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This gene encodes a member of the Ras family of small GTPases. The encoded protein undergoes a change in conformational state and activity, depending on whether it is bound to GTP or GDP. This protein is activated by several types of guanine nucleotide exchange factors (GEFs), and inactivated by two groups of GTPase-activating proteins (GAPs). The activation status of the encod... See more...
Aliases for RAP1A Gene
Aliases for RAP1A Gene
External Ids for RAP1A Gene
- HGNC: 9855
- Entrez Gene: 5906
- Ensembl: ENSG00000116473
- OMIM: 179520
- UniProtKB: P62834
Previous GeneCards Identifiers for RAP1A Gene
- GC01P112501
- GC01P110956
- GC01P111186
- GC01P111383
- GC01P111796
- GC01P111886
- GC01P111963
- GC01P112084
- GC01P110105
Summaries for RAP1A Gene
-
This gene encodes a member of the Ras family of small GTPases. The encoded protein undergoes a change in conformational state and activity, depending on whether it is bound to GTP or GDP. This protein is activated by several types of guanine nucleotide exchange factors (GEFs), and inactivated by two groups of GTPase-activating proteins (GAPs). The activation status of the encoded protein is therefore affected by the balance of intracellular levels of GEFs and GAPs. The encoded protein regulates signaling pathways that affect cell proliferation and adhesion, and may play a role in tumor malignancy. Pseudogenes of this gene have been defined on chromosomes 14 and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
GeneCards Summary for RAP1A Gene
RAP1A (RAP1A, Member Of RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAP1A include Kabuki Syndrome 1 and Leukocyte Adhesion Deficiency, Type Iii. Among its related pathways are NGF Pathway and RET signaling. Gene Ontology (GO) annotations related to this gene include GTP binding. An important paralog of this gene is RAP1B.
UniProtKB/Swiss-Prot Summary for RAP1A Gene
-
Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes. Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions.
Additional gene information for RAP1A Gene
- HGNC(9855)
- Entrez Gene(5906)
- Ensembl(ENSG00000116473)
- OMIM(179520)
- UniProtKB(P62834)
- Open Targets Platform(ENSG00000116473)
- Monarch Initiative
- Search for RAP1A at DataMed
- Search for RAP1A at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RAP1A Gene
Genomics for RAP1A Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for RAP1A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around RAP1A on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RAP1A
- Top Transcription factor binding sites by QIAGEN in the RAP1A gene promoter:
-
- Evi-1
- FOXD3
- HSF1 (long)
- HSF1short
- RORalpha2
Genomic Locations for RAP1A Gene
Genomic Locations for RAP1A Gene
- chr1:111,542,009-111,716,695
- (GRCh38/hg38)
- Size:
- 174,687 bases
- Orientation:
- Plus strand
- chr1:112,084,840-112,259,313
- (GRCh37/hg19)
- Size:
- 174,474 bases
- Orientation:
- Plus strand
Genomic View for RAP1A Gene
Genes around RAP1A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p13.2 by HGNC
- 1p13.2 by Entrez Gene
- 1p13.2 by Ensembl
RAP1A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RAP1A Gene
Proteins for RAP1A Gene
-
Protein details for RAP1A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P62834-RAP1A_HUMAN
- Recommended name:
- Ras-related protein Rap-1A
- Protein Accession:
- P62834
- P10113
Protein attributes for RAP1A Gene
- Size:
- 184 amino acids
- Molecular mass:
- 20987 Da
- Quaternary structure:
-
- Found in a complex, at least composed of ITGB1BP1, KRIT1 and RAP1A. Interacts (active GTP-bound form preferentially) with KRIT1 (via C-terminus FERM domain); the interaction does not induce the opening conformation of KRIT1. In its GTP-bound form interacts with PLCE1 and RADIL. Interacts with SGSM1, SGSM2 and SGSM3. Interacts (via GTP-bound active form) with RAPGEF2 (via Ras-associating domain).
Protein Expression for RAP1A Gene
Post-translational modifications for RAP1A Gene
Other Protein References for RAP1A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ RAP1A Antibody
- HUABIO Anti-RAP1A Antibody
-
Custom Antibody ServicesOriGene Antibodies for RAP1A
- Novus Biologicals Antibodies for RAP1A
-
Abcam antibodies for RAP1A
- Invitrogen Antibodies for RAP1A (AFLGC-RAP1A)
- antibodies-online: Show 36 available RAP1A Antibodies ranked by validation data
- Compare Top RAP1A Antibodies
-
Recommended
- 65 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 4 FACS Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 56 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 2 FACS Antibodies (anti-mouse)
- 23 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
-
Boster Bio Antibodies for RAP1A
-
Santa Cruz Biotechnology (SCBT) Antibodies for RAP1A
Protein Products
-
OriGene Purified Proteins for RAP1A
- Search Origene for MassSpec and Protein Over-expression Lysates for RAP1A
- Origene Custom Protein Services for RAP1A
- ProSpec Recombinant Proteins for RAP1A
-
Abcam proteins for RAP1A
Assay Products
-
Signalway ELISA kits for RAP1A
No data available for DME Specific Peptides for RAP1A Gene
Domains & Families for RAP1A Gene
Gene Families for RAP1A Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for RAP1A Gene
- InterPro:
- Blocks:
-
- Ras small GTPase, Ras type
- ProtoNet:
Suggested Antigen Peptide Sequences for RAP1A Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ75985, highly similar to Homo sapiens RAP1A, member of RAS oncogene family (RAP1A), transcript variant 2, mRNA (A8KAH9_HUMAN)
- Ras-related protein Krev-1 (RAP1A_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P62834- Family:
-
- Belongs to the small GTPase superfamily. Ras family.
Function for RAP1A Gene
Molecular function for RAP1A Gene
- UniProtKB/Swiss-Prot Function:
- Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes. Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activated by guanine nucleotide-exchange factors (GEF) EPAC and EPAC2 in a cAMP-dependent manner, and GFR.
- GENATLAS Biochemistry:
- RAP1A,Ras oncogene superfamily member (Krev1),morphologic reversion of ras-transformed cells
Phenotypes From GWAS Catalog for RAP1A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0003924 | GTPase activity | TAS,IBA | 21873635 |
| GO:0005515 | protein binding | IPI | 7791872 |
| GO:0005525 | GTP binding | IBA | 21873635 |
| GO:0017016 | Ras GTPase binding | IEA | -- |
Phenotypes for RAP1A Gene
- MGI mutant phenotypes for RAP1A:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for RAP1A:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Resistant to vaccinia virus (VACV-A4L) infection
- Decreased vaccinia virus (VACV) infection
- Decreased viability after Maraba virus infection
- Synthetic lethal with imatinib mesylate
- Synthetic lethal with c-Myc after tamoxifen stimulation
- Decreased viability with SS1P at EC30
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for RAP1A - Select products 50% OFF >
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- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for RAP1A
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RAP1A
-
Santa Cruz Biotechnology (SCBT) CRISPR for RAP1A
miRNA for RAP1A Gene
- miRTarBase miRNAs that target RAP1A
-
- hsa-miR-337-3p (MIRT006958)
- mmu-miR-425-5p (MIRT008796)
- hsa-let-7e-5p (MIRT051421)
- hsa-miR-3591-5p (MIRT448551)
- hsa-miR-1273e (MIRT448552)
- hsa-miR-4473 (MIRT448553)
- hsa-miR-4671-3p (MIRT448554)
- hsa-miR-636 (MIRT448555)
- hsa-miR-135a-3p (MIRT448556)
- hsa-miR-302c-3p (MIRT448557)
- hsa-miR-512-3p (MIRT448558)
- hsa-miR-520f-3p (MIRT448559)
- hsa-miR-4470 (MIRT512891)
- hsa-miR-759 (MIRT512892)
- hsa-miR-4761-5p (MIRT512893)
- hsa-miR-5000-5p (MIRT512894)
- hsa-miR-4735-3p (MIRT512895)
- hsa-miR-18b-5p (MIRT512896)
- hsa-miR-18a-5p (MIRT512897)
- hsa-miR-551b-5p (MIRT512898)
- hsa-miR-4799-5p (MIRT554934)
- hsa-miR-8059 (MIRT554935)
- hsa-miR-4471 (MIRT554936)
- hsa-miR-6837-3p (MIRT554937)
- hsa-miR-6754-3p (MIRT554938)
- hsa-miR-412-3p (MIRT554939)
- hsa-miR-6715a-3p (MIRT554940)
- hsa-miR-5692c (MIRT554941)
- hsa-miR-5692b (MIRT554942)
- hsa-miR-6822-5p (MIRT554943)
- hsa-miR-6750-5p (MIRT554944)
- hsa-miR-1277-5p (MIRT554945)
- hsa-miR-10a-3p (MIRT554946)
- hsa-miR-19a-3p (MIRT554947)
- hsa-miR-19b-3p (MIRT554948)
- hsa-miR-203a-3p (MIRT734682)
- hsa-miR-203a-5p (MIRT734748)
- hsa-miR-1268a (MIRT761765)
- hsa-miR-1268b (MIRT761767)
- hsa-miR-1272 (MIRT761784)
- hsa-miR-340-3p (MIRT765735)
- hsa-miR-4486 (MIRT769639)
- hsa-miR-4684-5p (MIRT771019)
- hsa-miR-548c-3p (MIRT774337)
- hsa-miR-585-3p (MIRT775339)
- hsa-miR-6771-3p (MIRT778650)
- hsa-miR-6827-3p (MIRT779933)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RAP1A
- Browse OriGene Inhibitory RNA Products For RAP1A
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Clone Products
- Applied Biological Materials (abm): Clones for RAP1A - Select products 50% OFF >
- * RAP1A as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG201691
- MR201691
- MR201691L3
- MR201691L4
- RC204137
- RC204137L1
- RC204137L2
- RC204137L3
- RC204137L4
- RC215248
- RC215248L3
- RC215248L4
- RC236366
- RG204137
- RG215248
- RR201148
- RR201148L3
- RR201148L4
- MR201691L3V
- MR201691L4V
- RC204137L1V
- RC204137L2V
- RC204137L3V
- RC204137L4V
- RC215248L3V
- RC215248L4V
- RR201148L3V
- RR201148L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for RAP1A
- Addgene plasmids for RAP1A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RAP1A
Cell Line Products
-
Horizon Cell Lines for RAP1A
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for RAP1A Gene
Localization for RAP1A Gene
Subcellular locations from UniProtKB/Swiss-Prot for RAP1A Gene
- Cell membrane. Lipid-anchor. Cytoplasm. Cytoplasm, perinuclear region. Cell junction. Early endosome. Note=Recruited from early endosome to late endosome compartment after nerve growth factor (NGF) stimulation. Localized with RAPGEF2 at cell-cell junctions (By similarity). Colocalized with RAPGEF2 in the perinuclear region. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| plasma membrane | 4 |
| extracellular | 4 |
| endosome | 4 |
| nucleus | 3 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA,IDA | 11359771 |
| GO:0005768 | endosome | IEA | -- |
| GO:0005769 | early endosome | ISS | -- |
| GO:0005770 | late endosome | IEA,ISS | -- |
| GO:0005829 | cytosol | TAS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for RAP1A Gene
Pathways & Interactions for RAP1A Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | Paradoxical activation of RAF signaling by kinase inactive BRAF | ||
| 3 | Focal Adhesion |
.61
.61
|
HGF Pathway
.33
|
| 4 | Development HGF signaling pathway |
Development HGF signaling pathway
.44
Development Neurotrophin family signaling
.44
|
|
| 5 | Activation of cAMP-Dependent PKA |
Activation of cAMP-Dependent PKA
.77
cAMP Pathway
.77
|
Activation of PKA through GPCR
.71
PKA Signaling
.56
|
Pathways by source for RAP1A Gene
3 Sino Biological pathways for RAP1A Gene
17 BioSystems pathways for RAP1A Gene
71 Reactome pathways for RAP1A Gene
1 PharmGKB pathway for RAP1A Gene
14 KEGG pathways for RAP1A Gene
24 GeneGo (Thomson Reuters) pathways for RAP1A Gene
- Cell adhesion Ephrins signaling
- Cytoskeleton remodeling FAK signaling
- Cytoskeleton remodeling_RalA regulation pathway
- Development A2A receptor signaling
- Development A2B receptor- action via G-protein alpha s
20 Qiagen pathways for RAP1A Gene
- Activation of cAMP-Dependent PKA
- Activation of PKA through GPCR
- Activation of PKC through GPCR
- cAMP Pathway
- CRHR Pathway
2 Cell Signaling Technology pathways for RAP1A Gene
Interacting Proteins for RAP1A Gene
Selected Interacting proteins:
P62834-RAP1A_HUMAN
ENSP00000358723
for RAP1A Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for RAP1A
SIGNOR curated interactions for RAP1A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007264 | small GTPase mediated signal transduction | IEA | -- |
| GO:0007399 | nervous system development | IEA | -- |
| GO:0009743 | response to carbohydrate | IEA | -- |
| GO:0010976 | positive regulation of neuron projection development | ISS | -- |
Drugs & Compounds for RAP1A Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| cyclic amp | Experimental | Pharma | 0 | |||
| Guanosine triphosphate | Experimental | Pharma | 0 | |||
| Salirasib | Investigational | Pharma | Inhibitor of active Ras protein, Ras inhibitor; also induces autophagy | 0 | ||
| Kobe0065 | Pharma | Ras inhibitor, H-Ras-cRaf1 interaction inhibitor; inhibits Raf signaling | 0 | |||
| kobe2602 | Pharma | Ras inhibitor | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(3) ApexBio Compounds for RAP1A Gene
Transcripts for RAP1A Gene
mRNA/cDNA for RAP1A Gene
- 5 REFSEQ mRNAs :
- 22 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000356415 1586 nts (view in UCSC)
- ENST00000369709 5024 nts (view in UCSC)
- ENST00000433097 666 nts (view in UCSC)
- ENST00000494982 1083 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for RAP1A - Select products 50% OFF >
- * RAP1A CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for RAP1A
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RAP1A
-
Santa Cruz Biotechnology (SCBT) CRISPR for RAP1A
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RAP1A
- Browse OriGene Inhibitory RNA Products For RAP1A
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAP1A
Clone Products
- Applied Biological Materials (abm): Clones for RAP1A - Select products 50% OFF >
- * RAP1A as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG201691
- MR201691
- MR201691L3
- MR201691L4
- RC204137
- RC204137L1
- RC204137L2
- RC204137L3
- RC204137L4
- RC215248
- RC215248L3
- RC215248L4
- RC236366
- RG204137
- RG215248
- RR201148
- RR201148L3
- RR201148L4
- MR201691L3V
- MR201691L4V
- RC204137L1V
- RC204137L2V
- RC204137L3V
- RC204137L4V
- RC215248L3V
- RC215248L4V
- RR201148L3V
- RR201148L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for RAP1A
- Addgene plasmids for RAP1A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RAP1A
Relevant External Links for RAP1A Gene
- GeneLoc Exon Structure for
- RAP1A
Expression for RAP1A Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Inner Cell Mass (Early Embryonic Tissues)
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Kidney (Urinary System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
-
Liver (Hepatobiliary System)
-
Adipose (Muscoskeletal System)
This gene is overexpressed in Adipocyte (26.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RAP1A Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RAP1A
SOURCE GeneReport for Unigene cluster for RAP1A Gene:
Hs.190334Evidence on tissue expression from TISSUES for RAP1A Gene
- Nervous system(4.7)
- Blood(4.6)
- Skin(4.5)
- Heart(3)
- Kidney(2.9)
- Intestine(2.8)
- Muscle(2.8)
- Lung(2.7)
- Spleen(2.7)
- Lymph node(2.7)
- Liver(2.6)
- Bone marrow(2.6)
- Thyroid gland(2.5)
- Adrenal gland(2.4)
- Stomach(2.4)
- Pancreas(2.1)
Primer Products
-
OriGene qPCR primer pairs for RAP1A
-
OriGene qPCR primer pairs and template standards for RAP1A
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAP1A Gene
Orthologs for RAP1A Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | RAP1A 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Dog (Canis familiaris) |
Mammalia | RAP1A 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | RAP1A 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Rap1a 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Rap1a 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | RAP1A 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | RAP1A 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | RAP1A 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | rap1a 30 |
|
||
| Str.17139 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.23802 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | rap1ab 31 |
|
ManyToMany | |
| rap1aa 30 31 |
|
ManyToMany | |||
| wufc66g06 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.9072 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | R 30 31 32 |
|
OneToMany | |
| Rap2l 32 |
|
|
|||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP001874 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | rrp-1 32 |
|
|
|
| rap-1 31 |
|
OneToMany | |||
| C25D7.7 32 |
|
|
|||
| C08F8.7 32 |
|
|
|||
| A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AFR464W 30 |
|
||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RSR1 33 33 |
|
|
|
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.8837 31 |
|
OneToMany | |
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU02167 30 |
|
- Species where no ortholog for RAP1A was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for RAP1A Gene
- ENSEMBL:
- Gene Tree for RAP1A (if available)
- TreeFam:
- Gene Tree for RAP1A (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for RAP1A: view image
Paralogs for RAP1A Gene
Paralogs for RAP1A Gene
(102) SIMAP similar genes for RAP1A Gene using alignment to 2 proteins:
- RAP1A_HUMAN
- A8KAH9_HUMAN
- RAP1B
- c-bas/has
- RAP2A
- DKFZp547A0616
- HRAS
- RAP2C
- RAP2B
- RALA
- NRAS
- KRAS
- DIRAS1
- RALB
- MRAS
- RRAS2
- RIT2
- DIRAS2
- RIT1
- RERG
- RAB10
- RAB8B
- RAB8A
- RHEB
- RAB3A
- RAB39B
- RRAS
- RAB3C
- RAB1C
- RAB1B
- RAB1A
- RAB19
- RAB26
- RAB21
- RAB13
- RAB12
- RAB30
- RAB37
- RHEBL1
- RASD2
- RAB3D
- RAB23
- RAB17
- DIRAS3
- RAB5C
- RAB3B
- RAB35
- RAB2B
- DKFZp313C1541
- RAB7A
- RAB5A
- RASD1
- RAN
- RAB9A
- RAB7L1
- RAB5B
- RAB43
- RAB39A
- RAB33B
- RAB2A
- RAB22A
- RAB11B
- RASL12
- RAB15
- REM1
- RAB33A
- RAB31
- RAB18
- RAB11A
- GEM
- RAB6A
- RAB9B
- RAB14
- ERAS
- RAB27A
- RAB41
- RAB28
- RHOJ
- RHOD
- RERGL
- REM2
- RASL11B
- RASL10B
- RAB7B
- RAB27B
- RAB6B
- RHOV
- RRAD
- RAB6C
- RHOC
- RHOQ
- RHOA
- RASEF
- RAB4A
- RHOG
- RHOB
- RASL11A
- RAC2
- RAB4B
- ARHG
- RHOU
- RAC3
- RAB44
- CDC42
Variants for RAP1A Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RAP1A Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 715994 | Likely Benign: not provided | 111,695,332(+) | T/C | INTRON_VARIANT | |
| 718795 | Benign: not provided | 111,697,503(+) | G/A | INTRON_VARIANT | |
| 723561 | Likely Benign: not provided | 111,697,430(+) | TG/T | INTRON_VARIANT | |
| 735795 | Likely Benign: not provided | 111,709,232(+) | C/T | SYNONYMOUS_VARIANT | |
| 748010 | Likely Benign: not provided | 111,704,444(+) | C/A | SYNONYMOUS_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2677467 | CNV | deletion | 23128226 |
| esv3305407 | CNV | mobile element insertion | 20981092 |
| esv3394544 | CNV | insertion | 20981092 |
| esv3421509 | CNV | insertion | 20981092 |
| esv3578108 | CNV | loss | 25503493 |
| esv3587194 | CNV | gain | 21293372 |
| esv3587195 | CNV | loss | 21293372 |
| nsv946141 | CNV | duplication | 23825009 |
| nsv947444 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
41.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.08;
1.87% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RAP1A Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAP1A Gene
Disorders for RAP1A Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| kabuki syndrome 1 |
|
|
| leukocyte adhesion deficiency, type iii |
|
|
| tuberous sclerosis |
|
|
| cerebral cavernous malformations |
|
|
| babesiosis |
|
|
Search RAP1A in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for RAP1A
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for RAP1A Gene
Publications for RAP1A Gene
- Mutation analysis of RAP1 gene in papillary thyroid carcinomas. (PMID: 18948674) Matsuse M … Yamashita S (Endocrine journal 2009) 3 23 41
- RA-GEF-1, a guanine nucleotide exchange factor for Rap1, is activated by translocation induced by association with Rap1*GTP and enhances Rap1-dependent B-Raf activation. (PMID: 11359771) Liao Y … Kataoka T (The Journal of biological chemistry 2001) 3 4 23
- RA-GEF, a novel Rap1A guanine nucleotide exchange factor containing a Ras/Rap1A-associating domain, is conserved between nematode and humans. (PMID: 10608844) Liao Y … Kataoka T (The Journal of biological chemistry 1999) 3 4 23
- The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue. (PMID: 7791872) Nassar N … Wittinghofer A (Nature 1995) 3 4 23
- The COOH-terminal domain of the Rap1A (Krev-1) protein is isoprenylated and supports transformation by an H-Ras:Rap1A chimeric protein. (PMID: 1899909) Buss JE … Der CJ (Molecular and cellular biology 1991) 3 4 23
ExternalLinks
Products for RAP1A Gene
- Custom Antibody ServicesOriGene Antibodies for RAP1A
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- MG201691
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- RG215248
- RR201148
- RR201148L3
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- RC215248L3V
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- RR201148L3V
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- High-throughput Antibody Production Service
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- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals proteins and lysates for RAP1A
- Browse Antibodies
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- ApexBio compounds for RAP1A
- VectorBuilder Custom and pre-made DNA vectors for RAP1A (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for RAP1A (ie. lentivirus, AAV, adenovirus)
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- Addgene plasmids for RAP1A
- antibodies-online: Show 36 available RAP1A Antibodies ranked by validation data
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- 65 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 4 FACS Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 56 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 2 FACS Antibodies (anti-mouse)
- 23 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- antibodies-online: Show 16 available RAP1A Elisa Kits ranked by validation data
- Compare Top RAP1A Elisa Kits
- antibodies-online: Show 9 available RAP1A Proteins ranked by validation data
- Compare Top RAP1A Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for RAP1A
- Search Santa Cruz Biotechnology (SCBT) for RAP1A siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for RAP1A
- Horizon Cell Lines for RAP1A
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RAP1A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RAP1A
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- Boster Bio Antibodies for RAP1A
- Browse Boster Bio ELISA Kits
Sources for RAP1A Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
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- (115) NCBI Bookshelf
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- (122) ENCODE
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- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
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- (128) SNPedia
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- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
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- (170) snOPY
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- (172) GENCODE
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- (175) Open Targets Platform
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- (177) snoDB
- (178) MirGeneDB