Aliases for RANGAP1 Gene
External Ids for RANGAP1 Gene
Previous HGNC Symbols for RANGAP1 Gene
Previous GeneCards Identifiers for RANGAP1 Gene
This gene encodes a protein that associates with the nuclear pore complex and participates in the regulation of nuclear transport. The encoded protein interacts with Ras-related nuclear protein 1 (RAN) and regulates guanosine triphosphate (GTP)-binding and exchange. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
GeneCards Summary for RANGAP1 Gene
RANGAP1 (Ran GTPase Activating Protein 1) is a Protein Coding gene. Diseases associated with RANGAP1 include Parkinson Disease 7, Autosomal Recessive Early-Onset and Dermatopathia Pigmentosa Reticularis. Among its related pathways are Signaling by GPCR and Transport of the SLBP independent Mature mRNA. Gene Ontology (GO) annotations related to this gene include GTPase activator activity.
UniProtKB/Swiss-Prot Summary for RANGAP1 Gene
GTPase activator for RAN (PubMed:8146159, PubMed:8896452, PubMed:16428860). Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export (PubMed:8896452, PubMed:27160050). Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export (PubMed:27160050).