Aliases for RAP2A Gene
External Ids for RAP2A Gene
Previous HGNC Symbols for RAP2A Gene
Previous GeneCards Identifiers for RAP2A Gene
GeneCards Summary for RAP2A Gene
RAP2A (RAP2A, Member Of RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAP2A include Cerebral Cavernous Malformations and Cerebral Cavernous Malformations 2. Among its related pathways are ERK Signaling and ADP signalling through P2Y purinoceptor 12. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAP2C.
UniProtKB/Swiss-Prot Summary for RAP2A Gene
Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading.