Aliases for RAPGEF4 Gene
External Ids for RAPGEF4 Gene
Previous GeneCards Identifiers for RAPGEF4 Gene
GeneCards Summary for RAPGEF4 Gene
RAPGEF4 (Rap Guanine Nucleotide Exchange Factor 4) is a Protein Coding gene. Diseases associated with RAPGEF4 include Lesch-Nyhan Syndrome and Inhalation Anthrax. Among its related pathways are Signaling by GPCR and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include guanyl-nucleotide exchange factor activity and Ras GTPase binding. An important paralog of this gene is RAPGEF3.
UniProtKB/Swiss-Prot Summary for RAPGEF4 Gene
Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2 (By similarity).