Aliases for RANBP9 Gene
External Ids for RANBP9 Gene
Previous GeneCards Identifiers for RANBP9 Gene
This gene encodes a protein that binds RAN, a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The protein encoded by this gene has also been shown to interact with several other proteins, including met proto-oncogene, homeodomain interacting protein kinase 2, androgen receptor, and cyclin-dependent kinase 11. [provided by RefSeq, Jul 2008]
GeneCards Summary for RANBP9 Gene
RANBP9 (RAN Binding Protein 9) is a Protein Coding gene. Among its related pathways are RET signaling and Cytoskeletal Signaling. Gene Ontology (GO) annotations related to this gene include enzyme binding and Ran GTPase binding. An important paralog of this gene is RANBP10.
UniProtKB/Swiss-Prot for RANBP9 Gene
May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. May be involved in signaling of ITGB2/LFA-1 and other integrins. Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation. Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity. Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA.