Free for academic non-profit institutions. Other users need a Commercial license

RARG Gene(Protein Coding)

Retinoic Acid Receptor Gamma

GCID:
GC12M053210
GIFtS:
57
Genes Participants
UDN Logo

Aliases for RARG Gene

Aliases for RARG Gene

  • Retinoic Acid Receptor Gamma 2 3 5
  • Nuclear Receptor Subfamily 1 Group B Member 3 3 4
  • RAR-Gamma 3 4
  • NR1B3 3 4
  • Retinoic Acid Nuclear Receptor Gamma Variant 1 3
  • Retinoic Acid Nuclear Receptor Gamma Variant 2 3
  • Retinoic Acid Receptor, Gamma 2
  • RARC 3

External Ids for RARG Gene

Previous GeneCards Identifiers for RARG Gene

  • GC12M053763
  • GC12M053518
  • GC12M053321
  • GC12M051890
  • GC12M053604
  • GC12M050646

Summaries for RARG Gene

Entrez Gene Summary for RARG Gene

  • This gene encodes a retinoic acid receptor that belongs to the nuclear hormone receptor family. Retinoic acid receptors (RARs) act as ligand-dependent transcriptional regulators. When bound to ligands, RARs activate transcription by binding as heterodimers to the retinoic acid response elements (RARE) found in the promoter regions of the target genes. In their unbound form, RARs repress transcription of their target genes. RARs are involved in various biological processes, including limb bud development, skeletal growth, and matrix homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for RARG Gene

RARG (Retinoic Acid Receptor Gamma) is a Protein Coding gene. Diseases associated with RARG include Paraneoplastic Polyneuropathy and Embryonal Carcinoma. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is RARB.

UniProtKB/Swiss-Prot for RARG Gene

  • Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5-AGGTCA-3 sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function (By similarity).

Tocris Summary for RARG Gene

  • Retinoic acid receptors (RARs) are nuclear hormone receptors of the NR1B class, which function as heterodimers with retinoid X receptors (RXRs). There are three distinct RAR subtypes: RARalpha, present in most tissue types; and RARbeta and RARgamma, with more selective expression.

Gene Wiki entry for RARG Gene

Additional gene information for RARG Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RARG Gene

Genomics for RARG Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for RARG Gene

Promoters and enhancers for RARG Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH12I053215 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 559.6 +12.1 12056 10.1 HDGF PKNOX1 CLOCK FOXA2 SMAD1 ARNT ZFP64 ARID4B SIN3A ZNF2 RARG MAP3K12 ITGB7 TNS2 SP1 IGFBP6 PFDN5 C12orf10 TARBP2 ZNF740
GH12I053229 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 550.8 -0.2 -216 8.4 HDGF PKNOX1 CLOCK NEUROD1 SIN3A ZBTB7B GLIS2 ZNF213 FOS DEK RARG KRT7-AS ESPL1 C12orf10 AAAS SOAT2 ENSG00000283536
GH12I054009 Promoter/Enhancer 3.2 VISTA EPDnew FANTOM5 Ensembl ENCODE dbSUPER 22.8 -789.1 -789116 25.8 HDGF PKNOX1 SMAD1 ARNT SIN3A FEZF1 ZNF2 POLR2B CBX5 ZNF213 HOXC4 HOXC6 HOXC5 GC12P054071 GC12P054093 PIR46464 PIR59725 PIR53546 PIR59985 AAAS
GH12I054051 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 22.8 -820.5 -820537 4.8 HDGF PKNOX1 SMAD1 ARNT FEZF1 ZNF2 ZNF213 ZNF143 SP3 JUNB HOXC4 AAAS ATF7 RARG HNRNPA1 ENSG00000260470 PCBP2 HOTAIR SP1 IGFBP6
GH12I053971 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12 -757.3 -757263 36.8 FEZF1 DMAP1 IRF4 ZNF213 ZNF416 ZNF143 ZNF548 SP3 NFYC ZNF610 HOXC11 HOXC9 HOXC6 HOXC10 GC12P054010 GC12P054044 MIR196A2 HNRNPA1 ZNF740 ENSG00000258344
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RARG on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RARG gene promoter:

Genomic Locations for RARG Gene

Genomic Locations for RARG Gene
chr12:53,210,566-53,232,980
(GRCh38/hg38)
Size:
22,415 bases
Orientation:
Minus strand
chr12:53,604,353-53,626,764
(GRCh37/hg19)

Genomic View for RARG Gene

Genes around RARG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RARG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RARG Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for RARG Gene

Proteins for RARG Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for RARG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13631-RARG_HUMAN
    Recommended name:
    Retinoic acid receptor gamma
    Protein Accession:
    P13631
    Secondary Accessions:
    • B7Z492
    • B7Z4F1
    • B7ZAE4
    • J3KNP6
    • P22932
    • Q15281
    • Q52LZ8
    • Q9BYX8
    • Q9H1I3
    • Q9UJ38

    Protein attributes for RARG Gene

    Size:
    454 amino acids
    Molecular mass:
    50342 Da
    Quaternary structure:
    • Homodimer. Heterodimer with a RXR molecule. Binds DNA preferentially as a RAR/RXR heterodimer. Forms a complex with PUS1 and the SRA1 RNA in the nucleus.
    SequenceCaution:
    • Sequence=CAA40548.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RARG Gene

    Alternative splice isoforms for RARG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RARG Gene

Protein Expression for RARG Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for RARG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RARG Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RARG Gene

Domains & Families for RARG Gene

Gene Families for RARG Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • FDA approved drug targets
  • Nuclear receptors
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for RARG Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for RARG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P13631

UniProtKB/Swiss-Prot:

RARG_HUMAN :
  • Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
  • Belongs to the nuclear hormone receptor family. NR1 subfamily.
Domain:
  • Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
Family:
  • Belongs to the nuclear hormone receptor family. NR1 subfamily.
genes like me logo Genes that share domains with RARG: view

Function for RARG Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for RARG Gene

GENATLAS Biochemistry:
retinoic acid receptor binding and activated by both all-trans (T-RA) and its 9-cis isomer (9-cis-RA) retinoic acids,gamma subunit,steroid/thyroid hormone receptor superfamily
UniProtKB/Swiss-Prot Function:
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5-AGGTCA-3 sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function (By similarity).

Phenotypes From GWAS Catalog for RARG Gene

Gene Ontology (GO) - Molecular Function for RARG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA --
GO:0003677 DNA binding ISS --
GO:0003700 DNA binding transcription factor activity ISS --
GO:0003707 steroid hormone receptor activity IEA --
GO:0003708 retinoic acid receptor activity IEA --
genes like me logo Genes that share ontologies with RARG: view
genes like me logo Genes that share phenotypes with RARG: view

Animal Models for RARG Gene

MGI Knock Outs for RARG:

Animal Model Products

  • Taconic Biosciences Mouse Models for RARG
Targeted motifs for RARG Gene
HOMER Transcription Factor Regulatory Elements motif RARG
  • Consensus sequence: AGGTCAAGGTCA Submotif: canonical Cell Type: ES GEO ID: GSE30538

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for RARG Gene

Localization for RARG Gene

Subcellular locations from UniProtKB/Swiss-Prot for RARG Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RARG gene
Compartment Confidence
nucleus 5
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RARG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IEA --
GO:0005634 nucleus IDA,ISS --
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex ISS --
GO:0016021 integral component of membrane NAS 17943189
genes like me logo Genes that share ontologies with RARG: view

Pathways & Interactions for RARG Gene

genes like me logo Genes that share pathways with RARG: view

SIGNOR curated interactions for RARG Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for RARG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II ISS --
GO:0001843 neural tube closure IEA --
GO:0002063 chondrocyte development IEA --
GO:0002068 glandular epithelial cell development IEA --
GO:0003406 retinal pigment epithelium development IEA --
genes like me logo Genes that share ontologies with RARG: view

Drugs & Compounds for RARG Gene

Products:

  1. Drug

(51) Drugs for RARG Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adapalene Approved Pharma Target, agonist, binder RAR尾 and RAR纬 agonist 78
Tazarotene Approved, Investigational Pharma Target, agonist, binder Topical retinoid;antiproliferative;inducer of TIG3 tumor suppressor 46
Acitretin Approved Pharma Target, agonist Metabolite of etretinate 30
Alitretinoin Approved, Investigational Pharma Target, agonist 17
Tretinoin Approved, Investigational Nutra Target, agonist, binder 242

(6) Additional Compounds for RARG Gene - From: IUPHAR, HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
all-trans-retinoic acid
  • (all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoate
  • (all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid
  • 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoate
  • 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid
  • Acide retinoique (French)
 Full agonist, Agonist 302-79-4
retinoic acid
302-79-4
9-cis-retinoic acid
  • 15-Apo-beta-caroten-15-oate
  • 15-Apo-beta-caroten-15-oic acid
  • 9-cis-Retinoate
  • 9-cis-Retinoic acid
  • 9-cis-Tretinoin
 Agonist

(5) Tocris Compounds for RARG Gene

Compound Action Cas Number
EC 23 Synthetic retinoid; induces differentiation of stem cells 104561-41-3
Isotretinoin Endogenous agonist for retinoic acid receptors; inducer of neuronal differentiation 4759-48-2
Liarozole dihydrochloride Blocks retinoic acid metabolism
Retinoic acid Endogenous retinoic acid receptor agonist 302-79-4
TTNPB Retinoic acid analog; RAR agonist 71441-28-6

(25) ApexBio Compounds for RARG Gene

Compound Action Cas Number
Acitretin Metabolite of etretinate 55079-83-9
Acitretin sodium 925701-88-8
Adapalene RAR尾 and RAR纬 agonist 106685-40-9
Adarotene Apoptosis inducer/DNA damage agent 496868-77-0
AGN 194310 pan-RAR antagonist 229961-45-9
AGN 195183 RARαagonist,potent and selective 191469-29-1
AGN 205327 Potent RARs agonist
AGN 205728 RARγ antagonist,potent and selective 859498-05-8
BMS 453 RAR agonist 166977-43-1
BMS 493 Pan-RAR inverse agonist 215030-90-3
BMS 961 Selective RARγ agonist 185629-22-5
CD 1530 RARγ receptor agonist,potent and selective 107430-66-0
CD 2665 Selective RARβ/γ antagonist 170355-78-9
CD 437 RARγ-selective agonist,potent and cell-permeable 125316-60-1
Ch 55 110368-33-7
EC 23 104561-41-3
ER 50891 187400-85-7
LE 135 155877-83-1
MM 11253 345952-44-5
Palovarotene 410528-02-8
Talarozole Cytochrome P450 inhibitor 201410-53-9
Tazarotene Topical retinoid;antiproliferative;inducer of TIG3 tumor suppressor 118292-40-3
Tretinoin (Aberela) 302-79-4
TTNPB (Arotinoid Acid) Potent RAR agonist 71441-28-6
Vitamin A Acetate Unsaturated nutritional hydrocarbons 127-47-9
genes like me logo Genes that share compounds with RARG: view

Drug Products

Transcripts for RARG Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for RARG Gene

(5) REFSEQ mRNAs :
(22) Additional mRNA sequences :
(159) Selected AceView cDNA sequences:
(18) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RARG Gene

Retinoic acid receptor, gamma:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RARG Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b · 10c ^
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - - - - -
SP4: -
SP5: - - - - - - - - - - - - - -
SP6: - - -
SP7: - -
SP8: - - -
SP9: - - - - - - - -
SP10: - - - - -
SP11: - - - - - -
SP12:
SP13:
SP14:

ExUns: 11 ^ 12 ^ 13a · 13b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for RARG Gene

GeneLoc Exon Structure for
RARG
ECgene alternative splicing isoforms for
RARG

Expression for RARG Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RARG Gene

mRNA expression in normal human tissues for RARG Gene
mRNA expression by BioGPS for RARG GenemRNA expression by GTEx for RARG Gene

mRNA differential expression in normal tissues according to GTEx for RARG Gene

This gene is overexpressed in Esophagus - Mucosa (x6.4), Skin - Sun Exposed (Lower leg) (x5.0), and Skin - Not Sun Exposed (Suprapubic) (x4.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RARG Gene



NURSA nuclear receptor signaling pathways regulating expression of RARG Gene:

RARG

SOURCE GeneReport for Unigene cluster for RARG Gene:

Hs.1497

Evidence on tissue expression from TISSUES for RARG Gene

  • Nervous system(4.4)
  • Intestine(4.3)
  • Blood(4.2)
  • Skin(2.6)
genes like me logo Genes that share expression patterns with RARG: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RARG Gene

Orthologs for RARG Gene

This gene was present in the common ancestor of animals.

Orthologs for RARG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia RARG 33 34
  • 99.56 (n)
dog
(Canis familiaris)
 Mammalia RARG 33 34
  • 93.52 (n)
cow
(Bos Taurus)
 Mammalia RARG 33 34
  • 93.29 (n)
mouse
(Mus musculus)
 Mammalia Rarg 33 16 34
  • 89.9 (n)
rat
(Rattus norvegicus)
 Mammalia Rarg 33
  • 89.16 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia RARG 34
  • 80 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia RARG 34
  • 79 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia LOC100485387 33
  • 73.19 (n)
zebrafish
(Danio rerio)
 Actinopterygii rargb 33 34
  • 79.16 (n)
rarga 34
  • 73 (a)
 OneToMany
fruit fly
(Drosophila melanogaster)
 Insecta Eip75B 35
  • 32 (a)
worm
(Caenorhabditis elegans)
 Secernentea sex-1 35
  • 30 (a)
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.8261 34
  • 38 (a)
 OneToMany
Species where no ortholog for RARG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RARG Gene

ENSEMBL:
Gene Tree for RARG (if available)
TreeFam:
Gene Tree for RARG (if available)

Paralogs for RARG Gene

Variants for RARG Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for RARG Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs769476878 likely-benign, Peters anomaly 53,215,734(-) G/A coding_sequence_variant, intron_variant, missense_variant
VAR_036061 A breast cancer sample p.Gly430Ser
rs1000086011 -- 53,222,232(-) A/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000213677 -- 53,217,223(-) G/C intron_variant
rs1000586203 -- 53,226,860(-) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RARG Gene

Variant ID Type Subtype PubMed ID
dgv2644n54 CNV loss 21841781
dgv2645n54 CNV loss 21841781
nsv1070110 CNV deletion 25765185
nsv469404 CNV loss 19166990
nsv470295 CNV gain 18288195
nsv517066 CNV loss 19592680
nsv558994 CNV loss 21841781
nsv558996 CNV loss 21841781
nsv832417 CNV gain 17160897

Variation tolerance for RARG Gene

Residual Variation Intolerance Score: 25.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.20; 69.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RARG Gene

Human Gene Mutation Database (HGMD)
RARG
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RARG

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RARG Gene

Disorders for RARG Gene

MalaCards: The human disease database

(4) MalaCards diseases for RARG Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
paraneoplastic polyneuropathy
embryonal carcinoma
  • primary extragonadal embryonal carcinoma
exfoliative ichthyosis
  • autosomal recessive exfoliative ichthyosis
ichthyosis bullosa of siemens
  • ibs
- elite association - COSMIC cancer census association via MalaCards
Search RARG in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RARG

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with RARG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RARG Gene

Publications for RARG Gene

  1. Genomic organization of the retinoic acid receptor gamma gene. (PMID: 1849262) Lehmann JM … Pfahl M (Nucleic acids research 1991) 2 3 4 22 58
  2. Murine isoforms of retinoic acid receptor gamma with specific patterns of expression. (PMID: 2157210) Kastner P … Chambon P (Proceedings of the National Academy of Sciences of the United States of America 1990) 3 4 22 58
  3. Rubella vaccine-induced cellular immunity: evidence of associations with polymorphisms in the Toll-like, vitamin A and D receptors, and innate immune response genes. (PMID: 19902255) Ovsyannikova IG … Poland GA (Human genetics 2010) 3 44 58
  4. Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease. (PMID: 20346360) Roberts KE … Pulmonary Vascular Complications of Liver Disease Study Group (Gastroenterology 2010) 3 44 58
  5. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PMID: 20602615) Ruaño G … Wu AH (Pharmacogenomics 2010) 3 44 58

Products for RARG Gene