Aliases for RAPGEF3 Gene
- Rap Guanine Nucleotide Exchange Factor 3 2 3 3 4 5
- Exchange Protein Directly Activated By CAMP 1 2 3 4
- CAMP-GEFI 2 3 4
- EPAC 2 3 4
- Rap1 Guanine-Nucleotide-Exchange Factor Directly Activated By CAMP 3 4
- CAMP-Regulated Guanine Nucleotide Exchange Factor I 3 4
- Rap Guanine Nucleotide Exchange Factor (GEF) 3 2 3
- Exchange Factor Directly Activated By CAMP 1 3 4
External Ids for RAPGEF3 Gene
Previous GeneCards Identifiers for RAPGEF3 Gene
GeneCards Summary for RAPGEF3 Gene
RAPGEF3 (Rap Guanine Nucleotide Exchange Factor 3) is a Protein Coding gene. Diseases associated with RAPGEF3 include Leukocyte Adhesion Deficiency, Type Iii and Cerebral Cavernous Malformations. Among its related pathways are Integration of energy metabolism and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include guanyl-nucleotide exchange factor activity and cAMP-dependent protein kinase regulator activity. An important paralog of this gene is RAPGEF4.
UniProtKB/Swiss-Prot Summary for RAPGEF3 Gene
Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin.
GTPases are a group of enzymes that catalyze hydrolysis of the gamma phosphate bond in guanine triphosphate (GTP) to form guanine diphosphate (GDP). Mg2+ ions are essential for catalytic activity. GTPases, often coupled to G proteins, are essential in signal transduction.