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Aliases for RARRES3 Gene

Aliases for RARRES3 Gene

  • Retinoic Acid Receptor Responder 3 2 3 5
  • Retinoic Acid Receptor Responder (Tazarotene Induced) 3 2 3
  • Retinoid-Inducible Gene 1 Protein 3 4
  • Tazarotene-Induced Gene 3 Protein 3 4
  • RAR-Responsive Protein TIG3 3 4
  • HRAS-Like Suppressor 4 3 4
  • HRSL4 3 4
  • RIG1 3 4
  • TIG3 3 4
  • Retinoic Acid Receptor Responder Protein 3 3
  • Retinoic Acid-Inducible Gene 1 3
  • EC 3.1.1.- 4
  • PLA1/2-3 3
  • HRASLS4 3

External Ids for RARRES3 Gene

Previous GeneCards Identifiers for RARRES3 Gene

  • GC11P065816
  • GC11P064879
  • GC11P063555
  • GC11P063079
  • GC11P063060
  • GC11P063304
  • GC11P059633

Summaries for RARRES3 Gene

Entrez Gene Summary for RARRES3 Gene

  • Retinoids exert biologic effects such as potent growth inhibitory and cell differentiation activities and are used in the treatment of hyperproliferative dermatological diseases. These effects are mediated by specific nuclear receptor proteins that are members of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. RARRES1, RARRES2, and RARRES3 are genes whose expression is upregulated by the synthetic retinoid tazarotene. RARRES3 is thought act as a tumor suppressor or growth regulator. [provided by RefSeq, Jul 2008]

GeneCards Summary for RARRES3 Gene

RARRES3 (Retinoic Acid Receptor Responder 3) is a Protein Coding gene. Diseases associated with RARRES3 include Psoriasis and Poland Syndrome. Among its related pathways are Metabolism and Acyl chain remodelling of PE. Gene Ontology (GO) annotations related to this gene include phospholipase A2 activity. An important paralog of this gene is HRASLS2.

UniProtKB/Swiss-Prot for RARRES3 Gene

  • Exhibits PLA1/2 activity, catalyzing the calcium-independent hydrolysis of acyl groups in various phosphotidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. N- and O-acylation activity is hardly detectable.

Gene Wiki entry for RARRES3 Gene

Additional gene information for RARRES3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RARRES3 Gene

Genomics for RARRES3 Gene

GeneHancer (GH) Regulatory Elements for RARRES3 Gene

Promoters and enhancers for RARRES3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I063530 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 555.2 -1.8 -1783 8.4 FOXA2 PKNOX1 ATF1 ARNT YY1 ETS1 ZNF766 FOS ATF7 RUNX3 RARRES3 CSKMT GANAB SNHG1 HRASLS2 ENSG00000203520 PLA2G16 TUT1 ENSG00000256789 NXF1
GH11I063563 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 18.1 +29.2 29205 5.8 HDGF PKNOX1 FOXA2 SMAD1 ARNT NEUROD1 SIN3A IRF4 ZNF766 ZNF207 HRASLS2 RARRES3 TTC9C ENSG00000203520 PLA2G16 ENSG00000256789 OTUB1 LOC105369335 GC11M063550
GH11I063504 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 12 -30.2 -30184 3.6 HDAC1 RAD21 ZBTB40 ZNF766 ZNF143 FOS ATF7 CREM SMARCA5 RXRA LGALS12 RARRES3 ENSG00000203520 PLA2G16 ENSG00000256789 ATL3 TMSB4XP5
GH11I063573 Enhancer 1.4 Ensembl ENCODE dbSUPER 11.3 +37.9 37866 2 HDGF PKNOX1 ATF1 FOXA2 ARNT ARID4B DMAP1 ETS1 YY1 ZNF766 LOC105369335 PLA2G16 ENSG00000203520 RARRES3 ENSG00000256789 HRASLS2 GC11M063550
GH11I063502 Enhancer 1 FANTOM5 Ensembl ENCODE 12 -33.6 -33605 2.3 L3MBTL2 NR4A1 BACH1 CBFA2T3 GABPA MITF POLR2A IKZF1 CUX1 MYC RARRES3 PLA2G16 ENSG00000203520 ENSG00000256789 ATL3 MARK2 RTN3 LGALS12 HRASLS5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RARRES3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RARRES3 gene promoter:

Genomic Locations for RARRES3 Gene

Genomic Locations for RARRES3 Gene
9,662 bases
Plus strand

Genomic View for RARRES3 Gene

Genes around RARRES3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RARRES3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RARRES3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RARRES3 Gene

Proteins for RARRES3 Gene

  • Protein details for RARRES3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Retinoic acid receptor responder protein 3
    Protein Accession:
    Secondary Accessions:
    • B2R599
    • B4DDW2
    • E7ENZ7
    • O95200

    Protein attributes for RARRES3 Gene

    164 amino acids
    Molecular mass:
    18179 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RARRES3 Gene

    Alternative splice isoforms for RARRES3 Gene


neXtProt entry for RARRES3 Gene

Post-translational modifications for RARRES3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RARRES3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RARRES3 Gene

Domains & Families for RARRES3 Gene

Gene Families for RARRES3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for RARRES3 Gene


Suggested Antigen Peptide Sequences for RARRES3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the H-rev107 family.
  • Belongs to the H-rev107 family.
genes like me logo Genes that share domains with RARRES3: view

Function for RARRES3 Gene

Molecular function for RARRES3 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=400 uM for dipalmitoyl-PC {ECO:0000269 PubMed:19615464}; Vmax=530 nmol/min/mg enzyme with dipalmitoyl-PC as substrate {ECO:0000269 PubMed:19615464}; Vmax=240 nmol/min/mg enzyme with dipalmitoyl-PE as substrate {ECO:0000269 PubMed:19615464}; pH dependence: Optimum pH is 8. {ECO:0000269 PubMed:19615464};
UniProtKB/Swiss-Prot Function:
Exhibits PLA1/2 activity, catalyzing the calcium-independent hydrolysis of acyl groups in various phosphotidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. N- and O-acylation activity is hardly detectable.
UniProtKB/Swiss-Prot Induction:
By all-trans-retinoic acid and synthetic retinoids.

Enzyme Numbers (IUBMB) for RARRES3 Gene

Gene Ontology (GO) - Molecular Function for RARRES3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004623 phospholipase A2 activity IDA 20100577
GO:0005515 protein binding IPI 22908223
GO:0016746 transferase activity, transferring acyl groups TAS --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with RARRES3: view
genes like me logo Genes that share phenotypes with RARRES3: view

Animal Model Products

CRISPR Products

miRNA for RARRES3 Gene

miRTarBase miRNAs that target RARRES3

Inhibitory RNA Products

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RARRES3 Gene

Localization for RARRES3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RARRES3 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RARRES3 gene
Compartment Confidence
cytosol 5
plasma membrane 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RARRES3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RARRES3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RARRES3 Gene

Pathways & Interactions for RARRES3 Gene

genes like me logo Genes that share pathways with RARRES3: view

Gene Ontology (GO) - Biological Process for RARRES3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006644 phospholipid metabolic process IDA,IEA 20100577
GO:0008285 negative regulation of cell proliferation IEA --
GO:0016042 lipid catabolic process IEA --
GO:0036152 phosphatidylethanolamine acyl-chain remodeling TAS --
genes like me logo Genes that share ontologies with RARRES3: view

No data available for SIGNOR curated interactions for RARRES3 Gene

Drugs & Compounds for RARRES3 Gene

(1) Drugs for RARRES3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for RARRES3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RARRES3: view

Transcripts for RARRES3 Gene

Unigene Clusters for RARRES3 Gene

Retinoic acid receptor responder (tazarotene induced) 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RARRES3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP2: -

Relevant External Links for RARRES3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RARRES3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RARRES3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RARRES3 Gene

This gene is overexpressed in Kidney - Cortex (x6.0).

NURSA nuclear receptor signaling pathways regulating expression of RARRES3 Gene:


SOURCE GeneReport for Unigene cluster for RARRES3 Gene:


mRNA Expression by UniProt/SwissProt for RARRES3 Gene:

Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for RARRES3 Gene

  • Lung(4.5)
  • Skin(4.4)
  • Spleen(4.3)
genes like me logo Genes that share expression patterns with RARRES3: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RARRES3 Gene

Orthologs for RARRES3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RARRES3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RARRES3 33 34
  • 99.8 (n)
(Canis familiaris)
Mammalia RARRES3 33 34
  • 75.57 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 43 (a)
-- 34
  • 40 (a)
-- 34
  • 39 (a)
-- 34
  • 34 (a)
-- 34
  • 26 (a)
(Danio rerio)
Actinopterygii LOC100330001 33
  • 58.49 (n)
CR383676.3 34
  • 50 (a)
CU138503.3 34
  • 45 (a)
zgc:92249 34
  • 45 (a)
zgc:154040 34
  • 43 (a)
Species where no ortholog for RARRES3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RARRES3 Gene

Gene Tree for RARRES3 (if available)
Gene Tree for RARRES3 (if available)

Paralogs for RARRES3 Gene

Paralogs for RARRES3 Gene

(4) SIMAP similar genes for RARRES3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RARRES3: view

Variants for RARRES3 Gene

Sequence variations from dbSNP and Humsavar for RARRES3 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000127828 -- 63,536,331(+) C/T upstream_transcript_variant
rs1000132274 -- 63,541,093(+) A/C intron_variant
rs1000160666 -- 63,536,521(+) T/C upstream_transcript_variant
rs1000341352 -- 63,544,396(+) C/A intron_variant
rs1000466034 -- 63,537,634(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RARRES3 Gene

Variant ID Type Subtype PubMed ID
nsv468588 CNV loss 19166990
nsv509417 CNV insertion 20534489
nsv555179 CNV loss 21841781
nsv975940 CNV duplication 23825009

Variation tolerance for RARRES3 Gene

Residual Variation Intolerance Score: 43.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.26; 5.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RARRES3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RARRES3 Gene

Disorders for RARRES3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for RARRES3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
poland syndrome
  • poland syndactyly
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for RARRES3

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with RARRES3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RARRES3 Gene

Publications for RARRES3 Gene

  1. Characterization of the human tumor suppressors TIG3 and HRASLS2 as phospholipid-metabolizing enzymes. (PMID: 19615464) Uyama T … Ueda N (Biochimica et biophysica acta 2009) 3 4 22 58
  2. Cloning and characterization of a novel retinoid-inducible gene 1(RIG1) deriving from human gastric cancer cells. (PMID: 10687848) Huang SL … Jiang SY (Molecular and cellular endocrinology 2000) 3 4 22 58
  3. Identification and characterization of a retinoid-induced class II tumor suppressor/growth regulatory gene. (PMID: 9843971) DiSepio D … Nagpal S (Proceedings of the National Academy of Sciences of the United States of America 1998) 3 4 22 58
  4. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PMID: 20588308) Silva LK … Teixeira MG (European journal of human genetics : EJHG 2010) 3 44 58
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58

Products for RARRES3 Gene

Sources for RARRES3 Gene

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