External Ids for RASAL3 Gene
Previous GeneCards Identifiers for RASAL3 Gene
This gene belongs to the Ras GTPase-activating proteins (RasGAP) family and encodes a protein with pleckstrin homology (PH), C2, and Ras GTPase-activation protein (RasGAP) domains. This protein is localized near or at the plasma membrane when expressed exogenously. Reduced expression of this gene in some cell lines resulted in increased levels of the active form of Ras (Ras-GTP), suggesting that this gene may play a role in negatively regulating the Ras signaling pathway. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2017]
GeneCards Summary for RASAL3 Gene
RASAL3 (RAS Protein Activator Like 3) is a Protein Coding gene. Diseases associated with RASAL3 include Suppression Of Tumorigenicity 12. Among its related pathways are RET signaling and Innate Immune System. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is DAB2IP.
UniProtKB/Swiss-Prot for RASAL3 Gene
Functions as a Ras GTPase-activating protein. Plays an important role in the expansion and functions of natural killer T (NKT) cells in the liver by negatively regulating RAS activity and the down-stream ERK signaling pathway.