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This gene encodes a protein that forms a complex with Ras-related nuclear protein (Ran) and metabolizes guanoside triphosphate (GTP). This complex participates in the regulation of the cell cycle by controlling transport of proteins and nucleic acids into the nucleus. There are multiple pseudogenes for this gene on chromosomes 9, 12, 17, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
RANBP1 (RAN Binding Protein 1) is a Protein Coding gene. Diseases associated with RANBP1 include Digeorge Syndrome and Ichthyosis, Congenital, Autosomal Recessive 9. Among its related pathways are E2F transcription factor network and HIV Life Cycle. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and GDP-dissociation inhibitor activity. An important paralog of this gene is RANBP2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005092 | GDP-dissociation inhibitor activity | IMP | 7616957 |
GO:0005096 | contributes_to GTPase activator activity | IBA | 21873635 |
GO:0005515 | protein binding | IPI | 7616957 |
GO:0031267 | small GTPase binding | TAS | -- |
GO:0045296 | cadherin binding | HDA | 25468996 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | TAS | 16130169 |
GO:0005635 | nuclear envelope | TAS | -- |
GO:0005643 | nuclear pore | IBA | 21873635 |
GO:0005737 | cytoplasm | IBA,TAS | 16130169 |
GO:0005813 | centrosome | IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | HIV Life Cycle |
.91
.64
|
.45
|
2 | Transport of the SLBP independent Mature mRNA | ||
3 | Cytoskeletal Signaling | ||
4 | Human T-cell leukemia virus 1 infection | ||
5 | Viral carcinogenesis |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007051 | spindle organization | IEA | -- |
GO:0007165 | signal transduction | TAS | 16130169 |
GO:0010976 | positive regulation of neuron projection development | IEA | -- |
GO:0016032 | viral process | TAS | -- |
GO:0035690 | cellular response to drug | IEA | -- |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | RANBP1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | RANBP1 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Ranbp1 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Ranbp1 30 |
|
||
Cow (Bos Taurus) |
Mammalia | RANBP1 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | RANBP1 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | RANBP1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | RANBP1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | RANBP1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ranbp1 30 |
|
||
MGC76028 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | ranbp1 30 31 |
|
OneToOne | |
Dr.12411 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.8810 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Nup358 31 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | npp-9 31 |
|
OneToOne | |
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AER002W 30 |
|
||
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0E17227g 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | YRB1 30 31 |
|
OneToOne | |
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | SIRANBP 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os03g0292800 30 |
|
||
Bread mold (Neurospora crassa) |
Ascomycetes | NCU00443 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | sbp1 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.9803 31 |
|
OneToOne | |
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.1880 30 |
|
SNP ID | Clinical significance and condition | Chr 22 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs150814421 | Benign: not provided | 20,126,989(+) |
G/A NM_001278639.2(RANBP1):c.774G>A (p.Ala258=) |
SYNONYMOUS | |
VAR_036567 | A breast cancer sample |
p.Glu16Asp |
|||
rs5746863 | - |
p.Ala145Val |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv4480n100 | CNV | gain | 25217958 |
dgv4481n100 | CNV | gain | 25217958 |
dgv726n67 | CNV | gain | 20364138 |
dgv7983n54 | CNV | gain | 21841781 |
esv2110469 | CNV | deletion | 18987734 |
esv2758825 | CNV | loss | 17122850 |
esv3557940 | CNV | deletion | 23714750 |
esv3647284 | CNV | gain | 21293372 |
esv3893434 | CNV | gain | 25118596 |
nsv1118943 | CNV | deletion | 24896259 |
nsv1131651 | CNV | deletion | 24896259 |
nsv471183 | CNV | loss | 18288195 |
nsv828938 | CNV | gain | 20364138 |
nsv828939 | CNV | loss | 20364138 |
nsv834133 | CNV | loss | 17160897 |
nsv953027 | CNV | deletion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
digeorge syndrome |
|
|
ichthyosis, congenital, autosomal recessive 9 |
|
|
velocardiofacial syndrome |
|
|