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This gene encodes a protein that associates with the nuclear pore complex and participates in the regulation of nuclear transport. The encoded protein interacts with Ras-related nuclear protein 1 (RAN) and regulates guanosine triphosphate (GTP)-binding and exchange. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] See more...
Aliases for RANGAP1 Gene
Aliases for RANGAP1 Gene
External Ids for RANGAP1 Gene
- HGNC: 9854
- NCBI Entrez Gene: 5905
- Ensembl: ENSG00000100401
- OMIM®: 602362
- UniProtKB/Swiss-Prot: P46060
Previous HGNC Symbols for RANGAP1 Gene
- SD
Previous GeneCards Identifiers for RANGAP1 Gene
- GC22M038256
- GC22M039884
- GC22M039966
- GC22M041641
- GC22M024606
Summaries for RANGAP1 Gene
-
This gene encodes a protein that associates with the nuclear pore complex and participates in the regulation of nuclear transport. The encoded protein interacts with Ras-related nuclear protein 1 (RAN) and regulates guanosine triphosphate (GTP)-binding and exchange. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
GeneCards Summary for RANGAP1 Gene
RANGAP1 (Ran GTPase Activating Protein 1) is a Protein Coding gene. Diseases associated with RANGAP1 include Parkinson Disease 7, Autosomal Recessive Early-Onset and Dermatopathia Pigmentosa Reticularis. Among its related pathways are Cell Cycle, Mitotic and Transport of the SLBP independent Mature mRNA. Gene Ontology (GO) annotations related to this gene include GTPase activator activity.
UniProtKB/Swiss-Prot Summary for RANGAP1 Gene
-
GTPase activator for RAN (PubMed:8146159, PubMed:8896452, PubMed:16428860). Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export (PubMed:8896452, PubMed:27160050). Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export (PubMed:27160050).
Additional gene information for RANGAP1 Gene
- HGNC (9854)
- NCBI Entrez Gene (5905)
- Ensembl (ENSG00000100401)
- OMIM® (602362)
- UniProtKB/Swiss-Prot (P46060)
- Open Targets Platform(ENSG00000100401)
- Monarch Initiative
- Alliance of Genome Resources
- Search for RANGAP1 at DataMed
- Search for RANGAP1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RANGAP1 Gene
Genomics for RANGAP1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for RANGAP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around RANGAP1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RANGAP1
- Top Transcription factor binding sites by QIAGEN in the RANGAP1 gene promoter:
-
- AhR
- AP-1
- ATF-2
- c-Jun
- CREB
- deltaCREB
- p53
Genomic Locations for RANGAP1 Gene
Latest Assembly
- chr22:41,244,779-41,302,369
- (GRCh38/hg38)
- Size:
- 57,591 bases
- Orientation:
- Minus strand
Previous Assembly
- chr22:41,640,783-41,698,373
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 57,591 bases
- Orientation:
- Minus strand
Genomic View for RANGAP1 Gene
Genes around RANGAP1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q13.2 by HGNC
- 22q13.2 by Entrez Gene
- 22q13.2 by Ensembl
RANGAP1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RANGAP1 Gene
Proteins for RANGAP1 Gene
-
Protein details for RANGAP1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P46060-RAGP1_HUMAN
- Recommended name:
- Ran GTPase-activating protein 1
- Protein Accession:
- P46060
- Q96JJ2
Protein attributes for RANGAP1 Gene
- Size:
- 587 amino acids
- Molecular mass:
- 63542 Da
- Quaternary structure:
-
- Homodimer (PubMed:8146159). Interacts with RAN (PubMed:7891706, PubMed:8896452, PubMed:16428860). Forms a complex with RANBP2/NUP358, NXF1 and NXT1 (PubMed:14729961). Forms a tight complex in association with RANBP2/NUP358 and UBE2I/UBC9, the ubiquitin-conjugating enzyme E2 (PubMed:15037602, PubMed:27160050, PubMed:15931224, PubMed:22194619). Interacts with UBE2I; the interaction conjugates SUMO1 to RANGAP1, and subsequently stabilizes interactions of sumoylated RANGAP1 with RANBP2/NUP358 (PubMed:15037602, PubMed:27160050, PubMed:15931224). The complex composed of RANBP2, SUMO1, RANGAP1 and UBE2I associates with nuclear pore complexes (PubMed:15037602, PubMed:15931224). Identified in a complex composed of RAN, RANBP2, sumoylated RANGAP1, UBE2I and XPO1 (PubMed:27160050). Identified in a complex composed of RAN, RANGAP1 and RANBP1 (PubMed:16428860). Interacts with TRAF6 (PubMed:18093978). Interacts with SUMO1 and SENP1 (PubMed:17099698). Interacts (when sumoylated) with MYCBP2; interaction inhibits MYCBP2 E3 ubiquitin-protein ligase activity and promotes MYCBP2 translocation to the nucleus (PubMed:26304119).
- SequenceCaution:
-
- Sequence=BAB47464.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for RANGAP1 Gene
Post-translational modifications for RANGAP1 Gene
- Phosphorylation occurs before nuclear envelope breakdown and continues throughout mitosis. Phosphorylated by the M-phase kinase cyclin B/Cdk1, in vitro. Differential timimg of dephosphorylation occurs during phases of mitosis. The phosphorylated form remains associated with RANBP2/NUP358 and the SUMO E2-conjugating enzyme, UBE2I, on nuclear pore complex (NPC) diassembly and during mitosis.
- Sumoylated (PubMed:11854305, PubMed:15037602, PubMed:26304119, PubMed:27160050). Sumoylation is necessary for targeting to the nuclear envelope (NE), and for association with mitotic spindles and kinetochores during mitosis (PubMed:11854305). Also required for interaction with RANBP2 and is mediated by UBE2I (PubMed:27160050).
-
Ubiquitination at Lys296, Lys452, and Lys524
- NX_P46060 (NX_P46060-1)
- Modification sites at PhosphoSitePlus
Other Protein References for RANGAP1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences RANGAP1 Antibody and RANGAP1 Monoclonal Antibody
- G Biosciences Immunotag™ RANGAP1 Antibody
- Novus Biologicals Antibodies for RANGAP1
-
Abcam antibodies for RANGAP1
- Invitrogen Antibodies for RANGAP1 (AFLGC-RANGAP1)
-
Santa Cruz Biotechnology (SCBT) Antibodies for RANGAP1
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for RANGAP1
- Origene Custom Protein Services for RANGAP1
-
Abcam proteins for RANGAP1
Assay products for research
- antibodies-online: Show 4 available RANGAP1 Elisa Kits ranked by validation data
- Compare Top RANGAP1 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for RANGAP1 Gene
Domains & Families for RANGAP1 Gene
Gene Families for RANGAP1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
- Transporters
Protein Domains for RANGAP1 Gene
- InterPro:
- Blocks:
-
- Leucine-rich repeat signature
Suggested Antigen Peptide Sequences for RANGAP1 Gene
- GenScript: Design optimal peptide antigens:
-
- Ran GTPase activating protein 1 (B0QYT3_HUMAN)
- Ran GTPase-activating protein 1 (RAGP1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P46060- Family:
-
- Belongs to the RNA1 family.
Function for RANGAP1 Gene
Molecular function for RANGAP1 Gene
- UniProtKB/Swiss-Prot Function:
- GTPase activator for RAN (PubMed:8146159, PubMed:8896452, PubMed:16428860). Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export (PubMed:8896452, PubMed:27160050). Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export (PubMed:27160050).
- GENATLAS Biochemistry:
- Ran GTPase activating protein 1,homolog of yeast Rna1p,component of the nuclear pore complex,highly concentrated at its cytoplasmic periphery,conjugating with UBL1 in a ATP dependent fashion,then associating with RANBP2. Involved in mRNA processing and transport
Phenotypes From GWAS Catalog for RANGAP1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | IDA | 26308891 |
| GO:0005096 | GTPase activator activity | TAS,IDA | 16428860 |
| GO:0005515 | protein binding | IEA,IPI | 14729961 |
| GO:0031267 | small GTPase binding | IPI | 16428860 |
| GO:0031625 | ubiquitin protein ligase binding | IEA | -- |
Phenotypes for RANGAP1 Gene
- MGI mutant phenotypes for RANGAP1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for RANGAP1:
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for RANGAP1 - Starting at $85 >
- * RANGAP1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for RANGAP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RANGAP1
-
Santa Cruz Biotechnology (SCBT) CRISPR for RANGAP1
miRNA for RANGAP1 Gene
- miRTarBase miRNAs that target RANGAP1
-
- hsa-miR-16-5p (MIRT031630)
- hsa-miR-1301-3p (MIRT036035)
- hsa-miR-331-3p (MIRT043425)
- hsa-miR-92a-3p (MIRT049661)
- hsa-miR-31-5p (MIRT049887)
- hsa-miR-4730 (MIRT453756)
- hsa-miR-7847-3p (MIRT453757)
- hsa-miR-6851-5p (MIRT453758)
- hsa-miR-6880-5p (MIRT453759)
- hsa-miR-3689d (MIRT453760)
- hsa-miR-7854-3p (MIRT453761)
- hsa-miR-3934-5p (MIRT453762)
- hsa-miR-764 (MIRT453763)
- hsa-miR-125a-3p (MIRT453764)
- hsa-miR-5197-5p (MIRT453765)
- mmu-miR-3087-3p (MIRT597535)
- mmu-miR-3470a (MIRT597536)
- mmu-miR-292a-5p (MIRT597537)
- mmu-miR-290a-5p (MIRT597538)
- mmu-miR-3084-3p (MIRT597539)
- mmu-miR-3110-5p (MIRT597540)
- mmu-miR-5125 (MIRT597541)
- hsa-miR-6749-3p (MIRT612590)
- hsa-miR-4707-3p (MIRT612591)
- hsa-miR-18a-3p (MIRT612592)
- hsa-miR-324-3p (MIRT612593)
- hsa-miR-1913 (MIRT612594)
- hsa-miR-150-5p (MIRT612595)
- hsa-miR-186-3p (MIRT612596)
- hsa-miR-520h (MIRT612597)
- hsa-miR-520g-3p (MIRT612598)
- hsa-miR-520e (MIRT612599)
- hsa-miR-520d-3p (MIRT612600)
- hsa-miR-520c-3p (MIRT612601)
- hsa-miR-520b (MIRT612602)
- hsa-miR-520a-3p (MIRT612603)
- hsa-miR-373-3p (MIRT612604)
- hsa-miR-372-3p (MIRT612605)
- hsa-miR-302e (MIRT612606)
- hsa-miR-302d-3p (MIRT612607)
- hsa-miR-302c-3p (MIRT612608)
- hsa-miR-302b-3p (MIRT612609)
- hsa-miR-302a-3p (MIRT612610)
- hsa-miR-93-5p (MIRT612611)
- hsa-miR-526b-3p (MIRT612612)
- hsa-miR-519d-3p (MIRT612613)
- hsa-miR-20b-5p (MIRT612614)
- hsa-miR-20a-5p (MIRT612615)
- hsa-miR-17-5p (MIRT612616)
- hsa-miR-106b-5p (MIRT612617)
- hsa-miR-106a-5p (MIRT612618)
- hsa-miR-129-5p (MIRT625442)
- hsa-miR-8055 (MIRT625443)
- hsa-miR-6864-3p (MIRT625444)
- hsa-miR-3672 (MIRT625445)
- hsa-miR-4753-3p (MIRT625446)
- hsa-miR-6873-3p (MIRT625447)
- hsa-miR-155-3p (MIRT625448)
- hsa-miR-223-3p (MIRT625449)
- hsa-miR-4697-3p (MIRT625450)
- hsa-miR-4524a-3p (MIRT625451)
- hsa-miR-130b-5p (MIRT625452)
- hsa-miR-6817-3p (MIRT625453)
- hsa-miR-7110-3p (MIRT625454)
- hsa-miR-1182 (MIRT625455)
- hsa-miR-4524b-3p (MIRT625456)
- hsa-miR-6796-3p (MIRT625457)
- hsa-miR-3159 (MIRT625458)
- hsa-miR-7151-3p (MIRT630565)
- hsa-miR-5095 (MIRT630566)
- hsa-miR-4438 (MIRT630567)
- hsa-miR-3149 (MIRT639235)
- hsa-miR-197-3p (MIRT639236)
- hsa-miR-4711-5p (MIRT639237)
- hsa-miR-7112-3p (MIRT639238)
- hsa-miR-4267 (MIRT639239)
- hsa-miR-153-5p (MIRT639240)
- hsa-miR-1250-3p (MIRT639241)
- hsa-miR-500b-3p (MIRT639242)
- hsa-miR-3124-3p (MIRT709232)
- hsa-miR-1238-3p (MIRT709233)
- hsa-miR-670-3p (MIRT709234)
- hsa-miR-452-3p (MIRT709235)
- hsa-miR-627-3p (MIRT709236)
- hsa-miR-483-3p (MIRT709237)
- hsa-miR-664a-3p (MIRT709238)
- hsa-miR-3142 (MIRT709239)
- hsa-miR-1245b-5p (MIRT709240)
- hsa-miR-32-3p (MIRT709241)
- hsa-miR-4753-5p (MIRT709242)
- hsa-miR-1207-5p (MIRT736052)
- hsa-miR-1286 (MIRT737062)
- hsa-miR-3158-3p (MIRT740465)
- hsa-miR-4323 (MIRT744052)
- hsa-miR-4436b-3p (MIRT744471)
- hsa-miR-4514 (MIRT745719)
- hsa-miR-4632-5p (MIRT746280)
- hsa-miR-4645-5p (MIRT746421)
- hsa-miR-4673 (MIRT746863)
- hsa-miR-4685-5p (MIRT746969)
- hsa-miR-4692 (MIRT747126)
- hsa-miR-4763-3p (MIRT748560)
- hsa-miR-6132 (MIRT752331)
- hsa-miR-6721-5p (MIRT753830)
- hsa-miR-6735-5p (MIRT754183)
- hsa-miR-6753-5p (MIRT754679)
- hsa-miR-6808-5p (MIRT756595)
- hsa-miR-6836-5p (MIRT757225)
- hsa-miR-6837-5p (MIRT757251)
- hsa-miR-6879-5p (MIRT758272)
- hsa-miR-6886-5p (MIRT758562)
- hsa-miR-6893-5p (MIRT758740)
- hsa-miR-7843-5p (MIRT759772)
- hsa-miR-7855-5p (MIRT759957)
- hsa-miR-873-5p (MIRT760323)
- hsa-miR-940 (MIRT760836)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RANGAP1
- Browse OriGene Inhibitory RNA Products For RANGAP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RANGAP1
Clone products for research
- Applied Biological Materials (abm): Clones for RANGAP1 - Starting at $45 >
- * RANGAP1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for RANGAP1
- Addgene plasmids for RANGAP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RANGAP1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RANGAP1 Gene
Localization for RANGAP1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for RANGAP1 Gene
- Cytoplasm. Nucleus, nucleoplasm. Nucleus envelope. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Cytoplasmic during interphase. Detected at the nuclear envelope during interphase (PubMed:11854305, PubMed:15037602). Targeted to the nuclear pores after sumoylation (PubMed:11854305). During mitosis, associates with mitotic spindles, but is essentially not detected at the spindle poles (PubMed:11854305, PubMed:15037602). Association with kinetochores appears soon after nuclear envelope breakdown and persists until late anaphase (PubMed:11854305). Mitotic location also requires sumoylation (PubMed:11854305). {ECO:0000269 PubMed:11854305, ECO:0000269 PubMed:15037602}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| cytoskeleton | 3 |
| plasma membrane | 2 |
| extracellular | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytosol (4)
- Nuclear membrane (4)
- Vesicles (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000775 | chromosome, centromeric region | IEA | -- |
| GO:0000776 | colocalizes_with kinetochore | IEA,IDA | 17363900 |
| GO:0000777 | condensed chromosome kinetochore | IEA | -- |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005635 | nuclear envelope | IDA,TAS | -- |
Pathways & Interactions for RANGAP1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | HIV Life Cycle |
.91
.64
|
.45
|
| 2 | Cell Cycle, Mitotic |
.83
|
.60
|
| 3 | Transport of the SLBP independent Mature mRNA | ||
| 4 | Mitotic Metaphase and Anaphase |
.94
|
|
| 5 | Mitotic Prometaphase | ||
Pathways by source for RANGAP1 Gene
3 BioSystems pathways for RANGAP1 Gene
25 Reactome pathways for RANGAP1 Gene
1 KEGG pathway for RANGAP1 Gene
1 GeneGo (Thomson Reuters) pathway for RANGAP1 Gene
- Proteolysis Putative SUMO-1 pathway
2 Qiagen pathways for RANGAP1 Gene
- Ran Pathway
- SUMO Pathway
Interacting Proteins for RANGAP1 Gene
Selected Interacting proteins:
P46060-RAGP1_HUMAN
ENSP00000401470
for RANGAP1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for RANGAP1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007165 | signal transduction | TAS,IEA | -- |
| GO:0016925 | protein sumoylation | TAS | -- |
| GO:0043547 | positive regulation of GTPase activity | IEA | -- |
| GO:0046826 | negative regulation of protein export from nucleus | IDA | 16449645 |
| GO:0048678 | response to axon injury | IEA | -- |
Transcripts for RANGAP1 Gene
mRNA/cDNA for RANGAP1 Gene
- 3 REFSEQ mRNAs :
- 15 NCBI additional mRNA sequence :
- 7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000356244 3828 nts (view in UCSC)
- ENST00000405486 3469 nts (view in UCSC)
- ENST00000418067 650 nts (view in UCSC)
- ENST00000422838 946 nts (view in UCSC)
- ENST00000446258 759 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for RANGAP1 - Starting at $85 >
- * RANGAP1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for RANGAP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RANGAP1
-
Santa Cruz Biotechnology (SCBT) CRISPR for RANGAP1
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RANGAP1
- Browse OriGene Inhibitory RNA Products For RANGAP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RANGAP1
Clone products for research
- Applied Biological Materials (abm): Clones for RANGAP1 - Starting at $45 >
- * RANGAP1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for RANGAP1
- Addgene plasmids for RANGAP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RANGAP1
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: |
| ExUns: | 15a | · | 15b | ^ | 16a | · | 16b | ^ | 17a | · | 17b |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||
| SP2: | - | - | |||||||||
| SP3: | - | - | |||||||||
| SP4: | |||||||||||
| SP5: | |||||||||||
| SP6: | |||||||||||
| SP7: | |||||||||||
| SP8: | |||||||||||
| SP9: | |||||||||||
| SP10: | |||||||||||
| SP11: | |||||||||||
| SP12: |
Relevant External Links for RANGAP1 Gene
- GeneLoc Exon Structure for
- RANGAP1
Expression for RANGAP1 Gene
This gene is overexpressed in Bone (14.4), Nasal epithelium (8.0), and Lymph node (7.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RANGAP1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RANGAP1
SOURCE GeneReport for Unigene cluster for RANGAP1 Gene:
Hs.183800mRNA Expression by UniProt/SwissProt for RANGAP1 Gene:
P46060-RAGP1_HUMAN
Tissue specificity:
Highly expressed in brain, thymus and testis.
Evidence on tissue expression from TISSUES for RANGAP1 Gene
- Nervous system(4.9)
- Kidney(4.5)
- Skin(4.5)
- Lung(3.1)
- Intestine(2.9)
- Eye(2.5)
- Blood(2.5)
- Heart(2.2)
- Liver(2.1)
- Bone marrow(2)
Primer products for research
-
OriGene qPCR primer pairs for RANGAP1
-
OriGene qPCR primer pairs and template standards for RANGAP1
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RANGAP1 Gene
Orthologs for RANGAP1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | RANGAP1 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | RANGAP1 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | RANGAP1 29 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Rangap1 29 |
|
||
| Mouse (Mus musculus) |
Mammalia | Rangap1 29 16 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | RANGAP1 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | RANGAP1 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | RANGAP1 29 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | RANGAP1 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | rangap1 29 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | rangap1-prov 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | rangap1a 29 30 |
|
OneToMany | |
| rangap1b 30 |
|
OneToMany | |||
| Dr.26558 29 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.1664 29 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | RanGap 30 |
|
OneToOne | |
| Worm (Caenorhabditis elegans) |
Secernentea | ran-2 30 31 |
|
OneToOne | |
| A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AFR525C 29 |
|
||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RNA1 29 30 32 |
|
OneToOne | |
| K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F25036g 29 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.9560 30 |
|
OneToOne | |
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU03207 29 |
|
||
| Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | rna1 29 |
|
- Species where no ortholog for RANGAP1 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for RANGAP1 Gene
- ENSEMBL:
- Gene Tree for RANGAP1 (if available)
- TreeFam:
- Gene Tree for RANGAP1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for RANGAP1: view image
- Alliance of Genome Resources:
- Additional Orthologs for RANGAP1
Paralogs for RANGAP1 Gene
No data available for Paralogs for RANGAP1 Gene
Variants for RANGAP1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RANGAP1 Gene
| SNP ID | Clinical significance and condition | Chr 22 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs2066780 | Benign: not provided | 41,256,246(-) |
C/T NM_002883.4(RANGAP1):c.933G>A (p.Leu311=) |
SYNONYMOUS | |
| rs2229755 | Benign: not provided | 41,254,367(-) |
G/C NM_002883.4(RANGAP1):c.1201C>G (p.Arg401Gly) |
MISSENSE | |
| rs2229752 | -- |
p.Glu133Gln |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv3637 | CNV | deletion | 18451855 |
| nsv3638 | CNV | insertion | 18451855 |
| nsv459888 | CNV | gain | 19166990 |
| nsv479885 | CNV | novel sequence insertion | 20440878 |
| nsv516925 | CNV | loss | 19592680 |
| nsv524585 | CNV | loss | 19592680 |
| nsv589049 | CNV | gain | 21841781 |
| nsv589050 | CNV | gain | 21841781 |
| nsv817997 | CNV | gain | 17921354 |
| nsv834207 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
27.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.35;
41.77% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RANGAP1 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RANGAP1 Gene
Disorders for RANGAP1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| parkinson disease 7, autosomal recessive early-onset |
|
|
| dermatopathia pigmentosa reticularis |
|
|
| prostate transitional cell carcinoma |
|
|
| frontotemporal dementia and/or amyotrophic lateral sclerosis 1 |
|
|
Search RANGAP1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for RANGAP1
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for RANGAP1 Gene
Publications for RANGAP1 Gene
- Human RanGTPase-activating protein RanGAP1 is a homologue of yeast Rna1p involved in mRNA processing and transport. (PMID: 7878053) Bischoff FR … Ponstingl H (Proceedings of the National Academy of Sciences of the United States of America 1995) 2 3 4 22
- Insights into E3 ligase activity revealed by a SUMO-RanGAP1-Ubc9-Nup358 complex. (PMID: 15931224) Reverter D … Lima CD (Nature 2005) 3 4 22
- Phosphorylation of RanGAP1 stabilizes its interaction with Ran and RanBP1. (PMID: 16428860) Takeda E … Yoneda Y (Cell structure and function 2005) 3 4 22
- RanGAP1*SUMO1 is phosphorylated at the onset of mitosis and remains associated with RanBP2 upon NPC disassembly. (PMID: 15037602) Swaminathan S … Melchior F (The Journal of cell biology 2004) 3 4 22
- Ubiquitous expression and testis-specific alternative polyadenylation of mRNA for the human Ran GTPase activator RanGAP1. (PMID: 8973340) Krebber H … Ponstingl H (Gene 1996) 3 4 22
ExternalLinks
Products for RANGAP1 Gene
- Custom Antibody Services
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- Search Origene for MassSpec and Protein Over-expression Lysates for RANGAP1
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- Origene shrna, sirna, and RNAi products in human, mouse, rat for RANGAP1
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- OriGene qPCR primer pairs for RANGAP1
- OriGene qPCR primer pairs and template standards for RANGAP1
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- Novus Biologicals proteins and lysates for RANGAP1
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- VectorBuilder Custom and pre-made DNA vectors for RANGAP1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for RANGAP1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for RANGAP1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for RANGAP1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for RANGAP1
- Addgene plasmids for RANGAP1
- antibodies-online: Show 27 available RANGAP1 Antibodies ranked by validation data
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- antibodies-online: Show 4 available RANGAP1 Elisa Kits ranked by validation data
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- Quality Products:
- antibodies-online: Show 6 available RANGAP1 Proteins ranked by validation data
- Compare Top RANGAP1 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for RANGAP1
- Search Santa Cruz Biotechnology (SCBT) for RANGAP1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for RANGAP1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RANGAP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RANGAP1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for RANGAP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RANGAP1
Sources for RANGAP1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
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- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
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- (37) dbSNP
- (38) GenAtlas
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- (43) Atlas
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- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
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