Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RANBP6 Gene

Aliases for RANBP6 Gene

  • RAN Binding Protein 6 2 3 5
  • RanBP6 4

External Ids for RANBP6 Gene

Previous GeneCards Identifiers for RANBP6 Gene

  • GC12M009341
  • GC12M009781
  • GC09M006001

Summaries for RANBP6 Gene

GeneCards Summary for RANBP6 Gene

RANBP6 (RAN Binding Protein 6) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include binding. An important paralog of this gene is IPO5.

UniProtKB/Swiss-Prot for RANBP6 Gene

  • May function in nuclear protein import as nuclear transport receptor.

Additional gene information for RANBP6 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RANBP6 Gene

Genomics for RANBP6 Gene

GeneHancer (GH) Regulatory Elements for RANBP6 Gene

Promoters and enhancers for RANBP6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I006014 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.3 261 2 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B E2F8 ZNF207 RANBP6 ERMP1 KIAA2026
GH09I005623 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 1.1 +388.2 388196 7.5 PKNOX1 SMAD1 ARID4B SIN3A IRF4 POLR2B ZNF766 ZNF207 ZNF143 SP3 RIC1 LOC105375967 PLGRKT KIAA2026 CD274 RANBP6 GC09P005625
GH09I005841 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 1.7 +171.9 171853 4.9 HDGF PKNOX1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZNF121 ATF7 RUNX3 GC09M005843 ERMP1 RANBP6 AK4P4
GH09I006024 Enhancer 0.8 Ensembl ENCODE 0.4 -8.6 -8561 0.4 CTCF ZBTB11 DPF2 RAD21 ZNF217 GATA3 IKZF1 SCRT2 PRDM10 CUX1 KIAA2026 RANBP6 ENSG00000228739
GH09I006037 Enhancer 0.2 Ensembl 0.3 -22.4 -22361 0.4 ENSG00000228739 RANBP6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RANBP6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RANBP6 gene promoter:

Genomic Locations for RANBP6 Gene

Genomic Locations for RANBP6 Gene
4,622 bases
Minus strand

Genomic View for RANBP6 Gene

Genes around RANBP6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RANBP6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RANBP6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RANBP6 Gene

Proteins for RANBP6 Gene

  • Protein details for RANBP6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ran-binding protein 6
    Protein Accession:
    Secondary Accessions:
    • Q5T7X4
    • Q7Z3V2
    • Q96E78

    Protein attributes for RANBP6 Gene

    1105 amino acids
    Molecular mass:
    124714 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAD97647.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for RANBP6 Gene

Post-translational modifications for RANBP6 Gene

  • Ubiquitination at Lys16
  • Modification sites at PhosphoSitePlus

Other Protein References for RANBP6 Gene

No data available for DME Specific Peptides for RANBP6 Gene

Domains & Families for RANBP6 Gene

Gene Families for RANBP6 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RANBP6 Gene

Suggested Antigen Peptide Sequences for RANBP6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the importin beta family.
  • Belongs to the importin beta family.
genes like me logo Genes that share domains with RANBP6: view

Function for RANBP6 Gene

Molecular function for RANBP6 Gene

UniProtKB/Swiss-Prot Function:
May function in nuclear protein import as nuclear transport receptor.

Phenotypes From GWAS Catalog for RANBP6 Gene

Gene Ontology (GO) - Molecular Function for RANBP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22190034
GO:0008139 nuclear localization sequence binding IBA --
GO:0008565 protein transporter activity IBA --
genes like me logo Genes that share ontologies with RANBP6: view
genes like me logo Genes that share phenotypes with RANBP6: view

miRNA for RANBP6 Gene

miRTarBase miRNAs that target RANBP6

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RANBP6 Gene

Localization for RANBP6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RANBP6 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RANBP6 gene
Compartment Confidence
nucleus 4
cytosol 3
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RANBP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IBA --
GO:0031965 nuclear membrane IBA --
GO:0034399 nuclear periphery IBA --
genes like me logo Genes that share ontologies with RANBP6: view

Pathways & Interactions for RANBP6 Gene

SuperPathways for RANBP6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RANBP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000060 protein import into nucleus, translocation IBA --
GO:0006607 NLS-bearing protein import into nucleus IBA --
GO:0006610 ribosomal protein import into nucleus IBA --
GO:0006810 transport IEA --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with RANBP6: view

No data available for Pathways by source and SIGNOR curated interactions for RANBP6 Gene

Drugs & Compounds for RANBP6 Gene

(1) Additional Compounds for RANBP6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RANBP6: view

Transcripts for RANBP6 Gene

Unigene Clusters for RANBP6 Gene

RAN binding protein 6:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RANBP6 Gene

No ASD Table

Relevant External Links for RANBP6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RANBP6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RANBP6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RANBP6 Gene

This gene is overexpressed in Bone (47.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RANBP6 Gene

NURSA nuclear receptor signaling pathways regulating expression of RANBP6 Gene:


SOURCE GeneReport for Unigene cluster for RANBP6 Gene:


Evidence on tissue expression from TISSUES for RANBP6 Gene

  • Nervous system(4.9)
  • Kidney(4.3)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with RANBP6: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RANBP6 Gene

Orthologs for RANBP6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RANBP6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RANBP6 33 34
  • 99.79 (n)
(Canis familiaris)
Mammalia RANBP6 33
  • 95.29 (n)
(Bos Taurus)
Mammalia RANBP6 33 34
  • 95.02 (n)
(Mus musculus)
Mammalia Ranbp6 33 16 34
  • 91.19 (n)
(Rattus norvegicus)
Mammalia Ranbp6 33
  • 91.07 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 79 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 76 (a)
(Gallus gallus)
Aves -- 34
  • 77 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 77 (a)
-- 34
  • 71 (a)
(Danio rerio)
Actinopterygii kpnb3 34
  • 74 (a)
fruit fly
(Drosophila melanogaster)
Insecta Karybeta3 34
  • 48 (a)
(Caenorhabditis elegans)
Secernentea imb-3 34
  • 34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PSE1 34
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10777 34
  • 48 (a)
Species where no ortholog for RANBP6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RANBP6 Gene

Gene Tree for RANBP6 (if available)
Gene Tree for RANBP6 (if available)

Paralogs for RANBP6 Gene

Paralogs for RANBP6 Gene

(1) SIMAP similar genes for RANBP6 Gene using alignment to 1 proteins: Pseudogenes for RANBP6 Gene

genes like me logo Genes that share paralogs with RANBP6: view

Variants for RANBP6 Gene

Sequence variations from dbSNP and Humsavar for RANBP6 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000900409 -- 6,015,894(-) G/C/T upstream_transcript_variant
rs1001368829 -- 6,015,404(-) T/G coding_sequence_variant, intron_variant, missense_variant
rs1001634296 -- 6,013,009(-) G/A/C 3_prime_UTR_variant, coding_sequence_variant, missense_variant
rs1001716726 -- 6,015,687(-) G/C/T upstream_transcript_variant
rs1002579898 -- 6,011,173(-) T/C 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for RANBP6 Gene

Variant ID Type Subtype PubMed ID
dgv1209n67 CNV gain 20364138
esv27855 CNV gain 19812545
nsv1015450 CNV loss 25217958
nsv1029665 CNV gain 25217958
nsv972646 CNV duplication 23825009

Variation tolerance for RANBP6 Gene

Residual Variation Intolerance Score: 11.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.13; 38.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RANBP6 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RANBP6 Gene

Disorders for RANBP6 Gene

Additional Disease Information for RANBP6

No disorders were found for RANBP6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RANBP6 Gene

Publications for RANBP6 Gene

  1. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. (PMID: 27432908) Li X … Wang W (Molecular & cellular proteomics : MCP 2016) 3 58
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal KB … Olsen JV (Science signaling 2015) 3 58

Products for RANBP6 Gene

Sources for RANBP6 Gene

Loading form....