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Aliases for RALYL Gene

Aliases for RALYL Gene

  • RALY RNA Binding Protein Like 2 3 5
  • Heterogeneous Nuclear Ribonucleoprotein C-Like 3 3 4
  • HnRNP Core Protein C-Like 3 3 4
  • HNRPCL3 3 4
  • RNA-Binding Raly-Like Protein 3
  • HRALYL 4

External Ids for RALYL Gene

Previous GeneCards Identifiers for RALYL Gene

  • GC08P085259
  • GC08P085095
  • GC08P080586

Summaries for RALYL Gene

GeneCards Summary for RALYL Gene

RALYL (RALY RNA Binding Protein Like) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and identical protein binding. An important paralog of this gene is RALY.

Gene Wiki entry for RALYL Gene

Additional gene information for RALYL Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RALYL Gene

Genomics for RALYL Gene

GeneHancer (GH) Regulatory Elements for RALYL Gene

Promoters and enhancers for RALYL Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J084182 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 655.5 +1.2 1204 3.8 CTCF MXI1 PKNOX1 USF1 ZNF362 BMI1 ZNF335 ZNF512B CBX8 POLR2A RALYL GC08P084192
GH08J084197 Promoter 0.5 EPDnew 650.4 +14.9 14922 0.1 RALYL GC08P084192 GC08M084209
GH08J083912 Promoter 0.5 EPDnew 650.1 -270.1 -270110 0.1 ENSG00000254202 RALYL GC08P083881
GH08J084289 Enhancer 0.8 Ensembl ENCODE 4.8 +106.7 106696 1.8 FOXA2 RXRA NFIB MAX REST RAD21 NR2F2 YY1 SP1 JUND RALYL GC08M084311 GC08M084209
GH08J084479 Enhancer 0.6 ENCODE 5.1 +298.0 298046 2.3 FOXA2 TRIM22 YY1 SP1 ATF3 IKZF1 TARDBP NBN HNF4G HNF4A GC08M084476 RALYL RNU6-1040P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RALYL on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RALYL gene promoter:
  • CUTL1
  • AREB6
  • POU2F1
  • POU2F1a

Genomic Locations for RALYL Gene

Genomic Locations for RALYL Gene
chr8:84,182,787-84,921,844
(GRCh38/hg38)
Size:
739,058 bases
Orientation:
Plus strand
chr8:85,095,022-85,834,079
(GRCh37/hg19)
Size:
739,058 bases
Orientation:
Plus strand

Genomic View for RALYL Gene

Genes around RALYL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RALYL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RALYL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RALYL Gene

Proteins for RALYL Gene

  • Protein details for RALYL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86SE5-RALYL_HUMAN
    Recommended name:
    RNA-binding Raly-like protein
    Protein Accession:
    Q86SE5
    Secondary Accessions:
    • B3KTH2
    • G3V129
    • Q6ZW87
    • Q8N1C2

    Protein attributes for RALYL Gene

    Size:
    291 amino acids
    Molecular mass:
    32331 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH31090.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for RALYL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RALYL Gene

Post-translational modifications for RALYL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RALYL Gene

Domains & Families for RALYL Gene

Gene Families for RALYL Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

Q86SE5

UniProtKB/Swiss-Prot:

RALYL_HUMAN :
  • Belongs to the RRM HNRPC family. RALY subfamily.
Family:
  • Belongs to the RRM HNRPC family. RALY subfamily.
genes like me logo Genes that share domains with RALYL: view

Function for RALYL Gene

Phenotypes From GWAS Catalog for RALYL Gene

Gene Ontology (GO) - Molecular Function for RALYL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IBA --
GO:0005515 protein binding IPI 16189514
GO:0042802 identical protein binding IPI 16189514
genes like me logo Genes that share ontologies with RALYL: view
genes like me logo Genes that share phenotypes with RALYL: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RALYL

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RALYL Gene

Localization for RALYL Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RALYL gene
Compartment Confidence
nucleus 5
plasma membrane 1
extracellular 1
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RALYL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with RALYL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RALYL Gene

Pathways & Interactions for RALYL Gene

SuperPathways for RALYL Gene

No Data Available

Gene Ontology (GO) - Biological Process for RALYL Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RALYL Gene

Drugs & Compounds for RALYL Gene

No Compound Related Data Available

Transcripts for RALYL Gene

Unigene Clusters for RALYL Gene

RALY RNA binding protein-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RALYL

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RALYL Gene

No ASD Table

Relevant External Links for RALYL Gene

GeneLoc Exon Structure for
RALYL
ECgene alternative splicing isoforms for
RALYL

Expression for RALYL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RALYL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RALYL Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x6.0), Brain - Anterior cingulate cortex (BA24) (x5.4), Brain - Frontal Cortex (BA9) (x5.4), Brain - Hypothalamus (x4.7), and Brain - Cerebellum (x4.3).

Protein differential expression in normal tissues from HIPED for RALYL Gene

This gene is overexpressed in Lung (51.8) and Fetal Brain (14.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RALYL Gene



Protein tissue co-expression partners for RALYL Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RALYL Gene:

RALYL

SOURCE GeneReport for Unigene cluster for RALYL Gene:

Hs.121663

mRNA Expression by UniProt/SwissProt for RALYL Gene:

Q86SE5-RALYL_HUMAN
Tissue specificity: Widely expressed, with highest levels in brain.

Evidence on tissue expression from TISSUES for RALYL Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with RALYL: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RALYL Gene

Orthologs for RALYL Gene

This gene was present in the common ancestor of animals.

Orthologs for RALYL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RALYL 34 33
  • 99.89 (n)
OneToOne
dog
(Canis familiaris)
Mammalia -- 34
  • 93 (a)
OneToMany
LOC487025 33
  • 92.42 (n)
-- 34
  • 90 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ralyl 16 34 33
  • 88.66 (n)
cow
(Bos Taurus)
Mammalia RALYL 34 33
  • 87.17 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 85 (a)
OneToMany
-- 34
  • 61 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 85 (a)
OneToMany
-- 34
  • 75 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 34
  • 92 (a)
OneToMany
RALYL 34 33
  • 84.07 (n)
OneToMany
lizard
(Anolis carolinensis)
Reptilia RALYL 34
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ralyl 33
  • 76.21 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100148343 33
  • 62.95 (n)
CABZ01071757.1 34
  • 46 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG42458 34
  • 11 (a)
OneToMany
Species where no ortholog for RALYL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RALYL Gene

ENSEMBL:
Gene Tree for RALYL (if available)
TreeFam:
Gene Tree for RALYL (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RALYL: view image

Paralogs for RALYL Gene

Paralogs for RALYL Gene

(7) SIMAP similar genes for RALYL Gene using alignment to 6 proteins:

  • RALYL_HUMAN
  • B3KT61_HUMAN
  • E5RG71_HUMAN
  • E5RIX9_HUMAN
  • E5RJ39_HUMAN
  • G3V129_HUMAN
genes like me logo Genes that share paralogs with RALYL: view

Variants for RALYL Gene

Sequence variations from dbSNP and Humsavar for RALYL Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000000017 -- 84,905,735(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000001274 -- 84,562,937(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000001762 -- 84,770,941(+) G/A intron_variant
rs1000008286 -- 84,484,695(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000008702 -- 84,730,374(+) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RALYL Gene

Variant ID Type Subtype PubMed ID
dgv1190n67 CNV loss 20364138
dgv12222n54 CNV loss 21841781
dgv12223n54 CNV loss 21841781
dgv12224n54 CNV loss 21841781
dgv12225n54 CNV loss 21841781
dgv12226n54 CNV loss 21841781
dgv149n17 CNV loss 16327808
dgv463n21 CNV gain 19592680
dgv7251n100 CNV loss 25217958
dgv7252n100 CNV loss 25217958
dgv7253n100 CNV loss 25217958
dgv7254n100 CNV gain 25217958
esv1023341 CNV insertion 17803354
esv1917544 CNV deletion 18987734
esv21659 CNV loss 19812545
esv21722 CNV loss 19812545
esv23119 CNV gain 19812545
esv2414076 CNV deletion 18987734
esv2421860 CNV deletion 20811451
esv2521393 CNV insertion 19546169
esv2669927 CNV deletion 23128226
esv2678686 CNV deletion 23128226
esv2737254 CNV deletion 23290073
esv2737255 CNV deletion 23290073
esv2737256 CNV deletion 23290073
esv2752268 CNV gain 17911159
esv2761174 CNV gain 21179565
esv2761218 CNV loss 21179565
esv2764062 CNV loss 21179565
esv28210 CNV gain 19812545
esv3304895 CNV mobile element insertion 20981092
esv3307107 CNV mobile element insertion 20981092
esv3396834 CNV insertion 20981092
esv3407934 CNV duplication 20981092
esv3410613 CNV insertion 20981092
esv3438881 CNV insertion 20981092
esv3543779 CNV deletion 23714750
esv3543780 CNV deletion 23714750
esv3572879 CNV loss 25503493
esv3572880 CNV loss 25503493
esv3572881 CNV loss 25503493
esv3617852 CNV loss 21293372
esv3617854 CNV loss 21293372
esv3617855 CNV loss 21293372
esv3617856 CNV gain 21293372
esv3617858 CNV loss 21293372
esv3617860 CNV loss 21293372
esv3617862 CNV loss 21293372
esv3617863 CNV loss 21293372
esv3617864 CNV loss 21293372
esv3891428 CNV loss 25118596
nsv1017411 CNV loss 25217958
nsv1030263 CNV gain 25217958
nsv1033771 CNV loss 25217958
nsv1068715 OTHER inversion 25765185
nsv1078617 CNV duplication 25765185
nsv1112473 CNV deletion 24896259
nsv1115111 CNV deletion 24896259
nsv1128435 CNV deletion 24896259
nsv1128977 CNV duplication 24896259
nsv1146309 CNV duplication 26484159
nsv1161778 CNV deletion 26073780
nsv1161779 CNV deletion 26073780
nsv436574 CNV deletion 17901297
nsv438067 CNV loss 16468122
nsv442524 CNV loss 18776908
nsv476627 CNV novel sequence insertion 20440878
nsv483126 CNV gain+loss 15286789
nsv499568 CNV loss 21111241
nsv515106 CNV loss 21397061
nsv522543 CNV loss 19592680
nsv611646 CNV loss 21841781
nsv611649 CNV loss 21841781
nsv611650 CNV loss 21841781
nsv6281 CNV deletion 18451855
nsv6282 CNV insertion 18451855
nsv6283 CNV insertion 18451855
nsv819991 CNV gain 19587683
nsv820872 CNV deletion 20802225
nsv824681 CNV loss 20364138
nsv831374 CNV loss 17160897
nsv831375 CNV gain 17160897
nsv831376 CNV gain 17160897
nsv8361 CNV gain 18304495
nsv972232 CNV deletion 23825009

Variation tolerance for RALYL Gene

Residual Variation Intolerance Score: 60.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.04; 21.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RALYL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RALYL

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RALYL Gene

Disorders for RALYL Gene

Additional Disease Information for RALYL

No disorders were found for RALYL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RALYL Gene

Publications for RALYL Gene

  1. A novel cDNA encodes a putative hRALY-like protein, hRALYL. (PMID: 12688537) Ji CN … Mao YM (Molecular biology reports 2003) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling. (PMID: 29128334) Malty RH … Babu M (Cell systems 2017) 3 58
  5. Cold-inducible RBM3 inhibits PERK phosphorylation through cooperation with NF90 to protect cells from endoplasmic reticulum stress. (PMID: 26472337) Zhu X … Wellmann S (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016) 3 58

Products for RALYL Gene

Sources for RALYL Gene

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