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RAPGEFL1 (Rap Guanine Nucleotide Exchange Factor Like 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include guanyl-nucleotide exchange factor activity and obsolete signal transducer activity, downstream of receptor. An important paralog of this gene is RAPGEF4.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005085 | guanyl-nucleotide exchange factor activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0016020 | membrane | TAS | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | TAS | -- |
GO:0007264 | small GTPase mediated signal transduction | IEA | -- |
GO:0007399 | nervous system development | TAS | -- |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | RAPGEFL1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | RAPGEFL1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | RAPGEFL1 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Rapgefl1 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Rapgefl1 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | RAPGEFL1 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | RAPGEFL1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | rapgefl1 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | LOC100149497 30 |
|
||
RAPGEFL1 31 |
|
OneToOne | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | Epac 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | epac-1 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs864622033 | Uncertain Significance: Malignant tumor of prostate | 40,188,883(+) | A/G | MISSENSE_VARIANT |
No disorders were found for RAPGEFL1 Gene.