Aliases for RARS1 Gene
External Ids for RARS1 Gene
Previous HGNC Symbols for RARS1 Gene
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Arginyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family. [provided by RefSeq, Jul 2008]
GeneCards Summary for RARS1 Gene
RARS1 (Arginyl-TRNA Synthetase 1) is a Protein Coding gene. Diseases associated with RARS1 include Leukodystrophy, Hypomyelinating, 9 and Embryonal Carcinoma. Among its related pathways are tRNA Aminoacylation and Amino Acid metabolism. An important paralog of this gene is RARS2.
UniProtKB/Swiss-Prot Summary for RARS1 Gene
Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis (PubMed:25288775). Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1 (PubMed:17443684).