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Aliases for RANBP10 Gene

Aliases for RANBP10 Gene

  • RAN Binding Protein 10 2 3 5
  • KIAA1464 4
  • RanBP10 4

External Ids for RANBP10 Gene

Previous GeneCards Identifiers for RANBP10 Gene

  • GC16M067533
  • GC16M066314
  • GC16M053629

Summaries for RANBP10 Gene

Entrez Gene Summary for RANBP10 Gene

  • RAN is a small GTPase involved in the assembly of microtubules to form mitotic spindles. The protein encoded by this gene is a cytoplasmic guanine nucleotide exchange factor (GEF) that binds beta-tubulin and has GEF activity toward RAN. The encoded protein plays a role in the formation of noncentrosomal microtubules. In addition, this protein may be involved in the regulation of D(1) receptor signaling by protein kinase C delta and protein kinase C gamma. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

GeneCards Summary for RANBP10 Gene

RANBP10 (RAN Binding Protein 10) is a Protein Coding gene. Among its related pathways are MET promotes cell motility and Development HGF signaling pathway. Gene Ontology (GO) annotations related to this gene include beta-tubulin binding and Ran guanyl-nucleotide exchange factor activity. An important paralog of this gene is RANBP9.

UniProtKB/Swiss-Prot for RANBP10 Gene

  • Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase (By similarity). May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function (By similarity). May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation. In contrast to RANBP9, does not interact with Sos and does not activate the Ras pathway.

Additional gene information for RANBP10 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RANBP10 Gene

Genomics for RANBP10 Gene

GeneHancer (GH) Regulatory Elements for RANBP10 Gene

Promoters and enhancers for RANBP10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I067803 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.9 853 3.7 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 RANBP10 TSNAXIP1 PRMT7 ENSG00000270165
GH16I067934 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 22.9 -129.6 -129615 4 HDGF PKNOX1 SMAD1 ARNT MLX ZFP64 ARID4B SIN3A FEZF1 ZNF2 ENSG00000261884 GC16P067936 PSMB10 EDC4 E2F4 NFATC3 RANBP10 ENSG00000263276 ENSG00000260891 ENSG00000270165
GH16I067841 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 21.3 -38.3 -38337 7.5 ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC ZNF610 THAP11 NUTF2 ZDHHC1 ENKD1 NAE1 EDC4 RANBP10 ZFP90 CTCF ENSG00000262514
GH16I067555 Enhancer 1.3 Ensembl ENCODE dbSUPER 31.3 +250.3 250344 2 ZNF493 ZFP64 ZNF121 ZNF213 KLF7 FOS ZNF202 ZC3H11A REST ZNF623 ZDHHC1 EDC4 ENSG00000260465 CENPT CTCF NAE1 E2F4 ENKD1 ENSG00000263276 ENSG00000270165
GH16I067854 Enhancer 1.5 FANTOM5 Ensembl ENCODE 22.2 -50.5 -50523 4.4 PKNOX1 FOXA2 MLX ARID4B NEUROD1 SIN3A DMAP1 ZNF48 ETS1 YY1 ENSG00000262141 RANBP10 ACD NRN1L TSNAXIP1 DUS2 PSKH1 PARD6A RIPOR1 PRMT7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RANBP10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RANBP10 gene promoter:

Genomic Locations for RANBP10 Gene

Genomic Locations for RANBP10 Gene
chr16:67,723,066-67,806,652
(GRCh38/hg38)
Size:
83,587 bases
Orientation:
Minus strand
chr16:67,757,005-67,840,555
(GRCh37/hg19)

Genomic View for RANBP10 Gene

Genes around RANBP10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RANBP10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RANBP10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RANBP10 Gene

Proteins for RANBP10 Gene

  • Protein details for RANBP10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6VN20-RBP10_HUMAN
    Recommended name:
    Ran-binding protein 10
    Protein Accession:
    Q6VN20
    Secondary Accessions:
    • A4FTY2
    • B4DID0
    • B4DQH9
    • E7EW27
    • Q9P264

    Protein attributes for RANBP10 Gene

    Size:
    620 amino acids
    Molecular mass:
    67257 Da
    Quaternary structure:
    • May form homodimers. Interacts with RAN and RANBP9. Interacts with the HGF receptor MET. Interacts with AR. Interacts with TUBB1. May interact with TUBB5 (By similarity).
    SequenceCaution:
    • Sequence=BAA95988.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for RANBP10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RANBP10 Gene

Post-translational modifications for RANBP10 Gene

  • Ubiquitination at Lys293 and isoforms=2, 3333
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RANBP10 Gene

Domains & Families for RANBP10 Gene

Gene Families for RANBP10 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

Q6VN20

UniProtKB/Swiss-Prot:

RBP10_HUMAN :
  • The SPRY domain mediates the interaction with MET.
  • Belongs to the RANBP9/10 family.
Domain:
  • The SPRY domain mediates the interaction with MET.
Family:
  • Belongs to the RANBP9/10 family.
genes like me logo Genes that share domains with RANBP10: view

Function for RANBP10 Gene

Molecular function for RANBP10 Gene

UniProtKB/Swiss-Prot Function:
Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase (By similarity). May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function (By similarity). May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation. In contrast to RANBP9, does not interact with Sos and does not activate the Ras pathway.

Phenotypes From GWAS Catalog for RANBP10 Gene

genes like me logo Genes that share phenotypes with RANBP10: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RANBP10 Gene

Localization for RANBP10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RANBP10 Gene

Cytoplasm, cytosol. Nucleus. Note=Predominantly cytoplasmic.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RANBP10 gene
Compartment Confidence
cytosol 5
nucleus 4
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for RANBP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RANBP10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RANBP10 Gene

Pathways & Interactions for RANBP10 Gene

genes like me logo Genes that share pathways with RANBP10: view

Pathways by source for RANBP10 Gene

Gene Ontology (GO) - Biological Process for RANBP10 Gene

None

No data available for SIGNOR curated interactions for RANBP10 Gene

Drugs & Compounds for RANBP10 Gene

No Compound Related Data Available

Transcripts for RANBP10 Gene

Unigene Clusters for RANBP10 Gene

RAN binding protein 10:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RANBP10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16
SP1:
SP2: - -
SP3:
SP4: -
SP5:
SP6:

Relevant External Links for RANBP10 Gene

GeneLoc Exon Structure for
RANBP10
ECgene alternative splicing isoforms for
RANBP10

Expression for RANBP10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RANBP10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RANBP10 Gene

This gene is overexpressed in Liver (8.9) and Pancreas (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RANBP10 Gene



Protein tissue co-expression partners for RANBP10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RANBP10 Gene:

RANBP10

SOURCE GeneReport for Unigene cluster for RANBP10 Gene:

Hs.368569

mRNA Expression by UniProt/SwissProt for RANBP10 Gene:

Q6VN20-RBP10_HUMAN
Tissue specificity: Broadly expressed, with highest levels in skeletal muscle.

Evidence on tissue expression from TISSUES for RANBP10 Gene

  • Nervous system(4.7)
  • Liver(4.3)
  • Lung(2.2)
genes like me logo Genes that share expression patterns with RANBP10: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RANBP10 Gene

Orthologs for RANBP10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RANBP10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RANBP10 33 34
  • 99.68 (n)
dog
(Canis familiaris)
Mammalia RANBP10 33 34
  • 93.6 (n)
cow
(Bos Taurus)
Mammalia RANBP10 33 34
  • 93.49 (n)
rat
(Rattus norvegicus)
Mammalia Ranbp10 33
  • 91.99 (n)
mouse
(Mus musculus)
Mammalia Ranbp10 33 16 34
  • 91.72 (n)
oppossum
(Monodelphis domestica)
Mammalia RANBP10 34
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RANBP10 34
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves RANBP10 33 34
  • 80.46 (n)
lizard
(Anolis carolinensis)
Reptilia RANBP10 34
  • 85 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ranbp10 33 34
  • 75.91 (n)
fruit fly
(Drosophila melanogaster)
Insecta RanBPM 34
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y54E5A.7 34
  • 23 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VID30 34 36
  • 13 (a)
OneToMany
Species where no ortholog for RANBP10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RANBP10 Gene

ENSEMBL:
Gene Tree for RANBP10 (if available)
TreeFam:
Gene Tree for RANBP10 (if available)

Paralogs for RANBP10 Gene

Paralogs for RANBP10 Gene

(1) SIMAP similar genes for RANBP10 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with RANBP10: view

Variants for RANBP10 Gene

Sequence variations from dbSNP and Humsavar for RANBP10 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000004764 -- 67,736,109(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000013726 -- 67,769,897(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000051477 -- 67,805,252(-) G/C genic_upstream_transcript_variant, intron_variant
rs1000061138 -- 67,767,581(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000063364 -- 67,799,125(-) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RANBP10 Gene

Variant ID Type Subtype PubMed ID
esv2662518 CNV deletion 23128226
esv3638893 CNV loss 21293372
nsv1842 CNV insertion 18451855
nsv522852 CNV gain 19592680
nsv524363 CNV loss 19592680
nsv572907 CNV loss 21841781
nsv952047 CNV deletion 24416366

Variation tolerance for RANBP10 Gene

Residual Variation Intolerance Score: 21.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.77; 33.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RANBP10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RANBP10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RANBP10 Gene

Disorders for RANBP10 Gene

Additional Disease Information for RANBP10

No disorders were found for RANBP10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RANBP10 Gene

Publications for RANBP10 Gene

  1. A novel MET-interacting protein shares high sequence similarity with RanBPM, but fails to stimulate MET-induced Ras/Erk signaling. (PMID: 14684163) Wang D … Wu G (Biochemical and biophysical research communications 2004) 2 3 4 58
  2. RanBP10 is a cytoplasmic guanine nucleotide exchange factor that modulates noncentrosomal microtubules. (PMID: 18347012) Schulze H … Shivdasani RA (The Journal of biological chemistry 2008) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for RANBP10 Gene

Sources for RANBP10 Gene

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