart(2.3)
  • Pancreas(2.3)
  • Intestine(2.2)
genes like me logo Genes that share expression patterns with RASD1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RASD1 Gene

Orthologs for RASD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RASD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RASD1 31 30
  • 99.88 (n)
OneToOne
dog
(Canis familiaris)
Mammalia RASD1 31 30
  • 96.54 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RASD1 31
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RASD1 31
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RASD1 31 30
  • 90.58 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Rasd1 17 31 30
  • 88.33 (n)
rat
(Rattus norvegicus)
Mammalia Rasd1 30
  • 88.33 (n)
chicken
(Gallus gallus)
Aves RASD1 31 30
  • 87.77 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RASD1 31
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rasd1 30
  • 77.82 (n)
Str.11968 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.21562 30
zebrafish
(Danio rerio)
Actinopterygii rasd1 31 30
  • 75.22 (n)
OneToOne
zgc65909 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6072 30
fruit fly
(Drosophila melanogaster)
Insecta CG8641 31 32 30
  • 56.82 (n)
OneToMany
EG:BACR37P7.8 32
  • 40 (a)
worm
(Caenorhabditis elegans)
Secernentea ssr-2 31
  • 25 (a)
ManyToMany
Species where no ortholog for RASD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RASD1 Gene

ENSEMBL:
Gene Tree for RASD1 (if available)
TreeFam:
Gene Tree for RASD1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RASD1: view image

Paralogs for RASD1 Gene

(17) SIMAP similar genes for RASD1 Gene using alignment to 1 proteins:

  • RASD1_HUMAN
genes like me logo Genes that share paralogs with RASD1: view

Variants for RASD1 Gene

Additional dbSNP identifiers (rs#s) for RASD1 Gene

Structural Variations from Database of Genomic Variants (DGV) for RASD1 Gene

Variant ID Type Subtype PubMed ID
nsv155 OTHER inversion 15895083
nsv499114 OTHER inversion 21111241

Variation tolerance for RASD1 Gene

Residual Variation Intolerance Score: 34.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.17; 23.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RASD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RASD1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RASD1 Gene

Disorders for RASD1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for RASD1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
malt worker's lung
  • alveolitis due to aspergillus clavatus
prostate leiomyosarcoma
  • leiomyosarcoma of the prostate
smith-magenis syndrome
  • sms
potocki-lupski syndrome
  • pls
- elite association - COSMIC cancer census association via MalaCards
Search RASD1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RASD1

genes like me logo Genes that share disorders with RASD1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RASD1 Gene

Publications for RASD1 Gene

  1. Identification of a glucocorticoid response element in the 3'-flanking region of the human Dexras1 gene. (PMID: 12818426) Kemppainen RJ … Ammons JM (Biochimica et biophysica acta 2003) 3 4 23 54
  2. Dexamethasone-induced Ras protein 1 negatively regulates protein kinase C delta: implications for adenylyl cyclase 2 signaling. (PMID: 16489124) Nguyen CH … Watts VJ (Molecular pharmacology 2006) 3 23 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. Activator of G-protein signaling 1 blocks GIRK channel activation by a G-protein-coupled receptor: apparent disruption of receptor signaling complexes. (PMID: 11842095) Takesono A … Lanier SM (The Journal of biological chemistry 2002) 3 23 54
  5. Nitrosopeptide mapping: a novel methodology reveals s-nitrosylation of dexras1 on a single cysteine residue. (PMID: 12498886) Jaffrey SR … Snyder SH (Chemistry & biology 2002) 3 4 54

Products for RASD1 Gene

Sources for RASD1 Gene