This gene was identified as a retinoid acid (RA) receptor-responsive gene. It encodes a type 1 membrane protein. The expression of this gene is upregulated by tazarotene as well as by retinoic acid receptors. The expression of this gene is found to be downregulated in prostate cancer, which is caused by the methylation of its promoter and CpG island. Alternatively spliced trans... See more...

Aliases for RARRES1 Gene

Aliases for RARRES1 Gene

  • Retinoic Acid Receptor Responder 1 2 3 5
  • Retinoic Acid Receptor Responder (Tazarotene Induced) 1 2 3
  • Retinoic Acid Receptor Responder Protein 1 3 4
  • Phorbol Ester-Induced Gene 1 Protein 3 4
  • Tazarotene-Induced Gene 1 Protein 3 4
  • RAR-Responsive Protein TIG1 3 4
  • Latexin-Like 2 3
  • PERG-1 3 4
  • TIG1 3 4
  • PEIG1 4
  • LXNL 3

External Ids for RARRES1 Gene

Previous GeneCards Identifiers for RARRES1 Gene

  • GC03M155675
  • GC03M159362
  • GC03M159696
  • GC03M159735
  • GC03M159897
  • GC03M158414
  • GC03M155810

Summaries for RARRES1 Gene

Entrez Gene Summary for RARRES1 Gene

  • This gene was identified as a retinoid acid (RA) receptor-responsive gene. It encodes a type 1 membrane protein. The expression of this gene is upregulated by tazarotene as well as by retinoic acid receptors. The expression of this gene is found to be downregulated in prostate cancer, which is caused by the methylation of its promoter and CpG island. Alternatively spliced transcript variant encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

GeneCards Summary for RARRES1 Gene

RARRES1 (Retinoic Acid Receptor Responder 1) is a Protein Coding gene. Diseases associated with RARRES1 include Plexiform Neurofibroma and Neurofibroma. An important paralog of this gene is LXN.

UniProtKB/Swiss-Prot Summary for RARRES1 Gene

  • Inhibitor of the cytoplasmic carboxypeptidase AGBL2, may regulate the alpha-tubulin tyrosination cycle.

Gene Wiki entry for RARRES1 Gene

Additional gene information for RARRES1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RARRES1 Gene

Genomics for RARRES1 Gene

GeneHancer (GH) Regulatory Elements for RARRES1 Gene

Promoters and enhancers for RARRES1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RARRES1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RARRES1

Top Transcription factor binding sites by QIAGEN in the RARRES1 gene promoter:
  • AP-1
  • c-Fos
  • c-Jun
  • FosB
  • GATA-1
  • GATA-2
  • GATA-3

Genomic Locations for RARRES1 Gene

Genomic Locations for RARRES1 Gene
chr3:158,696,892-158,732,691
(GRCh38/hg38)
Size:
35,800 bases
Orientation:
Minus strand
chr3:158,414,681-158,450,485
(GRCh37/hg19)
Size:
35,805 bases
Orientation:
Minus strand

Genomic View for RARRES1 Gene

Genes around RARRES1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RARRES1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RARRES1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RARRES1 Gene

Proteins for RARRES1 Gene

  • Protein details for RARRES1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49788-TIG1_HUMAN
    Recommended name:
    Retinoic acid receptor responder protein 1
    Protein Accession:
    P49788
    Secondary Accessions:
    • Q8N1D7

    Protein attributes for RARRES1 Gene

    Size:
    294 amino acids
    Molecular mass:
    33285 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RARRES1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RARRES1 Gene

Post-translational modifications for RARRES1 Gene

Other Protein References for RARRES1 Gene

No data available for DME Specific Peptides for RARRES1 Gene

Domains & Families for RARRES1 Gene

Gene Families for RARRES1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RARRES1 Gene

Blocks:
  • Proteinase inhibitor I47, latexin
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RARRES1 Gene

GenScript: Design optimal peptide antigens:
  • Tazarotene-induced gene 1 protein (TIG1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P49788

UniProtKB/Swiss-Prot:

TIG1_HUMAN :
  • Belongs to the protease inhibitor I47 (latexin) family.
Family:
  • Belongs to the protease inhibitor I47 (latexin) family.
genes like me logo Genes that share domains with RARRES1: view

Function for RARRES1 Gene

Molecular function for RARRES1 Gene

UniProtKB/Swiss-Prot Function:
Inhibitor of the cytoplasmic carboxypeptidase AGBL2, may regulate the alpha-tubulin tyrosination cycle.
UniProtKB/Swiss-Prot Induction:
By tazarotene and by all the retinoic acid receptors tested.

Phenotypes From GWAS Catalog for RARRES1 Gene

Gene Ontology (GO) - Molecular Function for RARRES1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008191 metalloendopeptidase inhibitor activity IBA 21873635
genes like me logo Genes that share ontologies with RARRES1: view
genes like me logo Genes that share phenotypes with RARRES1: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RARRES1 Gene

Localization for RARRES1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RARRES1 Gene

Membrane; Single-pass type III membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RARRES1 gene
Compartment Confidence
extracellular 4
nucleus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1
lysosome 1
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RARRES1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,TAS --
GO:0070062 extracellular exosome HDA 19199708
genes like me logo Genes that share ontologies with RARRES1: view

Pathways & Interactions for RARRES1 Gene

PathCards logo

SuperPathways for RARRES1 Gene

No Data Available

Interacting Proteins for RARRES1 Gene

;

SIGNOR curated interactions for RARRES1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for RARRES1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008285 negative regulation of cell proliferation TAS,IEA --
GO:0010951 negative regulation of endopeptidase activity IEA --
genes like me logo Genes that share ontologies with RARRES1: view

No data available for Pathways by source for RARRES1 Gene

Drugs & Compounds for RARRES1 Gene

(2) Drugs for RARRES1 Gene - From: DrugBank, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tretinoin Approved, Investigational Nutra Full agonist, Agonist, Antagonist, Target, agonist, binder 260

(2) Additional Compounds for RARRES1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RARRES1: view

Transcripts for RARRES1 Gene

mRNA/cDNA for RARRES1 Gene

2 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RARRES1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6
SP1: -
SP2:
SP3: - - -
SP4: -

Relevant External Links for RARRES1 Gene

GeneLoc Exon Structure for
RARRES1

Expression for RARRES1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RARRES1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RARRES1 Gene

This gene is overexpressed in Minor Salivary Gland (x5.5), Fallopian Tube (x5.1), Adipose - Visceral (Omentum) (x4.9), and Heart - Atrial Appendage (x4.5).

Protein differential expression in normal tissues from HIPED for RARRES1 Gene

This gene is overexpressed in Amniocyte (64.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RARRES1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RARRES1

SOURCE GeneReport for Unigene cluster for RARRES1 Gene:

Hs.131269

Evidence on tissue expression from TISSUES for RARRES1 Gene

  • Skin(4.1)
genes like me logo Genes that share expression patterns with RARRES1: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RARRES1 Gene

Orthologs for RARRES1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RARRES1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RARRES1 31 30
  • 88.96 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rarres1 30
  • 81.36 (n)
mouse
(Mus musculus)
Mammalia Rarres1 17 31 30
  • 79.86 (n)
cow
(Bos Taurus)
Mammalia RARRES1 31 30
  • 79.75 (n)
OneToOne
dog
(Canis familiaris)
Mammalia RARRES1 31
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RARRES1 31
  • 46 (a)
OneToOne
chicken
(Gallus gallus)
Aves RARRES1 31 30
  • 53.53 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RARRES1 31
  • 35 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rarres1 30
  • 55.16 (n)
zebrafish
(Danio rerio)
Actinopterygii lxn 31
  • 22 (a)
OneToMany
Species where no ortholog for RARRES1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RARRES1 Gene

ENSEMBL:
Gene Tree for RARRES1 (if available)
TreeFam:
Gene Tree for RARRES1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RARRES1: view image

Paralogs for RARRES1 Gene

Paralogs for RARRES1 Gene

(1) SIMAP similar genes for RARRES1 Gene using alignment to 1 proteins:

  • TIG1_HUMAN
genes like me logo Genes that share paralogs with RARRES1: view

Variants for RARRES1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RARRES1 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs11919919 - p.Asp158Val
rs7621322 - p.Asp42Gly

Additional dbSNP identifiers (rs#s) for RARRES1 Gene

Structural Variations from Database of Genomic Variants (DGV) for RARRES1 Gene

Variant ID Type Subtype PubMed ID
esv2763312 CNV gain 21179565
nsv1004124 CNV gain 25217958
nsv1007141 CNV loss 25217958
nsv1014255 CNV gain 25217958

Variation tolerance for RARRES1 Gene

Residual Variation Intolerance Score: 59% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.35; 76.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RARRES1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RARRES1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RARRES1 Gene

Disorders for RARRES1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for RARRES1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
plexiform neurofibroma
  • neurofibroma plexiform
neurofibroma
  • nerve sheath tumors
colon mucinous adenocarcinoma
  • colonic mucinous adenocarcinoma
cecum adenocarcinoma
  • cecal adenocarcinoma
prostate cancer
  • prostate cancer, somatic
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for RARRES1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with RARRES1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RARRES1 Gene

Publications for RARRES1 Gene

  1. Tazarotene-induced gene 1 (TIG1), a novel retinoic acid receptor-responsive gene in skin. (PMID: 8601727) Nagpal S … Chandraratna RA (The Journal of investigative dermatology 1996) 2 3 4 23 54
  2. Tumor suppressor RARRES1 interacts with cytoplasmic carboxypeptidase AGBL2 to regulate the α-tubulin tyrosination cycle. (PMID: 21303978) Sahab ZJ … Byers SW (Cancer research 2011) 3 4 54
  3. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PMID: 19834535) Wheeler HE … Kim SK (PLoS genetics 2009) 3 41 54
  4. Involvement of tazarotene-induced gene 1 in proliferation and differentiation of human adipose tissue-derived mesenchymal stem cells. (PMID: 19250291) Ohnishi S … Nagaya N (Cell proliferation 2009) 3 23 54
  5. DNA methylation of genes linked with retinoid signaling in gastric carcinoma: expression of the retinoid acid receptor beta, cellular retinol-binding protein 1, and tazarotene-induced gene 1 genes is associated with DNA methylation. (PMID: 16134180) Shutoh M … Yasui W (Cancer 2005) 3 23 54

Products for RARRES1 Gene

  • Biorbyt antibodies for RARRES1

Sources for RARRES1 Gene