Free for academic non-profit institutions. Other users need a Commercial license
RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene encodes a very large RAN-binding protein that immunolocalizes to the nuclear pore complex. The protein is a giant scaffold and mosaic cyclophilin-related nucleopor... See more...
Aliases for RANBP2 Gene
Aliases for RANBP2 Gene
External Ids for RANBP2 Gene
- HGNC: 9848
- Entrez Gene: 5903
- Ensembl: ENSG00000153201
- OMIM: 601181
- UniProtKB: P49792
Previous HGNC Symbols for RANBP2 Gene
- ANE1
Previous GeneCards Identifiers for RANBP2 Gene
- GC02P107241
- GC02P107814
- GC02P108911
- GC02P108957
- GC02P108794
- GC02P108702
- GC02P109335
- GC02P102934
Summaries for RANBP2 Gene
-
RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene encodes a very large RAN-binding protein that immunolocalizes to the nuclear pore complex. The protein is a giant scaffold and mosaic cyclophilin-related nucleoporin implicated in the Ran-GTPase cycle. The encoded protein directly interacts with the E2 enzyme UBC9 and strongly enhances SUMO1 transfer from UBC9 to the SUMO1 target SP100. These findings place sumoylation at the cytoplasmic filaments of the nuclear pore complex and suggest that, for some substrates, modification and nuclear import are linked events. This gene is partially duplicated in a gene cluster that lies in a hot spot for recombination on chromosome 2q. [provided by RefSeq, Jul 2008]
GeneCards Summary for RANBP2 Gene
RANBP2 (RAN Binding Protein 2) is a Protein Coding gene. Diseases associated with RANBP2 include Inflammatory Myofibroblastic Tumor and Familial Acute Necrotizing Encephalopathy. Among its related pathways are Metabolism of proteins and Mitotic Metaphase and Anaphase. Gene Ontology (GO) annotations related to this gene include RNA binding and peptidyl-prolyl cis-trans isomerase activity. An important paralog of this gene is RGPD5.
UniProtKB/Swiss-Prot Summary for RANBP2 Gene
-
E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:22194619, PubMed:15931224). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830).
Additional gene information for RANBP2 Gene
- Monarch Initiative
- Search for RANBP2 at DataMed
- Search for RANBP2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RANBP2 Gene
Genomics for RANBP2 Gene
GeneHancer (GH) Regulatory Elements for RANBP2 Gene
Promoters and enhancers for RANBP2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around RANBP2 on UCSC Golden Path with GeneCards custom track
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RANBP2
- Top Transcription factor binding sites by QIAGEN in the RANBP2 gene promoter:
-
- AP-1
- c-Fos
- c-Jun
- E47
- Nkx2-5
- p53
- Pax-5
- POU3F1
- Tal-1
Genomic Locations for RANBP2 Gene
Genomic Locations for RANBP2 Gene
- chr2:108,719,446-108,785,811
- (GRCh38/hg38)
- Size:
- 66,366 bases
- Orientation:
- Plus strand
- chr2:109,335,937-109,402,267
- (GRCh37/hg19)
- Size:
- 66,331 bases
- Orientation:
- Plus strand
Genomic View for RANBP2 Gene
Genes around RANBP2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q13 by HGNC
- 2q13 by Entrez Gene
- 2q13 by Ensembl
RANBP2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RANBP2 Gene
Proteins for RANBP2 Gene
-
Protein details for RANBP2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P49792-RBP2_HUMAN
- Recommended name:
- E3 SUMO-protein ligase RanBP2
- Protein Accession:
- P49792
- Q13074
- Q15280
- Q53TE2
- Q59FH7
Protein attributes for RANBP2 Gene
- Size:
- 3224 amino acids
- Molecular mass:
- 358199 Da
- Quaternary structure:
-
- Forms a complex with NXT1, NXF1 and RANGAP1 (PubMed:14729961). Forms a tight complex with RANBP1 and UBE2I (PubMed:15388847, PubMed:10078529, PubMed:15826666). Interacts with SUMO1 but not SUMO2 (PubMed:15388847, PubMed:10078529, PubMed:15826666). Interacts with PRKN (PubMed:16332688). Interacts with sumoylated RANGAP1 (PubMed:15378033, PubMed:10078529, PubMed:15826666). Interacts with CDCA8 (PubMed:19413330). Interacts with PML (isoform PML-4) (PubMed:22155184). Interacts with BICD2 (PubMed:20386726). Interacts with MCM3AP isoform GANP (PubMed:20005110).
Protein Expression for RANBP2 Gene
Selected DME Specific Peptides for RANBP2 Gene
- P49792:
-
- VKKIESFGS
- GLLSMAN
- KFEDENF
- TAENFRAL
- PRTAENF
- LCTGEKG
Post-translational modifications for RANBP2 Gene
- Polyubiquitinated by PRKN, which leads to proteasomal degradation.
- The inner channel of the NPC has a different redox environment from the cytoplasm and allows the formation of interchain disulfide bonds between some nucleoporins, the significant increase of these linkages upon oxidative stress reduces the permeability of the NPC.
-
Ubiquitination at Lys2125, Lys2396, Lys2522, and Lys2959
- NX_P49792 (NX_P49792-1)
- Modification sites at PhosphoSitePlus
Other Protein References for RANBP2 Gene
Antibody Products
- LifeSpan BioSciences RANBP2 / TRP1 Antibody (LS-B11329) and RANBP2 / TRP1 Antibody (LS-B15058)
- Creative Diagnostics Anti-RANBP2 monoclonal antibody, clone nBcdbn69496 [FITC]
- Creative Biolabs Recombinant Anti-Human RANBP2 Antibody
- Novus Biologicals Antibodies for RANBP2
-
Abcam antibodies for RANBP2
- Invitrogen Antibodies for RANBP2 (AFLGC-RANBP2)
- antibodies-online: Show 34 available RANBP2 Antibodies ranked by validation data
- Compare Top RANBP2 Antibodies
-
Recommended
- 12 IF (p) Antibodies (anti-human)
- 10 WB Antibodies (anti-human)
- 5 IHC (p) Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 1 IHC Antibody (anti-human)
- 12 IF (p) Antibodies (anti-mouse)
- 6 WB Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-rat)
- 4 WB Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
-
Boster Bio Antibodies for RANBP2
-
Santa Cruz Biotechnology (SCBT) Antibodies for RANBP2
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for RANBP2
- Origene Custom Protein Services for RANBP2
- Novus Biologicals proteins for RANBP2
-
Abcam proteins for RANBP2
Domains & Families for RANBP2 Gene
Gene Families for RANBP2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Plasma proteins
- Potential drug targets
- Predicted intracellular proteins
- Transporters
Protein Domains for RANBP2 Gene
- Blocks:
-
- Zn-finger, Ran-binding
- Peptidyl-prolyl cis-trans isomerase, cyclophilin type
- RanBP1 domain
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for RANBP2 Gene
- GenScript: Design optimal peptide antigens:
-
- p270 (RBP2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P49792UniProtKB/Swiss-Prot:
RBP2_HUMAN :- Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited.
- Belongs to the RanBP2 E3 ligase family.
- Domain:
-
- Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited.
- The PPIase cyclophilin-type domain has high structural similarity with PPIA, but has extremely low and barely detectable proline isomerase activity (in vitro) (PubMed:23353830). Only about half of the residues that surround the PPIA active site cleft are conserved.
- Family:
-
- Belongs to the RanBP2 E3 ligase family.
Function for RANBP2 Gene
Molecular function for RANBP2 Gene
- UniProtKB/Swiss-Prot Function:
- E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:22194619, PubMed:15931224). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830).
- GENATLAS Biochemistry:
- Ran (Ras-related small nuclear protein)component of the nuclear pore complex (NPC),involved in cell-cycle progression,nucleocytoplasmic transport,pre-mRNA processing
Enzyme Numbers (IUBMB) for RANBP2 Gene
Phenotypes From GWAS Catalog for RANBP2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | IEA | -- |
| GO:0003755 | NOT peptidyl-prolyl cis-trans isomerase activity | IEA,IDA | 20676357 |
| GO:0005096 | contributes_to GTPase activator activity | IBA | 21873635 |
| GO:0005515 | protein binding | IEA,IPI | 10078529 |
| GO:0008536 | Ran GTPase binding | IPI | 7603572 |
Phenotypes for RANBP2 Gene
- GenomeRNAi human phenotypes for RANBP2:
-
- Decreased DCP1a protein expression and assembly in processing bodies after arsenite stimulation
- Dynamic nuclei (hole, folded or small irregular)
- Strongly decreased NFAT1-GFP nuclear translocation
- Decreased HIV-1 infection
- Decreased shRNA abundance (Z-score < -2)
- Decreased viability of wild-type and TP53 knockout cells, decreased TP53 protein expression ratio (wild-type / TP53 knockout cells)
- Reduced mammosphere formation
- Increased shRNA abundance (Z-score > 2)
- Decreased p24 protein expression
- Decreased viability
- no effect
- Decreased Aire reporter expression
- Increased vaccinia virus (VACV) infection
- Nucleoplasmic pre-40S maturation defects
- Nuclear 40S maturation defects
- shRNA abundance <= 50%
- Decreased IL-8 secretion
- Increased transferrin (TF) endocytosis
Animal Model Products
-
Taconic Biosciences Mouse Models for RANBP2
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for RANBP2 - Select products 50% OFF >
- * RANBP2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for RANBP2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RANBP2
- genomics-online: gRNA clones - Search results for available RANBP2 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for RANBP2
miRNA for RANBP2 Gene
- miRTarBase miRNAs that target RANBP2
-
- hsa-mir-708-5p (MIRT037743)
- hsa-mir-106b-3p (MIRT038578)
- hsa-mir-421 (MIRT039354)
- hsa-mir-423-3p (MIRT042469)
- hsa-mir-186-5p (MIRT045244)
- hsa-mir-125b-5p (MIRT046041)
- hsa-let-7g-5p (MIRT046567)
- hsa-mir-92a-3p (MIRT049119)
- hsa-let-7e-5p (MIRT051582)
- hsa-let-7a-5p (MIRT052536)
- hsa-mir-7152-5p (MIRT654466)
- hsa-mir-3074-5p (MIRT654467)
- hsa-mir-1200 (MIRT654468)
- hsa-mir-378a-5p (MIRT654469)
- hsa-mir-539-5p (MIRT654470)
- hsa-mir-3124-3p (MIRT654471)
- hsa-mir-3140-5p (MIRT654472)
- hsa-mir-520h (MIRT654473)
- hsa-mir-520g-3p (MIRT654474)
- hsa-mir-3973 (MIRT654475)
- hsa-mir-551b-5p (MIRT654476)
- hsa-mir-6507-3p (MIRT654477)
- hsa-mir-4311 (MIRT654478)
- hsa-mir-4439 (MIRT654479)
- hsa-mir-943 (MIRT654480)
- hsa-mir-6826-3p (MIRT654481)
- hsa-mir-3136-5p (MIRT654482)
- hsa-mir-4667-3p (MIRT654483)
- hsa-mir-1470 (MIRT654484)
- hsa-mir-6795-3p (MIRT654485)
- hsa-mir-6887-3p (MIRT654486)
- hsa-mir-5003-5p (MIRT654487)
- hsa-mir-542-3p (MIRT711394)
- hsa-mir-4504 (MIRT711395)
- hsa-mir-642b-3p (MIRT711396)
- hsa-mir-642a-3p (MIRT711397)
- hsa-mir-4501 (MIRT711398)
- hsa-mir-8087 (MIRT711399)
- hsa-mir-7161-5p (MIRT711400)
- hsa-mir-548u (MIRT711401)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RANBP2
- Browse OriGene Inhibitory RNA Products For RANBP2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RANBP2
- genomics-online: shRNA clones - Search results for available RANBP2 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for RANBP2 - Select products 50% OFF >
- * RANBP2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Addgene plasmids for RANBP2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RANBP2
- genomics-online: cdna clones - Search results for available RANBP2 gene related products
- orf clones - Search results for available RANBP2 gene related products
No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for RANBP2 Gene
Localization for RANBP2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for RANBP2 Gene
- Nucleus. Nucleus membrane. Nucleus, nuclear pore complex. Nucleus envelope. Note=Detected in diffuse and discrete intranuclear foci (PubMed:11839768). Cytoplasmic filaments (PubMed:7775481). {ECO:0000269 PubMed:11839768, ECO:0000269 PubMed:7775481}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| mitochondrion | 3 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| endoplasmic reticulum | 2 |
| golgi apparatus | 2 |
| extracellular | 1 |
| peroxisome | 1 |
| endosome | 1 |
| lysosome | 1 |
- Nuclear membrane (4)
- Vesicles (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA | 21873635 |
| GO:0005635 | nuclear envelope | IEA,TAS | -- |
| GO:0005642 | annulate lamellae | IDA | 20386726 |
| GO:0005643 | nuclear pore | IBA,IDA | 17098863 |
| GO:0005737 | cytoplasm | IBA | 21873635 |
Pathways & Interactions for RANBP2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Transport of the SLBP independent Mature mRNA |
.55
|
|
| 2 | HIV Life Cycle |
.91
.64
|
.45
|
| 3 | Cell Cycle, Mitotic |
.83
|
.60
|
| 4 | Mitotic Prophase |
.57
|
|
| 5 | Influenza Viral RNA Transcription and Replication | ||
Pathways by source for RANBP2 Gene
3 BioSystems pathways for RANBP2 Gene
71 Reactome pathways for RANBP2 Gene
1 KEGG pathway for RANBP2 Gene
3 GeneGo (Thomson Reuters) pathways for RANBP2 Gene
- DNA damage Role of SUMO in p53 regulation
- Proteolysis Putative SUMO-1 pathway
- Transcription_P53 signaling pathway
2 Qiagen pathways for RANBP2 Gene
- Ran Pathway
- SUMO Pathway
UniProtKB/Swiss-Prot P49792-RBP2_HUMAN
- Pathway: Protein modification; protein sumoylation.
Interacting Proteins for RANBP2 Gene
Selected Interacting proteins:
P49792-RBP2_HUMAN
ENSP00000283195
for RANBP2 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for RANBP2
SIGNOR curated interactions for RANBP2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000413 | protein peptidyl-prolyl isomerization | IEA | -- |
| GO:0001975 | response to amphetamine | IEA | -- |
| GO:0006110 | regulation of glycolytic process | TAS | -- |
| GO:0006111 | regulation of gluconeogenesis | IEA | -- |
| GO:0006406 | mRNA export from nucleus | TAS | -- |
Drugs & Compounds for RANBP2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Guanosine triphosphate | Experimental | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for RANBP2 Gene
mRNA/cDNA for RANBP2 Gene
- 1 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000283195 11708 bps (ENST00000283195.11)
- ENST00000425282 367 bps (ENST00000425282.4)
- ENST00000495506 544 bps (ENST00000495506.1)
- ENST00000495924 646 bps (ENST00000495924.1)
- ENST00000629728 156 bps (ENST00000629728.1)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for RANBP2 - Select products 50% OFF >
- * RANBP2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for RANBP2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RANBP2
- genomics-online: gRNA clones - Search results for available RANBP2 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for RANBP2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RANBP2
- Browse OriGene Inhibitory RNA Products For RANBP2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RANBP2
- genomics-online: shRNA clones - Search results for available RANBP2 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for RANBP2 - Select products 50% OFF >
- * RANBP2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Addgene plasmids for RANBP2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RANBP2
- genomics-online: cdna clones - Search results for available RANBP2 gene related products
- orf clones - Search results for available RANBP2 gene related products
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | · | 16c | ^ | 17 | ^ | 18a | · | 18b | ^ | 19 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||||||||||
| SP6: |
Relevant External Links for RANBP2 Gene
- GeneLoc Exon Structure for
- RANBP2
Expression for RANBP2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Testis (Reproductive System)
- XY Germ Cells Testis Cord
-
Gonad
- XY Germ Cells Testis Cord
- Blood (Hematopoietic System)
This gene is overexpressed in Serum (28.2) and Peripheral blood mononuclear cells (9.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RANBP2 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RANBP2
SOURCE GeneReport for Unigene cluster for RANBP2 Gene:
Hs.199561Evidence on tissue expression from TISSUES for RANBP2 Gene
- Nervous system(4.8)
- Liver(4.4)
- Blood(4.2)
- Eye(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for RANBP2 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- nervous
- respiratory
- skeletal muscle
Regions:
Head and neck:
- brain
- cerebrospinal fluid
- head
- meninges
- neck
Thorax:
- lung
Limb:
- lower limb
- upper limb
General:
- spinal cord
Primer Products
-
OriGene qPCR primer pairs for RANBP2
- genomics-online: primer clones - Search results for available RANBP2 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RANBP2 Gene
Orthologs for RANBP2 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | RANBP2 31 30 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | RANBP2 31 30 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Ranbp2 31 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | RANBP2 31 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | RANBP2 31 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | RANBP2 31 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | -- 31 |
|
ManyToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.7285 30 |
|
||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.1708 30 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | Dr.29687 30 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Cyp1 32 |
|
|
|
| CG5071 31 |
|
OneToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | T22F3.12 31 |
|
ManyToMany | |
| Y17G9B.4 31 |
|
ManyToMany | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | YRB1 33 |
|
|
|
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for RANBP2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for RANBP2 Gene
- ENSEMBL:
- Gene Tree for RANBP2 (if available)
- TreeFam:
- Gene Tree for RANBP2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for RANBP2: view image
Paralogs for RANBP2 Gene
Paralogs for RANBP2 Gene
(26) SIMAP similar genes for RANBP2 Gene using alignment to 2 proteins:
- RBP2_HUMAN
- F8WBP7_HUMAN
Variants for RANBP2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RANBP2 Gene
| SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 639153 | Uncertain Significance: Encephalopathy, acute, infection-induced, 3, suceptibility to | 108,763,534(+) | A/G | MISSENSE_VARIANT | |
| 639815 | Uncertain Significance: Encephalopathy, acute, infection-induced, 3, suceptibility to | 108,765,749(+) | A/G | MISSENSE_VARIANT | |
| 640266 | Uncertain Significance: Encephalopathy, acute, infection-induced, 3, suceptibility to | 108,719,626(+) | A/C | MISSENSE_VARIANT | |
| 641155 | Uncertain Significance: Encephalopathy, acute, infection-induced, 3, suceptibility to | 108,768,229(+) | G/T | MISSENSE_VARIANT | |
| 641524 | Uncertain Significance: Encephalopathy, acute, infection-induced, 3, suceptibility to | 108,736,169(+) | C/G | MISSENSE_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv4036n100 | CNV | gain | 25217958 |
| esv2720498 | CNV | deletion | 23290073 |
| nsv1149522 | OTHER | inversion | 26484159 |
| nsv961856 | CNV | duplication | 23825009 |
| nsv963685 | CNV | duplication | 23825009 |
| nsv963686 | CNV | duplication | 23825009 |
| nsv963832 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
8.81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.15;
75.76% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RANBP2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RANBP2 Gene
Disorders for RANBP2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| inflammatory myofibroblastic tumor |
|
|
| familial acute necrotizing encephalopathy |
|
|
| encephalopathy, acute, infection-induced 4 |
|
|
| encephalopathy |
|
|
| influenza |
|
|
Search RANBP2 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
RBP2_HUMAN- Encephalopathy, acute, infection-induced, 3 (IIAE3) [MIM:608033]: A rapidly progressive encephalopathy manifesting in susceptible individuals with seizures and coma. It can occur within days in otherwise healthy children after common viral infections such as influenza and parainfluenza, without evidence of viral infection of the brain or inflammatory cell infiltration. Brain T2-weighted magnetic resonance imaging reveals characteristic symmetric lesions present in the thalami, pons and brainstem. {ECO:0000269 PubMed:19118815}. Note=The disease is caused by mutations affecting the gene represented in this entry. Mutations in the RANBP2 gene predispose to IIAE3, but by themselves are insufficient to make the phenotype fully penetrant; additional genetic and environmental factors are required (PubMed:19118815). {ECO:0000269 PubMed:19118815}.
Additional Disease Information for RANBP2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for RANBP2 Gene
Publications for RANBP2 Gene
- Infection-triggered familial or recurrent cases of acute necrotizing encephalopathy caused by mutations in a component of the nuclear pore, RANBP2. (PMID: 19118815) Neilson DE … Warman ML (American journal of human genetics 2009) 2 3 4 23 54
- Bicaudal D2, dynein, and kinesin-1 associate with nuclear pore complexes and regulate centrosome and nuclear positioning during mitotic entry. (PMID: 20386726) Splinter D … Akhmanova A (PLoS biology 2010) 3 4 23 54
- Parkin ubiquitinates and promotes the degradation of RanBP2. (PMID: 16332688) Um JW … Chung KC (The Journal of biological chemistry 2006) 3 4 23 54
- Unique binding interactions among Ubc9, SUMO and RanBP2 reveal a mechanism for SUMO paralog selection. (PMID: 15608651) Tatham MH … Hay RT (Nature structural & molecular biology 2005) 3 4 23 54
- Solution structure of the Ran-binding domain 2 of RanBP2 and its interaction with the C terminus of Ran. (PMID: 15826666) Geyer JP … Kalbitzer HR (Journal of molecular biology 2005) 3 4 23 54
ExternalLinks
Products for RANBP2 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for RANBP2
- Origene Custom Protein Services for RANBP2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RANBP2
- Browse OriGene Inhibitory RNA Products For RANBP2
- OriGene qPCR primer pairs for RANBP2
- OriGene CRISPR knockouts for RANBP2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For RANBP2
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for RANBP2
- Novus Biologicals proteins for RANBP2
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for RANBP2
- Abcam proteins for RANBP2
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Taconic Biosciences Mouse Models for RANBP2
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for RANBP2 (AFLGC-RANBP2)
- VectorBuilder Custom and pre-made DNA vectors for RANBP2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for RANBP2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for RANBP2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for RANBP2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for RANBP2
- Addgene plasmids for RANBP2
- antibodies-online: Show 34 available RANBP2 Antibodies ranked by validation data
- Compare Top RANBP2 Antibodies
- Recommended
- 12 IF (p) Antibodies (anti-human)
- 10 WB Antibodies (anti-human)
- 5 IHC (p) Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 1 IHC Antibody (anti-human)
- 12 IF (p) Antibodies (anti-mouse)
- 6 WB Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-rat)
- 4 WB Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- antibodies-online: Search results for available RANBP2 related products ranked by validation data
- antibodies-online: Search results for available RANBP2 related products ranked by validation data
- Santa Cruz Biotechnology (SCBT) Antibodies for RANBP2
- Search Santa Cruz Biotechnology (SCBT) for RANBP2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for RANBP2
- genomics-online: cdna clones - Search results for available RANBP2 gene related products
- orf clones - Search results for available RANBP2 gene related products
- genomics-online: gRNA clones - Search results for available RANBP2 gene related products
- genomics-online: primer clones - Search results for available RANBP2 gene related products
- genomics-online: shRNA clones - Search results for available RANBP2 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RANBP2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RANBP2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for RANBP2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RANBP2
- Boster Bio Antibodies for RANBP2
- Browse Boster Bio ELISA Kits
Sources for RANBP2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) H-invDB
- (47) HORDE
- (48) HUGE
- (49) IMGT
- (50) Leiden
- (51) miRBase
- (52) DME
- (53) OriGene
- (54) PubMed
- (55) R&D Systems
- (56) TGDB
- (57) Tocris
- (58) Abcam
- (59) Novus Biologicals
- (60) ProSpec
- (61) Sino Biological
- (62) GenScript
- (63) Qiagen
- (64) OCA
- (65) Proteopedia
- (66) MOPED
- (67) neXtProt
- (68) Reactome
- (69) GeneGo (Thomson Reuters)
- (70) DISEASES
- (71) SIMAP
- (72) GenomeRNAi
- (73) LifeMap
- (74) miRTarBase
- (75) MalaCards
- (76) Invitrogen
- (77) BitterDB
- (78) ESI-BIO
- (79) RefSeq
- (80) BioSystems
- (81) MaxQB
- (82) IUPHAR
- (83) BioGPS
- (84) Illumina
- (85) COMPARTMENTS
- (86) HOMER
- (87) PaxDb
- (88) ApexBio
- (89) Addgene
- (90) antibodies-online
- (91) CYP
- (92) NONCODE
- (93) TreeFam
- (94) PathCards
- (95) GeneReviews
- (96) GeneTex
- (97) Taconic Biosciences
- (98) GTEx
- (99) ProteomicsDB
- (100) SCBT
- (101) DGIdb
- (102) ClinicalTrials
- (103) RVIS
- (104) SIGNOR
- (105) diseasecard
- (106) NIH Rare Diseases
- (107) Orphanet
- (108) UMLS
- (109) GTR
- (110) Disease Ontology
- (111) Genetics Home Reference
- (112) MeSH
- (113) MedlinePlus
- (114) CDC
- (115) NINDS
- (116) NCBI Bookshelf
- (117) ClinVar
- (118) Gene Damage Index
- (119) HPO
- (120) UDN
- (121) VISTA
- (122) FANTOM5
- (123) ENCODE
- (124) ProSci
- (125) Horizon
- (126) The Signaling Pathways Project (SPP)
- (127) IID
- (128) VectorBuilder
- (129) SNPedia
- (130) BRCA Exchange
- (131) CIViC
- (132) ProteoGenix
- (133) dbSUPER
- (134) TISSUES
- (135) Gene ORGANizer
- (136) abm
- (137) Human Protein Atlas
- (138) GWAS Catalog
- (139) Monarch Initiative
- (140) DataMed
- (141) HumanCyc
- (142) genomics-online
- (143) UCNEbase
- (144) EPDnew
- (145) Applied Biosystems
- (146) GlyConnect
- (147) Aminode
- (148) GeneCopoeia
- (149) GPS-Prot
- (150) RNACentral
- (151) LncRNADisease
- (152) LOVD
- (153) miR2Disease
- (154) DiseaseEnhancer
- (155) Boster Bio
- (156) Biorbyt
- (157) Biocompare
- (158) Mastermind
- (159) CTD^2 Dashboard
- (160) CraniofacialAtlas
- (161) GeneImprint
- (162) Synthego
- (163) Bio Basic
- (164) ENA
- (165) GtRNAdb
- (166) LncBase
- (167) LncBook
- (168) LNCipedia
- (169) LncRNAdb
- (170) Modomics
- (171) PDBe
- (172) Rfam
- (173) SILVA
- (174) snOPY
- (175) SRPDB
- (176) GENCODE
- (177) TarBase
- (178) MyBioSource
- (179) Signalway Antibody