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Aliases for RASA4 Gene

Aliases for RASA4 Gene

  • RAS P21 Protein Activator 4 2 3 5
  • Calcium-Promoted Ras Inactivator 3 4
  • RasGAP-Activating-Like Protein 2 3 4
  • CAPRI 3 4
  • GAPL 3 4
  • Ras GTPase-Activating Protein 4 3
  • Ca2+-Promoted Ras Inactivator 3
  • Ras P21 Protein Activator 4 4
  • KIAA0538 4

External Ids for RASA4 Gene

Previous GeneCards Identifiers for RASA4 Gene

  • GC07M101781
  • GC07M101782
  • GC07M101813
  • GC07M102001
  • GC07M102007
  • GC07M102220
  • GC07M043952

Summaries for RASA4 Gene

Entrez Gene Summary for RASA4 Gene

  • This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for RASA4 Gene

RASA4 (RAS P21 Protein Activator 4) is a Protein Coding gene. Diseases associated with RASA4 include Pancreas Adenocarcinoma. Among its related pathways are RET signaling and HIV Life Cycle. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is RASA4B.

UniProtKB/Swiss-Prot for RASA4 Gene

  • Ca(2+)-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis.

Gene Wiki entry for RASA4 Gene

Additional gene information for RASA4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASA4 Gene

Genomics for RASA4 Gene

GeneHancer (GH) Regulatory Elements for RASA4 Gene

Promoters and enhancers for RASA4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J102616 Promoter/Enhancer 1.3 EPDnew Ensembl dbSUPER 650.7 +0.1 57 1 RB1 RASA4 ENSG00000270249 ENSG00000205236 ENSG00000279168
GH07J102594 Promoter 1 EPDnew Ensembl 650.3 +22.7 22657 0.2 ENSG00000270249 RASA4 ENSG00000205236 ENSG00000279168
GH07J102617 Enhancer 0.2 dbSUPER 650.7 -1.1 -1050 0.8 RASA4 PIR51755 ENSG00000205236 ENSG00000279168
GH07J102713 Enhancer 1.1 Ensembl ENCODE dbSUPER 20 -97.9 -97869 3.3 CTCF RB1 FEZF1 BMI1 ZNF143 ATF7 PRDM10 IKZF2 SRF SMARCA5 POLR2J2 RASA4 RASA4DP FAM185A FBXL13
GH07J102748 Promoter/Enhancer 1.5 Ensembl ENCODE 14.2 -132.4 -132358 1.8 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A ZNF2 YY1 POLR2B E2F8 FAM185A POLR2J2 RASA4DP SPDYE2 RASA4 DNAJC2 ARMC10 FBXL13 CRYZP1 ENSG00000213385
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RASA4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RASA4 gene promoter:
  • NF-YB
  • NF-YA
  • NF-Y
  • CP1A
  • CBF-B
  • CBF-A
  • CBF(2)
  • c-Rel
  • Lmo2
  • HOXA5

Genomic Locations for RASA4 Gene

Genomic Locations for RASA4 Gene
42,952 bases
Minus strand
37,113 bases
Minus strand

Genomic View for RASA4 Gene

Genes around RASA4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RASA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RASA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASA4 Gene

Proteins for RASA4 Gene

  • Protein details for RASA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras GTPase-activating protein 4
    Protein Accession:
    Secondary Accessions:
    • O60286
    • Q14CQ4
    • Q86UW3
    • Q96QU0

    Protein attributes for RASA4 Gene

    803 amino acids
    Molecular mass:
    90458 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAB97935.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAP22345.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAA25464.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for RASA4 Gene


neXtProt entry for RASA4 Gene

Post-translational modifications for RASA4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RASA4 Gene

Domains & Families for RASA4 Gene

Gene Families for RASA4 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry



  • The PH domain does not bind phosphatidylinositol 4,5-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate. This lack of binding activity is due to Leu-592, compared to Arg found in other family members.
  • The PH domain does not bind phosphatidylinositol 4,5-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate. This lack of binding activity is due to Leu-592, compared to Arg found in other family members.
genes like me logo Genes that share domains with RASA4: view

Function for RASA4 Gene

Molecular function for RASA4 Gene

UniProtKB/Swiss-Prot Function:
Ca(2+)-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis.

Phenotypes From GWAS Catalog for RASA4 Gene

Gene Ontology (GO) - Molecular Function for RASA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IDA,IEA 11448776
GO:0005543 phospholipid binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RASA4: view
genes like me logo Genes that share phenotypes with RASA4: view

Animal Models for RASA4 Gene

MGI Knock Outs for RASA4:

Animal Model Products

miRNA for RASA4 Gene

miRTarBase miRNAs that target RASA4

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RASA4 Gene

Localization for RASA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RASA4 Gene

Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Note=Localized to the cytosol as a result of its lack of phosphoinositide binding activity. Upon agonist-stimulated calcium mobilization, utilizes the C2A and C2B domains to associate with the plasma membrane.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RASA4 gene
Compartment Confidence
cytosol 5
plasma membrane 4

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RASA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005886 colocalizes_with plasma membrane IDA,IEA 16009725
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with RASA4: view

Pathways & Interactions for RASA4 Gene

SuperPathways for RASA4 Gene

SuperPathway Contained pathways
1 RET signaling
2 Developmental Biology
3 Cytokine Signaling in Immune system
4 HIV Life Cycle
5 Innate Immune System
genes like me logo Genes that share pathways with RASA4: view

Pathways by source for RASA4 Gene

Gene Ontology (GO) - Biological Process for RASA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0007165 signal transduction IEA --
GO:0034260 negative regulation of GTPase activity IMP 11448776
GO:0035556 intracellular signal transduction IEA --
GO:0043087 regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with RASA4: view

No data available for SIGNOR curated interactions for RASA4 Gene

Drugs & Compounds for RASA4 Gene

(2) Drugs for RASA4 Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
Salirasib Investigational Pharma Inhibitor of active Ras protein, Ras inhibitor; also induces autophagy 0
genes like me logo Genes that share compounds with RASA4: view

Transcripts for RASA4 Gene

mRNA/cDNA for RASA4 Gene

(5) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(17) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RASA4 Gene

RAS p21 protein activator 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RASA4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^
SP3: -
SP4: -
SP7: -
SP8: - - -
SP9: - - -
SP11: - - -
SP12: -

ExUns: 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b · 24c
SP4: - -
SP9: - -
SP11: - -
SP12: - -
SP13: - -

Relevant External Links for RASA4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RASA4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RASA4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RASA4 Gene

This gene is overexpressed in Muscle - Skeletal (x9.9).

Protein differential expression in normal tissues from HIPED for RASA4 Gene

This gene is overexpressed in Ovary (20.7), Prostate (20.5), Urinary Bladder (14.7), and Retina (13.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RASA4 Gene

Protein tissue co-expression partners for RASA4 Gene

NURSA nuclear receptor signaling pathways regulating expression of RASA4 Gene:


SOURCE GeneReport for Unigene cluster for RASA4 Gene:


mRNA Expression by UniProt/SwissProt for RASA4 Gene:

Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for RASA4 Gene

  • Nervous system(4.8)
  • Blood(4.3)
  • Liver(4)
genes like me logo Genes that share expression patterns with RASA4: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RASA4 Gene

Orthologs for RASA4 Gene

This gene was present in the common ancestor of animals.

Orthologs for RASA4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC742087 33
  • 99.29 (n)
-- 34
  • 99 (a)
(Bos Taurus)
Mammalia -- 34
  • 90 (a)
RASA4 33
  • 89.53 (n)
(Canis familiaris)
Mammalia RASA4 33
  • 89.53 (n)
-- 34
  • 85 (a)
(Rattus norvegicus)
Mammalia Rasa4 33
  • 84.62 (n)
(Mus musculus)
Mammalia Rasa4 16 34 33
  • 84.37 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 69 (a)
-- 34
  • 66 (a)
(Gallus gallus)
Aves RASA4 33
  • 74.06 (n)
-- 34
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488193 33
  • 63.94 (n)
(Danio rerio)
Actinopterygii rasa4 34 33
  • 64.49 (n)
fruit fly
(Drosophila melanogaster)
Insecta Gap1 34
  • 19 (a)
(Caenorhabditis elegans)
Secernentea gap-1 34
  • 23 (a)
Species where no ortholog for RASA4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RASA4 Gene

Gene Tree for RASA4 (if available)
Gene Tree for RASA4 (if available)
Evolutionary constrained regions (ECRs) for RASA4: view image

Paralogs for RASA4 Gene

Paralogs for RASA4 Gene

(9) SIMAP similar genes for RASA4 Gene using alignment to 9 proteins:

  • B7ZL55_HUMAN
  • E5RK78_HUMAN
  • H0YB35_HUMAN
  • Q2NL74_HUMAN
genes like me logo Genes that share paralogs with RASA4: view

Variants for RASA4 Gene

Sequence variations from dbSNP and Humsavar for RASA4 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1003473758 -- 102,612,371(-) G/T intron_variant
rs1004679248 -- 102,603,865(-) C/A intron_variant
rs1005660489 -- 102,612,330(-) CCC/CCCC intron_variant
rs1006043556 -- 102,596,457(-) T/G intron_variant
rs1012904728 -- 102,613,734(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RASA4 Gene

Variant ID Type Subtype PubMed ID
dgv11541n54 CNV loss 21841781
dgv11542n54 CNV loss 21841781
dgv11543n54 CNV loss 21841781
dgv11544n54 CNV loss 21841781
dgv11545n54 CNV loss 21841781
dgv11546n54 CNV loss 21841781
dgv11547n54 CNV loss 21841781
dgv11548n54 CNV loss 21841781
dgv11549n54 CNV loss 21841781
dgv11550n54 CNV loss 21841781
dgv11551n54 CNV loss 21841781
dgv1944e212 CNV loss 25503493
dgv23n31 CNV gain 19718026
dgv3894e59 CNV duplication 20981092
dgv3902e59 CNV duplication 20981092
dgv3903e59 CNV duplication 20981092
dgv3904e59 CNV duplication 20981092
dgv3905e59 CNV duplication 20981092
dgv6538n100 CNV gain 25217958
dgv6539n100 CNV gain 25217958
dgv6540n100 CNV gain 25217958
esv2734946 CNV deletion 23290073
esv27624 CNV gain+loss 19812545
esv2764015 CNV loss 21179565
esv3353259 CNV duplication 20981092
esv3358316 CNV duplication 20981092
esv3384577 CNV duplication 20981092
esv3397016 CNV duplication 20981092
esv3411488 CNV duplication 20981092
esv3425603 CNV duplication 20981092
esv3891167 CNV loss 25118596
esv3891168 CNV gain+loss 25118596
esv3891169 CNV gain+loss 25118596
esv3891171 CNV loss 25118596
esv7079 CNV loss 19470904
nsv1077498 CNV duplication 25765185
nsv1110493 CNV duplication 24896259
nsv1119230 CNV duplication 24896259
nsv1128956 CNV duplication 24896259
nsv1128957 CNV duplication 24896259
nsv1139905 CNV duplication 24896259
nsv1148488 CNV duplication 26484159
nsv1149852 CNV duplication 26484159
nsv1152853 CNV duplication 26484159
nsv1153073 CNV duplication 26484159
nsv428182 CNV gain 18775914
nsv433392 CNV gain 18776910
nsv436086 CNV insertion 17901297
nsv436552 CNV deletion 17901297
nsv469682 CNV gain+loss 16826518
nsv471451 CNV gain 19718026
nsv471643 CNV gain+loss 15918152
nsv482112 CNV gain 20164927
nsv499135 CNV loss 21111241
nsv499529 CNV loss 21111241
nsv509219 CNV insertion 20534489
nsv5879 CNV deletion 18451855
nsv608005 CNV gain 21841781
nsv608046 CNV loss 21841781
nsv608048 CNV loss 21841781
nsv608054 CNV loss 21841781
nsv8192 CNV gain 18304495
nsv831083 CNV loss 17160897
nsv9 CNV deletion 15895083
nsv981563 CNV duplication 23825009

Variation tolerance for RASA4 Gene

Gene Damage Index Score: 0.41; 9.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RASA4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASA4 Gene

Disorders for RASA4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RASA4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
pancreas adenocarcinoma
  • pancreatic adenocarcinoma
- elite association - COSMIC cancer census association via MalaCards
Search RASA4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RASA4

genes like me logo Genes that share disorders with RASA4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RASA4 Gene

Publications for RASA4 Gene

  1. CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway. (PMID: 11448776) Lockyer PJ … Cullen PJ (Current biology : CB 2001) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 58
  5. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 3 4 58

Products for RASA4 Gene

Sources for RASA4 Gene

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