Aliases for RAP1GAP2 Gene
External Ids for RAP1GAP2 Gene
Previous HGNC Symbols for RAP1GAP2 Gene
Previous GeneCards Identifiers for RAP1GAP2 Gene
This gene encodes a GTPase-activating protein that activates the small guanine-nucleotide-binding protein Rap1 in platelets. The protein interacts with synaptotagmin-like protein 1 and Rab27 and regulates secretion of dense granules from platelets at sites of endothelial damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
GeneCards Summary for RAP1GAP2 Gene
RAP1GAP2 (RAP1 GTPase Activating Protein 2) is a Protein Coding gene. Among its related pathways are Innate Immune System and Rap1 signalling. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is RAP1GAP.
UniProtKB/Swiss-Prot for RAP1GAP2 Gene
GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state.