RAN is a small GTPase involved in the assembly of microtubules to form mitotic spindles. The protein encoded by this gene is a cytoplasmic guanine nucleotide exchange factor (GEF) that binds beta-tubulin and has GEF activity toward RAN. The encoded protein plays a role in the formation of noncentrosomal microtubules. In addition, this protein may be involved in the regulation o... See more...

Aliases for RANBP10 Gene

Aliases for RANBP10 Gene

  • RAN Binding Protein 10 2 3 5
  • Ran-Binding Protein 10 3 4
  • KIAA1464 4
  • RanBP10 4

External Ids for RANBP10 Gene

Previous GeneCards Identifiers for RANBP10 Gene

  • GC16M067533
  • GC16M066314
  • GC16M053629

Summaries for RANBP10 Gene

Entrez Gene Summary for RANBP10 Gene

  • RAN is a small GTPase involved in the assembly of microtubules to form mitotic spindles. The protein encoded by this gene is a cytoplasmic guanine nucleotide exchange factor (GEF) that binds beta-tubulin and has GEF activity toward RAN. The encoded protein plays a role in the formation of noncentrosomal microtubules. In addition, this protein may be involved in the regulation of D(1) receptor signaling by protein kinase C delta and protein kinase C gamma. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

GeneCards Summary for RANBP10 Gene

RANBP10 (RAN Binding Protein 10) is a Protein Coding gene. Diseases associated with RANBP10 include Penicilliosis and Leech Infestation. Among its related pathways are Signaling by GPCR and Development HGF signaling pathway. Gene Ontology (GO) annotations related to this gene include beta-tubulin binding and Ran guanyl-nucleotide exchange factor activity. An important paralog of this gene is RANBP9.

UniProtKB/Swiss-Prot Summary for RANBP10 Gene

  • May act as an adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation (PubMed:18222118). Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase. May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function (By similarity).

Additional gene information for RANBP10 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RANBP10 Gene

Genomics for RANBP10 Gene

GeneHancer (GH) Regulatory Elements for RANBP10 Gene

Promoters and enhancers for RANBP10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J067803 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +0.8 772 3.8 FOXK2 ZBTB40 ZNF217 SIN3A NRF1 TCF12 POLR2G SP1 NCOR1 GTF2E2 RANBP10 TSNAXIP1 CTCF PRMT7 ENSG00000270165 RF00017-2109
GH16J067808 Enhancer 0.3 Ensembl 500.7 -1.9 -1949 0.4 ZNF335 RANBP10 TSNAXIP1 PRMT7 piR-44130 RF00017-2109
GH16J067841 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas 24.3 -38.3 -38305 7.5 HNRNPK ZBTB40 ZNF217 EP300 CTCF SIN3A TCF12 NRF1 ZNF300 USF1 NUTF2 ZDHHC1 EDC4 ENKD1 NAE1 CENPT RANBP10 ACD CTCF ZFP90
GH16J067934 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 18.6 -129.6 -129615 4 FOXK2 ZBTB40 SIN3A NRF1 MYC POLR2G USF1 SP1 NCOR1 GTF2E2 ENSG00000261884 PSMB10 lnc-PSKH1-1 PSKH1 E2F4 CTCF EDC4 NFATC3 SLC12A4 RANBP10
GH16J067854 Promoter/Enhancer 1.5 FANTOM5 Ensembl ENCODE 22.2 -50.5 -50515 4.4 EP300 ZNF217 USF1 NCOR1 FOS ZIC2 CLOCK ZBTB11 RFX1 CUX1 ENSG00000262141 RANBP10 ACD NRN1L TSNAXIP1 DUS2 PSKH1 PARD6A RIPOR1 PRMT7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RANBP10 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RANBP10

Top Transcription factor binding sites by QIAGEN in the RANBP10 gene promoter:
  • AML1a
  • ATF
  • E47
  • Egr-2
  • MIF-1
  • Nkx3-1
  • NRF-2
  • RSRFC4
  • Tal-1

Genomic Locations for RANBP10 Gene

Genomic Locations for RANBP10 Gene
chr16:67,723,070-67,806,652
(GRCh38/hg38)
Size:
83,583 bases
Orientation:
Minus strand
chr16:67,757,005-67,840,555
(GRCh37/hg19)
Size:
83,551 bases
Orientation:
Minus strand

Genomic View for RANBP10 Gene

Genes around RANBP10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RANBP10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RANBP10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RANBP10 Gene

Proteins for RANBP10 Gene

  • Protein details for RANBP10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6VN20-RBP10_HUMAN
    Recommended name:
    Ran-binding protein 10
    Protein Accession:
    Q6VN20
    Secondary Accessions:
    • A4FTY2
    • B4DID0
    • B4DQH9
    • E7EW27
    • Q9P264

    Protein attributes for RANBP10 Gene

    Size:
    620 amino acids
    Molecular mass:
    67257 Da
    Quaternary structure:
    • May form homodimers (PubMed:18222118). Identified in the CTLH complex that contains GID4, RANBP9 and/or RANBP10, MKLN1, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, ARMC8, WDR26 and YPEL5 (PubMed:29911972). Within this complex, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, WDR26, and RANBP9 and/or RANBP10 form the catalytic core, while GID4, MKLN1, ARMC8 and YPEL5 have ancillary roles (PubMed:29911972). Interacts with RAN and RANBP9 (PubMed:14684163, PubMed:18222118). Interacts with the HGF receptor MET (PubMed:14684163). Interacts with AR (PubMed:18222118). Interacts with TUBB1 (PubMed:18347012). Interacts with YPEL5 (PubMed:20580816). May interact with TUBB5 (By similarity). Interacts with DDX4 (By similarity).
    SequenceCaution:
    • Sequence=BAA95988.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for RANBP10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RANBP10 Gene

Post-translational modifications for RANBP10 Gene

  • Ubiquitination at Lys293 and Lys333
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RANBP10 Gene

Domains & Families for RANBP10 Gene

Gene Families for RANBP10 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RANBP10 Gene

Blocks:
  • Lissencephaly type-1-like homology motif
  • CTLH, C-terminal to LisH motif
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RANBP10 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ31165 fis, clone KIDNE1000121, highly similar to Homo sapiens RAN binding protein 10 (RANBP10), mRNA (B3KP49_HUMAN)
  • cDNA FLJ57982, highly similar to Homo sapiens RAN binding protein 10 (RANBP10), mRNA (B4DHL9_HUMAN)
  • cDNA FLJ58184, highly similar to Homo sapiens RAN binding protein 10 (RANBP10), mRNA (B4DID0_HUMAN)
  • cDNA FLJ58041, highly similar to Homo sapiens RAN binding protein 10 (RANBP10), mRNA (B4DQH9_HUMAN)
  • Ran-binding protein 10 (RBP10_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6VN20

UniProtKB/Swiss-Prot:

RBP10_HUMAN :
  • The SPRY domain mediates the interaction with MET.
  • Belongs to the RANBP9/10 family.
Domain:
  • The SPRY domain mediates the interaction with MET.
Family:
  • Belongs to the RANBP9/10 family.
genes like me logo Genes that share domains with RANBP10: view

Function for RANBP10 Gene

Molecular function for RANBP10 Gene

UniProtKB/Swiss-Prot Function:
May act as an adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation (PubMed:18222118). Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase. May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function (By similarity).

Phenotypes From GWAS Catalog for RANBP10 Gene

Gene Ontology (GO) - Molecular Function for RANBP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI,IEA 20580816
genes like me logo Genes that share ontologies with RANBP10: view
genes like me logo Genes that share phenotypes with RANBP10: view

Animal Models for RANBP10 Gene

MGI Knock Outs for RANBP10:

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RANBP10 Gene

Localization for RANBP10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RANBP10 Gene

Cytoplasm, cytosol. Nucleus. Note=Predominantly cytoplasmic.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RANBP10 gene
Compartment Confidence
cytosol 5
nucleus 4
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for RANBP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IDA 29911972
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RANBP10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RANBP10 Gene

Pathways & Interactions for RANBP10 Gene

genes like me logo Genes that share pathways with RANBP10: view

Pathways by source for RANBP10 Gene

Gene Ontology (GO) - Biological Process for RANBP10 Gene

None

No data available for SIGNOR curated interactions for RANBP10 Gene

Drugs & Compounds for RANBP10 Gene

No Compound Related Data Available

Transcripts for RANBP10 Gene

mRNA/cDNA for RANBP10 Gene

4 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RANBP10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16
SP1:
SP2: - -
SP3:
SP4: -
SP5:
SP6:

Relevant External Links for RANBP10 Gene

GeneLoc Exon Structure for
RANBP10

Expression for RANBP10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RANBP10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RANBP10 Gene

This gene is overexpressed in Liver (8.9) and Pancreas (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RANBP10 Gene



Protein tissue co-expression partners for RANBP10 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RANBP10

SOURCE GeneReport for Unigene cluster for RANBP10 Gene:

Hs.368569

mRNA Expression by UniProt/SwissProt for RANBP10 Gene:

Q6VN20-RBP10_HUMAN
Tissue specificity: Broadly expressed, with highest levels in skeletal muscle.

Evidence on tissue expression from TISSUES for RANBP10 Gene

  • Nervous system(4.7)
  • Liver(4.3)
  • Lung(2.2)
genes like me logo Genes that share expression patterns with RANBP10: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RANBP10 Gene

Orthologs for RANBP10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RANBP10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RANBP10 31 30
  • 99.68 (n)
OneToOne
dog
(Canis familiaris)
Mammalia RANBP10 31 30
  • 93.6 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RANBP10 31 30
  • 93.49 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ranbp10 30
  • 91.99 (n)
mouse
(Mus musculus)
Mammalia Ranbp10 17 31 30
  • 91.72 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RANBP10 31
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RANBP10 31
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves RANBP10 31 30
  • 80.46 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RANBP10 31
  • 85 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ranbp10 31 30
  • 75.91 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta RanBPM 31
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y54E5A.7 31
  • 23 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VID30 33 31
  • 13 (a)
Species where no ortholog for RANBP10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RANBP10 Gene

ENSEMBL:
Gene Tree for RANBP10 (if available)
TreeFam:
Gene Tree for RANBP10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RANBP10: view image

Paralogs for RANBP10 Gene

Paralogs for RANBP10 Gene

(1) SIMAP similar genes for RANBP10 Gene using alignment to 9 proteins:

  • RBP10_HUMAN
  • B3KP49_HUMAN
  • B4DHL9_HUMAN
  • B4DID0_HUMAN
  • B4DQH9_HUMAN
  • R4GMX7_HUMAN
  • R4GMX8_HUMAN
  • R4GN91_HUMAN
  • R4GNA3_HUMAN
genes like me logo Genes that share paralogs with RANBP10: view

Variants for RANBP10 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RANBP10 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
689677 Uncertain Significance: Marfanoid habitus and intellectual disability 67,729,452(-) C/T MISSENSE_VARIANT
770255 Benign: not provided 67,806,363(-) G/A SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT
779167 Benign: not provided 67,729,795(-) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for RANBP10 Gene

Structural Variations from Database of Genomic Variants (DGV) for RANBP10 Gene

Variant ID Type Subtype PubMed ID
esv2662518 CNV deletion 23128226
esv3638893 CNV loss 21293372
nsv1842 CNV insertion 18451855
nsv522852 CNV gain 19592680
nsv524363 CNV loss 19592680
nsv572907 CNV loss 21841781
nsv952047 CNV deletion 24416366

Variation tolerance for RANBP10 Gene

Residual Variation Intolerance Score: 21.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.77; 33.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RANBP10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RANBP10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RANBP10 Gene

Disorders for RANBP10 Gene

MalaCards: The human disease database

(3) MalaCards diseases for RANBP10 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
penicilliosis
leech infestation
  • hirudiniasis
lissencephaly
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for RANBP10

genes like me logo Genes that share disorders with RANBP10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RANBP10 Gene

Publications for RANBP10 Gene

  1. A novel MET-interacting protein shares high sequence similarity with RanBPM, but fails to stimulate MET-induced Ras/Erk signaling. (PMID: 14684163) Wang D … Wu G (Biochemical and biophysical research communications 2004) 2 3 4 54
  2. The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation. (PMID: 29911972) Lampert F … Peter M (eLife 2018) 3 4 54
  3. YPEL5 protein of the YPEL gene family is involved in the cell cycle progression by interacting with two distinct proteins RanBPM and RanBP10. (PMID: 20580816) Hosono K … Minoshima S (Genomics 2010) 3 4 54
  4. RanBP10 is a cytoplasmic guanine nucleotide exchange factor that modulates noncentrosomal microtubules. (PMID: 18347012) Schulze H … Shivdasani RA (The Journal of biological chemistry 2008) 3 4 54
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54

Products for RANBP10 Gene

Sources for RANBP10 Gene