Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RANBP17 Gene

Aliases for RANBP17 Gene

  • RAN Binding Protein 17 2 3 5

External Ids for RANBP17 Gene

Previous GeneCards Identifiers for RANBP17 Gene

  • GC05P170523
  • GC05P170991
  • GC05P170224
  • GC05P170270
  • GC05P170271
  • GC05P170237
  • GC05P170221
  • GC05P165386

Summaries for RANBP17 Gene

Entrez Gene Summary for RANBP17 Gene

  • The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-17 is a member of the importin-beta superfamily of nuclear transport receptors.[supplied by OMIM, Jul 2002]

GeneCards Summary for RANBP17 Gene

RANBP17 (RAN Binding Protein 17) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include GTP binding and Ran GTPase binding. An important paralog of this gene is XPO7.

UniProtKB/Swiss-Prot for RANBP17 Gene

  • May function as a nuclear transport receptor.

Additional gene information for RANBP17 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RANBP17 Gene

Genomics for RANBP17 Gene

GeneHancer (GH) Regulatory Elements for RANBP17 Gene

Promoters and enhancers for RANBP17 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I170861 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE 550.8 +0.7 672 2.3 SIN3A ZNF76 YBX1 ZBTB7B ZNF335 ZNF143 RCOR1 EGR2 SMARCA5 SP3 RANBP17 GABRP LOC100419059 RN7SL623P
GH05I169969 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 9.9 -890.9 -890866 2.8 JUN MAX ATF2 NR2F2 SP1 ZNF23 JUND GATA3 CREB1 FOSL2 FAM196B ENSG00000253269 RANBP17 DOCK2
GH05I170772 Enhancer 0.6 ENCODE dbSUPER 10 -88.6 -88563 1.8 ZIC2 MAFK GC05P170775 RANBP17 RN7SL623P ENSG00000253348 GABRP
GH05I170791 Enhancer 0.5 ENCODE 10.2 -70.3 -70338 0.2 ZNF335 CTCF ZNF654 RFX1 ZNF143 SMC3 RAD21 GABRP RANBP17 RN7SL623P ENSG00000253858 ENSG00000253348 GC05P170775
GH05I171131 Enhancer 0.6 UCNEbase 6.6 +270.0 270026 0.3 PKNOX1 PRDM6 POLR2A RANBP17 GC05P171081 GC05P171202
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RANBP17 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RANBP17 gene promoter:

Genomic Locations for RANBP17 Gene

Genomic Locations for RANBP17 Gene
438,581 bases
Plus strand

Genomic View for RANBP17 Gene

Genes around RANBP17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RANBP17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RANBP17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RANBP17 Gene

Proteins for RANBP17 Gene

  • Protein details for RANBP17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ran-binding protein 17
    Protein Accession:
    Secondary Accessions:
    • Q8IU74

    Protein attributes for RANBP17 Gene

    1088 amino acids
    Molecular mass:
    124375 Da
    Quaternary structure:
    • Binds to nucleoporins and the GTP-bound form of Ran.
    • Sequence=BAB55427.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RANBP17 Gene


neXtProt entry for RANBP17 Gene

Post-translational modifications for RANBP17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RANBP17 Gene

Domains & Families for RANBP17 Gene

Gene Families for RANBP17 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for RANBP17 Gene

Suggested Antigen Peptide Sequences for RANBP17 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the exportin family.
  • Belongs to the exportin family.
genes like me logo Genes that share domains with RANBP17: view

Function for RANBP17 Gene

Molecular function for RANBP17 Gene

UniProtKB/Swiss-Prot Function:
May function as a nuclear transport receptor.

Phenotypes From GWAS Catalog for RANBP17 Gene

Gene Ontology (GO) - Molecular Function for RANBP17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005049 nuclear export signal receptor activity IBA --
GO:0005525 GTP binding NAS 11024021
GO:0008536 Ran GTPase binding IEA,IBA --
genes like me logo Genes that share ontologies with RANBP17: view

Phenotypes for RANBP17 Gene

genes like me logo Genes that share phenotypes with RANBP17: view

Animal Model Products

CRISPR Products

miRNA for RANBP17 Gene

miRTarBase miRNAs that target RANBP17

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RANBP17 Gene

Localization for RANBP17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RANBP17 Gene

Cytoplasm. Nucleus. Nucleus, nuclear pore complex.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RANBP17 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 1
peroxisome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear bodies (2)
  • Nuclear membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RANBP17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005643 nuclear pore IBA,NAS 11024021
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with RANBP17: view

Pathways & Interactions for RANBP17 Gene

SuperPathways for RANBP17 Gene

No Data Available

SIGNOR curated interactions for RANBP17 Gene


Gene Ontology (GO) - Biological Process for RANBP17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006606 protein import into nucleus NAS 11024021
GO:0006611 protein export from nucleus IBA --
GO:0006810 transport IEA --
GO:0006886 intracellular protein transport IEA --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with RANBP17: view

No data available for Pathways by source for RANBP17 Gene

Drugs & Compounds for RANBP17 Gene

(1) Drugs for RANBP17 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RANBP17: view

Transcripts for RANBP17 Gene

Unigene Clusters for RANBP17 Gene

RAN binding protein 17:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for RANBP17 Gene

No ASD Table

Relevant External Links for RANBP17 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RANBP17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RANBP17 Gene

mRNA differential expression in normal tissues according to GTEx for RANBP17 Gene

This gene is overexpressed in Testis (x5.1).

Protein differential expression in normal tissues from HIPED for RANBP17 Gene

This gene is overexpressed in Testis (41.2) and Brain (17.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RANBP17 Gene

Protein tissue co-expression partners for RANBP17 Gene

NURSA nuclear receptor signaling pathways regulating expression of RANBP17 Gene:


SOURCE GeneReport for Unigene cluster for RANBP17 Gene:


mRNA Expression by UniProt/SwissProt for RANBP17 Gene:

Tissue specificity: Highly expressed in testis, moderately in pancreas and weakly in other tissues studied.

Evidence on tissue expression from TISSUES for RANBP17 Gene

  • Thyroid gland(4.2)
genes like me logo Genes that share expression patterns with RANBP17: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for RANBP17 Gene

Orthologs for RANBP17 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RANBP17 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RANBP17 33 34
  • 99.63 (n)
(Canis familiaris)
Mammalia RANBP17 33 34
  • 94.39 (n)
(Bos Taurus)
Mammalia RANBP17 33 34
  • 93.85 (n)
(Rattus norvegicus)
Mammalia Ranbp17 33
  • 90.2 (n)
(Mus musculus)
Mammalia Ranbp17 33 16 34
  • 89.98 (n)
(Ornithorhynchus anatinus)
Mammalia RANBP17 34
  • 89 (a)
(Monodelphis domestica)
Mammalia RANBP17 34
  • 87 (a)
(Gallus gallus)
Aves LOC769940 33
  • 76.94 (n)
RANBP17 34
  • 72 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 84 (a)
-- 34
  • 80 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ranbp16 34
  • 53 (a)
(Caenorhabditis elegans)
Secernentea C35A5.8 35 34
  • 40 (a)
(Triticum aestivum)
Liliopsida Ta.23305 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 51 (a)
Species where no ortholog for RANBP17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • zebrafish (Danio rerio)

Evolution for RANBP17 Gene

Gene Tree for RANBP17 (if available)
Gene Tree for RANBP17 (if available)

Paralogs for RANBP17 Gene

Paralogs for RANBP17 Gene

(2) SIMAP similar genes for RANBP17 Gene using alignment to 9 proteins: Pseudogenes for RANBP17 Gene

genes like me logo Genes that share paralogs with RANBP17: view

Variants for RANBP17 Gene

Sequence variations from dbSNP and Humsavar for RANBP17 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000002188 -- 171,020,376(+) C/A genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant
rs1000005393 -- 171,236,181(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000006793 -- 171,160,989(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000011330 -- 171,292,243(+) C/A genic_downstream_transcript_variant, intron_variant
rs1000012964 -- 171,111,018(+) C/A/G genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RANBP17 Gene

Variant ID Type Subtype PubMed ID
esv1010423 CNV deletion 20482838
esv1782186 CNV deletion 17803354
esv2731086 CNV deletion 23290073
esv2731087 CNV deletion 23290073
esv2731088 CNV deletion 23290073
esv2762567 CNV loss 21179565
esv3306589 CNV mobile element insertion 20981092
esv3410773 CNV insertion 20981092
esv3570550 CNV loss 25503493
esv3570551 CNV loss 25503493
esv3575897 CNV gain 25503493
esv3607572 CNV loss 21293372
esv3607573 CNV loss 21293372
esv3607574 CNV loss 21293372
esv3607575 CNV gain 21293372
esv3607576 CNV loss 21293372
esv3607577 CNV loss 21293372
esv6863 CNV gain 19470904
nsv1028839 CNV gain 25217958
nsv1074346 CNV deletion 25765185
nsv328840 CNV deletion 16902084
nsv507308 OTHER sequence alteration 20534489
nsv508386 CNV deletion 20534489
nsv5129 CNV deletion 18451855
nsv5130 CNV insertion 18451855
nsv5131 CNV deletion 18451855
nsv518091 CNV loss 19592680
nsv520782 CNV gain 19592680
nsv525376 CNV loss 19592680
nsv600262 CNV gain 21841781
nsv830550 CNV loss 17160897
nsv955881 CNV deletion 24416366
nsv969013 CNV duplication 23825009

Variation tolerance for RANBP17 Gene

Residual Variation Intolerance Score: 54.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.57; 65.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RANBP17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RANBP17 Gene

Disorders for RANBP17 Gene

Additional Disease Information for RANBP17

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for RANBP17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RANBP17 Gene

Publications for RANBP17 Gene

  1. Identification of two novel RanGTP-binding proteins belonging to the importin beta superfamily. (PMID: 11024021) Kutay U … Bischoff FR (The Journal of biological chemistry 2000) 2 3 4 58
  2. Identification of a novel putative Ran-binding protein and its close homologue. (PMID: 11071879) Koch P … Janssen JW (Biochemical and biophysical research communications 2000) 3 4 22 58
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for RANBP17 Gene

Sources for RANBP17 Gene

Loading form....