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Aliases for RANGRF Gene

Aliases for RANGRF Gene

  • RAN Guanine Nucleotide Release Factor 2 3 5
  • Ran-Binding Protein MOG1 3 4
  • RANGNRF 3 4
  • MOG1 3 4
  • MOG1 Homolog (S. Cerevisiae) 2
  • MOG1 Homolog 3
  • HSPC165 3
  • HSPC236 3

External Ids for RANGRF Gene

Previous GeneCards Identifiers for RANGRF Gene

  • GC17P008133
  • GC17P008087
  • GC17P008191

Summaries for RANGRF Gene

Entrez Gene Summary for RANGRF Gene

  • This gene encodes a protein that has been shown to function as a guanine nucleotide release factor in mouse and to regulate the expression and function of the Nav1.5 cardiac sodium channel in human. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]

GeneCards Summary for RANGRF Gene

RANGRF (RAN Guanine Nucleotide Release Factor) is a Protein Coding gene. Diseases associated with RANGRF include Brugada Syndrome and Sick Sinus Syndrome. Among its related pathways are Cardiac conduction and Phase 0 - rapid depolarisation. Gene Ontology (GO) annotations related to this gene include guanyl-nucleotide exchange factor activity and protein transporter activity.

UniProtKB/Swiss-Prot for RANGRF Gene

  • May regulate the intracellular trafficking of RAN. In cardiac cells seems to regulate the cell surface localization of SCN5A.

Additional gene information for RANGRF Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RANGRF Gene

Genomics for RANGRF Gene

GeneHancer (GH) Regulatory Elements for RANGRF Gene

Promoters and enhancers for RANGRF Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I008287 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.6 587 2.6 PKNOX1 ATF1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 GLIS2 RANGRF PFAS ARHGEF15 GC17M008518 PIR39549 SLC25A35
GH17I008149 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10 -131.1 -131068 16 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF416 ZNF143 PER1 VAMP2 ENSG00000265749 CYB5D1 CTC1 DVL2 PFAS CNTROB SENP3 POLR2A
GH17I008379 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.3 +94.4 94363 6.2 ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF143 MCM3 SP3 NFYC ZNF610 ENSG00000263809 RPL26 ENSG00000265749 PFAS SNORD10 EIF4A1 CTC1 POLR2A SNORA48 TP53
GH17I007931 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 9.9 -355.9 -355895 2.8 HDGF PKNOX1 SMAD1 FOXA2 ARID4B NEUROD1 SIN3A ZNF2 ZBTB7B YY1 CNTROB TRAPPC1 ENSG00000262730 PFAS DVL2 CYB5D1 SCARNA21 CHD3 SENP3 CTC1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RANGRF on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RANGRF gene promoter:

Genomic Locations for RANGRF Gene

Genomic Locations for RANGRF Gene
1,706 bases
Plus strand

Genomic View for RANGRF Gene

Genes around RANGRF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RANGRF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RANGRF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RANGRF Gene

Proteins for RANGRF Gene

  • Protein details for RANGRF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ran guanine nucleotide release factor
    Protein Accession:
    Secondary Accessions:
    • D3DTR6
    • Q68DI3
    • Q9BR68
    • Q9HD48
    • Q9NRU9
    • Q9P001
    • Q9P0P2

    Protein attributes for RANGRF Gene

    186 amino acids
    Molecular mass:
    20448 Da
    Quaternary structure:
    • Monomer (By similarity). Interacts with RAN, RAN-GTP and RAN-GDP. Forms a complex with RAN-GTP and RANBP1 (By similarity). Interacts with the cytoplasmic loop 2 of SCN5A.
    • Sequence=AAF29129.1; Type=Frameshift; Positions=62, 93; Evidence={ECO:0000305}; Sequence=AAF87316.1; Type=Frameshift; Positions=62; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RANGRF Gene

    Alternative splice isoforms for RANGRF Gene


neXtProt entry for RANGRF Gene

Post-translational modifications for RANGRF Gene

  • Ubiquitination at Lys120
  • Modification sites at PhosphoSitePlus

Other Protein References for RANGRF Gene

No data available for DME Specific Peptides for RANGRF Gene

Domains & Families for RANGRF Gene

Gene Families for RANGRF Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RANGRF Gene


Suggested Antigen Peptide Sequences for RANGRF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MOG1 family.
  • Belongs to the MOG1 family.
genes like me logo Genes that share domains with RANGRF: view

Function for RANGRF Gene

Molecular function for RANGRF Gene

UniProtKB/Swiss-Prot Function:
May regulate the intracellular trafficking of RAN. In cardiac cells seems to regulate the cell surface localization of SCN5A.

Gene Ontology (GO) - Molecular Function for RANGRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity ISS --
GO:0005087 Ran guanyl-nucleotide exchange factor activity ISS --
GO:0008536 Ran GTPase binding ISS --
GO:0008565 protein transporter activity IMP 23420830
GO:0017080 sodium channel regulator activity IMP 23420830
genes like me logo Genes that share ontologies with RANGRF: view

Phenotypes for RANGRF Gene

GenomeRNAi human phenotypes for RANGRF:
genes like me logo Genes that share phenotypes with RANGRF: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RANGRF Gene

Localization for RANGRF Gene

Subcellular locations from UniProtKB/Swiss-Prot for RANGRF Gene

Nucleus. Cytoplasm. Note=May shuttle between the nucleus and cytoplasm. {ECO:0000269 PubMed:11290418}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RANGRF gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 4
endoplasmic reticulum 4
extracellular 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RANGRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 11290418
GO:0005654 nucleoplasm ISS --
GO:0005737 cytoplasm IDA,IEA 11290418
GO:0005791 rough endoplasmic reticulum IDA 23420830
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with RANGRF: view

Pathways & Interactions for RANGRF Gene

genes like me logo Genes that share pathways with RANGRF: view

Pathways by source for RANGRF Gene

Gene Ontology (GO) - Biological Process for RANGRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002027 regulation of heart rate TAS 21621375
GO:0003254 regulation of membrane depolarization IMP 23420830
GO:0006810 transport IEA --
GO:0006888 ER to Golgi vesicle-mediated transport IMP 23420830
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with RANGRF: view

No data available for SIGNOR curated interactions for RANGRF Gene

Drugs & Compounds for RANGRF Gene

(1) Drugs for RANGRF Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RANGRF: view

Transcripts for RANGRF Gene

Unigene Clusters for RANGRF Gene

RAN guanine nucleotide release factor:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for RANGRF Gene

No ASD Table

Relevant External Links for RANGRF Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RANGRF Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RANGRF Gene

Protein differential expression in normal tissues from HIPED for RANGRF Gene

This gene is overexpressed in Ovary (15.6), Heart (9.5), and Lymph node (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RANGRF Gene

NURSA nuclear receptor signaling pathways regulating expression of RANGRF Gene:


SOURCE GeneReport for Unigene cluster for RANGRF Gene:


mRNA Expression by UniProt/SwissProt for RANGRF Gene:

Tissue specificity: Isoform 1 and isoform 2 are ubiquitously expressed.

Evidence on tissue expression from TISSUES for RANGRF Gene

  • Blood(4.2)
  • Bone marrow(4.2)
  • Lung(4.2)
  • Nervous system(2.5)
  • Heart(2)
genes like me logo Genes that share expression patterns with RANGRF: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RANGRF Gene

Orthologs for RANGRF Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RANGRF Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RANGRF 33 34
  • 98.92 (n)
(Bos Taurus)
Mammalia RANGRF 33 34
  • 88.89 (n)
(Canis familiaris)
Mammalia RANGRF 33 34
  • 86.74 (n)
(Mus musculus)
Mammalia Rangrf 33 16 34
  • 86.49 (n)
Gm10355 34
  • 86 (a)
(Rattus norvegicus)
Mammalia Rangrf 33
  • 86.13 (n)
(Monodelphis domestica)
Mammalia RANGRF 34
  • 46 (a)
(Anolis carolinensis)
Reptilia RANGRF 34
  • 47 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rangrf 33
  • 55.87 (n)
(Danio rerio)
Actinopterygii rangrf 33 34
  • 52.27 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MOG1 34 36
  • 22 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G69680 33
  • 46.14 (n)
(Oryza sativa)
Liliopsida Os04g0459600 33
  • 47.16 (n)
Species where no ortholog for RANGRF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RANGRF Gene

Gene Tree for RANGRF (if available)
Gene Tree for RANGRF (if available)

Paralogs for RANGRF Gene

No data available for Paralogs for RANGRF Gene

Variants for RANGRF Gene

Sequence variations from dbSNP and Humsavar for RANGRF Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs138959557 benign, not specified, Cardiac arrhythmia 8,289,331(+) T/C coding_sequence_variant, synonymous_variant
rs140704891 likely-benign, benign, not specified, Cardiac arrhythmia 8,289,059(+) G/A/T coding_sequence_variant, missense_variant, stop_gained
rs150856064 uncertain-significance, not specified, Cardiac arrhythmia 8,288,840(+) C/A/T coding_sequence_variant, missense_variant
rs200305092 likely-benign, not specified, Cardiac arrhythmia 8,288,815(+) G/C coding_sequence_variant, synonymous_variant
rs201882524 uncertain-significance, Cardiac arrhythmia 8,289,585(+) C/T 3_prime_UTR_variant, coding_sequence_variant, intron_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for RANGRF Gene

Variant ID Type Subtype PubMed ID
nsv833353 CNV loss 17160897

Variation tolerance for RANGRF Gene

Residual Variation Intolerance Score: 44.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.54; 11.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RANGRF Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RANGRF Gene

Disorders for RANGRF Gene

MalaCards: The human disease database

(2) MalaCards diseases for RANGRF Gene - From: HGMD, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
brugada syndrome
  • bangungut
sick sinus syndrome
  • sinus node infection
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for RANGRF

genes like me logo Genes that share disorders with RANGRF: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RANGRF Gene

Publications for RANGRF Gene

  1. Identification and characterization of the human MOG1 gene. (PMID: 11290418) Marfatia KA … Corbett AH (Gene 2001) 2 3 4 58
  2. Identification of a new co-factor, MOG1, required for the full function of cardiac sodium channel Nav 1.5. (PMID: 18184654) Wu L … Wang QK (The Journal of biological chemistry 2008) 3 4 58
  3. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 3 4 58
  4. Mitosis-specific acetylation tunes Ran effector binding for chromosome segregation. (PMID: 29040603) Bao X … Shi Y (Journal of molecular cell biology 2018) 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for RANGRF Gene

Sources for RANGRF Gene

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