RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1).... See more...

Aliases for RAN Gene

Aliases for RAN Gene

  • RAN, Member RAS Oncogene Family 2 3 5
  • ARA24 2 3 4
  • Androgen Receptor-Associated Protein 24 3 4
  • GTP-Binding Nuclear Protein Ran 3 4
  • Ras-Related Nuclear Protein 3 4
  • Ras-Like Protein TC4 3 4
  • GTPase Ran 3 4
  • Gsp1 2 3
  • TC4 2 3
  • Guanosine Triphosphatase Ran 3
  • Member RAS Oncogene Family 3
  • OK/SW-Cl.81 3
  • RanGTPase 3
  • RAN 5

External Ids for RAN Gene

Previous GeneCards Identifiers for RAN Gene

  • GC12P129785
  • GC12P131119
  • GC12P030224
  • GC12P129709
  • GC12P129881
  • GC12P131356
  • GC12P128338

Summaries for RAN Gene

Entrez Gene Summary for RAN Gene

  • RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease. [provided by RefSeq, Jul 2008]

GeneCards Summary for RAN Gene

RAN (RAN, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAN include Teratocarcinoma and Parkinson Disease 22, Autosomal Dominant. Among its related pathways are Cell cycle_Spindle assembly and chromosome separation and Transport of the SLBP independent Mature mRNA. Gene Ontology (GO) annotations related to this gene include GTP binding.

UniProtKB/Swiss-Prot Summary for RAN Gene

  • GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs (PubMed:10400640, PubMed:8276887, PubMed:8896452, PubMed:8636225, PubMed:8692944, PubMed:9351834, PubMed:9428644, PubMed:9822603, PubMed:26272610). Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis (PubMed:7819259, PubMed:8896452, PubMed:8636225, PubMed:8692944, PubMed:9351834, PubMed:9428644, PubMed:9822603, PubMed:29040603, PubMed:11336674, PubMed:26272610). Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport (PubMed:8896452, PubMed:9351834, PubMed:9428644). Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (PubMed:20485264). RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation (PubMed:10408446, PubMed:29040603). Required for normal progress through mitosis (PubMed:8421051, PubMed:12194828, PubMed:29040603). The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (PubMed:18591255). Acts as a negative regulator of the kinase activity of VRK1 and VRK2 (PubMed:18617507). Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases (PubMed:10400640).

Gene Wiki entry for RAN Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RAN Gene

Genomics for RAN Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RAN Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J130870 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +0.6 632 4.6 CREB1 CTCF HNRNPL ATF7 RFX1 LEF1 KDM1A ZNF692 POLR2A BACH1 NONHSAG012760.2 RAN STX2 ENSG00000256250 ENSG00000256299 MN309617 ADGRD1
GH12J130869 Enhancer 0.7 ENCODE 0.7 -2.6 -2602 0.1 JUND DPF2 MGA EGR1 TRIM28 TRIM24 FOSL1 ZFHX2 ZNF592 ZNF18 RF00026-272 RNU6-1077P RAN HSALNG0095145 STX2
GH12J130878 Enhancer 0.9 ENCODE 0.4 +7.6 7612 2.8 PRDM10 RFX1 POLR2A BACH1 LARP7 RBFOX2 PKNOX1 SMAD5 TCF12 ZNF740 HSALNG0095150 STX2 ENSG00000255933 ENSG00000256299 ENSG00000256250 RAN RF00017-1341 ADGRD1
GH12J130876 Enhancer 0.6 Ensembl 0.7 +4.7 4722 0.4 RBFOX2 POLR2A ZNF316 MAFF MAFK RBM22 ZNF18 RXRA ZNF362 SP1 MN309617 lnc-STX2-8 STX2 RAN ADGRD1
GH12J130849 Enhancer 1 Ensembl ENCODE 0.4 -21.8 -21809 2 TEAD4 TFE3 CEBPA MNT SOX13 ZNF140 TCF7 CTBP1 NFE2 ZNF316 STX2 ENSG00000256250 SFSWAP HSALNG0095145 piR-46389-004 RAN
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RAN on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RAN

Top Transcription factor binding sites by QIAGEN in the RAN gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • c-Myc
  • GR
  • GR-alpha
  • Max

Genomic Locations for RAN Gene

Genomic Locations for RAN Gene
chr12:130,871,879-130,877,678
(GRCh38/hg38)
Size:
5,800 bases
Orientation:
Plus strand
chr12:131,356,424-131,362,223
(GRCh37/hg19)
Size:
5,800 bases
Orientation:
Plus strand

Genomic View for RAN Gene

Genes around RAN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAN Gene

Proteins for RAN Gene

  • Protein details for RAN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62826-RAN_HUMAN
    Recommended name:
    GTP-binding nuclear protein Ran
    Protein Accession:
    P62826
    Secondary Accessions:
    • A8K3Z8
    • P17080
    • P28746
    • P28747
    • Q6IPB2
    • Q86V08
    • Q8NI90
    • Q9CSP3
    • Q9CWI7
    • Q9CZA2
    • Q9UDJ5
    • Q9UEU9

    Protein attributes for RAN Gene

    Size:
    216 amino acids
    Molecular mass:
    24423 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Monomer. Interacts with RANGAP1, which promotes RAN-mediated GTP hydrolysis (PubMed:7819259, PubMed:9428644). Interacts with KPNB1 (PubMed:8896452, PubMed:9428644, PubMed:10367892). Interaction with KPNB1 inhibits RANGAP1-mediated stimulation of GTPase activity (PubMed:9428644). Interacts with RCC1 which promotes the exchange of RAN-bound GDP by GTP (PubMed:1961752, PubMed:7819259, PubMed:12194828, PubMed:11336674). Interaction with KPNB1 inhibits RCC1-mediated exchange of RAN-bound GDP by GTP (PubMed:8896452). Interacts (GTP-bound form) with TNPO1; the interaction is direct (PubMed:9351834). Interacts (GTP-bound form) with TNPO3; the interaction is direct (PubMed:23878195, PubMed:24915079, PubMed:24449914). Interacts with KPNB1 and with TNPO1; both inhibit RAN GTPase activity (PubMed:8896452, PubMed:9428644). Interacts (via C-terminus) with RANBP1, which alleviates the inhibition of RAN GTPase activity (PubMed:7891706, PubMed:8896452, PubMed:9428644, PubMed:11832950). Interacts with RANGRF, which promotes the release of bound guanine nucleotide (PubMed:29040603). RANGRF and RCC1 compete for an overlapping binding site on RAN (PubMed:29040603). Identified in a complex with KPNA2 and CSE1L; interaction with RANBP1 mediates dissociation of RAN from this complex (PubMed:9428644). Interaction with both RANBP1 and KPNA2 promotes dissociation of the complex between RAN and KPNB1 (PubMed:9428644). Identified in a complex composed of RAN, RANGAP1 and RANBP1 (PubMed:16428860). Identified in a complex that contains TNPO1, RAN and RANBP1 (PubMed:9428644). Identified in a nuclear export complex with XPO1 (PubMed:9323133, PubMed:15574331, PubMed:10209022). Found in a nuclear export complex with RANBP3 and XPO1 (PubMed:11571268, PubMed:11425870). Interacts with RANBP2/NUP358 (PubMed:10078529, PubMed:26272610). Interaction with RANBP1 or RANBP2 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (PubMed:20485264). Component of a nuclear export receptor complex composed of KPNB1, RAN, SNUPN and XPO1 (PubMed:10209022, PubMed:19389996). Found in a nuclear export complex with RAN, XPO5 and pre-miRNA (By similarity). Interacts (GTP-bound form) with XPO5 (By similarity). Part of a complex consisting of RANBP9, RAN, DYRK1B and COPS5 (PubMed:14500717). Interacts with RANBP9 and RANBP10 (PubMed:14684163). Interacts in its GTP-bound form with BIRC5/survivin at S and M phases of the cell cycle (PubMed:18591255). Interacts with TERT; the interaction requires hydrogen peroxide-mediated phosphorylation of TERT and transports TERT to the nucleus (PubMed:12808100). Interacts with MAD2L2 (PubMed:19753112). Interacts with VRK1 and VRK3 (PubMed:18617507). Interacts with isoform 1 and isoform 2 of VRK2 (PubMed:18617507). Interacts with NEMP1 and KPNB1 (By similarity). Interacts (GDP-bound form) with NUTF2; regulates RAN nuclear import (PubMed:9822603, PubMed:10679025, PubMed:18266911). Interacts with CAPG; mediates CAPG nuclear import (PubMed:10679025, PubMed:18266911). Interacts with NUP153 (PubMed:18611384, PubMed:19505478). Interacts with the AR N-terminal poly-Gln region; the interaction with AR is inversely correlated with the poly-Gln length (PubMed:10400640). Interacts with MYCBP2, which promotes RAN-mediated GTP hydrolysis (PubMed:26304119). Interacts with EPG5 (PubMed:29130391).
    • (Microbial infection) In case of HIV-1 infection, found in a complex with HIV-1 Rev, RNAs containing a Rev response element (RRE) and XPO1.
    • (Microbial infection) Found in a complex with HTLV-1 Rex, RANBP3 and XPO1.
    • (Microbial infection) Interacts with Mengo encephalomyocarditis virus Leader protein; the complex L-RAN recruits cellular kinases responsible for the L-induced nucleocytoplasmic trafficking inhibition.
    SequenceCaution:
    • Sequence=BAB93486.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RAN Gene

neXtProt entry for RAN Gene

Post-translational modifications for RAN Gene

  • Acetylation by KAT5 at Lys-134 is increased during mitosis, impairs RANGRF binding and enhances RCC1 binding (PubMed:29040603). Acetylation at Lys-37 enhances the association with nuclear export components (PubMed:31075303). Deacetylation of Lys-37 by SIRT7 regulates the nuclear export of NF-kappa-B subunit RELA/p65 (PubMed:31075303).
  • Ubiquitination at Lys23, Lys38, Lys60, Lys99, Lys123, Lys127, Lys134, Lys141, Lys142, Lys152, and Lys159
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RAN Gene

Domains & Families for RAN Gene

Gene Families for RAN Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transporters

Protein Domains for RAN Gene

Suggested Antigen Peptide Sequences for RAN Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ92821, Homo sapiens RAN, member RAS oncogene family (RAN), mRNA (A8K3Z8_HUMAN)
  • cDNA, FLJ79092, highly similar to GTP-binding nuclear protein Ran (B4DV51_HUMAN)
  • Ras-related nuclear protein (RAN_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P62826

UniProtKB/Swiss-Prot:

RAN_HUMAN :
  • Belongs to the small GTPase superfamily. Ran family.
Family:
  • Belongs to the small GTPase superfamily. Ran family.
genes like me logo Genes that share domains with RAN: view

Function for RAN Gene

Molecular function for RAN Gene

UniProtKB/Swiss-Prot Function:
GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs (PubMed:10400640, PubMed:8276887, PubMed:8896452, PubMed:8636225, PubMed:8692944, PubMed:9351834, PubMed:9428644, PubMed:9822603, PubMed:26272610). Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis (PubMed:7819259, PubMed:8896452, PubMed:8636225, PubMed:8692944, PubMed:9351834, PubMed:9428644, PubMed:9822603, PubMed:29040603, PubMed:11336674, PubMed:26272610). Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport (PubMed:8896452, PubMed:9351834, PubMed:9428644). Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (PubMed:20485264). RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation (PubMed:10408446, PubMed:29040603). Required for normal progress through mitosis (PubMed:8421051, PubMed:12194828, PubMed:29040603). The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (PubMed:18591255). Acts as a negative regulator of the kinase activity of VRK1 and VRK2 (PubMed:18617507). Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases (PubMed:10400640).
GENATLAS Biochemistry:
Ras related GTPase component of the nuclear protein complex (NPC) mediating nucleocytoplasmic transport of proteins and ribonucleoproteins,expressed in a human teratocarcinoma cell line and in a range of human cell types

Phenotypes From GWAS Catalog for RAN Gene

Gene Ontology (GO) - Molecular Function for RAN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0000287 magnesium ion binding IDA 11336674
GO:0003682 chromatin binding TAS 1961752
GO:0003723 RNA binding HDA 22658674
GO:0003924 GTPase activity IEA,TAS 10400640
genes like me logo Genes that share ontologies with RAN: view
genes like me logo Genes that share phenotypes with RAN: view

Animal Model Products

CRISPR Products

miRNA for RAN Gene

miRTarBase miRNAs that target RAN

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAN

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAN Gene

Localization for RAN Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAN Gene

Nucleus. Nucleus envelope. Cytoplasm, cytosol. Cytoplasm. Melanosome. Note=Predominantly nuclear during interphase (PubMed:8421051, PubMed:12194828, PubMed:10679025). Becomes dispersed throughout the cytoplasm during mitosis (PubMed:8421051, PubMed:12194828). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). {ECO:0000269 PubMed:10679025, ECO:0000269 PubMed:12194828, ECO:0000269 PubMed:17081065, ECO:0000269 PubMed:8421051}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAN gene
Compartment Confidence
cytoskeleton 5
nucleus 5
endosome 5
cytosol 5
extracellular 4
mitochondrion 3
plasma membrane 2
endoplasmic reticulum 2
peroxisome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RAN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 colocalizes_with chromatin IDA 1961752
GO:0005634 nucleus IEA,IDA 9822603
GO:0005635 nuclear envelope IEA,IDA 27541860
GO:0005643 nuclear pore NAS 8421051
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with RAN: view

Pathways & Interactions for RAN Gene

genes like me logo Genes that share pathways with RAN: view

Pathways by source for RAN Gene

1 GeneGo (Thomson Reuters) pathway for RAN Gene
  • Cell cycle_Spindle assembly and chromosome separation
4 Qiagen pathways for RAN Gene
  • JAK-STAT Pathway
  • Ran Pathway
  • SMAD Signaling Network
  • SUMO Pathway
1 Cell Signaling Technology pathway for RAN Gene

SIGNOR curated interactions for RAN Gene

Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for RAN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000054 ribosomal subunit export from nucleus IBA 21873635
GO:0000055 ribosomal large subunit export from nucleus IMP 12773398
GO:0000056 ribosomal small subunit export from nucleus IMP 12773398
GO:0000070 mitotic sister chromatid segregation IMP 29040603
GO:0000278 mitotic cell cycle TAS 8421051
genes like me logo Genes that share ontologies with RAN: view

Drugs & Compounds for RAN Gene

(14) Drugs for RAN Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma Target 0
Guanosine triphosphate Experimental Pharma 0

(10) Additional Compounds for RAN Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RAN: view

Transcripts for RAN Gene

mRNA/cDNA for RAN Gene

3 REFSEQ mRNAs :
22 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAN

Alternative Splicing Database (ASD) splice patterns (SP) for RAN Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b
SP1: -
SP2: - -
SP3: -
SP4: - - - - - - -
SP5:
SP6:

Relevant External Links for RAN Gene

GeneLoc Exon Structure for
RAN

Expression for RAN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RAN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RAN Gene



Protein tissue co-expression partners for RAN Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RAN

SOURCE GeneReport for Unigene cluster for RAN Gene:

Hs.10842

mRNA Expression by UniProt/SwissProt for RAN Gene:

P62826-RAN_HUMAN
Tissue specificity: Expressed in a variety of tissues.

Evidence on tissue expression from TISSUES for RAN Gene

  • Nervous system(5)
  • Skin(4.9)
  • Liver(4.9)
  • Blood(4.8)
  • Lung(4.7)
  • Intestine(4.1)
  • Pancreas(4)
  • Eye(4)
  • Kidney(4)
  • Stomach(3.2)
  • Heart(3.1)
  • Spleen(3)
  • Muscle(3)
  • Lymph node(2.8)
  • Bone marrow(2.7)
  • Thyroid gland(2.4)
  • Bone(2.4)
  • Adrenal gland(2.3)
genes like me logo Genes that share expression patterns with RAN: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAN Gene

Orthologs for RAN Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RAN Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RAN 30 31
  • 99.85 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 99 (a)
OneToMany
-- 31
  • 94 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia 1700009N14Rik 31
  • 93 (a)
OneToOne
Ran 30 17
  • 89.66 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia RAN 31
  • 93 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia RAN 30 31
  • 92.75 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ran 30
  • 89.2 (n)
Dog
(Canis familiaris)
Mammalia RAN 30 31
  • 87.5 (n)
OneToOne
Chicken
(Gallus gallus)
Aves RAN 30 31
  • 88.58 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia RAN 31
  • 97 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ran 30
  • 84.1 (n)
Str.6581 30
African clawed frog
(Xenopus laevis)
Amphibia ran-1-prov 30
Zebrafish
(Danio rerio)
Actinopterygii ran 30 31
  • 79.75 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007699 30
  • 75.73 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta ran 30
  • 71.91 (n)
ran-like 31 32
  • 59 (a)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea ran-1 30 31 32
  • 73.95 (n)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GSP2 31
  • 79 (a)
OneToMany
GSP1 30 31
  • 70.75 (n)
OneToMany
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A04499g 30
  • 72.06 (n)
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AGR294C 30
  • 71.57 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons RAN2 30
  • 71.22 (n)
Rice
(Oryza sativa)
Liliopsida Os01g0611100 30
  • 68.93 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes spi1 30
  • 69.03 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU09269 30
  • 68.46 (n)
Species where no ortholog for RAN was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for RAN Gene

ENSEMBL:
Gene Tree for RAN (if available)
TreeFam:
Gene Tree for RAN (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RAN: view image

Paralogs for RAN Gene

genes like me logo Genes that share paralogs with RAN: view

No data available for Paralogs for RAN Gene

Variants for RAN Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RAN Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
713516 Benign: not provided 130,873,046(+) C/T SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT

Additional dbSNP identifiers (rs#s) for RAN Gene

Structural Variations from Database of Genomic Variants (DGV) for RAN Gene

Variant ID Type Subtype PubMed ID
nsv1070149 CNV deletion 25765185
nsv1112627 CNV deletion 24896259
nsv983375 CNV duplication 23825009

Variation tolerance for RAN Gene

Residual Variation Intolerance Score: 35.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.06; 21.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RAN Gene

Human Gene Mutation Database (HGMD)
RAN
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAN

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAN Gene

Disorders for RAN Gene

MalaCards: The human disease database

(10) MalaCards diseases for RAN Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
teratocarcinoma
  • mixed embryonal carcinoma and teratoma
parkinson disease 22, autosomal dominant
  • park22
newcastle disease
  • newcastle's disease
fragile x tremor/ataxia syndrome
  • fxtas
hutchinson-gilford progeria syndrome
  • hgps
- elite association - COSMIC cancer census association via MalaCards
Search RAN in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RAN

genes like me logo Genes that share disorders with RAN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RAN Gene

Publications for RAN Gene

  1. A new role for nuclear transport factor 2 and Ran: nuclear import of CapG. (PMID: 18266911) Van Impe K … Gettemans J (Traffic (Copenhagen, Denmark) 2008) 3 4 23
  2. The crystal structure of the Ran-Nup153ZnF2 complex: a general Ran docking site at the nuclear pore complex. (PMID: 18611384) Schrader N … Vetter IR (Structure (London, England : 1993) 2008) 3 4 23
  3. Proteomics identification of nuclear Ran GTPase as an inhibitor of human VRK1 and VRK2 (vaccinia-related kinase) activities. (PMID: 18617507) Sanz-García M … Lazo PA (Molecular & cellular proteomics : MCP 2008) 3 4 23
  4. Phosphorylation of RanGAP1 stabilizes its interaction with Ran and RanBP1. (PMID: 16428860) Takeda E … Yoneda Y (Cell structure and function 2005) 3 4 23
  5. Targeting of RCC1 to chromosomes is required for proper mitotic spindle assembly in human cells. (PMID: 12194828) Moore W … Clarke PR (Current biology : CB 2002) 3 4 23

Products for RAN Gene

Sources for RAN Gene