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Aliases for RAP1GAP2 Gene

Aliases for RAP1GAP2 Gene

  • RAP1 GTPase Activating Protein 2 2 3 5
  • GTPase-Activating Rap/Ran-GAP Domain-Like Protein 4 3 4
  • GTPase Activating Rap/RanGAP Domain-Like 4 2 3
  • GTPase Activating RANGAP Domain-Like 4 2 3
  • GARNL4 3 4
  • Rap1 GTPase-Activating Protein 2 3
  • KIAA1039 4
  • Rap1GAP2 4
  • RAP1GA3 3
  • RAP1GA2 4

External Ids for RAP1GAP2 Gene

Previous HGNC Symbols for RAP1GAP2 Gene

  • GARNL4

Previous GeneCards Identifiers for RAP1GAP2 Gene

  • GC17P002646
  • GC17P002680

Summaries for RAP1GAP2 Gene

Entrez Gene Summary for RAP1GAP2 Gene

  • This gene encodes a GTPase-activating protein that activates the small guanine-nucleotide-binding protein Rap1 in platelets. The protein interacts with synaptotagmin-like protein 1 and Rab27 and regulates secretion of dense granules from platelets at sites of endothelial damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

GeneCards Summary for RAP1GAP2 Gene

RAP1GAP2 (RAP1 GTPase Activating Protein 2) is a Protein Coding gene. Among its related pathways are Rap1 signalling and Innate Immune System. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is RAP1GAP.

UniProtKB/Swiss-Prot for RAP1GAP2 Gene

  • GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state.

Additional gene information for RAP1GAP2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAP1GAP2 Gene

Genomics for RAP1GAP2 Gene

GeneHancer (GH) Regulatory Elements for RAP1GAP2 Gene

Promoters and enhancers for RAP1GAP2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J002755 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 650.7 -0.2 -207 0.3 KLF17 ZNF2 ZNF335 KLF7 EGR2 ZNF280D SP3 ZNF398 ELF1 ZEB2 RAP1GAP2 GC17P002753 CLUH
GH17J002795 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 650.3 +40.8 40845 2.4 CTCF POLR2A ZSCAN4 MAX MNT RAP1GAP2 GC17M002839
GH17J002756 Enhancer 0.8 ENCODE 650.7 +0.7 718 0.8 ZNF2 ZNF335 GLIS2 KLF7 EGR2 USF2 ZNF398 ZEB2 SREBF1 GLIS1 RAP1GAP2 CLUH GC17M002839
GH17J002389 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 15 -356.7 -356686 18.6 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF263 MNT GC17M002401 GC17M002400 GC17M002387 METTL16 PRPF8 SMYD4 SMG6 HNRNPA1P16 ENSG00000263345
GH17J002851 Enhancer 1.1 Ensembl ENCODE dbSUPER 17.8 +98.1 98068 3.7 MXI1 USF1 SIN3A HIC1 E2F1 ZNF335 ZFHX2 ZBTB48 PRDM10 ZNF600 RAP1GAP2 METTL16 ENSG00000261916 GC17M002857 GC17M002839
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RAP1GAP2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for RAP1GAP2 Gene

Genomic Locations for RAP1GAP2 Gene
282,044 bases
Plus strand
260,686 bases
Plus strand

Genomic View for RAP1GAP2 Gene

Genes around RAP1GAP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAP1GAP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAP1GAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAP1GAP2 Gene

Proteins for RAP1GAP2 Gene

  • Protein details for RAP1GAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rap1 GTPase-activating protein 2
    Protein Accession:
    Secondary Accessions:
    • B2RTY5
    • Q684P4
    • Q6AI00
    • Q6ZVF0
    • Q9UPW2

    Protein attributes for RAP1GAP2 Gene

    730 amino acids
    Molecular mass:
    80056 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RAP1GAP2 Gene


neXtProt entry for RAP1GAP2 Gene

Post-translational modifications for RAP1GAP2 Gene

  • In vitro phosphorylated by cGMP-dependent protein kinase 1 (cGKI) at Ser-7; the phosphorylation probably does not regulate GAP activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RAP1GAP2 Gene

Domains & Families for RAP1GAP2 Gene

Gene Families for RAP1GAP2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RAP1GAP2 Gene


Suggested Antigen Peptide Sequences for RAP1GAP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RAP1GAP2: view

No data available for UniProtKB/Swiss-Prot for RAP1GAP2 Gene

Function for RAP1GAP2 Gene

Molecular function for RAP1GAP2 Gene

UniProtKB/Swiss-Prot Function:
GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state.

Phenotypes From GWAS Catalog for RAP1GAP2 Gene

Gene Ontology (GO) - Molecular Function for RAP1GAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity EXP 16076873
GO:0005515 protein binding IPI 24284068
genes like me logo Genes that share ontologies with RAP1GAP2: view

Phenotypes for RAP1GAP2 Gene

genes like me logo Genes that share phenotypes with RAP1GAP2: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAP1GAP2 Gene

Localization for RAP1GAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAP1GAP2 Gene

Cytoplasm. Cytoplasm, perinuclear region.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAP1GAP2 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
plasma membrane 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nuclear membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RAP1GAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 21399614
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IGI 24284068
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with RAP1GAP2: view

Pathways & Interactions for RAP1GAP2 Gene

genes like me logo Genes that share pathways with RAP1GAP2: view

Pathways by source for RAP1GAP2 Gene

3 Reactome pathways for RAP1GAP2 Gene

Gene Ontology (GO) - Biological Process for RAP1GAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008361 regulation of cell size IMP 24284068
GO:0010977 negative regulation of neuron projection development IEA --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction IEA --
genes like me logo Genes that share ontologies with RAP1GAP2: view

No data available for SIGNOR curated interactions for RAP1GAP2 Gene

Drugs & Compounds for RAP1GAP2 Gene

No Compound Related Data Available

Transcripts for RAP1GAP2 Gene

Unigene Clusters for RAP1GAP2 Gene

RAP1 GTPase activating protein 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAP1GAP2 Gene

No ASD Table

Relevant External Links for RAP1GAP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RAP1GAP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAP1GAP2 Gene

Protein differential expression in normal tissues from HIPED for RAP1GAP2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (21.5) and Platelet (18.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RAP1GAP2 Gene

Protein tissue co-expression partners for RAP1GAP2 Gene

NURSA nuclear receptor signaling pathways regulating expression of RAP1GAP2 Gene:


SOURCE GeneReport for Unigene cluster for RAP1GAP2 Gene:


mRNA Expression by UniProt/SwissProt for RAP1GAP2 Gene:

Tissue specificity: Isoform 1 and isoform 2 are expressed in platelets with isoform 2 being the predominant form. Expressed in lymphocytes, heart, testis and pancreas.

Evidence on tissue expression from TISSUES for RAP1GAP2 Gene

  • Nervous system(4.4)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with RAP1GAP2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAP1GAP2 Gene

Orthologs for RAP1GAP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RAP1GAP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RAP1GAP2 34 33
  • 97.95 (n)
(Bos Taurus)
Mammalia RAP1GAP2 34 33
  • 91.14 (n)
(Canis familiaris)
Mammalia RAP1GAP2 34 33
  • 90.4 (n)
(Mus musculus)
Mammalia Rap1gap2 16 34 33
  • 89.55 (n)
(Rattus norvegicus)
Mammalia Rap1gap2 33
  • 88.24 (n)
(Monodelphis domestica)
Mammalia RAP1GAP2 34
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia RAP1GAP2 34
  • 84 (a)
(Gallus gallus)
Aves RAP1GAP2 34 33
  • 81.12 (n)
(Anolis carolinensis)
Reptilia RAP1GAP2 34
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495015 33
  • 72.1 (n)
(Danio rerio)
Actinopterygii rap1gap2a 34
  • 70 (a)
rap1gap2b 34 33
  • 66.81 (n)
fruit fly
(Drosophila melanogaster)
Insecta Rapgap1 34
  • 30 (a)
(Caenorhabditis elegans)
Secernentea F53A10.2 34
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 51 (a)
Species where no ortholog for RAP1GAP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAP1GAP2 Gene

Gene Tree for RAP1GAP2 (if available)
Gene Tree for RAP1GAP2 (if available)
Evolutionary constrained regions (ECRs) for RAP1GAP2: view image

Paralogs for RAP1GAP2 Gene

Paralogs for RAP1GAP2 Gene

(1) SIMAP similar genes for RAP1GAP2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RAP1GAP2: view

Variants for RAP1GAP2 Gene

Sequence variations from dbSNP and Humsavar for RAP1GAP2 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000004387 -- 2,875,712(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000012902 -- 2,966,091(+) A/T genic_upstream_transcript_variant, intron_variant
rs1000042148 -- 2,920,369(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000046494 -- 3,023,108(+) T/A intron_variant
rs1000047982 -- 2,805,061(+) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RAP1GAP2 Gene

Variant ID Type Subtype PubMed ID
dgv1405n106 CNV deletion 24896259
dgv402e201 CNV deletion 23290073
dgv403e201 CNV deletion 23290073
dgv404e201 CNV deletion 23290073
dgv524e199 CNV deletion 23128226
dgv69n73 CNV deletion 24416366
esv1118636 CNV deletion 17803354
esv1294904 CNV insertion 17803354
esv1353865 CNV insertion 17803354
esv1684182 CNV deletion 17803354
esv1759238 CNV deletion 17803354
esv2072081 CNV deletion 18987734
esv2425553 CNV deletion 19546169
esv24712 CNV loss 19812545
esv2573108 CNV deletion 19546169
esv2627871 CNV insertion 19546169
esv2659929 CNV deletion 23128226
esv2660206 CNV deletion 23128226
esv2661610 CNV deletion 23128226
esv2664485 CNV deletion 23128226
esv2674855 CNV deletion 23128226
esv2677834 CNV deletion 23128226
esv2715508 CNV deletion 23290073
esv2715510 CNV deletion 23290073
esv2715511 CNV deletion 23290073
esv2715513 CNV deletion 23290073
esv2715515 CNV deletion 23290073
esv2715517 CNV deletion 23290073
esv2715520 CNV deletion 23290073
esv2715521 CNV deletion 23290073
esv2715522 CNV deletion 23290073
esv2715523 CNV deletion 23290073
esv2715524 CNV deletion 23290073
esv2715525 CNV deletion 23290073
esv2740912 CNV deletion 23290073
esv2742768 CNV deletion 23290073
esv29841 CNV gain 19812545
esv3429880 CNV insertion 20981092
esv3554008 CNV deletion 23714750
esv3582487 CNV loss 25503493
esv3639722 CNV loss 21293372
esv3639723 CNV loss 21293372
esv3639724 CNV loss 21293372
esv3639726 CNV loss 21293372
esv3639727 CNV loss 21293372
esv3639728 CNV loss 21293372
esv3639729 CNV loss 21293372
esv3639730 CNV loss 21293372
esv3639731 CNV loss 21293372
esv3639732 CNV loss 21293372
esv994444 CNV deletion 20482838
nsv1057894 CNV gain 25217958
nsv1065489 CNV gain 25217958
nsv1065764 CNV gain 25217958
nsv1070795 CNV deletion 25765185
nsv1071362 CNV deletion 25765185
nsv112042 CNV deletion 16902084
nsv1130702 CNV deletion 24896259
nsv472336 CNV novel sequence insertion 20440878
nsv472505 CNV novel sequence insertion 20440878
nsv475761 CNV novel sequence insertion 20440878
nsv478918 CNV novel sequence insertion 20440878
nsv512470 CNV loss 21212237
nsv574226 CNV loss 21841781
nsv574227 CNV loss 21841781
nsv574228 CNV loss 21841781
nsv7288 OTHER inversion 18451855
nsv821347 CNV deletion 20802225
nsv821474 CNV duplication 20802225

Variation tolerance for RAP1GAP2 Gene

Residual Variation Intolerance Score: 15.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.49; 91.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RAP1GAP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAP1GAP2 Gene

Disorders for RAP1GAP2 Gene

Additional Disease Information for RAP1GAP2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for RAP1GAP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAP1GAP2 Gene

Publications for RAP1GAP2 Gene

  1. Rap1GAP2 is a new GTPase-activating protein of Rap1 expressed in human platelets. (PMID: 15632203) Schultess J … Smolenski AP (Blood 2005) 2 3 4 58
  2. GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease. (PMID: 21658281) Aouizerat BE … Tseng ZH (BMC cardiovascular disorders 2011) 3 44 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 3 4 58
  5. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 58

Products for RAP1GAP2 Gene

Sources for RAP1GAP2 Gene

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