Aliases for RANGAP1 Gene
Aliases for RANGAP1 Gene
External Ids for RANGAP1 Gene
- HGNC: 9854
- Entrez Gene: 5905
- Ensembl: ENSG00000100401
- OMIM: 602362
- UniProtKB: P46060
Previous HGNC Symbols for RANGAP1 Gene
- SD
Previous GeneCards Identifiers for RANGAP1 Gene
- GC22M038256
- GC22M039884
- GC22M039966
- GC22M041641
- GC22M024606
Summaries for RANGAP1 Gene
-
This gene encodes a protein that associates with the nuclear pore complex and participates in the regulation of nuclear transport. The encoded protein interacts with Ras-related nuclear protein 1 (RAN) and regulates guanosine triphosphate (GTP)-binding and exchange. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
GeneCards Summary for RANGAP1 Gene
RANGAP1 (Ran GTPase Activating Protein 1) is a Protein Coding gene. Diseases associated with RANGAP1 include Amyotrophic Lateral Sclerosis 4, Juvenile. Among its related pathways are Cell Cycle, Mitotic and SUMOylation. Gene Ontology (GO) annotations related to this gene include GTPase activator activity.
UniProtKB/Swiss-Prot for RANGAP1 Gene
-
GTPase activator for RAN (PubMed:8146159, PubMed:8896452, PubMed:16428860). Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export (PubMed:8896452, PubMed:27160050). Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export (PubMed:27160050).
Additional gene information for RANGAP1 Gene
- Monarch Initiative
- Search for RANGAP1 at DataMed
- Search for RANGAP1 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RANGAP1 Gene
Genomics for RANGAP1 Gene
GeneHancer (GH) Regulatory Elements for RANGAP1 Gene
Promoters and enhancers for RANGAP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around RANGAP1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the RANGAP1 gene promoter:
-
- ATF-2
- deltaCREB
- CREB
- c-Jun
- AP-1
- AhR
- p53
Regulatory Element Products
Genomic Locations for RANGAP1 Gene
Genomic Locations for RANGAP1 Gene
- chr22:41,244,777-41,302,210
- (GRCh38/hg38)
- Size:
- 57,434 bases
- Orientation:
- Minus strand
- chr22:41,641,615-41,682,255
- (GRCh37/hg19)
- Size:
- 40,641 bases
- Orientation:
- Minus strand
Genomic View for RANGAP1 Gene
Genes around RANGAP1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q13.2 by Entrez Gene
- 22q13.2 by HGNC
- 22q13.2 by Ensembl
RANGAP1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RANGAP1 Gene
Proteins for RANGAP1 Gene
-
Protein details for RANGAP1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P46060-RAGP1_HUMAN
- Recommended name:
- Ran GTPase-activating protein 1
- Protein Accession:
- P46060
- Q96JJ2
Protein attributes for RANGAP1 Gene
- Size:
- 587 amino acids
- Molecular mass:
- 63542 Da
- Quaternary structure:
-
- Homodimer (PubMed:8146159). Interacts with RAN (PubMed:7891706, PubMed:8896452, PubMed:16428860). Forms a complex with RANBP2/NUP358, NXF1 and NXT1 (PubMed:14729961). Forms a tight complex in association with RANBP2/NUP358 and UBE2I/UBC9, the ubiquitin-conjugating enzyme E2 (PubMed:15037602, PubMed:27160050, PubMed:15931224, PubMed:22194619). Interacts with UBE2I; the interaction conjugates SUMO1 to RANGAP1, and subsequently stabilizes interactions of sumoylated RANGAP1 with RANBP2/NUP358 (PubMed:15037602, PubMed:27160050, PubMed:15931224). The complex composed of RANBP2, SUMO1, RANGAP1 and UBE2I associates with nuclear pore complexes (PubMed:15037602, PubMed:15931224). Identified in a complex composed of RAN, RANBP2, sumoylated RANGAP1, UBE2I and XPO1 (PubMed:27160050). Identified in a complex composed of RAN, RANGAP1 and RANBP1 (PubMed:16428860). Interacts with TRAF6 (PubMed:18093978). Interacts with SUMO1 and SENP1 (PubMed:17099698).
- SequenceCaution:
-
- Sequence=BAB47464.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for RANGAP1 Gene
Post-translational modifications for RANGAP1 Gene
- Phosphorylation occurs before nuclear envelope breakdown and continues throughout mitosis. Phosphorylated by the M-phase kinase cyclin B/Cdk1, in vitro. Differential timimg of dephosphorylation occurs during phases of mitosis. The phosphorylated form remains associated with RANBP2/NUP358 and the SUMO E2-conjugating enzyme, UBE2I, on nuclear pore complex (NPC) diassembly and during mitosis.
- Sumoylated (PubMed:11854305, PubMed:15037602, PubMed:27160050). Sumoylation is necessary for targeting to the nuclear envelope (NE), and for association with mitotic spindles and kinetochores during mitosis (PubMed:11854305). Also required for interaction with RANBP2 and is mediated by UBE2I (PubMed:27160050).
- Ubiquitination at posLast=452452 and Lys296
- Modification sites at PhosphoSitePlus
Other Protein References for RANGAP1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for RANGAP1 (RanGAP1)
- Novus Biologicals Antibodies for RANGAP1
-
Abcam antibodies for RANGAP1
- Invitrogen Antibodies for RANGAP1 (AFLGC-RANGAP1)
- GeneTex RANGAP1 Antibody for RANGAP1
-
Santa Cruz Biotechnology (SCBT) Antibodies for RANGAP1
Protein Products
-
OriGene Purified Proteins for RANGAP1
- Search Origene for MassSpec and Protein Over-expression Lysates for RANGAP1
- Origene Custom Protein Services for RANGAP1
- Search GeneTex for Proteins for RANGAP1
-
Abcam proteins for RANGAP1
Assay Products
No data available for DME Specific Peptides for RANGAP1 Gene
Domains & Families for RANGAP1 Gene
Gene Families for RANGAP1 Gene
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
- Transporters
Protein Domains for RANGAP1 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for RANGAP1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P46060- Family:
-
- Belongs to the RNA1 family.
Function for RANGAP1 Gene
Molecular function for RANGAP1 Gene
- UniProtKB/Swiss-Prot Function:
- GTPase activator for RAN (PubMed:8146159, PubMed:8896452, PubMed:16428860). Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export (PubMed:8896452, PubMed:27160050). Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export (PubMed:27160050).
- GENATLAS Biochemistry:
- Ran GTPase activating protein 1,homolog of yeast Rna1p,component of the nuclear pore complex,highly concentrated at its cytoplasmic periphery,conjugating with UBL1 in a ATP dependent fashion,then associating with RANBP2. Involved in mRNA processing and transport
Phenotypes From GWAS Catalog for RANGAP1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | IDA | 26308891 |
| GO:0005096 | GTPase activator activity | IDA,IEA | 16428860 |
| GO:0005515 | protein binding | IEA,IPI | 14729961 |
| GO:0008536 | Ran GTPase binding | IPI | 16428860 |
| GO:0031625 | ubiquitin protein ligase binding | IEA | -- |
Phenotypes for RANGAP1 Gene
- MGI mutant phenotypes for RANGAP1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for RANGAP1:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for RANGAP1
-
CRISPR Products
-
OriGene CRISPR knockouts for RANGAP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RANGAP1
- genomics-online: gRNA clones - Search results for available RANGAP1 gene related products
- Applied Biological Materials CRISPR for RANGAP1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for RANGAP1
- GenScript: Design CRISPR guide RNA sequences for RANGAP1
miRNA for RANGAP1 Gene
- miRTarBase miRNAs that target RANGAP1
-
- hsa-mir-16-5p (MIRT031630)
- hsa-mir-1301-3p (MIRT036035)
- hsa-mir-331-3p (MIRT043425)
- hsa-mir-92a-3p (MIRT049661)
- hsa-mir-31-5p (MIRT049887)
- hsa-mir-4730 (MIRT453756)
- hsa-mir-7847-3p (MIRT453757)
- hsa-mir-6851-5p (MIRT453758)
- hsa-mir-6880-5p (MIRT453759)
- hsa-mir-3689d (MIRT453760)
- hsa-mir-7854-3p (MIRT453761)
- hsa-mir-3934-5p (MIRT453762)
- hsa-mir-764 (MIRT453763)
- hsa-mir-125a-3p (MIRT453764)
- hsa-mir-5197-5p (MIRT453765)
- hsa-mir-6749-3p (MIRT612590)
- hsa-mir-4707-3p (MIRT612591)
- hsa-mir-18a-3p (MIRT612592)
- hsa-mir-324-3p (MIRT612593)
- hsa-mir-1913 (MIRT612594)
- hsa-mir-150-5p (MIRT612595)
- hsa-mir-186-3p (MIRT612596)
- hsa-mir-520h (MIRT612597)
- hsa-mir-520g-3p (MIRT612598)
- hsa-mir-520e (MIRT612599)
- hsa-mir-520d-3p (MIRT612600)
- hsa-mir-520c-3p (MIRT612601)
- hsa-mir-520b (MIRT612602)
- hsa-mir-520a-3p (MIRT612603)
- hsa-mir-373-3p (MIRT612604)
- hsa-mir-372-3p (MIRT612605)
- hsa-mir-302e (MIRT612606)
- hsa-mir-302d-3p (MIRT612607)
- hsa-mir-302c-3p (MIRT612608)
- hsa-mir-302b-3p (MIRT612609)
- hsa-mir-302a-3p (MIRT612610)
- hsa-mir-93-5p (MIRT612611)
- hsa-mir-526b-3p (MIRT612612)
- hsa-mir-519d-3p (MIRT612613)
- hsa-mir-20b-5p (MIRT612614)
- hsa-mir-20a-5p (MIRT612615)
- hsa-mir-17-5p (MIRT612616)
- hsa-mir-106b-5p (MIRT612617)
- hsa-mir-106a-5p (MIRT612618)
- hsa-mir-129-5p (MIRT625442)
- hsa-mir-8055 (MIRT625443)
- hsa-mir-6864-3p (MIRT625444)
- hsa-mir-3672 (MIRT625445)
- hsa-mir-4753-3p (MIRT625446)
- hsa-mir-6873-3p (MIRT625447)
- hsa-mir-155-3p (MIRT625448)
- hsa-mir-223-3p (MIRT625449)
- hsa-mir-4697-3p (MIRT625450)
- hsa-mir-4524a-3p (MIRT625451)
- hsa-mir-130b-5p (MIRT625452)
- hsa-mir-6817-3p (MIRT625453)
- hsa-mir-7110-3p (MIRT625454)
- hsa-mir-1182 (MIRT625455)
- hsa-mir-4524b-3p (MIRT625456)
- hsa-mir-6796-3p (MIRT625457)
- hsa-mir-3159 (MIRT625458)
- hsa-mir-7151-3p (MIRT630565)
- hsa-mir-5095 (MIRT630566)
- hsa-mir-4438 (MIRT630567)
- hsa-mir-3149 (MIRT639235)
- hsa-mir-197-3p (MIRT639236)
- hsa-mir-4711-5p (MIRT639237)
- hsa-mir-7112-3p (MIRT639238)
- hsa-mir-4267 (MIRT639239)
- hsa-mir-153-5p (MIRT639240)
- hsa-mir-1250-3p (MIRT639241)
- hsa-mir-500b-3p (MIRT639242)
- hsa-mir-3124-3p (MIRT709232)
- hsa-mir-1238-3p (MIRT709233)
- hsa-mir-670-3p (MIRT709234)
- hsa-mir-452-3p (MIRT709235)
- hsa-mir-627-3p (MIRT709236)
- hsa-mir-483-3p (MIRT709237)
- hsa-mir-664a-3p (MIRT709238)
- hsa-mir-3142 (MIRT709239)
- hsa-mir-1245b-5p (MIRT709240)
- hsa-mir-32-3p (MIRT709241)
- hsa-mir-4753-5p (MIRT709242)
- hsa-mir-1207-5p (MIRT736052)
- hsa-mir-1286 (MIRT737062)
- hsa-mir-3158-3p (MIRT740465)
- hsa-mir-4323 (MIRT744052)
- hsa-mir-4436b-3p (MIRT744471)
- hsa-mir-4514 (MIRT745719)
- hsa-mir-4632-5p (MIRT746280)
- hsa-mir-4645-5p (MIRT746421)
- hsa-mir-4673 (MIRT746863)
- hsa-mir-4685-5p (MIRT746969)
- hsa-mir-4692 (MIRT747126)
- hsa-mir-4763-3p (MIRT748560)
- hsa-mir-6132 (MIRT752331)
- hsa-mir-6721-5p (MIRT753830)
- hsa-mir-6735-5p (MIRT754183)
- hsa-mir-6753-5p (MIRT754679)
- hsa-mir-6808-5p (MIRT756595)
- hsa-mir-6836-5p (MIRT757225)
- hsa-mir-6837-5p (MIRT757251)
- hsa-mir-6879-5p (MIRT758272)
- hsa-mir-6886-5p (MIRT758562)
- hsa-mir-6893-5p (MIRT758740)
- hsa-mir-7843-5p (MIRT759772)
- hsa-mir-7855-5p (MIRT759957)
- hsa-mir-873-5p (MIRT760323)
- hsa-mir-940 (MIRT760836)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RANGAP1
- Browse OriGene Inhibitory RNA Products For RANGAP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RANGAP1
- genomics-online: shRNA clones - Search results for available RANGAP1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for RANGAP1
- Addgene plasmids for RANGAP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RANGAP1
- genomics-online: cdna clones - Search results for available RANGAP1 gene related products
- orf clones - Search results for available RANGAP1 gene related products
- Applied Biological Materials Clones for RANGAP1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RANGAP1 Gene
Localization for RANGAP1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for RANGAP1 Gene
- Cytoplasm. Nucleus, nucleoplasm. Nucleus envelope. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Cytoplasmic during interphase. Detected at the nuclear envelope during interphase (PubMed:11854305, PubMed:15037602). Targeted to the nuclear pores after sumoylation (PubMed:11854305). During mitosis, associates with mitotic spindles, but is essentially not detected at the spindle poles (PubMed:11854305, PubMed:15037602). Association with kinetochores appears soon after nuclear envelope breakdown and persists until late anaphase (PubMed:11854305). Mitotic location also requires sumoylation (PubMed:11854305). {ECO:0000269 PubMed:11854305, ECO:0000269 PubMed:15037602}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| cytoskeleton | 4 |
- Cytosol (4)
- Nuclear membrane (4)
- Vesicles (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000776 | colocalizes_with kinetochore | IDA,IEA | 17363900 |
| GO:0000777 | condensed chromosome kinetochore | IEA | -- |
| GO:0000922 | spindle pole | IEA | -- |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005635 | nuclear envelope | TAS | -- |
Pathways & Interactions for RANGAP1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | HIV Life Cycle |
.91
.64
|
.45
|
| 2 | Cell Cycle, Mitotic |
.83
|
.60
|
| 3 | Transport of the SLBP independent Mature mRNA | ||
| 4 | Mitotic Metaphase and Anaphase |
.94
|
|
| 5 | Mitotic Prometaphase | ||
Pathways by source for RANGAP1 Gene
3 BioSystems pathways for RANGAP1 Gene
25 Reactome pathways for RANGAP1 Gene
1 KEGG pathway for RANGAP1 Gene
1 GeneGo (Thomson Reuters) pathway for RANGAP1 Gene
2 Qiagen pathways for RANGAP1 Gene
Interacting Proteins for RANGAP1 Gene
Selected Interacting proteins:
ENSP00000348577
P46060-RAGP1_HUMAN
for RANGAP1 Gene via
STRING
MINT
UniProtKB
IID
GPS-Prot Interaction Network for RANGAP1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007062 | sister chromatid cohesion | TAS | -- |
| GO:0007165 | signal transduction | IEA,TAS | -- |
| GO:0016925 | protein sumoylation | TAS | -- |
| GO:0043547 | positive regulation of GTPase activity | IEA | -- |
| GO:0046826 | negative regulation of protein export from nucleus | IDA | 16449645 |
Transcripts for RANGAP1 Gene
mRNA/cDNA for RANGAP1 Gene
- (17) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (323) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000405486 3469 bps (uc003azt.5)
- ENST00000356244 3060 bps (uc003azu.5)
- ENST00000455915 4222 bps (uc003azs.5)
- ENST00000446258 759 bps (uc062eqe.1)
- ENST00000452543 603 bps (uc062eqf.1)
Unigene Clusters for RANGAP1 Gene
- Ran GTPase activating protein 1:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for RANGAP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RANGAP1
- genomics-online: gRNA clones - Search results for available RANGAP1 gene related products
- Applied Biological Materials CRISPR for RANGAP1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for RANGAP1
- GenScript: Design CRISPR guide RNA sequences for RANGAP1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RANGAP1
- Browse OriGene Inhibitory RNA Products For RANGAP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RANGAP1
- genomics-online: shRNA clones - Search results for available RANGAP1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for RANGAP1
- Addgene plasmids for RANGAP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RANGAP1
- genomics-online: cdna clones - Search results for available RANGAP1 gene related products
- orf clones - Search results for available RANGAP1 gene related products
- Applied Biological Materials Clones for RANGAP1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: |
| ExUns: | 15a | · | 15b | ^ | 16a | · | 16b | ^ | 17a | · | 17b |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||
| SP2: | - | - | |||||||||
| SP3: | - | - | |||||||||
| SP4: | |||||||||||
| SP5: | |||||||||||
| SP6: | |||||||||||
| SP7: | |||||||||||
| SP8: | |||||||||||
| SP9: | |||||||||||
| SP10: | |||||||||||
| SP11: | |||||||||||
| SP12: |
Expression for RANGAP1 Gene
This gene is overexpressed in Bone (14.4), Nasal epithelium (8.0), and Lymph node (7.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RANGAP1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of RANGAP1 Gene:
RANGAP1SOURCE GeneReport for Unigene cluster for RANGAP1 Gene:
Hs.183800mRNA Expression by UniProt/SwissProt for RANGAP1 Gene:
P46060-RAGP1_HUMAN
Tissue specificity:
Highly expressed in brain, thymus and testis.
Evidence on tissue expression from TISSUES for RANGAP1 Gene
- Nervous system(4.9)
- Kidney(4.3)
- Skin(4.2)
- Lung(2.7)
- Intestine(2.3)
Primer Products
-
OriGene qPCR primer pairs for RANGAP1
-
OriGene qPCR primer pairs and template standards for RANGAP1
- genomics-online: primer clones - Search results for available RANGAP1 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RANGAP1 Gene
Orthologs for RANGAP1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | RANGAP1 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | RANGAP1 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | RANGAP1 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Rangap1 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Rangap1 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | RANGAP1 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | RANGAP1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | RANGAP1 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | RANGAP1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | rangap1 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | rangap1-prov 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | rangap1a 34 33 |
|
OneToMany | |
| rangap1b 34 |
|
OneToMany | |||
| Dr.26558 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.1664 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | RanGap 34 |
|
OneToOne | |
| worm (Caenorhabditis elegans) |
Secernentea | ran-2 34 35 |
|
OneToOne | |
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AFR525C 33 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RNA1 36 34 33 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F25036g 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.9560 34 |
|
OneToOne | |
| bread mold (Neurospora crassa) |
Ascomycetes | NCU03207 33 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | rna1 33 |
|
- Species where no ortholog for RANGAP1 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for RANGAP1 Gene
- ENSEMBL:
- Gene Tree for RANGAP1 (if available)
- TreeFam:
- Gene Tree for RANGAP1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for RANGAP1: view image
Paralogs for RANGAP1 Gene
No data available for Paralogs for RANGAP1 Gene
Variants for RANGAP1 Gene
| SNP ID | Clin | Chr 22 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000026024 | -- | 41,292,518(-) | T/A | genic_upstream_transcript_variant, intron_variant | |
| rs1000107155 | -- | 41,272,476(-) | C/T | intron_variant | |
| rs1000134488 | -- | 41,257,718(-) | C/T | intron_variant | |
| rs1000145489 | -- | 41,289,152(-) | C/T | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000187188 | -- | 41,257,510(-) | A/G | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv3637 | CNV | deletion | 18451855 |
| nsv3638 | CNV | insertion | 18451855 |
| nsv459888 | CNV | gain | 19166990 |
| nsv479885 | CNV | novel sequence insertion | 20440878 |
| nsv516925 | CNV | loss | 19592680 |
| nsv524585 | CNV | loss | 19592680 |
| nsv589049 | CNV | gain | 21841781 |
| nsv589050 | CNV | gain | 21841781 |
| nsv817997 | CNV | gain | 17921354 |
| nsv834207 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
27.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.35;
41.77% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RANGAP1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RANGAP1 Gene
Disorders for RANGAP1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| amyotrophic lateral sclerosis 4, juvenile |
|
|
Search RANGAP1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for RANGAP1
No data available for UniProtKB/Swiss-Prot and Genatlas for RANGAP1 Gene
Publications for RANGAP1 Gene
- Human RanGTPase-activating protein RanGAP1 is a homologue of yeast Rna1p involved in mRNA processing and transport. (PMID: 7878053) Bischoff FR … Ponstingl H (Proceedings of the National Academy of Sciences of the United States of America 1995) 2 3 4 22 58
- Phosphorylation of RanGAP1 stabilizes its interaction with Ran and RanBP1. (PMID: 16428860) Takeda E … Yoneda Y (Cell structure and function 2005) 3 4 22 58
- Insights into E3 ligase activity revealed by a SUMO-RanGAP1-Ubc9-Nup358 complex. (PMID: 15931224) Reverter D … Lima CD (Nature 2005) 3 4 22 58
- RanGAP1*SUMO1 is phosphorylated at the onset of mitosis and remains associated with RanBP2 upon NPC disassembly. (PMID: 15037602) Swaminathan S … Melchior F (The Journal of cell biology 2004) 3 4 22 58
- Ubiquitous expression and testis-specific alternative polyadenylation of mRNA for the human Ran GTPase activator RanGAP1. (PMID: 8973340) Krebber H … Ponstingl H (Gene 1996) 3 4 22 58
Products for RANGAP1 Gene
- R&D Systems Antibodies for RANGAP1 (RanGAP1)
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- Invitrogen Antibodies for RANGAP1 (AFLGC-RANGAP1)
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- antibodies-online: Search results for 95 available RANGAP1 Antibodies ranked by validation data
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- antibodies-online: Search results for 2 available RANGAP1 Elisa Kits ranked by validation data
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- Recommended
- antibodies-online: Search results for 6 available RANGAP1 Proteins ranked by validation data
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- GeneTex RANGAP1 Antibody for RANGAP1
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- Santa Cruz Biotechnology (SCBT) Antibodies for RANGAP1
- Search Santa Cruz Biotechnology (SCBT) for RANGAP1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for RANGAP1
- genomics-online: cdna clones - Search results for available RANGAP1 gene related products
- orf clones - Search results for available RANGAP1 gene related products
- genomics-online: gRNA clones - Search results for available RANGAP1 gene related products
- genomics-online: primer clones - Search results for available RANGAP1 gene related products
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- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RANGAP1
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Sources for RANGAP1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt