Aliases for RAPGEF3 Gene

Aliases for RAPGEF3 Gene

  • Rap Guanine Nucleotide Exchange Factor 3 2 3 3 4 5
  • Exchange Protein Directly Activated By CAMP 1 2 3 4
  • Rap1 Guanine-Nucleotide-Exchange Factor Directly Activated By CAMP 3 4
  • CAMP-Regulated Guanine Nucleotide Exchange Factor I 3 4
  • Rap Guanine Nucleotide Exchange Factor (GEF) 3 2 3
  • Exchange Factor Directly Activated By CAMP 1 3 4
  • CAMP-GEFI 3 4
  • EPAC 1 3 4
  • EPAC1 3 4
  • EPAC 3 4
  • RAP Guanine-Nucleotide-Exchange Factor (GEF) 3 2
  • 9330170P05Rik 3
  • HSU79275 3
  • Bcm910 3
  • CGEF1 4

External Ids for RAPGEF3 Gene

Previous GeneCards Identifiers for RAPGEF3 Gene

  • GC12M046418
  • GC12M046419
  • GC12M048128
  • GC12M045159

Summaries for RAPGEF3 Gene

GeneCards Summary for RAPGEF3 Gene

RAPGEF3 (Rap Guanine Nucleotide Exchange Factor 3) is a Protein Coding gene. Diseases associated with RAPGEF3 include Leukocyte Adhesion Deficiency, Type Iii and Lesch-Nyhan Syndrome. Among its related pathways are Class I MHC mediated antigen processing and presentation and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include guanyl-nucleotide exchange factor activity and cAMP-dependent protein kinase regulator activity. An important paralog of this gene is RAPGEF4.

UniProtKB/Swiss-Prot Summary for RAPGEF3 Gene

  • Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin.

Tocris Summary for RAPGEF3 Gene

  • GTPases are a group of enzymes that catalyze hydrolysis of the gamma phosphate bond in guanine triphosphate (GTP) to form guanine diphosphate (GDP). Mg2+ ions are essential for catalytic activity. GTPases, often coupled to G proteins, are essential in signal transduction.

Gene Wiki entry for RAPGEF3 Gene

Additional gene information for RAPGEF3 Gene

No data available for Entrez Gene Summary , CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RAPGEF3 Gene

Genomics for RAPGEF3 Gene

GeneHancer (GH) Regulatory Elements for RAPGEF3 Gene

Promoters and enhancers for RAPGEF3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J047769 Promoter/Enhancer 1 Ensembl dbSUPER 500.7 +1.3 1339 0.6 ATF2 OSR2 CEBPG CEBPB ZNF213 ZBTB48 IKZF3 ZNF843 RCOR1 PRDM6 ENSG00000277173 RAPGEF3 SLC48A1
GH12J047770 Promoter/Enhancer 0.9 Ensembl dbSUPER 500.7 -0.2 -160 1.2 ZNF316 ZBTB17 MAFF MAFK ZNF335 IKZF3 MAFG ZBTB33 ZBTB21 SP7 RAPGEF3 ENSG00000268069 NONHSAG011022.2 SLC48A1
GH12J047771 Enhancer 0.8 ENCODE dbSUPER 500.7 +0.8 807 0.2 CEBPB ZBTB17 TRIM24 CEBPG ZNF335 EP300 RFX5 BCL6 STAT3 RXRA ENSG00000277173 RAPGEF3 SLC48A1
GH12J047804 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 16.3 -46.7 -46708 25.6 RXRA HNRNPK ZBTB40 ZNF217 EP300 CTCF NRF1 TCF12 POLR2G USF1 HDAC7 ENSG00000274737 KANSL2 CCNT1 LOC390314 SENP1 RAPGEF3 ASB8 VDR SLC48A1
GH12J047751 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 16.5 +15.3 15261 9.2 ZNF217 CTCF NRF1 MYC USF1 PHF8 JUND TEAD4 FOS ZNF639 SLC48A1 lnc-TMEM106C-7 ENDOU RAPGEF3 ENSG00000268069 ENSG00000257433 lnc-HDAC7-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RAPGEF3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RAPGEF3

Top Transcription factor binding sites by QIAGEN in the RAPGEF3 gene promoter:
  • ATF
  • Sp1
  • YY1

Genomic Locations for RAPGEF3 Gene

Genomic Locations for RAPGEF3 Gene
chr12:47,734,363-47,771,040
(GRCh38/hg38)
Size:
36,678 bases
Orientation:
Minus strand
chr12:48,128,453-48,164,823
(GRCh37/hg19)
Size:
36,371 bases
Orientation:
Minus strand

Genomic View for RAPGEF3 Gene

Genes around RAPGEF3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAPGEF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAPGEF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAPGEF3 Gene

Proteins for RAPGEF3 Gene

  • Protein details for RAPGEF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95398-RPGF3_HUMAN
    Recommended name:
    Rap guanine nucleotide exchange factor 3
    Protein Accession:
    O95398
    Secondary Accessions:
    • A8K2G5
    • E7EQC8
    • O95634
    • Q8WVN0

    Protein attributes for RAPGEF3 Gene

    Size:
    923 amino acids
    Molecular mass:
    103751 Da
    Quaternary structure:
    • Interacts with PDE3B.
    SequenceCaution:
    • Sequence=AAD02890.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAD12740.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for RAPGEF3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAPGEF3 Gene

Post-translational modifications for RAPGEF3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RAPGEF3 Gene

Domains & Families for RAPGEF3 Gene

Gene Families for RAPGEF3 Gene

Protein Domains for RAPGEF3 Gene

Blocks:
  • Cyclic nucleotide-binding domain
  • Guanine-nucleotide dissociation stimulator CDC25
  • Pleckstrin putative G-protein interacting domain
  • cAMP-dependent protein kinase signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RAPGEF3 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ75149, highly similar to Homo sapiens Rap guanine nucleotide exchange factor (GEF) 3, mRNA (A8K2G5_HUMAN)
  • RAPGEF3 protein (Q569L6_HUMAN)
  • cAMP-regulated guanine nucleotide exchange factor I (RPGF3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95398

UniProtKB/Swiss-Prot:

RPGF3_HUMAN :
  • The DEP domain is involved in membrane localization independent from regulation by cAMP.
Domain:
  • The DEP domain is involved in membrane localization independent from regulation by cAMP.
genes like me logo Genes that share domains with RAPGEF3: view

Function for RAPGEF3 Gene

Molecular function for RAPGEF3 Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin.

Phenotypes From GWAS Catalog for RAPGEF3 Gene

Gene Ontology (GO) - Molecular Function for RAPGEF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity TAS 9853756
GO:0005515 protein binding IPI 21393242
GO:0017034 Rap guanyl-nucleotide exchange factor activity IMP 21840392
GO:0019904 protein domain specific binding IPI 21047789
GO:0030552 cAMP binding IEA --
genes like me logo Genes that share ontologies with RAPGEF3: view
genes like me logo Genes that share phenotypes with RAPGEF3: view

Animal Models for RAPGEF3 Gene

MGI Knock Outs for RAPGEF3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAPGEF3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RAPGEF3 Gene

Localization for RAPGEF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAPGEF3 Gene

Endomembrane system.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAPGEF3 gene
Compartment Confidence
plasma membrane 5
cytosol 4
nucleus 3
extracellular 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
endosome 2
lysosome 2
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RAPGEF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane TAS --
GO:0005902 microvillus IDA 21047789
GO:0012505 endomembrane system IEA --
GO:0016020 membrane TAS 10777494
genes like me logo Genes that share ontologies with RAPGEF3: view

Pathways & Interactions for RAPGEF3 Gene

PathCards logo

SuperPathways for RAPGEF3 Gene

SuperPathway Contained pathways
1 Response to elevated platelet cytosolic Ca2+
2 Integration of energy metabolism
3 Integrin alphaIIb beta3 signaling
4 Development A2A receptor signaling
.43
.43
5 G-protein signaling G-Protein alpha-i signaling cascades
.55
.44
genes like me logo Genes that share pathways with RAPGEF3: view

Pathways by source for RAPGEF3 Gene

7 GeneGo (Thomson Reuters) pathways for RAPGEF3 Gene
  • Development A2A receptor signaling
  • Development A2B receptor- action via G-protein alpha s
  • Development Beta-adrenergic receptors regulation of ERK
  • Development G-Proteins mediated regulation MARK-ERK signaling
  • G-protein signaling G-Protein alpha-s signaling cascades
2 Cell Signaling Technology pathways for RAPGEF3 Gene

Gene Ontology (GO) - Biological Process for RAPGEF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0007165 signal transduction TAS 9853756
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0019933 cAMP-mediated signaling NAS 16177794
GO:0032486 Rap protein signal transduction IMP 21840392
genes like me logo Genes that share ontologies with RAPGEF3: view

No data available for SIGNOR curated interactions for RAPGEF3 Gene

Drugs & Compounds for RAPGEF3 Gene

(15) Drugs for RAPGEF3 Gene - From: ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
Salirasib Investigational Pharma Inhibitor of active Ras protein, Ras inhibitor; also induces autophagy 0

(9) Additional Compounds for RAPGEF3 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ESI 09
263707-16-0

(4) Tocris Compounds for RAPGEF3 Gene

Compound Action Cas Number
8-CPT-2Me-cAMP, sodium salt Selective Epac activator 634207-53-7
8-pCPT-2-O-Me-cAMP-AM Selective Epac activator; cell-permeable analog of 8CPT-2Me-cAMP (Cat. No. 1645) 1152197-23-3
ESI 09 EPAC inhibitor 263707-16-0
Salirasib Ras inhibitor; also induces autophagy 162520-00-5

(4) ApexBio Compounds for RAPGEF3 Gene

Compound Action Cas Number
8-CPT-2Me-cAMP, sodium salt EPAC agonist, selective 634207-53-7
8-pCPT-2-O-Me-cAMP-AM 1152197-23-3
MitMAB 1119-97-7
OctMAB 1120-02-1
genes like me logo Genes that share compounds with RAPGEF3: view

Transcripts for RAPGEF3 Gene

mRNA/cDNA for RAPGEF3 Gene

3 REFSEQ mRNAs :
22 NCBI additional mRNA sequence :
20 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAPGEF3

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAPGEF3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^
SP1: - - - -
SP2: - - -
SP3: - - - - - - - -
SP4:
SP5:
SP6: - -
SP7: -
SP8:
SP9:
SP10:
SP11:

ExUns: 20a · 20b · 20c ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29a · 29b · 29c · 29d
SP1: - -
SP2: - - -
SP3: - -
SP4: - -
SP5:
SP6:
SP7:
SP8:
SP9: - -
SP10:
SP11: -

Relevant External Links for RAPGEF3 Gene

GeneLoc Exon Structure for
RAPGEF3

Expression for RAPGEF3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RAPGEF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RAPGEF3 Gene

This gene is overexpressed in Urine (34.6) and Fetal Brain (34.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RAPGEF3 Gene



Protein tissue co-expression partners for RAPGEF3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RAPGEF3

SOURCE GeneReport for Unigene cluster for RAPGEF3 Gene:

Hs.8578

mRNA Expression by UniProt/SwissProt for RAPGEF3 Gene:

O95398-RPGF3_HUMAN
Tissue specificity: Widely expressed with highest levels in adult kidney, heart, thyroid and brain, and fetal kidney.

Evidence on tissue expression from TISSUES for RAPGEF3 Gene

  • Nervous system(4.9)
  • Kidney(4.5)
  • Muscle(4.5)
  • Heart(2.8)
  • Thyroid gland(2.2)
  • Lung(2.1)
  • Pancreas(2.1)
genes like me logo Genes that share expression patterns with RAPGEF3: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAPGEF3 Gene

Orthologs for RAPGEF3 Gene

This gene was present in the common ancestor of animals.

Orthologs for RAPGEF3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAPGEF3 31 30
  • 99.75 (n)
OneToOne
dog
(Canis familiaris)
Mammalia RAPGEF3 31 30
  • 91.83 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RAPGEF3 31 30
  • 90.86 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Rapgef3 17 31 30
  • 87.97 (n)
rat
(Rattus norvegicus)
Mammalia Rapgef3 30
  • 87.48 (n)
chicken
(Gallus gallus)
Aves RAPGEF3 31 30
  • 70.73 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAPGEF3 31
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rapgef3 30
  • 63.69 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC101886094 30
  • 60.82 (n)
rapgef3 31
  • 54 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Epac 31
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea epac-1 31
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 38 (a)
OneToMany
Species where no ortholog for RAPGEF3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAPGEF3 Gene

ENSEMBL:
Gene Tree for RAPGEF3 (if available)
TreeFam:
Gene Tree for RAPGEF3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RAPGEF3: view image

Paralogs for RAPGEF3 Gene

(11) SIMAP similar genes for RAPGEF3 Gene using alignment to 8 proteins:

  • RPGF3_HUMAN
  • F8VRX1_HUMAN
  • F8VVJ6_HUMAN
  • F8VXK1_HUMAN
  • F8W0N0_HUMAN
  • H0YHS2_HUMAN
  • H0YIP6_HUMAN
  • Q569L6_HUMAN
genes like me logo Genes that share paralogs with RAPGEF3: view

Variants for RAPGEF3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RAPGEF3 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
714535 Likely Benign: not provided 47,751,067(-) T/C MISSENSE_VARIANT
714536 Benign: not provided 47,757,977(-) C/T SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT
715031 Benign: not provided 47,737,684(-) G/A SYNONYMOUS_VARIANT
723845 Likely Benign: not provided 47,751,503(-) C/T MISSENSE_VARIANT
734096 Benign: not provided 47,748,103(-) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for RAPGEF3 Gene

Structural Variations from Database of Genomic Variants (DGV) for RAPGEF3 Gene

Variant ID Type Subtype PubMed ID
dgv94n21 CNV loss 19592680
nsv470289 CNV gain 18288195
nsv518315 CNV loss 19592680
nsv696 CNV insertion 18451855

Variation tolerance for RAPGEF3 Gene

Residual Variation Intolerance Score: 74.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.77; 93.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RAPGEF3 Gene

Human Gene Mutation Database (HGMD)
RAPGEF3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAPGEF3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAPGEF3 Gene

Disorders for RAPGEF3 Gene

MalaCards: The human disease database

(5) MalaCards diseases for RAPGEF3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
leukocyte adhesion deficiency, type iii
  • lad3
lesch-nyhan syndrome
  • lns
cerebral cavernous malformations
  • cam
asthma
  • asthma, susceptibility to
polycystic liver disease
  • congenital cystic liver disease
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for RAPGEF3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with RAPGEF3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RAPGEF3 Gene

Publications for RAPGEF3 Gene

  1. Association study of the Epac gene and tobacco smoking and nicotine dependence. (PMID: 15274052) Chen X … Kendler KS (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2004) 3 23 41 54
  2. Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs. (PMID: 10777494) de Rooij J … Bos JL (The Journal of biological chemistry 2000) 2 3 4 54
  3. Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP. (PMID: 9853756) de Rooij J … Bos JL (Nature 1998) 3 4 23 54
  4. A family of cAMP-binding proteins that directly activate Rap1. (PMID: 9856955) Kawasaki H … Graybiel AM (Science (New York, N.Y.) 1998) 2 3 4 54
  5. A phosphodiesterase 3B-based signaling complex integrates exchange protein activated by cAMP 1 and phosphatidylinositol 3-kinase signals in human arterial endothelial cells. (PMID: 21393242) Wilson LS … Maurice DH (The Journal of biological chemistry 2011) 3 4 54

Products for RAPGEF3 Gene

Sources for RAPGEF3 Gene