Aliases for RASAL2 Gene
Aliases for RASAL2 Gene
External Ids for RASAL2 Gene
- HGNC: 9874
- Entrez Gene: 9462
- Ensembl: ENSG00000075391
- OMIM: 606136
- UniProtKB: Q9UJF2
Previous GeneCards Identifiers for RASAL2 Gene
- GC01P175834
- GC01P173491
- GC01P174643
- GC01P175303
- GC01P174795
- GC01P176329
- GC01P149291
Summaries for RASAL2 Gene
-
This gene encodes a protein that contains the GAP-related domain (GRD), a characteristic domain of GTPase-activating proteins (GAPs). GAPs function as activators of Ras superfamily of small GTPases. The protein encoded by this gene is able to complement the defective RasGAP function in a yeast system. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
GeneCards Summary for RASAL2 Gene
RASAL2 (RAS Protein Activator Like 2) is a Protein Coding gene. Among its related pathways are RET signaling and Cytoskeletal Signaling. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is DAB2IP.
UniProtKB/Swiss-Prot for RASAL2 Gene
-
Inhibitory regulator of the Ras-cyclic AMP pathway.
Additional gene information for RASAL2 Gene
- Monarch Initiative
- Search for RASAL2 at DataMed
- Search for RASAL2 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASAL2 Gene
Genomics for RASAL2 Gene
GeneHancer (GH) Regulatory Elements for RASAL2 Gene
Promoters and enhancers for RASAL2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around RASAL2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the RASAL2 gene promoter:
-
- HFH-1
- Zic1
- Sox9
- Hlf
- NRSF form 2
- NRSF form 1
- E47
- p300
- Nkx2-2
- HNF-1A
Regulatory Element Products
Genomic Locations for RASAL2 Gene
Genomic Locations for RASAL2 Gene
- chr1:178,093,729-178,484,147
- (GRCh38/hg38)
- Size:
- 390,419 bases
- Orientation:
- Plus strand
- chr1:178,062,864-178,448,649
- (GRCh37/hg19)
- Size:
- 385,786 bases
- Orientation:
- Plus strand
Genomic View for RASAL2 Gene
Genes around RASAL2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q25.2 by Entrez Gene
- 1q25.2 by HGNC
- 1q25.2 by Ensembl
RASAL2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RASAL2 Gene
Proteins for RASAL2 Gene
-
Protein details for RASAL2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UJF2-NGAP_HUMAN
- Recommended name:
- Ras GTPase-activating protein nGAP
- Protein Accession:
- Q9UJF2
- F8W755
- O95174
- Q2TB22
- Q5TFU9
Protein attributes for RASAL2 Gene
- Size:
- 1139 amino acids
- Molecular mass:
- 128558 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAI10612.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for RASAL2 Gene
Post-translational modifications for RASAL2 Gene
Other Protein References for RASAL2 Gene
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for RASAL2
- Novus Biologicals Antibodies for RASAL2
- Invitrogen Antibodies for RASAL2 (AFLGC-RASAL2)
- GeneTex RASAL2 Antibody for RASAL2
-
Boster Bio Antibodies for RASAL2
-
Santa Cruz Biotechnology (SCBT) Antibodies for RASAL2
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for RASAL2
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- Search GeneTex for Proteins for RASAL2
Assay Products
No data available for DME Specific Peptides for RASAL2 Gene
Domains & Families for RASAL2 Gene
Gene Families for RASAL2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for RASAL2 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for RASAL2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for RASAL2 Gene
Function for RASAL2 Gene
Molecular function for RASAL2 Gene
- UniProtKB/Swiss-Prot Function:
- Inhibitory regulator of the Ras-cyclic AMP pathway.
Phenotypes From GWAS Catalog for RASAL2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005096 | GTPase activator activity | IBA,TAS | -- |
| GO:0005515 | protein binding | IPI | 15324660 |
Phenotypes for RASAL2 Gene
- MGI mutant phenotypes for RASAL2:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for RASAL2:
Animal Models for RASAL2 Gene
- MGI Knock Outs for RASAL2:
-
- Rasal2 Rasal2<tm1a(EUCOMM)Wtsi>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for RASAL2
-
CRISPR Products
-
OriGene CRISPR knockouts for RASAL2
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- Overview of 89 available RASAL2 gene related products
- Applied Biological Materials CRISPR for RASAL2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for RASAL2
- GenScript: Design CRISPR guide RNA sequences for RASAL2
miRNA for RASAL2 Gene
- miRTarBase miRNAs that target RASAL2
-
- hsa-mir-98-5p (MIRT027468)
- hsa-mir-26b-5p (MIRT029026)
- hsa-mir-15a-3p (MIRT038984)
- hsa-mir-125b-5p (MIRT045969)
- hsa-mir-99a-5p (MIRT048603)
- hsa-mir-92a-3p (MIRT048987)
- hsa-mir-203a-3p (MIRT053439)
- hsa-mir-6867-5p (MIRT469542)
- hsa-mir-511-3p (MIRT469543)
- hsa-mir-5583-3p (MIRT469544)
- hsa-mir-129-5p (MIRT654442)
- hsa-mir-4639-5p (MIRT654443)
- hsa-mir-513c-3p (MIRT654444)
- hsa-mir-513a-3p (MIRT654445)
- hsa-mir-3606-3p (MIRT654446)
- hsa-mir-30b-5p (MIRT732514)
- hsa-mir-30c-5p (MIRT732515)
- hsa-mir-136-5p (MIRT734470)
miRNA Products
Inhibitory RNA Products
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- Overview of 89 available RASAL2 gene related products
Clone Products
-
OriGene ORF clones in human for RASAL2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for RASAL2
- Addgene plasmids for RASAL2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RASAL2
- Applied Biological Materials Clones for RASAL2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for RASAL2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RASAL2 Gene
Localization for RASAL2 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| plasma membrane | 4 |
| nucleus | 2 |
- Focal adhesion sites (2)
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IBA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane | IBA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for RASAL2 Gene
Pathways & Interactions for RASAL2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | Developmental Biology |
.51
|
|
| 3 | Cytokine Signaling in Immune system | ||
| 4 | HIV Life Cycle |
.45
|
|
| 5 | Innate Immune System |
.61
|
|
Pathways by source for RASAL2 Gene
53 Reactome pathways for RASAL2 Gene
1 KEGG pathway for RASAL2 Gene
1 Cell Signaling Technology pathway for RASAL2 Gene
Interacting Proteins for RASAL2 Gene
Selected Interacting proteins:
Q9UJF2-NGAP_HUMAN
ENSP00000356621
for RASAL2 Gene via
UniProtKB
STRING
MINT
IID
GPS-Prot Interaction Network for RASAL2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0007165 | signal transduction | IEA,TAS | 9877179 |
| GO:0043087 | regulation of GTPase activity | IEA | -- |
| GO:0043547 | positive regulation of GTPase activity | IEA | -- |
| GO:0046580 | negative regulation of Ras protein signal transduction | IBA | -- |
No data available for SIGNOR curated interactions for RASAL2 Gene
Transcripts for RASAL2 Gene
mRNA/cDNA for RASAL2 Gene
- (12) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (7) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000367649 4378 bps (uc001glq.4)
- ENST00000465723 718 bps (uc057nof.1)
- ENST00000462775 14453 bps (uc001glr.4)
- ENST00000433130 2385 bps (uc057nog.1)
- ENST00000463079 650 bps (uc057noh.1)
Unigene Clusters for RASAL2 Gene
- RAS protein activator like 2:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for RASAL2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RASAL2
- genomics-online: gRNA clones - Search results for 89 available RASAL2 gene related products
- Overview of 89 available RASAL2 gene related products
- Applied Biological Materials CRISPR for RASAL2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for RASAL2
- GenScript: Design CRISPR guide RNA sequences for RASAL2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RASAL2
- Browse OriGene Inhibitory RNA Products For RASAL2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RASAL2
- genomics-online: shRNA clones - Search results for 89 available RASAL2 gene related products
- Overview of 89 available RASAL2 gene related products
Clone Products
-
OriGene ORF clones in human for RASAL2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Addgene plasmids for RASAL2
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- Applied Biological Materials Clones for RASAL2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for RASAL2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Eye (Sensory Organs)
This gene is overexpressed in Synovial fluid (13.9), Milk (11.6), and Uterus (6.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RASAL2 Gene
NURSA nuclear receptor signaling pathways regulating expression of RASAL2 Gene:
RASAL2SOURCE GeneReport for Unigene cluster for RASAL2 Gene:
Hs.496139Evidence on tissue expression from TISSUES for RASAL2 Gene
- Heart(4.2)
- Liver(4.1)
- Nervous system(3.6)
Primer Products
-
OriGene qPCR primer pairs for RASAL2
- genomics-online: primer clones - Search results for 89 available RASAL2 gene related products
- Overview of 89 available RASAL2 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RASAL2 Gene
Orthologs for RASAL2 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | RASAL2 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | RASAL2 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | RASAL2 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Rasal2 16 34 33 |
|
||
| cow (Bos Taurus) |
Mammalia | RASAL2 34 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | RASAL2 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | RASAL2 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | RASAL2 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | rasal2 33 |
|
||
| Str.11362 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.1575 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | rasal2 34 33 |
|
OneToOne | |
| Dr.24417 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.7799 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG42684 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | gap-2 34 35 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | BUD2 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.6146 34 |
|
OneToMany |
- Species where no ortholog for RASAL2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for RASAL2 Gene
- ENSEMBL:
- Gene Tree for RASAL2 (if available)
- TreeFam:
- Gene Tree for RASAL2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for RASAL2: view image
Paralogs for RASAL2 Gene
Variants for RASAL2 Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs193921085 | uncertain-significance, Malignant tumor of prostate | 178,473,216(+) | G/T | coding_sequence_variant, stop_gained, stop_lost, terminator_codon_variant | |
| rs765646105 | A colorectal cancer sample | 178,442,684(+) | A/T | coding_sequence_variant, missense_variant | |
| VAR_035542 | A breast cancer sample | p.Glu379Asp | |||
| rs1000002711 | -- | 178,295,917(+) | G/A | genic_upstream_transcript_variant, intron_variant | |
| rs1000019746 | -- | 178,095,798(+) | G/C | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2534493 | CNV | deletion | 19546169 |
| esv2606666 | CNV | deletion | 19546169 |
| esv3416886 | CNV | duplication | 20981092 |
| esv3588029 | CNV | loss | 21293372 |
| esv3588030 | CNV | loss | 21293372 |
| esv3588031 | CNV | loss | 21293372 |
| esv3588032 | CNV | loss | 21293372 |
| esv3588033 | CNV | loss | 21293372 |
| nsv1142076 | CNV | tandem duplication | 24896259 |
| nsv473443 | CNV | novel sequence insertion | 20440878 |
| nsv508670 | CNV | deletion | 20534489 |
| nsv548252 | CNV | gain | 21841781 |
| nsv946518 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
5.63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.40;
42.45% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RASAL2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASAL2 Gene
Disorders for RASAL2 Gene
Additional Disease Information for RASAL2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for RASAL2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RASAL2 Gene
Publications for RASAL2 Gene
- A novel human RasGAP-like gene that maps within the prostate cancer susceptibility locus at chromosome 1q25. (PMID: 9877179) Noto S … Hatakeyama M (FEBS letters 1998) 2 3 4 58
- Analyses of shared genetic factors between asthma and obesity in children. (PMID: 20816195) Melén E … Lasky-Su J (The Journal of allergy and clinical immunology 2010) 3 44 58
- Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population. (PMID: 20571754) Fontaine-Bisson B … Franks PW (Diabetologia 2010) 3 44 58
- Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. (PMID: 19079260) Thorleifsson G … Stefansson K (Nature genetics 2009) 3 44 58
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
Products for RASAL2 Gene
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- Overview of 89 available RASAL2 gene related products
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Sources for RASAL2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
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