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Aliases for RAP2A Gene

Aliases for RAP2A Gene

  • RAP2A, Member Of RAS Oncogene Family 2 3 5
  • RbBP-30 3 4
  • RAP2, Member Of RAS Oncogene Family (K-Rev) 3
  • Ras-Related Protein Rap-2a 3
  • K-Rev 3
  • KREV 3
  • RAP2 3

External Ids for RAP2A Gene

Previous HGNC Symbols for RAP2A Gene

  • RAP2

Previous GeneCards Identifiers for RAP2A Gene

  • GC13P096446
  • GC13P092473
  • GC13P096923
  • GC13P095784
  • GC13P096884
  • GC13P098086
  • GC13P078683

Summaries for RAP2A Gene

GeneCards Summary for RAP2A Gene

RAP2A (RAP2A, Member Of RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are ADP signalling through P2Y purinoceptor 12 and ERK Signaling. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAP2C.

UniProtKB/Swiss-Prot for RAP2A Gene

  • Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading.

Gene Wiki entry for RAP2A Gene

Additional gene information for RAP2A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAP2A Gene

Genomics for RAP2A Gene

GeneHancer (GH) Regulatory Elements for RAP2A Gene

Promoters and enhancers for RAP2A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13I097430 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 561.4 -0.7 -747 5.9 HDGF PKNOX1 SMAD1 FOXA2 ARID4B NEUROD1 SIN3A DMAP1 IRF4 YY1 RAP2A GC13M097429 ENSG00000276573 PIR62272
GH13I097366 Enhancer 1 Ensembl ENCODE dbSUPER 12.1 -66.9 -66855 2 SCRT1 CTCF PKNOX1 MAX RAD21 POLR2A SCRT2 MYC RUNX3 RAP2A MBNL2 GC13M097364 RNA5SP37 GC13P097385
GH13I097368 Enhancer 0.9 Ensembl ENCODE dbSUPER 12.1 -64.8 -64793 1.3 IRF2 RXRA MAX HNF4A ZBTB17 RAP2A MBNL2 RNA5SP37 GC13M097364 GC13P097385
GH13I096993 Promoter/Enhancer 1.2 EPDnew Ensembl 5.4 -439.9 -439909 0.9 CTCF ZNF2 ZNF335 ZFHX2 GLIS2 POLR2A ZBTB48 PATZ1 ZNF600 ZBTB20 OXGR1 GC13P096994 RAP2A TULP3P1 LINC00359
GH13I097429 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 4.3 -4.4 -4373 1 L3MBTL2 ZNF189 MAX CEBPB CEBPG ZNF148 MITF ATF4 ZFHX2 SCRT2 RAP2A MBNL2 PIR62272 GC13M097429
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RAP2A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RAP2A gene promoter:

Genomic Locations for RAP2A Gene

Genomic Locations for RAP2A Gene
chr13:97,434,221-97,469,128
(GRCh38/hg38)
Size:
34,908 bases
Orientation:
Plus strand
chr13:98,086,475-98,121,382
(GRCh37/hg19)

Genomic View for RAP2A Gene

Genes around RAP2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAP2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAP2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAP2A Gene

Proteins for RAP2A Gene

  • Protein details for RAP2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10114-RAP2A_HUMAN
    Recommended name:
    Ras-related protein Rap-2a
    Protein Accession:
    P10114
    Secondary Accessions:
    • B2RCJ1
    • Q5JSC1
    • Q5JSC2

    Protein attributes for RAP2A Gene

    Size:
    183 amino acids
    Molecular mass:
    20615 Da
    Quaternary structure:
    • Interacts (GTP-bound form) with RUNDC3A. Interacts with RGS14; the interaction is GTP-dependent (By similarity). Interacts with PLCE1. Interacts with ARHGAP29, SGSM1, SGSM2 and SGSM3. Interacts (GTP-bound form preferentially) with TNIK (via the CNH domain); the interaction is direct and recruits RAP2A to the E3 ubiquitin ligase NEDD4. Interacts with MINK1. Interacts (GTP-bound form preferentially) with MAP4K4. Interacts with cytoskeletal actin.

    Three dimensional structures from OCA and Proteopedia for RAP2A Gene

neXtProt entry for RAP2A Gene

Post-translational modifications for RAP2A Gene

  • Palmitoylated. Palmitoylation is required for association with recycling endosome membranes and activation of TNIK.
  • Ubiquitinated; undergoes Lys-63 monoubiquitination and diubiquitination by NEDD4. Multiple lysine residues are probably modified. Ubiquitination requires TNIK, prevents interaction with effectors and inactivates RAP2A.

Other Protein References for RAP2A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RAP2A Gene

Domains & Families for RAP2A Gene

Gene Families for RAP2A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for RAP2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P10114

UniProtKB/Swiss-Prot:

RAP2A_HUMAN :
  • The effector domain mediates the interaction with RUNDC3A.
  • Belongs to the small GTPase superfamily. Ras family.
Domain:
  • The effector domain mediates the interaction with RUNDC3A.
Family:
  • Belongs to the small GTPase superfamily. Ras family.
genes like me logo Genes that share domains with RAP2A: view

Function for RAP2A Gene

Molecular function for RAP2A Gene

GENATLAS Biochemistry:
RAP2A,Ras oncogene superfamily member (K-rev),overexpressed in sporadic breast cancer,grade I
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by the guanine nucleotide-exchange factors RAPGEF3 and RAPGEF4 in a cAMP-dependent manner. Nucleotide exchange is also specifically stimulated by RAPGEF5, RASGEF1A and RASGEF1B.
UniProtKB/Swiss-Prot Function:
Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading.

Phenotypes From GWAS Catalog for RAP2A Gene

Gene Ontology (GO) - Molecular Function for RAP2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IMP 9312017
GO:0003924 GTPase activity IEA,IDA 1900290
GO:0005515 protein binding IPI 14966141
GO:0005525 GTP binding IMP,IEA 9312017
GO:0019003 GDP binding IMP 9312017
genes like me logo Genes that share ontologies with RAP2A: view
genes like me logo Genes that share phenotypes with RAP2A: view

Clone Products

  • Addgene plasmids for RAP2A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAP2A Gene

Localization for RAP2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAP2A Gene

Recycling endosome membrane; Lipid-anchor; Cytoplasmic side. Midbody. Note=May also localize to the Golgi (PubMed:7962206) and the gelatinase-containing granules of neutrophils (PubMed:8391995). Colocalizes with RASGEF1B to midbody at telophase (PubMed:23894443). {ECO:0000269 PubMed:23894443, ECO:0000269 PubMed:7962206, ECO:0000269 PubMed:8391995}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAP2A gene
Compartment Confidence
plasma membrane 5
extracellular 5
endosome 5
cytosol 4
nucleus 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for RAP2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IEA --
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane IDA 22797597
GO:0016020 membrane IEA --
GO:0030496 midbody IEA --
genes like me logo Genes that share ontologies with RAP2A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RAP2A Gene

Pathways & Interactions for RAP2A Gene

genes like me logo Genes that share pathways with RAP2A: view

Pathways by source for RAP2A Gene

1 GeneGo (Thomson Reuters) pathway for RAP2A Gene
2 Qiagen pathways for RAP2A Gene

Gene Ontology (GO) - Biological Process for RAP2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IMP 22797597
GO:0007165 signal transduction IEA --
GO:0030033 microvillus assembly IMP 22797597
GO:0030336 negative regulation of cell migration IEA --
GO:0031532 actin cytoskeleton reorganization IDA 15342639
genes like me logo Genes that share ontologies with RAP2A: view

No data available for SIGNOR curated interactions for RAP2A Gene

Drugs & Compounds for RAP2A Gene

(4) Drugs for RAP2A Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma Target 0
cyclic amp Experimental Pharma 0
Guanosine diphosphate Experimental Pharma Target 0

(1) Additional Compounds for RAP2A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RAP2A: view

Transcripts for RAP2A Gene

mRNA/cDNA for RAP2A Gene

Unigene Clusters for RAP2A Gene

RAP2A, member of RAS oncogene family:
Representative Sequences:

Clone Products

  • Addgene plasmids for RAP2A

Alternative Splicing Database (ASD) splice patterns (SP) for RAP2A Gene

No ASD Table

Relevant External Links for RAP2A Gene

GeneLoc Exon Structure for
RAP2A
ECgene alternative splicing isoforms for
RAP2A

Expression for RAP2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAP2A Gene

Protein differential expression in normal tissues from HIPED for RAP2A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (21.8), Brain (15.7), and Frontal cortex (10.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RAP2A Gene



NURSA nuclear receptor signaling pathways regulating expression of RAP2A Gene:

RAP2A

SOURCE GeneReport for Unigene cluster for RAP2A Gene:

Hs.508480

Evidence on tissue expression from TISSUES for RAP2A Gene

  • Nervous system(4.9)
  • Lymph node(4.2)
  • Heart(2)
  • Lung(2)
genes like me logo Genes that share expression patterns with RAP2A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAP2A Gene

Orthologs for RAP2A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAP2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAP2A 33 34
  • 99.82 (n)
oppossum
(Monodelphis domestica)
Mammalia RAP2A 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAP2A 33 34
  • 94.9 (n)
mouse
(Mus musculus)
Mammalia Rap2a 33 16 34
  • 94.35 (n)
cow
(Bos Taurus)
Mammalia RAP2A 33 34
  • 93.26 (n)
chicken
(Gallus gallus)
Aves RAP2A 33 34
  • 89.62 (n)
lizard
(Anolis carolinensis)
Reptilia RAP2A 34
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rap2a 33
  • 83.06 (n)
zebrafish
(Danio rerio)
Actinopterygii CABZ01067868.1 34
  • 97 (a)
OneToMany
rap2ab 33 34
  • 85.25 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9348 33
fruit fly
(Drosophila melanogaster)
Insecta Rap2l 35 34
  • 69 (a)
worm
(Caenorhabditis elegans)
Secernentea rap-2 33 34
  • 63.48 (n)
C25D7.7 35
  • 59 (a)
C08F8.7 35
  • 48 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RSR1 34
  • 35 (a)
OneToMany
Species where no ortholog for RAP2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAP2A Gene

ENSEMBL:
Gene Tree for RAP2A (if available)
TreeFam:
Gene Tree for RAP2A (if available)

Paralogs for RAP2A Gene

genes like me logo Genes that share paralogs with RAP2A: view

Variants for RAP2A Gene

Sequence variations from dbSNP and Humsavar for RAP2A Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1000035438 -- 97,462,775(+) G/A/C intron_variant
rs1000144834 -- 97,456,332(+) C/T intron_variant
rs1000201646 -- 97,442,445(+) A/G intron_variant
rs1000222244 -- 97,445,937(+) G/A intron_variant
rs1000222448 -- 97,435,168(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RAP2A Gene

Variant ID Type Subtype PubMed ID
nsv832694 CNV gain 17160897
nsv7246 OTHER inversion 18451855
nsv562823 CNV loss 21841781
nsv562794 CNV loss 21841781
nsv476200 CNV novel sequence insertion 20440878
nsv1131062 CNV deletion 24896259
nsv1071118 CNV deletion 25765185
esv3633293 OTHER inversion 21293372
esv3633292 CNV loss 21293372
esv3550942 CNV deletion 23714750
esv2747855 CNV deletion 23290073
esv2664226 CNV deletion 23128226
esv21981 CNV loss 19812545
esv21921 CNV loss 19812545
dgv3335n54 CNV loss 21841781
dgv3334n54 CNV loss 21841781
dgv3333n54 CNV loss 21841781
dgv3332n54 CNV loss 21841781
dgv3331n54 CNV loss 21841781
dgv1019n106 OTHER inversion 24896259
dgv1018n106 CNV deletion 24896259

Variation tolerance for RAP2A Gene

Residual Variation Intolerance Score: 39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.08; 1.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RAP2A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAP2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAP2A Gene

Disorders for RAP2A Gene

Additional Disease Information for RAP2A

Genetic Association Database
(GAD)
Tumor Gene Database
(TGDB)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for RAP2A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAP2A Gene

Publications for RAP2A Gene

  1. RasGEF1A and RasGEF1B are guanine nucleotide exchange factors that discriminate between Rap GTP-binding proteins and mediate Rap2-specific nucleotide exchange. (PMID: 19645719) Yaman E … Tazebay UH (The FEBS journal 2009) 3 4 22 58
  2. Rap2 function requires palmitoylation and recycling endosome localization. (PMID: 19061864) Uechi Y … Kariya K (Biochemical and biophysical research communications 2009) 3 4 22 58
  3. Biochemical characterization of RGS14: RGS14 activity towards G-protein alpha subunits is independent of its binding to Rap2A. (PMID: 16246175) Mittal V … Linder ME (The Biochemical journal 2006) 3 4 22 58
  4. Mitogen-activated protein kinase kinase kinase kinase 4 as a putative effector of Rap2 to activate the c-Jun N-terminal kinase. (PMID: 14966141) Machida N … Kariya K (The Journal of biological chemistry 2004) 3 4 22 58
  5. Structure of the small G protein Rap2 in a non-catalytic complex with GTP. (PMID: 10591105) Ménétrey J … Cherfils J (Proteins 1999) 3 4 22 58

Products for RAP2A Gene

  • Addgene plasmids for RAP2A

Sources for RAP2A Gene

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