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Aliases for RANBP1 Gene

Aliases for RANBP1 Gene

  • RAN Binding Protein 1 2 3 5
  • Testis Secretory Sperm-Binding Protein Li 221n 3
  • Ran-Specific GTPase-Activating Protein 3
  • HpaII Tiny Fragments Locus 9A 3
  • Ran-Binding Protein 1 4
  • RanBP1 4
  • HTF9A 3

External Ids for RANBP1 Gene

Previous GeneCards Identifiers for RANBP1 Gene

  • GC22P017045
  • GC22P018478
  • GC22P018479
  • GC22P003725

Summaries for RANBP1 Gene

Entrez Gene Summary for RANBP1 Gene

  • This gene encodes a protein that forms a complex with Ras-related nuclear protein (Ran) and metabolizes guanoside triphosphate (GTP). This complex participates in the regulation of the cell cycle by controlling transport of proteins and nucleic acids into the nucleus. There are multiple pseudogenes for this gene on chromosomes 9, 12, 17, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for RANBP1 Gene

RANBP1 (RAN Binding Protein 1) is a Protein Coding gene. Diseases associated with RANBP1 include Velocardiofacial Syndrome. Among its related pathways are E2F transcription factor network and Transport of the SLBP independent Mature mRNA. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and GDP-dissociation inhibitor activity.

UniProtKB/Swiss-Prot for RANBP1 Gene

  • Inhibits GTP exchange on Ran. Forms a Ran-GTP-RANBP1 trimeric complex. Increase GTP hydrolysis induced by the Ran GTPase activating protein RANGAP1. May act in an intracellular signaling pathway which may control the progression through the cell cycle by regulating the transport of protein and nucleic acids across the nuclear membrane.

Gene Wiki entry for RANBP1 Gene

Additional gene information for RANBP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RANBP1 Gene

Genomics for RANBP1 Gene

GeneHancer (GH) Regulatory Elements for RANBP1 Gene

Promoters and enhancers for RANBP1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22I020114 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 561.2 +1.3 1308 4.6 CLOCK MLX ZFP64 FEZF1 DMAP1 SLC30A9 E2F8 ZNF143 ZNF263 SP3 TRMT2A RANBP1 MED15 RPL7AP70 LZTR1 ZDHHC8 UFD1 DGCR8 SCARF2 THAP7
GH22I020113 Enhancer 0.5 ENCODE 550.8 -2.0 -1982 0.2 HIC1 ZNF282 POLR2A GLIS1 SUPT5H GC22M020115 MIR6816 RANBP1 CCDC188 ENSG00000243762 TRMT2A
GH22I019477 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 19.4 -636.7 -636688 3.8 HDGF HNRNPUL1 PKNOX1 CLOCK SMAD1 FOXA2 ARNT ARID4B SIN3A YBX1 UFD1 CDC45 DGCR8 TRMT2A RPL7AP70 DGCR11 ENSG00000273300 RPL8P5 LINC01311 RANBP1
GH22I020078 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.8 -34.4 -34417 5.2 CLOCK MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 DGCR8 LZTR1 TRMT2A MED15 RPL7AP70 RPL8P5 UFD1 ENSG00000273300 LOC100420177 ENSG00000243762
GH22I019717 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 15.9 -397.3 -397252 2.3 HDGF PKNOX1 ARNT SIN3A ZNF2 POLR2B ZNF207 ZNF143 ZNF263 SP5 SEPT5 SEPT5-GP1BB DGCR8 LINC01311 RANBP1 ZNF74 TRMT2A UFD1 ABHD17AP4 KLHL22
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RANBP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RANBP1 gene promoter:

Genomic Locations for RANBP1 Gene

Genomic Locations for RANBP1 Gene
11,420 bases
Plus strand

Genomic View for RANBP1 Gene

Genes around RANBP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RANBP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RANBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RANBP1 Gene

Proteins for RANBP1 Gene

  • Protein details for RANBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ran-specific GTPase-activating protein
    Protein Accession:
    Secondary Accessions:
    • Q53EY3

    Protein attributes for RANBP1 Gene

    201 amino acids
    Molecular mass:
    23310 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RANBP1 Gene

    Alternative splice isoforms for RANBP1 Gene


neXtProt entry for RANBP1 Gene

Post-translational modifications for RANBP1 Gene

  • Ubiquitination at Lys76 and isoforms=2134
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RANBP1 Gene

Domains & Families for RANBP1 Gene

Gene Families for RANBP1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for RANBP1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the RANBP1 family.
  • Belongs to the RANBP1 family.
genes like me logo Genes that share domains with RANBP1: view

Function for RANBP1 Gene

Molecular function for RANBP1 Gene

GENATLAS Biochemistry:
Ran (Ras-related small nuclear protein) binding protein 1,stimulating Ran GAP1-induced GTP hydrolysis by RAS-related protein Ran/TC4,also,in absence of RAS-GAP negative regulator of the regulator of chromosome condensation (CHC1L) in association with Ran/TC4
UniProtKB/Swiss-Prot Function:
Inhibits GTP exchange on Ran. Forms a Ran-GTP-RANBP1 trimeric complex. Increase GTP hydrolysis induced by the Ran GTPase activating protein RANGAP1. May act in an intracellular signaling pathway which may control the progression through the cell cycle by regulating the transport of protein and nucleic acids across the nuclear membrane.

Phenotypes From GWAS Catalog for RANBP1 Gene

Gene Ontology (GO) - Molecular Function for RANBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005092 GDP-dissociation inhibitor activity IMP 7616957
GO:0005096 contributes_to GTPase activator activity IBA --
GO:0005515 protein binding IPI 7616957
GO:0008536 Ran GTPase binding TAS 7882974
GO:0045296 cadherin binding IDA 25468996
genes like me logo Genes that share ontologies with RANBP1: view
genes like me logo Genes that share phenotypes with RANBP1: view

Animal Models for RANBP1 Gene

MGI Knock Outs for RANBP1:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RANBP1 Gene

Localization for RANBP1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RANBP1 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 4

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RANBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus TAS,IEA 16130169
GO:0005635 nuclear envelope TAS --
GO:0005737 cytoplasm TAS,IEA 16130169
GO:0005813 centrosome IEA,IBA --
genes like me logo Genes that share ontologies with RANBP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RANBP1 Gene

Pathways & Interactions for RANBP1 Gene

genes like me logo Genes that share pathways with RANBP1: view

Pathways by source for RANBP1 Gene

1 BioSystems pathway for RANBP1 Gene
2 KEGG pathways for RANBP1 Gene
2 Qiagen pathways for RANBP1 Gene
1 Cell Signaling Technology pathway for RANBP1 Gene

Gene Ontology (GO) - Biological Process for RANBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IBA --
GO:0006405 RNA export from nucleus IBA --
GO:0006511 ubiquitin-dependent protein catabolic process IBA --
GO:0006606 protein import into nucleus IBA --
GO:0007051 spindle organization IEA,IBA --
genes like me logo Genes that share ontologies with RANBP1: view

No data available for SIGNOR curated interactions for RANBP1 Gene

Drugs & Compounds for RANBP1 Gene

(4) Drugs for RANBP1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Approved, Investigational Pharma Target 202
Guanosine triphosphate Experimental Pharma 0
Phenethyl isothiocyanate Investigational Pharma Target 12

(3) Additional Compounds for RANBP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RANBP1: view

Transcripts for RANBP1 Gene

Unigene Clusters for RANBP1 Gene

RAN binding protein 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RANBP1 Gene

No ASD Table

Relevant External Links for RANBP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RANBP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RANBP1 Gene

Protein differential expression in normal tissues from HIPED for RANBP1 Gene

This gene is overexpressed in Bone (22.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RANBP1 Gene

Protein tissue co-expression partners for RANBP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RANBP1 Gene:


SOURCE GeneReport for Unigene cluster for RANBP1 Gene:


Evidence on tissue expression from TISSUES for RANBP1 Gene

  • Liver(4.5)
  • Heart(4.4)
  • Blood(4.2)
  • Nervous system(3.1)
  • Lung(2.6)
  • Spleen(2.3)
  • Intestine(2.1)
  • Kidney(2)
genes like me logo Genes that share expression patterns with RANBP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RANBP1 Gene

Orthologs for RANBP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RANBP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RANBP1 33 34
  • 100 (n)
(Canis familiaris)
Mammalia RANBP1 33 34
  • 91.92 (n)
(Mus musculus)
Mammalia Ranbp1 33 16 34
  • 88.89 (n)
(Rattus norvegicus)
Mammalia Ranbp1 33
  • 88.5 (n)
(Bos Taurus)
Mammalia RANBP1 33 34
  • 86.73 (n)
(Ornithorhynchus anatinus)
Mammalia RANBP1 34
  • 80 (a)
(Monodelphis domestica)
Mammalia RANBP1 34
  • 75 (a)
(Gallus gallus)
Aves RANBP1 33 34
  • 81.44 (n)
(Anolis carolinensis)
Reptilia RANBP1 34
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ranbp1 33
  • 73.91 (n)
MGC76028 33
(Danio rerio)
Actinopterygii ranbp1 33 34
  • 72.93 (n)
Dr.12411 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8810 33
fruit fly
(Drosophila melanogaster)
Insecta Nup358 34
(Caenorhabditis elegans)
Secernentea npp-9 34
  • 1 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER002W 33
  • 59.37 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E17227g 33
  • 56.72 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YRB1 33 34
  • 55.85 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons SIRANBP 33
  • 53.98 (n)
(Oryza sativa)
Liliopsida Os03g0292800 33
  • 58.79 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU00443 33
  • 61.9 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sbp1 33
  • 59.26 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9803 34
  • 48 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1880 33
Species where no ortholog for RANBP1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RANBP1 Gene

Gene Tree for RANBP1 (if available)
Gene Tree for RANBP1 (if available)

Paralogs for RANBP1 Gene

genes like me logo Genes that share paralogs with RANBP1: view

No data available for Paralogs for RANBP1 Gene

Variants for RANBP1 Gene

Sequence variations from dbSNP and Humsavar for RANBP1 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
VAR_036567 A breast cancer sample p.Glu16Asp
rs1000071889 -- 20,120,598(+) C/T intron_variant
rs1000172388 -- 20,117,260(+) C/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000499497 -- 20,127,350(+) C/T 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant
rs1001019119 -- 20,116,097(+) A/G 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RANBP1 Gene

Variant ID Type Subtype PubMed ID
dgv4480n100 CNV gain 25217958
dgv4481n100 CNV gain 25217958
dgv726n67 CNV gain 20364138
dgv7983n54 CNV gain 21841781
esv2110469 CNV deletion 18987734
esv2758825 CNV loss 17122850
esv3557940 CNV deletion 23714750
esv3647284 CNV gain 21293372
esv3893434 CNV gain 25118596
nsv1118943 CNV deletion 24896259
nsv1131651 CNV deletion 24896259
nsv471183 CNV loss 18288195
nsv828938 CNV gain 20364138
nsv828939 CNV loss 20364138
nsv834133 CNV loss 17160897
nsv953027 CNV deletion 24416366

Variation tolerance for RANBP1 Gene

Residual Variation Intolerance Score: 34.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.15; 3.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RANBP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RANBP1 Gene

Disorders for RANBP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RANBP1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
velocardiofacial syndrome
  • chromosome 22q11.2 deletion syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for RANBP1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with RANBP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RANBP1 Gene

Publications for RANBP1 Gene

  1. RanBP1, a Ras-like nuclear G protein binding to Ran/TC4, inhibits RCC1 via Ran/TC4. (PMID: 7616957) Hayashi N … Nishimoto T (Molecular & general genetics : MGG 1995) 2 3 4 22 58
  2. A role for RanBP1 in the release of CRM1 from the nuclear pore complex in a terminal step of nuclear export. (PMID: 10330396) Kehlenbach RH … Gerace L (The Journal of cell biology 1999) 2 3 22 58
  3. Co-activation of RanGTPase and inhibition of GTP dissociation by Ran-GTP binding protein RanBP1. (PMID: 7882974) Bischoff FR … Ponstingl H (The EMBO journal 1995) 3 4 22 58
  4. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson JE … Couch FJ (Breast cancer research and treatment 2011) 3 44 58
  5. RanBP1 downregulation sensitizes cancer cells to taxol in a caspase-3-dependent manner. (PMID: 19270727) Rensen WM … Lavia P (Oncogene 2009) 3 22 58

Products for RANBP1 Gene

Sources for RANBP1 Gene

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