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Aliases for RAP2C Gene

Aliases for RAP2C Gene

  • RAP2C, Member Of RAS Oncogene Family 2 3 5

External Ids for RAP2C Gene

Previous GeneCards Identifiers for RAP2C Gene

  • GC0XM129282
  • GC0XM130042
  • GC0XM131062
  • GC0XM131164
  • GC0XM131337
  • GC0XM120741

Summaries for RAP2C Gene

Entrez Gene Summary for RAP2C Gene

  • The protein encoded by this gene is a member of the Ras-related protein subfamily of the Ras GTPase superfamily. Members of this family are small GTPases that act as molecular switches to regulate cellular proliferation, differentiation, and apoptosis. This protein has been reported to activate in vitro transcriptional activity of the serum response element. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]

GeneCards Summary for RAP2C Gene

RAP2C (RAP2C, Member Of RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Innate Immune System and ERK Signaling. Gene Ontology (GO) annotations related to this gene include GTP binding and transcription coactivator activity. An important paralog of this gene is RAP2A.

UniProtKB/Swiss-Prot for RAP2C Gene

  • Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May play a role in SRE-mediated gene transcription.

Additional gene information for RAP2C Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAP2C Gene

Genomics for RAP2C Gene

GeneHancer (GH) Regulatory Elements for RAP2C Gene

Promoters and enhancers for RAP2C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI132215 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 567.2 +1.7 1749 4.7 ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF143 SP3 SP5 MXD4 REST RAP2C RAP2C-AS1
GH0XI132485 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 15.5 -269.4 -269414 6.1 FOXA2 SIN3A FEZF1 ZNF2 YY1 GLIS2 ATF7 RUNX3 REST PPARG MBNL3 RAP2C FRMD7 GC0XM132373
GH0XI132118 Enhancer 0.5 ENCODE 16.6 +99.5 99495 2.3 SMARCE1 ZNF217 CTBP1 PKNOX1 ZFP36 FRMD7 RAP2C STK26
GH0XI132022 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 3.4 +195.2 195181 4.3 ATF1 ARID4B SIN3A BRCA1 POLR2B GLIS2 E2F8 RUNX3 SP3 GTF2B STK26 RAP2C MBNL3 FRMD7
GH0XI131752 Enhancer 1.2 Ensembl ENCODE dbSUPER 5.2 +466.5 466502 1.9 INSM2 KLF17 RAD21 YY1 GLIS2 ZSCAN5C SCRT2 ATF7 KLF7 BCLAF1 RAP2C PIR47283 GC0XP131789 FIRRE
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RAP2C on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RAP2C gene promoter:

Genomic Locations for RAP2C Gene

Genomic Locations for RAP2C Gene
chrX:132,203,024-132,219,480
(GRCh38/hg38)
Size:
16,457 bases
Orientation:
Minus strand
chrX:131,337,053-131,353,471
(GRCh37/hg19)

Genomic View for RAP2C Gene

Genes around RAP2C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAP2C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAP2C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAP2C Gene

Proteins for RAP2C Gene

  • Protein details for RAP2C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3L5-RAP2C_HUMAN
    Recommended name:
    Ras-related protein Rap-2c
    Protein Accession:
    Q9Y3L5
    Secondary Accessions:
    • B3KWD6
    • Q5H9H9
    • Q9BTS0

    Protein attributes for RAP2C Gene

    Size:
    183 amino acids
    Molecular mass:
    20745 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RAP2C Gene

Post-translational modifications for RAP2C Gene

  • Palmitoylated. Palmitoylation is required for association with recycling endosome membranes and activation of TNIK.
  • Ubiquitination at Lys108

Other Protein References for RAP2C Gene

No data available for DME Specific Peptides for RAP2C Gene

Domains & Families for RAP2C Gene

Gene Families for RAP2C Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for RAP2C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y3L5

UniProtKB/Swiss-Prot:

RAP2C_HUMAN :
  • Belongs to the small GTPase superfamily. Ras family.
Family:
  • Belongs to the small GTPase superfamily. Ras family.
genes like me logo Genes that share domains with RAP2C: view

Function for RAP2C Gene

Molecular function for RAP2C Gene

UniProtKB/Swiss-Prot Function:
Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May play a role in SRE-mediated gene transcription.

Phenotypes From GWAS Catalog for RAP2C Gene

Gene Ontology (GO) - Molecular Function for RAP2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IDA 17447155
GO:0003924 GTPase activity IEA --
GO:0005525 GTP binding IDA,IEA 16213650
GO:0019003 GDP binding IDA 16213650
genes like me logo Genes that share ontologies with RAP2C: view
genes like me logo Genes that share phenotypes with RAP2C: view

Animal Model Products

miRNA for RAP2C Gene

miRTarBase miRNAs that target RAP2C

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAP2C Gene

Localization for RAP2C Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAP2C Gene

Cytoplasm. Recycling endosome membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAP2C gene
Compartment Confidence
plasma membrane 5
extracellular 5
endosome 5
cytosol 4
mitochondrion 2
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for RAP2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA,IEA 17447155
GO:0005768 endosome IEA --
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane TAS --
GO:0005923 bicellular tight junction IDA 23885123
genes like me logo Genes that share ontologies with RAP2C: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RAP2C Gene

Pathways & Interactions for RAP2C Gene

genes like me logo Genes that share pathways with RAP2C: view

Pathways by source for RAP2C Gene

3 Reactome pathways for RAP2C Gene
1 KEGG pathway for RAP2C Gene
1 Qiagen pathway for RAP2C Gene

Gene Ontology (GO) - Biological Process for RAP2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0030033 NOT microvillus assembly IMP 22797597
GO:0030336 negative regulation of cell migration ISS --
GO:0031954 positive regulation of protein autophosphorylation ISS --
GO:0032486 Rap protein signal transduction ISS --
genes like me logo Genes that share ontologies with RAP2C: view

No data available for SIGNOR curated interactions for RAP2C Gene

Drugs & Compounds for RAP2C Gene

No Compound Related Data Available

Transcripts for RAP2C Gene

Unigene Clusters for RAP2C Gene

RAP2C, member of RAS oncogene family:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAP2C Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10
SP1: - - - - - - -
SP2: - - -
SP3: - -
SP4: -
SP5: -

Relevant External Links for RAP2C Gene

GeneLoc Exon Structure for
RAP2C
ECgene alternative splicing isoforms for
RAP2C

Expression for RAP2C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAP2C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAP2C Gene

This gene is overexpressed in Uterus (x6.2).

Protein differential expression in normal tissues from HIPED for RAP2C Gene

This gene is overexpressed in Brain (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RAP2C Gene



Protein tissue co-expression partners for RAP2C Gene

NURSA nuclear receptor signaling pathways regulating expression of RAP2C Gene:

RAP2C

SOURCE GeneReport for Unigene cluster for RAP2C Gene:

Hs.119889

mRNA Expression by UniProt/SwissProt for RAP2C Gene:

Q9Y3L5-RAP2C_HUMAN
Tissue specificity: Expressed in liver, skeletal muscle, prostate, uterus, rectum, stomach, and bladder and to a lower extent in brain, kidney, pancreas, and bone marrow. Expressed in mononuclear leukocytes and megakaryocytes.

Evidence on tissue expression from TISSUES for RAP2C Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with RAP2C: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RAP2C Gene

Orthologs for RAP2C Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAP2C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAP2C 34
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RAP2C 33 34
  • 97.63 (n)
dog
(Canis familiaris)
Mammalia RAP2C 33 34
  • 97.45 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RAP2C 34
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAP2C 34
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rap2c 33
  • 95.45 (n)
mouse
(Mus musculus)
Mammalia Rap2c 33 16 34
  • 94.9 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia rap2c 33
  • 80.69 (n)
Str.3585 33
African clawed frog
(Xenopus laevis)
Amphibia rap2c-prov 33
zebrafish
(Danio rerio)
Actinopterygii rap2c 33 34
  • 76.32 (n)
fruit fly
(Drosophila melanogaster)
Insecta Rap2l 34
  • 69 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rap-2 34
  • 70 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RSR1 34
  • 35 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4500 33
Species where no ortholog for RAP2C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAP2C Gene

ENSEMBL:
Gene Tree for RAP2C (if available)
TreeFam:
Gene Tree for RAP2C (if available)

Paralogs for RAP2C Gene

Pseudogenes.org Pseudogenes for RAP2C Gene

genes like me logo Genes that share paralogs with RAP2C: view

Variants for RAP2C Gene

Sequence variations from dbSNP and Humsavar for RAP2C Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000105946 -- 132,207,160(-) A/G intron_variant
rs1000124538 -- 132,213,112(-) A/G intron_variant
rs1000761896 -- 132,213,823(-) C/A intron_variant
rs1001315145 -- 132,207,322(-) G/A intron_variant
rs1001344460 -- 132,206,497(-) T/A intron_variant

Variation tolerance for RAP2C Gene

Residual Variation Intolerance Score: 39.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.04; 0.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RAP2C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAP2C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RAP2C Gene

Disorders for RAP2C Gene

Additional Disease Information for RAP2C

No disorders were found for RAP2C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAP2C Gene

Publications for RAP2C Gene

  1. Cloning and characterization of the human gene RAP2C, a novel member of Ras family, which activates transcriptional activities of SRE. (PMID: 17447155) Guo Z … Yu L (Molecular biology reports 2007) 3 4 58
  2. Identification and biochemical characterization of Rap2C, a new member of the Rap family of small GTP-binding proteins. (PMID: 16213650) Paganini S … Torti M (Biochimie 2006) 3 4 58
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for RAP2C Gene

Sources for RAP2C Gene

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