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Aliases for RASA4B Gene

Aliases for RASA4B Gene

  • RAS P21 Protein Activator 4B 2 3 5
  • Putative Ras GTPase-Activating Protein 4B 3
  • Ras GTPase-Activating Protein 4B 3

External Ids for RASA4B Gene

Previous GeneCards Identifiers for RASA4B Gene

  • GC00U923094
  • GC07M101915
  • GC07M102122
  • GC07M101483

Summaries for RASA4B Gene

GeneCards Summary for RASA4B Gene

RASA4B (RAS P21 Protein Activator 4B) is a Protein Coding gene. Among its related pathways are Ras signaling pathway. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is RASA4.

UniProtKB/Swiss-Prot for RASA4B Gene

  • Ca(2+)-dependent Ras GTPase-activating protein, that may play a role in the Ras-MAPK pathway.

Additional gene information for RASA4B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASA4B Gene

Genomics for RASA4B Gene

GeneHancer (GH) Regulatory Elements for RASA4B Gene

Promoters and enhancers for RASA4B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J102517 Promoter/Enhancer 1.2 EPDnew Ensembl dbSUPER 650.7 0.0 -20 0.8 RASA4B ENSG00000272949
GH07J102493 Promoter 0.5 EPDnew 650.3 +24.5 24474 0.1 RASA4B GC07M102479 ENSG00000272949
GH07J102518 Enhancer 0.2 dbSUPER 650.7 -1.1 -1052 0.8 RASA4B ENSG00000272949
GH07J102419 Enhancer 1.3 Ensembl ENCODE dbSUPER 10.1 +97.1 97131 2.8 PKNOX1 ARNT TCF12 ZNF766 GATA2 ATF7 CAVIN1 NCOA1 ZNF592 MBD2 LOC105375433 ORAI2 ENSG00000272949 LRWD1 ALKBH4 DNAJC2 RASA4B CRYZP1 MIR548O LOC100630923
GH07J101933 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 5.7 +582.0 582018 4.4 FOXA2 SIN3A STAT5A BATF RAD21 YY1 ETS1 EGR1 ZNF143 ATF7 CUX1 RASA4B ENSG00000272219 GC07P101859
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RASA4B on UCSC Golden Path with GeneCards custom track

Genomic Locations for RASA4B Gene

Genomic Locations for RASA4B Gene
35,337 bases
Minus strand
35,337 bases
Minus strand

Genomic View for RASA4B Gene

Genes around RASA4B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RASA4B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RASA4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASA4B Gene

Proteins for RASA4B Gene

  • Protein details for RASA4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras GTPase-activating protein 4B
    Protein Accession:

    Protein attributes for RASA4B Gene

    803 amino acids
    Molecular mass:
    90406 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RASA4B Gene

Post-translational modifications for RASA4B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RASA4B Gene

No data available for DME Specific Peptides for RASA4B Gene

Domains & Families for RASA4B Gene

Gene Families for RASA4B Gene

Suggested Antigen Peptide Sequences for RASA4B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RASA4B: view

No data available for UniProtKB/Swiss-Prot for RASA4B Gene

Function for RASA4B Gene

Molecular function for RASA4B Gene

UniProtKB/Swiss-Prot Function:
Ca(2+)-dependent Ras GTPase-activating protein, that may play a role in the Ras-MAPK pathway.

Phenotypes From GWAS Catalog for RASA4B Gene

Gene Ontology (GO) - Molecular Function for RASA4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IBA --
GO:0005543 phospholipid binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RASA4B: view

Animal Model Products

CRISPR Products

miRNA for RASA4B Gene

miRTarBase miRNAs that target RASA4B

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RASA4B

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RASA4B Gene

Localization for RASA4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RASA4B Gene

Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RASA4B gene
Compartment Confidence
cytosol 5
plasma membrane 3
nucleus 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (1)
  • Vesicles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RASA4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with RASA4B: view

Pathways & Interactions for RASA4B Gene

SuperPathways for RASA4B Gene

SuperPathway Contained pathways
1 Ras signaling pathway
genes like me logo Genes that share pathways with RASA4B: view

Pathways by source for RASA4B Gene

1 KEGG pathway for RASA4B Gene

Gene Ontology (GO) - Biological Process for RASA4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0035556 intracellular signal transduction IEA --
GO:0043087 regulation of GTPase activity IEA --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0046580 negative regulation of Ras protein signal transduction IEA,IBA --
genes like me logo Genes that share ontologies with RASA4B: view

No data available for SIGNOR curated interactions for RASA4B Gene

Drugs & Compounds for RASA4B Gene

No Compound Related Data Available

Transcripts for RASA4B Gene

mRNA/cDNA for RASA4B Gene

(5) REFSEQ mRNAs :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RASA4B

Alternative Splicing Database (ASD) splice patterns (SP) for RASA4B Gene

No ASD Table

Relevant External Links for RASA4B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RASA4B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RASA4B Gene

mRNA differential expression in normal tissues according to GTEx for RASA4B Gene

This gene is overexpressed in Muscle - Skeletal (x9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RASA4B Gene

NURSA nuclear receptor signaling pathways regulating expression of RASA4B Gene:

genes like me logo Genes that share expression patterns with RASA4B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RASA4B Gene

Orthologs for RASA4B Gene

This gene was present in the common ancestor of animals.

Orthologs for RASA4B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 34
  • 93 (a)
(Bos Taurus)
Mammalia -- 34
  • 85 (a)
(Mus musculus)
Mammalia Rasa4 34
  • 81 (a)
(Canis familiaris)
Mammalia -- 34
  • 80 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 66 (a)
-- 34
  • 61 (a)
(Gallus gallus)
Aves -- 34
  • 62 (a)
(Danio rerio)
Actinopterygii rasa4 34
  • 59 (a)
fruit fly
(Drosophila melanogaster)
Insecta Gap1 34
  • 18 (a)
(Caenorhabditis elegans)
Secernentea gap-1 34
  • 22 (a)
Species where no ortholog for RASA4B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RASA4B Gene

Gene Tree for RASA4B (if available)
Gene Tree for RASA4B (if available)

Paralogs for RASA4B Gene

Paralogs for RASA4B Gene

(4) SIMAP similar genes for RASA4B Gene using alignment to 3 proteins:

  • F8W6L0_HUMAN
genes like me logo Genes that share paralogs with RASA4B: view

Variants for RASA4B Gene

Sequence variations from dbSNP and Humsavar for RASA4B Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1001492099 -- 102,507,216(-) G/A intron_variant
rs1008378953 -- 102,514,777(-) GGG/GG intron_variant
rs1009035682 -- 102,508,876(-) G/A/T intron_variant
rs1009129184 -- 102,486,647(-) G/T genic_downstream_transcript_variant, intron_variant
rs1010511456 -- 102,511,472(-) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RASA4B Gene

Variant ID Type Subtype PubMed ID
dgv11541n54 CNV loss 21841781
dgv11542n54 CNV loss 21841781
dgv11543n54 CNV loss 21841781
dgv11544n54 CNV loss 21841781
dgv11545n54 CNV loss 21841781
dgv11546n54 CNV loss 21841781
dgv11547n54 CNV loss 21841781
dgv11548n54 CNV loss 21841781
dgv11549n54 CNV loss 21841781
dgv11550n54 CNV loss 21841781
dgv11551n54 CNV loss 21841781
dgv1944e212 CNV loss 25503493
dgv23n31 CNV gain 19718026
dgv3893e59 CNV duplication 20981092
dgv3894e59 CNV duplication 20981092
dgv3895e59 CNV duplication 20981092
dgv3896e59 CNV duplication 20981092
dgv3897e59 CNV duplication 20981092
dgv3902e59 CNV duplication 20981092
dgv3903e59 CNV duplication 20981092
dgv3904e59 CNV duplication 20981092
dgv3905e59 CNV duplication 20981092
dgv6538n100 CNV gain 25217958
dgv6539n100 CNV gain 25217958
dgv6540n100 CNV gain 25217958
esv2734946 CNV deletion 23290073
esv27624 CNV gain+loss 19812545
esv2764015 CNV loss 21179565
esv3353259 CNV duplication 20981092
esv3358316 CNV duplication 20981092
esv3359069 CNV duplication 20981092
esv3363111 CNV duplication 20981092
esv3384577 CNV duplication 20981092
esv3397016 CNV duplication 20981092
esv3401050 CNV duplication 20981092
esv3411488 CNV duplication 20981092
esv3424877 CNV duplication 20981092
esv3425603 CNV duplication 20981092
esv3451508 CNV duplication 20981092
esv3891167 CNV loss 25118596
esv3891168 CNV gain+loss 25118596
esv3891169 CNV gain+loss 25118596
esv3891171 CNV loss 25118596
esv7079 CNV loss 19470904
nsv1076629 CNV duplication 25765185
nsv1077498 CNV duplication 25765185
nsv1110491 CNV duplication 24896259
nsv1110492 CNV duplication 24896259
nsv1110493 CNV duplication 24896259
nsv1119230 CNV duplication 24896259
nsv1128955 CNV duplication 24896259
nsv1128956 CNV duplication 24896259
nsv1128957 CNV duplication 24896259
nsv1139905 CNV duplication 24896259
nsv1145864 CNV duplication 26484159
nsv1146127 CNV duplication 26484159
nsv1148488 CNV duplication 26484159
nsv1149852 CNV duplication 26484159
nsv1150251 CNV duplication 26484159
nsv1152853 CNV duplication 26484159
nsv1153073 CNV duplication 26484159
nsv1153574 CNV duplication 26484159
nsv428182 CNV gain 18775914
nsv433392 CNV gain 18776910
nsv436086 CNV insertion 17901297
nsv436552 CNV deletion 17901297
nsv469682 CNV gain+loss 16826518
nsv471451 CNV gain 19718026
nsv471643 CNV gain+loss 15918152
nsv482112 CNV gain 20164927
nsv499135 CNV loss 21111241
nsv499529 CNV loss 21111241
nsv509219 CNV insertion 20534489
nsv5879 CNV deletion 18451855
nsv608005 CNV gain 21841781
nsv608046 CNV loss 21841781
nsv608048 CNV loss 21841781
nsv608054 CNV loss 21841781
nsv8192 CNV gain 18304495
nsv831083 CNV loss 17160897
nsv9 CNV deletion 15895083
nsv949919 CNV duplication 24416366
nsv970919 CNV duplication 23825009
nsv970920 CNV duplication 23825009
nsv981563 CNV duplication 23825009

Variation tolerance for RASA4B Gene

Gene Damage Index Score: 11.00; 92.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RASA4B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASA4B Gene

Disorders for RASA4B Gene

Additional Disease Information for RASA4B

No disorders were found for RASA4B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RASA4B Gene

Publications for RASA4B Gene

  1. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 58
  2. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. (PMID: 28065597) Yao Z … Stagljar I (Molecular cell 2017) 3 58
  3. CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway. (PMID: 11448776) Lockyer PJ … Cullen PJ (Current biology : CB 2001) 3 58
  4. Toward a complete human genome sequence. (PMID: 9847074) Sanger Center … Genome Sequencing Center (Genome research 1998) 3 58

Products for RASA4B Gene

Sources for RASA4B Gene

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