Aliases for RARS Gene
External Ids for RARS Gene
Previous GeneCards Identifiers for RARS Gene
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Arginyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family. [provided by RefSeq, Jul 2008]
GeneCards Summary for RARS Gene
RARS (Arginyl-TRNA Synthetase) is a Protein Coding gene. Diseases associated with RARS include Leukodystrophy, Hypomyelinating, 9 and Embryonal Carcinoma. Among its related pathways are Gene Expression and tRNA Aminoacylation. Gene Ontology (GO) annotations related to this gene include nucleotide binding and aminoacyl-tRNA ligase activity. An important paralog of this gene is RARS2.
UniProtKB/Swiss-Prot for RARS Gene
Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis (PubMed:25288775). Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1 (PubMed:17443684).