This gene encodes a retinoic acid receptor that belongs to the nuclear hormone receptor family. Retinoic acid receptors (RARs) act as ligand-dependent transcriptional regulators. When bound to ligands, RARs activate transcription by binding as heterodimers to the retinoic acid response elements (RARE) found in the promoter regions of the target genes. In their unbound form, RAR... See more...

Aliases for RARG Gene

Aliases for RARG Gene

  • Retinoic Acid Receptor Gamma 2 3 4 5
  • Nuclear Receptor Subfamily 1 Group B Member 3 3 4
  • RAR-Gamma 3 4
  • NR1B3 3 4
  • Retinoic Acid Nuclear Receptor Gamma Variant 1 3
  • Retinoic Acid Nuclear Receptor Gamma Variant 2 3
  • Retinoic Acid Receptor, Gamma 2
  • RARC 3

External Ids for RARG Gene

Previous GeneCards Identifiers for RARG Gene

  • GC12M053763
  • GC12M053518
  • GC12M053321
  • GC12M051890
  • GC12M053604
  • GC12M050646

Summaries for RARG Gene

Entrez Gene Summary for RARG Gene

  • This gene encodes a retinoic acid receptor that belongs to the nuclear hormone receptor family. Retinoic acid receptors (RARs) act as ligand-dependent transcriptional regulators. When bound to ligands, RARs activate transcription by binding as heterodimers to the retinoic acid response elements (RARE) found in the promoter regions of the target genes. In their unbound form, RARs repress transcription of their target genes. RARs are involved in various biological processes, including limb bud development, skeletal growth, and matrix homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for RARG Gene

RARG (Retinoic Acid Receptor Gamma) is a Protein Coding gene. Diseases associated with RARG include Embryonal Carcinoma and Exfoliative Ichthyosis. Among its related pathways are ERK Signaling and Signaling by Retinoic Acid. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is RARB.

UniProtKB/Swiss-Prot Summary for RARG Gene

  • Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function (By similarity).

Tocris Summary for RARG Gene

  • Retinoic acid receptors (RARs) are nuclear hormone receptors of the NR1B class, which function as heterodimers with retinoid X receptors (RXRs). There are three distinct RAR subtypes: RARalpha, present in most tissue types; and RARbeta and RARgamma, with more selective expression.

Gene Wiki entry for RARG Gene

Additional gene information for RARG Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RARG Gene

Genomics for RARG Gene

GeneHancer (GH) Regulatory Elements for RARG Gene

Promoters and enhancers for RARG Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J053215 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 509.6 +11.9 11937 10.3 CTCF SIN3A NRF1 TCF12 POLR2G USF1 SP1 TEAD4 PHB2 ZFX RARG lnc-ITGB7-3 ITGB7 MAP3K12 TNS2 SP1 IGFBP6 PFDN5 C12orf10 TARBP2
GH12J053229 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 -0.2 -216 8.4 HNRNPK ZNF217 TCF12 USF1 TEAD4 ZNF10 ZIC2 ZBTB10 CLOCK ZNF623 RARG lnc-ITGB7-5 ESPL1 C12orf10 AAAS SOAT2 ENSG00000283536
GH12J053971 Promoter/Enhancer 2.7 VISTA EPDnew FANTOM5 Ensembl ENCODE dbSUPER 42.8 -770.3 -770332 63 HNRNPK ZBTB40 ZNF217 CTCF ZSCAN5C NRF1 TCF12 POLR2G USF1 NCOR1 HOXC8 HOXC4 HOXC11 HOXC9 HOXC6 HOXC10 HOXC5 HNRNPA1 ATF7 ZNF740
GH12J054051 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 22.8 -820.5 -820537 4.8 ZBTB40 ZSCAN5C USF1 PHF8 ZNF639 ZNF10 ZIC2 ZBTB10 ZNF423 ZNF623 HOXC4 AAAS ATF7 RARG HNRNPA1 ENSG00000260470 PCBP2 HOTAIR SP1 IGFBP6
GH12J053498 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 14.3 -267.6 -267626 5 HNRNPK ZBTB40 ZNF217 EP300 SIN3A TCF12 USF1 POLR2G SP1 GTF2E2 MAP3K12 TARBP2 ENSG00000270175 lnc-NPFF-4 KRT1 ZNF740 AAAS ATF7 HNRNPA1 CBX5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RARG on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RARG

Top Transcription factor binding sites by QIAGEN in the RARG gene promoter:
  • p300
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for RARG Gene

Genomic Locations for RARG Gene
chr12:53,210,566-53,232,980
(GRCh38/hg38)
Size:
22,415 bases
Orientation:
Minus strand
chr12:53,604,353-53,626,764
(GRCh37/hg19)
Size:
22,412 bases
Orientation:
Minus strand

Genomic View for RARG Gene

Genes around RARG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RARG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RARG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RARG Gene

Proteins for RARG Gene

  • Protein details for RARG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13631-RARG_HUMAN
    Recommended name:
    Retinoic acid receptor gamma
    Protein Accession:
    P13631
    Secondary Accessions:
    • B7Z492
    • B7Z4F1
    • B7ZAE4
    • J3KNP6
    • P22932
    • Q15281
    • Q52LZ8
    • Q9BYX8
    • Q9H1I3
    • Q9UJ38

    Protein attributes for RARG Gene

    Size:
    454 amino acids
    Molecular mass:
    50342 Da
    Quaternary structure:
    • Homodimer. Heterodimer with a RXR molecule. Binds DNA preferentially as a RAR/RXR heterodimer. Forms a complex with PUS1 and the SRA1 RNA in the nucleus.
    SequenceCaution:
    • Sequence=CAA40548.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RARG Gene

    Alternative splice isoforms for RARG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RARG Gene

Post-translational modifications for RARG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RARG Gene

Domains & Families for RARG Gene

Gene Families for RARG Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • FDA approved drug targets
  • Nuclear receptors
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for RARG Gene

Blocks:
  • Steroid hormone receptor signature
  • Retinoic acid receptor (1B nuclear receptor) signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RARG Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ75202, highly similar to Homo sapiens, retinoic acid receptor, gamma (A8K3H3_HUMAN)
  • cDNA FLJ54482, highly similar to Retinoic acid receptor gamma-2 (B7Z4F1_HUMAN)
  • Retinoic acid nuclear receptor gamma variant 2 (F1D8P1_HUMAN)
  • Retinoic acid receptor gamma (Q9BZI0_HUMAN)
  • Nuclear receptor subfamily 1 group B member 3 (RARG_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P13631

UniProtKB/Swiss-Prot:

RARG_HUMAN :
  • Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
  • Belongs to the nuclear hormone receptor family. NR1 subfamily.
Domain:
  • Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
Family:
  • Belongs to the nuclear hormone receptor family. NR1 subfamily.
genes like me logo Genes that share domains with RARG: view

Function for RARG Gene

Molecular function for RARG Gene

UniProtKB/Swiss-Prot Function:
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function (By similarity).
GENATLAS Biochemistry:
retinoic acid receptor binding and activated by both all-trans (T-RA) and its 9-cis isomer (9-cis-RA) retinoic acids,gamma subunit,steroid/thyroid hormone receptor superfamily

Phenotypes From GWAS Catalog for RARG Gene

Gene Ontology (GO) - Molecular Function for RARG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IBA 21873635
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0003677 DNA binding ISS --
GO:0003700 DNA-binding transcription factor activity ISS --
genes like me logo Genes that share ontologies with RARG: view
genes like me logo Genes that share phenotypes with RARG: view

Animal Models for RARG Gene

MGI Knock Outs for RARG:

Animal Model Products

  • Taconic Biosciences Mouse Models for RARG
Targeted motifs for RARG Gene
HOMER Transcription Factor Regulatory Elements motif RARG
  • Consensus sequence: AGGTCAAGGTCA Submotif: canonical Cell Type: ES GEO ID: GSE30538

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for RARG Gene

Localization for RARG Gene

Subcellular locations from UniProtKB/Swiss-Prot for RARG Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RARG gene
Compartment Confidence
nucleus 5
plasma membrane 2
extracellular 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RARG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IBA,ISS --
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex ISS --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with RARG: view

Pathways & Interactions for RARG Gene

genes like me logo Genes that share pathways with RARG: view

Pathways by source for RARG Gene

5 Qiagen pathways for RARG Gene
  • all-trans-Retinoic Acid Mediated Apoptosis
  • all-trans-Retinoic Acid Signaling in Brain
  • Molecular Mechanisms of Cancer
  • Nuclear Receptor Activation by Vitamin-A
  • RAR-Gamma-RXR-Alpha Degradation
1 GeneTex pathway for RARG Gene

SIGNOR curated interactions for RARG Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for RARG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II ISS --
GO:0001843 neural tube closure IEA --
GO:0002063 chondrocyte development IEA --
GO:0002068 glandular epithelial cell development IEA --
GO:0003417 growth plate cartilage development IEA --
genes like me logo Genes that share ontologies with RARG: view

Drugs & Compounds for RARG Gene

(54) Drugs for RARG Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adapalene Approved Pharma Target, agonist, binder RAR尾 and RAR纬 agonist 89
Tazarotene Approved, Investigational Pharma Target, agonist, binder Topical retinoid;antiproliferative;inducer of TIG3 tumor suppressor 48
Tretinoin Approved, Investigational Nutra Full agonist, Agonist, Antagonist, Target, agonist, binder 260
Acitretin Approved Pharma Target, agonist Metabolite of etretinate 31
Alitretinoin Approved, Investigational Pharma Agonist, Target, agonist 17

(4) Additional Compounds for RARG Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
retinoic acid
302-79-4
Liarozole dihydrochloride

(5) Tocris Compounds for RARG Gene

Compound Action Cas Number
EC 23 Synthetic retinoid; induces differentiation of stem cells 104561-41-3
Isotretinoin Endogenous agonist for retinoic acid receptors; inducer of neuronal differentiation 4759-48-2
Liarozole dihydrochloride Blocks retinoic acid metabolism
Retinoic acid Endogenous retinoic acid receptor agonist 302-79-4
TTNPB Retinoic acid analog; RAR agonist 71441-28-6

(25) ApexBio Compounds for RARG Gene

Compound Action Cas Number
Acitretin Metabolite of etretinate 55079-83-9
Acitretin sodium 925701-88-8
Adapalene RAR尾 and RAR纬 agonist 106685-40-9
Adarotene Apoptosis inducer/DNA damage agent 496868-77-0
AGN 194310 pan-RAR antagonist 229961-45-9
AGN 195183 RARαagonist,potent and selective 191469-29-1
AGN 205327 Potent RARs agonist
AGN 205728 RARγ antagonist,potent and selective 859498-05-8
BMS 453 RAR agonist 166977-43-1
BMS 493 Pan-RAR inverse agonist 215030-90-3
BMS 961 Selective RARγ agonist 185629-22-5
CD 1530 RARγ receptor agonist,potent and selective 107430-66-0
CD 2665 Selective RARβ/γ antagonist 170355-78-9
CD 437 RARγ-selective agonist,potent and cell-permeable 125316-60-1
Ch 55 110368-33-7
EC 23 104561-41-3
ER 50891 187400-85-7
LE 135 155877-83-1
MM 11253 345952-44-5
Palovarotene 410528-02-8
Talarozole Cytochrome P450 inhibitor 201410-53-9
Tazarotene Topical retinoid;antiproliferative;inducer of TIG3 tumor suppressor 118292-40-3
Tretinoin (Aberela) 302-79-4
TTNPB (Arotinoid Acid) Potent RAR agonist 71441-28-6
Vitamin A Acetate Unsaturated nutritional hydrocarbons 127-47-9
genes like me logo Genes that share compounds with RARG: view

Drug Products

Transcripts for RARG Gene

mRNA/cDNA for RARG Gene

5 REFSEQ mRNAs :
27 NCBI additional mRNA sequence :
18 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RARG Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b · 10c ^
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - - - - -
SP4: -
SP5: - - - - - - - - - - - - - -
SP6: - - -
SP7: - -
SP8: - - -
SP9: - - - - - - - -
SP10: - - - - -
SP11: - - - - - -
SP12:
SP13:
SP14:

ExUns: 11 ^ 12 ^ 13a · 13b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for RARG Gene

GeneLoc Exon Structure for
RARG

Expression for RARG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RARG Gene

mRNA differential expression in normal tissues according to GTEx for RARG Gene

This gene is overexpressed in Esophagus - Mucosa (x6.4), Skin - Sun Exposed (Lower leg) (x5.0), and Skin - Not Sun Exposed (Suprapubic) (x4.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RARG Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RARG

SOURCE GeneReport for Unigene cluster for RARG Gene:

Hs.1497

mRNA Expression by UniProt/SwissProt for RARG Gene:

P13631-RARG_HUMAN
Tissue specificity: Expressed in aortic endothelial cells (at protein level).

Evidence on tissue expression from TISSUES for RARG Gene

  • Nervous system(4.4)
  • Intestine(4.3)
  • Blood(4.2)
  • Skin(2.5)
genes like me logo Genes that share expression patterns with RARG: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RARG Gene

Orthologs for RARG Gene

This gene was present in the common ancestor of animals.

Orthologs for RARG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RARG 31 30
  • 99.56 (n)
OneToOne
dog
(Canis familiaris)
Mammalia RARG 31 30
  • 93.52 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RARG 31 30
  • 93.29 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Rarg 17 31 30
  • 89.9 (n)
rat
(Rattus norvegicus)
Mammalia Rarg 30
  • 89.16 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RARG 31
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RARG 31
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485387 30
  • 73.19 (n)
zebrafish
(Danio rerio)
Actinopterygii rargb 31 30
  • 79.16 (n)
OneToMany
rarga 31
  • 73 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Eip75B 32
  • 32 (a)
worm
(Caenorhabditis elegans)
Secernentea sex-1 32
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8261 31
  • 38 (a)
OneToMany
Species where no ortholog for RARG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RARG Gene

ENSEMBL:
Gene Tree for RARG (if available)
TreeFam:
Gene Tree for RARG (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RARG: view image

Paralogs for RARG Gene

(45) SIMAP similar genes for RARG Gene using alignment to 5 proteins:

  • RARG_HUMAN
  • H3BMH6_HUMAN
  • H3BMK1_HUMAN
  • H3BMY6_HUMAN
  • Q9BZI0_HUMAN
genes like me logo Genes that share paralogs with RARG: view

Variants for RARG Gene