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Aliases for RAMP3 Gene

Aliases for RAMP3 Gene

  • Receptor Activity Modifying Protein 3 2 3 5
  • Calcitonin-Receptor-Like Receptor Activity-Modifying Protein 3 4
  • CRLR Activity-Modifying Protein 3 4

External Ids for RAMP3 Gene

Previous GeneCards Identifiers for RAMP3 Gene

  • GC07P044843
  • GC07P044938
  • GC07P044970

Summaries for RAMP3 Gene

Entrez Gene Summary for RAMP3 Gene

  • The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP3) protein, CRLR functions as an adrenomedullin receptor. [provided by RefSeq, Jul 2008]

GeneCards Summary for RAMP3 Gene

RAMP3 (Receptor Activity Modifying Protein 3) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Presynaptic function of Kainate receptors. Gene Ontology (GO) annotations related to this gene include receptor activity and coreceptor activity. An important paralog of this gene is RAMP1.

UniProtKB/Swiss-Prot for RAMP3 Gene

  • Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.

Tocris Summary for RAMP3 Gene

  • Calcitonin and related receptors are a family of G-protein-coupled receptors that comprises of eight subtypes; CT, AMY1, AMY2, AMY3, CALCR, CGRP, AM1 and AM2. The main function of CT receptors is to inhibit bone reabsorption and enhance calcium excretion by the kidneys.

Gene Wiki entry for RAMP3 Gene

Additional gene information for RAMP3 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAMP3 Gene

Genomics for RAMP3 Gene

GeneHancer (GH) Regulatory Elements for RAMP3 Gene

Promoters and enhancers for RAMP3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I045157 Promoter 0.7 EPDnew 550.8 +0.0 4 0.1 SUZ12 EZH2 RAMP3 GC07P045166 GC07P045063
GH07I044975 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.8 -178.8 -178846 6.5 PKNOX1 SMAD1 FEZF1 IRF4 POLR2B ZNF143 ATF7 RUNX3 JUNB REST MYO1G CCM2 ENSG00000260997 PURB RAMP3 SNHG15 OGDH ZMIZ2
GH07I045108 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 12 -46.8 -46833 4 HDGF PKNOX1 CLOCK SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 TBRG4 SNHG15 NACAD CCM2 RAMP3 SNORA5B GC07P045063
GH07I044983 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 10.8 -172.1 -172129 5.2 HDGF PKNOX1 SMAD1 ARNT SIN3A ZNF2 IRF4 YY1 POLR2B ZNF766 SNHG15 SNORA9 GC07M044985 DDX56 CCM2 POLM SNORA5C ENSG00000260997 TMED4 SNORA5A
GH07I044982 Enhancer 0.7 ENCODE dbSUPER 10.8 -175.0 -175011 0.2 POLR2A BCLAF1 SUPT5H ZBTB17 RAMP3 MYO1G SNORA9 GC07M044985
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RAMP3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RAMP3 gene promoter:

Genomic Locations for RAMP3 Gene

Genomic Locations for RAMP3 Gene
chr7:45,157,768-45,186,302
(GRCh38/hg38)
Size:
28,535 bases
Orientation:
Plus strand
chr7:45,197,367-45,225,901
(GRCh37/hg19)

Genomic View for RAMP3 Gene

Genes around RAMP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAMP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAMP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAMP3 Gene

Proteins for RAMP3 Gene

  • Protein details for RAMP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60896-RAMP3_HUMAN
    Recommended name:
    Receptor activity-modifying protein 3
    Protein Accession:
    O60896
    Secondary Accessions:
    • Q7Z2Y1

    Protein attributes for RAMP3 Gene

    Size:
    148 amino acids
    Molecular mass:
    16518 Da
    Quaternary structure:
    • Heterodimer of CALCRL and RAMP3 (By similarity). Interacts with GPER1.

neXtProt entry for RAMP3 Gene

Post-translational modifications for RAMP3 Gene

  • Glycosylation at Asn29, Asn58, Asn71, and Asn103

Other Protein References for RAMP3 Gene

No data available for DME Specific Peptides for RAMP3 Gene

Domains & Families for RAMP3 Gene

Gene Families for RAMP3 Gene

HGNC:
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • Predicted membrane proteins

Protein Domains for RAMP3 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O60896

UniProtKB/Swiss-Prot:

RAMP3_HUMAN :
  • Belongs to the RAMP family.
Family:
  • Belongs to the RAMP family.
genes like me logo Genes that share domains with RAMP3: view

Function for RAMP3 Gene

Molecular function for RAMP3 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.

Phenotypes From GWAS Catalog for RAMP3 Gene

Gene Ontology (GO) - Molecular Function for RAMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001605 adrenomedullin receptor activity IPI 10882736
GO:0004872 receptor activity IDA --
GO:0005515 protein binding IPI 15613468
GO:0008565 protein transporter activity IDA 9620797
GO:0015026 coreceptor activity IEA --
genes like me logo Genes that share ontologies with RAMP3: view
genes like me logo Genes that share phenotypes with RAMP3: view

Animal Models for RAMP3 Gene

MGI Knock Outs for RAMP3:

Animal Model Products

Clone Products

  • Addgene plasmids for RAMP3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for RAMP3 Gene

Localization for RAMP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAMP3 Gene

Cell membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Note=Moves from intracellular puncta to the plasma membrane in a RAMP3-dependent manner.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAMP3 gene
Compartment Confidence
plasma membrane 5
lysosome 4
extracellular 3

Gene Ontology (GO) - Cellular Components for RAMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA 23674134
GO:0005764 colocalizes_with lysosome IDA,TAS 15613468
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9620797
GO:0009986 cell surface IDA 10882736
genes like me logo Genes that share ontologies with RAMP3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RAMP3 Gene

Pathways & Interactions for RAMP3 Gene

genes like me logo Genes that share pathways with RAMP3: view

Gene Ontology (GO) - Biological Process for RAMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001921 positive regulation of receptor recycling IDA 15613468
GO:0006810 transport IEA --
GO:0006816 calcium ion transport IDA 10882736
GO:0006886 intracellular protein transport IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with RAMP3: view

No data available for SIGNOR curated interactions for RAMP3 Gene

Drugs & Compounds for RAMP3 Gene

(5) Drugs for RAMP3 Gene - From: DrugBank, DGIdb, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pramlintide Approved, Investigational Pharma Target, agonist 43
CGRP (rat) Pharma Potent vasodilator 0

(4) Additional Compounds for RAMP3 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
alpha-CGRP (human)
90954-53-3

(5) Tocris Compounds for RAMP3 Gene

Compound Action Cas Number
alpha-CGRP (human) CGRP receptor agonist 90954-53-3
Calcitonin (salmon) Affects bone formation and resorption 47931-85-1
CGRP (rat) Potent vasodilator 83651-90-5
PHM 27 (human) Potent calcitonin receptor agonist; endogenous analog of human VIP 118025-43-7
SUN-B 8155 Non-peptide calcitonin (CT) receptor agonist 345893-91-6
genes like me logo Genes that share compounds with RAMP3: view

Transcripts for RAMP3 Gene

Unigene Clusters for RAMP3 Gene

Receptor (G protein-coupled) activity modifying protein 3:
Representative Sequences:

Clone Products

  • Addgene plasmids for RAMP3

Alternative Splicing Database (ASD) splice patterns (SP) for RAMP3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b
SP1: - - - -
SP2: -
SP3: - - - - -
SP4: - -
SP5:

Relevant External Links for RAMP3 Gene

GeneLoc Exon Structure for
RAMP3
ECgene alternative splicing isoforms for
RAMP3

Expression for RAMP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAMP3 Gene

mRNA differential expression in normal tissues according to GTEx for RAMP3 Gene

This gene is overexpressed in Lung (x4.4).

NURSA nuclear receptor signaling pathways regulating expression of RAMP3 Gene:

RAMP3

SOURCE GeneReport for Unigene cluster for RAMP3 Gene:

Hs.25691

mRNA Expression by UniProt/SwissProt for RAMP3 Gene:

O60896-RAMP3_HUMAN
Tissue specificity: Strongly expressed in lung, breast, immune system and fetal tissues.

Evidence on tissue expression from TISSUES for RAMP3 Gene

  • Lung(4.4)
  • Nervous system(4.3)
  • Heart(2.5)
  • Kidney(2.5)
  • Muscle(2.4)
genes like me logo Genes that share expression patterns with RAMP3: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAMP3 Gene

Orthologs for RAMP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RAMP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAMP3 33 34
  • 99.1 (n)
mouse
(Mus musculus)
Mammalia Ramp3 33 16 34
  • 84.87 (n)
dog
(Canis familiaris)
Mammalia LOC100855938 33
  • 83.94 (n)
RAMP3 34
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ramp3 33
  • 82.31 (n)
cow
(Bos Taurus)
Mammalia RAMP3 33 34
  • 79.5 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RAMP3 34
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAMP3 34
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAMP3 33 34
  • 66.39 (n)
lizard
(Anolis carolinensis)
Reptilia RAMP3 34
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ramp3 33
  • 56.8 (n)
zebrafish
(Danio rerio)
Actinopterygii si:ch73-334d15.2 34
  • 22 (a)
ManyToMany
Species where no ortholog for RAMP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAMP3 Gene

ENSEMBL:
Gene Tree for RAMP3 (if available)
TreeFam:
Gene Tree for RAMP3 (if available)

Paralogs for RAMP3 Gene

Paralogs for RAMP3 Gene

(2) SIMAP similar genes for RAMP3 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with RAMP3: view

Variants for RAMP3 Gene

Sequence variations from dbSNP and Humsavar for RAMP3 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000059701 -- 45,157,703(+) G/A upstream_transcript_variant
rs1000095418 -- 45,155,998(+) G/C upstream_transcript_variant
rs1000180748 -- 45,172,988(+) G/T genic_upstream_transcript_variant, intron_variant
rs1000327216 -- 45,168,975(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000604267 -- 45,183,770(+) C/T 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for RAMP3 Gene

Variant ID Type Subtype PubMed ID
esv28566 CNV gain 19812545
esv3613016 CNV loss 21293372
nsv516731 CNV loss 19592680
nsv830986 CNV loss 17160897
nsv950209 CNV deletion 24416366

Variation tolerance for RAMP3 Gene

Residual Variation Intolerance Score: 76.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.78; 66.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RAMP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAMP3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAMP3 Gene

Disorders for RAMP3 Gene

Additional Disease Information for RAMP3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for RAMP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAMP3 Gene

Publications for RAMP3 Gene

  1. G-protein-coupled receptor 30 interacts with receptor activity-modifying protein 3 and confers sex-dependent cardioprotection. (PMID: 23674134) Lenhart PM … Caron KM (Journal of molecular endocrinology 2013) 3 4 58
  2. Functional characterization of two human receptor activity-modifying protein 3 variants. (PMID: 20034525) Bailey RJ … Hay DL (Peptides 2010) 3 22 58
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  4. Molecular basis of association of receptor activity-modifying protein 3 with the family B G protein-coupled secretin receptor. (PMID: 19886671) Harikumar KG … Miller LJ (Biochemistry 2009) 3 22 58
  5. Identification of N-terminal receptor activity-modifying protein residues important for calcitonin gene-related peptide, adrenomedullin, and amylin receptor function. (PMID: 18593822) Qi T … Hay DL (Molecular pharmacology 2008) 3 22 58

Products for RAMP3 Gene

  • Addgene plasmids for RAMP3

Sources for RAMP3 Gene

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