Aliases for RASA3 Gene
External Ids for RASA3 Gene
Previous GeneCards Identifiers for RASA3 Gene
This gene encodes a protein that binds inositol 1,3,4,5-tetrakisphosphate and stimulates the GTPase activity of Ras p21. This protein functions as a negative regulator of the Ras signalling pathway. It is localized to the cell membrane via a pleckstrin homology (PH) domain in the C-terminal region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
GeneCards Summary for RASA3 Gene
RASA3 (RAS P21 Protein Activator 3) is a Protein Coding gene. Diseases associated with RASA3 include Paralytic Poliomyelitis and Poliomyelitis. Among its related pathways are RET signaling and Ras signaling pathway. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and calcium-release channel activity. An important paralog of this gene is RASA2.
UniProtKB/Swiss-Prot Summary for RASA3 Gene
Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) with high affinity. Might be a specific IP4 receptor.