Aliases for RASA3 Gene
External Ids for RASA3 Gene
Previous GeneCards Identifiers for RASA3 Gene
This gene encodes a protein that binds inositol 1,3,4,5-tetrakisphosphate and stimulates the GTPase activity of Ras p21. This protein functions as a negative regulator of the Ras signalling pathway. It is localized to the cell membrane via a pleckstrin homology (PH) domain in the C-terminal region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
GeneCards Summary for RASA3 Gene
RASA3 (RAS P21 Protein Activator 3) is a Protein Coding gene. Diseases associated with RASA3 include Bleeding Disorder, Platelet-Type, 18. Among its related pathways are Signaling by GPCR and G-protein signaling Ras family GTPases in kinase cascades (scheme). Gene Ontology (GO) annotations related to this gene include GTPase activator activity and calcium-release channel activity. An important paralog of this gene is RASA2.
UniProtKB/Swiss-Prot Summary for RASA3 Gene
Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) with high affinity. Might be a specific IP4 receptor.