The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a r... See more...

Aliases for RAMP2 Gene

Aliases for RAMP2 Gene

  • Receptor Activity Modifying Protein 2 2 3 5
  • Receptor Activity-Modifying Protein 2 3 4
  • CRLR Activity-Modifying Protein 2 3 4
  • Calcitonin Receptor-Like Receptor Activity Modifying Protein 2 3
  • Calcitonin-Receptor-Like Receptor Activity-Modifying Protein 2 4
  • Receptor (G Protein-Coupled) Activity Modifying Protein 2 3
  • Receptor (Calcitonin) Activity Modifying Protein 2 3

External Ids for RAMP2 Gene

Previous GeneCards Identifiers for RAMP2 Gene

  • GC17P040484
  • GC17P043075
  • GC17P040821
  • GC17P041286
  • GC17P038166
  • GC17P040913
  • GC17P036678

Summaries for RAMP2 Gene

Entrez Gene Summary for RAMP2 Gene

  • The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface. [provided by RefSeq, Jul 2008]

GeneCards Summary for RAMP2 Gene

RAMP2 (Receptor Activity Modifying Protein 2) is a Protein Coding gene. Diseases associated with RAMP2 include Pheochromocytoma and Cartilage Cancer. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include protein transporter activity and coreceptor activity. An important paralog of this gene is RAMP1.

UniProtKB/Swiss-Prot Summary for RAMP2 Gene

  • Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.

Tocris Summary for RAMP2 Gene

  • Calcitonin and related receptors are a family of G-protein-coupled receptors that comprises of eight subtypes; CT, AMY1, AMY2, AMY3, CALCR, CGRP, AM1 and AM2. The main function of CT receptors is to inhibit bone reabsorption and enhance calcium excretion by the kidneys.

Gene Wiki entry for RAMP2 Gene

Additional gene information for RAMP2 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RAMP2 Gene

Genomics for RAMP2 Gene

GeneHancer (GH) Regulatory Elements for RAMP2 Gene

Promoters and enhancers for RAMP2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J042763 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 505.8 +3.8 3829 3.8 CTCF REST ZNF423 ZBTB26 RFX1 KLF7 ZBTB25 TGIF2 RAD21 ZBTB7A RAMP2 HSALNG0116566 RAMP2-AS1 TUBG2 RF00017-2391
GH17J042760 Enhancer 0.7 ENCODE 500.7 +1.8 1771 0.2 NR2F2 MYNN TCF12 ZNF207 SMARCA5 IKZF1 NR2F1 NFATC3 TBX21 KLF5 HSALNG0116566 RAMP2 RAMP2-AS1
GH17J042758 Enhancer 0.3 Ensembl 500.7 -0.1 -146 0.2 ZNF121 RAMP2 HMGN2P15 RAMP2-AS1
GH17J042674 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.4 -80.0 -80045 12 RXRA FOXK2 HNRNPK ZBTB40 ZNF217 EP300 CTCF SIN3A NRF1 TCF12 CNTNAP1 CCR10 PLEKHH3 ENSG00000267042 TUBG2 ENSG00000267340 ENSG00000267002 HSD17B1P1 RETREG3 HMGN2P15
GH17J042822 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 11.5 +65.5 65453 2.2 EP300 ZBTB40 CTCF SIN3A TCF12 POLR2G GTF2E2 PHF8 PHB2 ZFX MIR6781 PSME3 lnc-COA3-4 lnc-PSME3-1 BECN1 CNTD1 COA3 AOC2 AOC3 VPS25
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RAMP2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RAMP2

Top Transcription factor binding sites by QIAGEN in the RAMP2 gene promoter:
  • AP-4
  • CUTL1
  • FOXJ2
  • FOXJ2 (long isoform)
  • Hlf
  • LCR-F1
  • MAZR
  • PPAR-gamma1
  • PPAR-gamma2
  • STAT5B

Genomic Locations for RAMP2 Gene

Genomic Locations for RAMP2 Gene
chr17:42,758,447-42,763,041
(GRCh38/hg38)
Size:
4,595 bases
Orientation:
Plus strand
chr17:40,910,465-40,915,059
(GRCh37/hg19)
Size:
4,595 bases
Orientation:
Plus strand

Genomic View for RAMP2 Gene

Genes around RAMP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAMP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAMP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAMP2 Gene

Proteins for RAMP2 Gene

  • Protein details for RAMP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60895-RAMP2_HUMAN
    Recommended name:
    Receptor activity-modifying protein 2
    Protein Accession:
    O60895
    Secondary Accessions:
    • A7L9S6
    • K7EMD3
    • Q8N1F2

    Protein attributes for RAMP2 Gene

    Size:
    175 amino acids
    Molecular mass:
    19608 Da
    Quaternary structure:
    • Heterodimer of CALCRL and RAMP2.

    Three dimensional structures from OCA and Proteopedia for RAMP2 Gene

    Alternative splice isoforms for RAMP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAMP2 Gene

Post-translational modifications for RAMP2 Gene

  • Glycosylation at Asn130
  • Modification sites at PhosphoSitePlus

Other Protein References for RAMP2 Gene

No data available for DME Specific Peptides for RAMP2 Gene

Domains & Families for RAMP2 Gene

Gene Families for RAMP2 Gene

HGNC:
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for RAMP2 Gene

Blocks:
  • Receptor activity modifying protein
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RAMP2 Gene

GenScript: Design optimal peptide antigens:
  • Receptor activity modifying protein 2 (A7L9S6_HUMAN)
  • Calcitonin-receptor-like receptor activity-modifying protein 2 (RAMP2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O60895

UniProtKB/Swiss-Prot:

RAMP2_HUMAN :
  • Belongs to the RAMP family.
Family:
  • Belongs to the RAMP family.
genes like me logo Genes that share domains with RAMP2: view

Function for RAMP2 Gene

Molecular function for RAMP2 Gene

UniProtKB/Swiss-Prot Function:
Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.

Phenotypes From GWAS Catalog for RAMP2 Gene

Gene Ontology (GO) - Molecular Function for RAMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001605 adrenomedullin receptor activity IPI 9620797
GO:0005515 protein binding IPI 9620797
GO:0008565 protein transporter activity IEA --
GO:0015026 coreceptor activity ISS --
GO:0097643 contributes_to amylin receptor activity IGI 22500019
genes like me logo Genes that share ontologies with RAMP2: view
genes like me logo Genes that share phenotypes with RAMP2: view

Animal Models for RAMP2 Gene

MGI Knock Outs for RAMP2:

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for RAMP2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for RAMP2 Gene

Localization for RAMP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAMP2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAMP2 gene
Compartment Confidence
plasma membrane 5
lysosome 4
mitochondrion 3
extracellular 2
cytosol 2
cytoskeleton 1
nucleus 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RAMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IDA 11804624
GO:0005737 cytoplasm IDA 10882736
GO:0005764 lysosome TAS 10882736
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9620797
genes like me logo Genes that share ontologies with RAMP2: view

Pathways & Interactions for RAMP2 Gene

genes like me logo Genes that share pathways with RAMP2: view

Gene Ontology (GO) - Biological Process for RAMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IDA 20596610
GO:0001570 vasculogenesis IMP 16964401
GO:0001666 response to hypoxia IEA --
GO:0002040 sprouting angiogenesis ISS --
GO:0006816 calcium ion transport IBA,IDA 10882736
genes like me logo Genes that share ontologies with RAMP2: view

No data available for SIGNOR curated interactions for RAMP2 Gene

Drugs & Compounds for RAMP2 Gene

(5) Drugs for RAMP2 Gene - From: DrugBank, DGIdb, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pramlintide Approved, Investigational Pharma Target, agonist 52
CGRP (rat) Pharma Potent vasodilator 0
PHM 27 (human) Pharma Potent calcitonin receptor agonist; endogenous analog of human VIP 0
SUN-B 8155 Pharma Non-peptide calcitonin (CT) receptor agonist 0

(4) Additional Compounds for RAMP2 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
alpha-CGRP (human)
90954-53-3
Calcitonin (salmon)
47931-85-1

(5) Tocris Compounds for RAMP2 Gene

Compound Action Cas Number
alpha-CGRP (human) CGRP receptor agonist 90954-53-3
Calcitonin (salmon) Affects bone formation and resorption 47931-85-1
CGRP (rat) Potent vasodilator 83651-90-5
PHM 27 (human) Potent calcitonin receptor agonist; endogenous analog of human VIP 118025-43-7
SUN-B 8155 Non-peptide calcitonin (CT) receptor agonist 345893-91-6
genes like me logo Genes that share compounds with RAMP2: view

Transcripts for RAMP2 Gene

mRNA/cDNA for RAMP2 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for RAMP2

Alternative Splicing Database (ASD) splice patterns (SP) for RAMP2 Gene

No ASD Table

Relevant External Links for RAMP2 Gene

GeneLoc Exon Structure for
RAMP2

Expression for RAMP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RAMP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAMP2 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x4.1).

Protein differential expression in normal tissues from HIPED for RAMP2 Gene

This gene is overexpressed in Fetal gut (58.3) and Fetal heart (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RAMP2 Gene



Protein tissue co-expression partners for RAMP2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RAMP2

SOURCE GeneReport for Unigene cluster for RAMP2 Gene:

Hs.514193

mRNA Expression by UniProt/SwissProt for RAMP2 Gene:

O60895-RAMP2_HUMAN
Tissue specificity: Strongly expressed in lung, breast, immune system and fetal tissues.

Evidence on tissue expression from TISSUES for RAMP2 Gene

  • Heart(4.6)
  • Pancreas(4.1)
  • Muscle(2.7)
  • Kidney(2.6)
  • Lung(2.5)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with RAMP2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RAMP2 Gene

Orthologs for RAMP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RAMP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAMP2 31 30
  • 97.71 (n)
OneToOne
dog
(Canis familiaris)
Mammalia RAMP2 30
  • 84.95 (n)
-- 31
  • 67 (a)
OneToMany
-- 31
  • 63 (a)
OneToMany
cow
(Bos Taurus)
Mammalia RAMP2 31 30
  • 83.72 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ramp2 30
  • 77.26 (n)
mouse
(Mus musculus)
Mammalia Ramp2 17 31 30
  • 75.29 (n)
oppossum
(Monodelphis domestica)
Mammalia RAMP2 31
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAMP2 31 30
  • 62.28 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAMP2 31
  • 50 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ramp2 31
  • 19 (a)
OneToOne
Species where no ortholog for RAMP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAMP2 Gene

ENSEMBL:
Gene Tree for RAMP2 (if available)
TreeFam:
Gene Tree for RAMP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RAMP2: view image

Paralogs for RAMP2 Gene

Paralogs for RAMP2 Gene

(2) SIMAP similar genes for RAMP2 Gene using alignment to 6 proteins:

  • RAMP2_HUMAN
  • A7L9S6_HUMAN
  • K7EKQ3_HUMAN
  • K7EMD3_HUMAN
  • K7ENJ8_HUMAN
  • K7EPN3_HUMAN
genes like me logo Genes that share paralogs with RAMP2: view

Variants for RAMP2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RAMP2 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
750255 Likely Benign: not provided 42,762,744(+) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for RAMP2 Gene

Structural Variations from Database of Genomic Variants (DGV) for RAMP2 Gene

Variant ID Type Subtype PubMed ID
esv33998 OTHER inversion 15654335
nsv1146669 OTHER inversion 26484159
nsv833450 CNV loss 17160897

Variation tolerance for RAMP2 Gene

Residual Variation Intolerance Score: 55.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.85; 17.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RAMP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAMP2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAMP2 Gene

Disorders for RAMP2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for RAMP2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
pheochromocytoma
  • pcc
cartilage cancer
  • chondrogenic neoplasm
lutembacher's syndrome
  • lutembacher syndrome
migraine with or without aura 1
  • migraine with or without aura, susceptibility to, 1
- elite association - COSMIC cancer census association via MalaCards
Search RAMP2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RAMP2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with RAMP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RAMP2 Gene

Publications for RAMP2 Gene

  1. Lack of linkage and association of adrenomedullin and its receptor genes in French Caucasian rheumatoid arthritis trio families. (PMID: 19210874) Michou L … Lioté F (Clinical and experimental rheumatology 2008) 3 23 41 54
  2. Structural basis for extracellular interactions between calcitonin receptor-like receptor and receptor activity-modifying protein 2 for adrenomedullin-specific binding. (PMID: 22102369) Kusano S … Yokoyama S (Protein science : a publication of the Protein Society 2012) 3 4 54
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41 54
  4. Function of the cytoplasmic tail of human calcitonin receptor-like receptor in complex with receptor activity-modifying protein 2. (PMID: 20074556) Kuwasako K … Kato J (Biochemical and biophysical research communications 2010) 3 23 54
  5. The GPCR modulator protein RAMP2 is essential for angiogenesis and vascular integrity. (PMID: 18097473) Ichikawa-Shindo Y … Shindo T (The Journal of clinical investigation 2008) 3 23 54

Products for RAMP2 Gene

Sources for RAMP2 Gene