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Aliases for RANGAP1 Gene

Aliases for RANGAP1 Gene

  • Ran GTPase Activating Protein 1 2 3 5
  • SD 3 4
  • Segregation Distorter Homolog (Drosophila) 2
  • Ran GTPase-Activating Protein 1 3
  • Segregation Distorter Homolog 3
  • Segregation Distortion 3
  • KIAA1835 4
  • RanGAP1 4
  • RANGAP 3
  • Fug1 3

External Ids for RANGAP1 Gene

Previous HGNC Symbols for RANGAP1 Gene

  • SD

Previous GeneCards Identifiers for RANGAP1 Gene

  • GC22M038256
  • GC22M039884
  • GC22M039966
  • GC22M041641
  • GC22M024606

Summaries for RANGAP1 Gene

Entrez Gene Summary for RANGAP1 Gene

  • This gene encodes a protein that associates with the nuclear pore complex and participates in the regulation of nuclear transport. The encoded protein interacts with Ras-related nuclear protein 1 (RAN) and regulates guanosine triphosphate (GTP)-binding and exchange. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for RANGAP1 Gene

RANGAP1 (Ran GTPase Activating Protein 1) is a Protein Coding gene. Diseases associated with RANGAP1 include Amyotrophic Lateral Sclerosis 4, Juvenile. Among its related pathways are Cell Cycle, Mitotic and SUMOylation. Gene Ontology (GO) annotations related to this gene include GTPase activator activity.

UniProtKB/Swiss-Prot for RANGAP1 Gene

  • GTPase activator for RAN (PubMed:8146159, PubMed:8896452, PubMed:16428860). Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export (PubMed:8896452, PubMed:27160050). Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export (PubMed:27160050).

Gene Wiki entry for RANGAP1 Gene

Additional gene information for RANGAP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RANGAP1 Gene

Genomics for RANGAP1 Gene

GeneHancer (GH) Regulatory Elements for RANGAP1 Gene

Promoters and enhancers for RANGAP1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J041284 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 663.7 +13.9 13889 8.1 FEZF1 DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC SSRP1 ZNF610 RANGAP1 EP300 XRCC6 ENSG00000272834 EP300-AS1 ENSG00000232754 ENSG00000227413 L3MBTL2 NAGA ZC3H7B
GH22J041300 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 650.7 -0.7 -728 4.4 PKNOX1 ARID4B SIN3A DMAP1 YY1 ZNF213 ZNF143 KLF13 SP3 SP5 GC22P041304 RANGAP1 ZC3H7B ENSG00000235513 MEI1 TEF CYP2D7 SGSM3
GH22J041281 Promoter 0.5 EPDnew 662.6 +20.6 20551 0.1 RANGAP1 ENSG00000232754 L3MBTL2 RNU6-375P CSDC2 GC22M043033 MIR6889
GH22J041261 Enhancer 0.6 dbSUPER 23.9 +38.5 38503 5.8 PKNOX1 RFX1 GLI4 ZSCAN16 GLIS1 MYNN ZNF524 HNF4A PRDM1 RANGAP1 ENSG00000235513 ZC3H7B RNU6-375P MEI1 SGSM3 MIR6889 GC22M043033
GH22J041090 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 5.7 +209.3 209344 4.7 HDGF FOXA2 SMAD1 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 EP300 MIR1281 PHF5A ENSG00000272834 L3MBTL2 XRCC6 ENSG00000235513 EP300-AS1 ENSG00000232754 ENSG00000227413
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RANGAP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RANGAP1 gene promoter:
  • ATF-2
  • deltaCREB
  • CREB
  • c-Jun
  • AP-1
  • AhR
  • p53

Genomic Locations for RANGAP1 Gene

Genomic Locations for RANGAP1 Gene
57,434 bases
Minus strand
40,641 bases
Minus strand

Genomic View for RANGAP1 Gene

Genes around RANGAP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RANGAP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RANGAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RANGAP1 Gene

Proteins for RANGAP1 Gene

  • Protein details for RANGAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ran GTPase-activating protein 1
    Protein Accession:
    Secondary Accessions:
    • Q96JJ2

    Protein attributes for RANGAP1 Gene

    587 amino acids
    Molecular mass:
    63542 Da
    Quaternary structure:
    • Homodimer (PubMed:8146159). Interacts with RAN (PubMed:7891706, PubMed:8896452, PubMed:16428860). Forms a complex with RANBP2/NUP358, NXF1 and NXT1 (PubMed:14729961). Forms a tight complex in association with RANBP2/NUP358 and UBE2I/UBC9, the ubiquitin-conjugating enzyme E2 (PubMed:15037602, PubMed:27160050, PubMed:15931224, PubMed:22194619). Interacts with UBE2I; the interaction conjugates SUMO1 to RANGAP1, and subsequently stabilizes interactions of sumoylated RANGAP1 with RANBP2/NUP358 (PubMed:15037602, PubMed:27160050, PubMed:15931224). The complex composed of RANBP2, SUMO1, RANGAP1 and UBE2I associates with nuclear pore complexes (PubMed:15037602, PubMed:15931224). Identified in a complex composed of RAN, RANBP2, sumoylated RANGAP1, UBE2I and XPO1 (PubMed:27160050). Identified in a complex composed of RAN, RANGAP1 and RANBP1 (PubMed:16428860). Interacts with TRAF6 (PubMed:18093978). Interacts with SUMO1 and SENP1 (PubMed:17099698).
    • Sequence=BAB47464.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RANGAP1 Gene

neXtProt entry for RANGAP1 Gene

Post-translational modifications for RANGAP1 Gene

  • Phosphorylation occurs before nuclear envelope breakdown and continues throughout mitosis. Phosphorylated by the M-phase kinase cyclin B/Cdk1, in vitro. Differential timimg of dephosphorylation occurs during phases of mitosis. The phosphorylated form remains associated with RANBP2/NUP358 and the SUMO E2-conjugating enzyme, UBE2I, on nuclear pore complex (NPC) diassembly and during mitosis.
  • Sumoylated (PubMed:11854305, PubMed:15037602, PubMed:27160050). Sumoylation is necessary for targeting to the nuclear envelope (NE), and for association with mitotic spindles and kinetochores during mitosis (PubMed:11854305). Also required for interaction with RANBP2 and is mediated by UBE2I (PubMed:27160050).
  • Ubiquitination at posLast=452452 and Lys296
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RANGAP1 Gene

Domains & Families for RANGAP1 Gene

Gene Families for RANGAP1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transporters

Protein Domains for RANGAP1 Gene

Suggested Antigen Peptide Sequences for RANGAP1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the RNA1 family.
  • Belongs to the RNA1 family.
genes like me logo Genes that share domains with RANGAP1: view

Function for RANGAP1 Gene

Molecular function for RANGAP1 Gene

UniProtKB/Swiss-Prot Function:
GTPase activator for RAN (PubMed:8146159, PubMed:8896452, PubMed:16428860). Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export (PubMed:8896452, PubMed:27160050). Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export (PubMed:27160050).
GENATLAS Biochemistry:
Ran GTPase activating protein 1,homolog of yeast Rna1p,component of the nuclear pore complex,highly concentrated at its cytoplasmic periphery,conjugating with UBL1 in a ATP dependent fashion,then associating with RANBP2. Involved in mRNA processing and transport

Phenotypes From GWAS Catalog for RANGAP1 Gene

Gene Ontology (GO) - Molecular Function for RANGAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 26308891
GO:0005096 GTPase activator activity IDA,IEA 16428860
GO:0005515 protein binding IEA,IPI 14729961
GO:0008536 Ran GTPase binding IPI 16428860
GO:0031625 ubiquitin protein ligase binding IEA --
genes like me logo Genes that share ontologies with RANGAP1: view
genes like me logo Genes that share phenotypes with RANGAP1: view

Animal Model Products

CRISPR Products

miRNA for RANGAP1 Gene

miRTarBase miRNAs that target RANGAP1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RANGAP1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RANGAP1 Gene

Localization for RANGAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RANGAP1 Gene

Cytoplasm. Nucleus, nucleoplasm. Nucleus envelope. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Cytoplasmic during interphase. Detected at the nuclear envelope during interphase (PubMed:11854305, PubMed:15037602). Targeted to the nuclear pores after sumoylation (PubMed:11854305). During mitosis, associates with mitotic spindles, but is essentially not detected at the spindle poles (PubMed:11854305, PubMed:15037602). Association with kinetochores appears soon after nuclear envelope breakdown and persists until late anaphase (PubMed:11854305). Mitotic location also requires sumoylation (PubMed:11854305). {ECO:0000269 PubMed:11854305, ECO:0000269 PubMed:15037602}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RANGAP1 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nuclear membrane (4)
  • Vesicles (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RANGAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 colocalizes_with kinetochore IDA,IEA 17363900
GO:0000777 condensed chromosome kinetochore IEA --
GO:0000922 spindle pole IEA --
GO:0005634 nucleus IEA --
GO:0005635 nuclear envelope TAS --
genes like me logo Genes that share ontologies with RANGAP1: view

Pathways & Interactions for RANGAP1 Gene

genes like me logo Genes that share pathways with RANGAP1: view

Pathways by source for RANGAP1 Gene

1 GeneGo (Thomson Reuters) pathway for RANGAP1 Gene
2 Qiagen pathways for RANGAP1 Gene

SIGNOR curated interactions for RANGAP1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for RANGAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007062 sister chromatid cohesion TAS --
GO:0007165 signal transduction IEA,TAS --
GO:0016925 protein sumoylation TAS --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0046826 negative regulation of protein export from nucleus IDA 16449645
genes like me logo Genes that share ontologies with RANGAP1: view

Drugs & Compounds for RANGAP1 Gene

(1) Drugs for RANGAP1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for RANGAP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RANGAP1: view

Transcripts for RANGAP1 Gene

Unigene Clusters for RANGAP1 Gene

Ran GTPase activating protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RANGAP1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RANGAP1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^
SP1: - - - - - - -
SP3: -
SP4: - - - - - -
SP5: - - - - -
SP6: - - - - - -
SP7: - - - - - - - - - - -
SP8: - - - - - - - -
SP10: - -

ExUns: 15a · 15b ^ 16a · 16b ^ 17a · 17b
SP2: - -
SP3: - -

Relevant External Links for RANGAP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RANGAP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RANGAP1 Gene

Protein differential expression in normal tissues from HIPED for RANGAP1 Gene

This gene is overexpressed in Bone (14.4), Nasal epithelium (8.0), and Lymph node (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RANGAP1 Gene

Protein tissue co-expression partners for RANGAP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RANGAP1 Gene:


SOURCE GeneReport for Unigene cluster for RANGAP1 Gene:


mRNA Expression by UniProt/SwissProt for RANGAP1 Gene:

Tissue specificity: Highly expressed in brain, thymus and testis.

Evidence on tissue expression from TISSUES for RANGAP1 Gene

  • Nervous system(4.9)
  • Kidney(4.3)
  • Skin(4.2)
  • Lung(2.7)
  • Intestine(2.3)
genes like me logo Genes that share expression patterns with RANGAP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RANGAP1 Gene

Orthologs for RANGAP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RANGAP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RANGAP1 34 33
  • 98.69 (n)
(Canis familiaris)
Mammalia RANGAP1 34 33
  • 89.72 (n)
(Bos Taurus)
Mammalia RANGAP1 34 33
  • 87.69 (n)
(Rattus norvegicus)
Mammalia Rangap1 33
  • 86.18 (n)
(Mus musculus)
Mammalia Rangap1 16 34 33
  • 86.09 (n)
(Monodelphis domestica)
Mammalia RANGAP1 34
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia RANGAP1 34
  • 82 (a)
(Gallus gallus)
Aves RANGAP1 34 33
  • 75.46 (n)
(Anolis carolinensis)
Reptilia RANGAP1 34
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rangap1 33
  • 68.39 (n)
African clawed frog
(Xenopus laevis)
Amphibia rangap1-prov 33
(Danio rerio)
Actinopterygii rangap1a 34 33
  • 63.95 (n)
rangap1b 34
  • 57 (a)
Dr.26558 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1664 33
fruit fly
(Drosophila melanogaster)
Insecta RanGap 34
  • 7 (a)
(Caenorhabditis elegans)
Secernentea ran-2 34 35
  • 12 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR525C 33
  • 47.05 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RNA1 36 34 33
  • 44.23 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F25036g 33
  • 42.81 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9560 34
  • 50 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03207 33
  • 49.64 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rna1 33
  • 45.43 (n)
Species where no ortholog for RANGAP1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RANGAP1 Gene

Gene Tree for RANGAP1 (if available)
Gene Tree for RANGAP1 (if available)
Evolutionary constrained regions (ECRs) for RANGAP1: view image

Paralogs for RANGAP1 Gene

No data available for Paralogs for RANGAP1 Gene

Variants for RANGAP1 Gene

Sequence variations from dbSNP and Humsavar for RANGAP1 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000026024 -- 41,292,518(-) T/A genic_upstream_transcript_variant, intron_variant
rs1000107155 -- 41,272,476(-) C/T intron_variant
rs1000134488 -- 41,257,718(-) C/T intron_variant
rs1000145489 -- 41,289,152(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000187188 -- 41,257,510(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RANGAP1 Gene

Variant ID Type Subtype PubMed ID
nsv3637 CNV deletion 18451855
nsv3638 CNV insertion 18451855
nsv459888 CNV gain 19166990
nsv479885 CNV novel sequence insertion 20440878
nsv516925 CNV loss 19592680
nsv524585 CNV loss 19592680
nsv589049 CNV gain 21841781
nsv589050 CNV gain 21841781
nsv817997 CNV gain 17921354
nsv834207 CNV loss 17160897

Variation tolerance for RANGAP1 Gene

Residual Variation Intolerance Score: 27.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.35; 41.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RANGAP1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RANGAP1 Gene

Disorders for RANGAP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RANGAP1 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
amyotrophic lateral sclerosis 4, juvenile
  • als4
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for RANGAP1

genes like me logo Genes that share disorders with RANGAP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RANGAP1 Gene

Publications for RANGAP1 Gene

  1. Human RanGTPase-activating protein RanGAP1 is a homologue of yeast Rna1p involved in mRNA processing and transport. (PMID: 7878053) Bischoff FR … Ponstingl H (Proceedings of the National Academy of Sciences of the United States of America 1995) 2 3 4 22 58
  2. Phosphorylation of RanGAP1 stabilizes its interaction with Ran and RanBP1. (PMID: 16428860) Takeda E … Yoneda Y (Cell structure and function 2005) 3 4 22 58
  3. Insights into E3 ligase activity revealed by a SUMO-RanGAP1-Ubc9-Nup358 complex. (PMID: 15931224) Reverter D … Lima CD (Nature 2005) 3 4 22 58
  4. RanGAP1*SUMO1 is phosphorylated at the onset of mitosis and remains associated with RanBP2 upon NPC disassembly. (PMID: 15037602) Swaminathan S … Melchior F (The Journal of cell biology 2004) 3 4 22 58
  5. Ubiquitous expression and testis-specific alternative polyadenylation of mRNA for the human Ran GTPase activator RanGAP1. (PMID: 8973340) Krebber H … Ponstingl H (Gene 1996) 3 4 22 58

Products for RANGAP1 Gene

Sources for RANGAP1 Gene

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