Aliases for RAP1GAP2 Gene
External Ids for RAP1GAP2 Gene
Previous HGNC Symbols for RAP1GAP2 Gene
Previous GeneCards Identifiers for RAP1GAP2 Gene
This gene encodes a GTPase-activating protein that activates the small guanine-nucleotide-binding protein Rap1 in platelets. The protein interacts with synaptotagmin-like protein 1 and Rab27 and regulates secretion of dense granules from platelets at sites of endothelial damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
GeneCards Summary for RAP1GAP2 Gene
RAP1GAP2 (RAP1 GTPase Activating Protein 2) is a Protein Coding gene. Among its related pathways are Rap1 signalling and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is RAP1GAP.
UniProtKB/Swiss-Prot Summary for RAP1GAP2 Gene
GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state.