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This gene encodes a member of the heterogeneous nuclear ribonucleoprotein (hnRNP) gene family. This protein may play a role in pre-mRNA splicing and in embryonic development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
RALY (RALY Heterogeneous Nuclear Ribonucleoprotein) is a Protein Coding gene. Diseases associated with RALY include Skin Carcinoma In Situ and Dermatosis Papulosa Nigra. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is RALYL.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003676 | nucleic acid binding | IEA | -- |
GO:0003712 | transcription coregulator activity | IEA,ISS | -- |
GO:0003723 | RNA binding | IEA,IBA | 21873635 |
GO:0005515 | protein binding | IPI | 22365833 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | TAS,IDA | 22720776 |
GO:0005681 | spliceosomal complex | IEA | -- |
GO:0071013 | catalytic step 2 spliceosome | IDA | 11991638 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000398 | mRNA splicing, via spliceosome | IC | 11991638 |
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
GO:0006397 | mRNA processing | IEA | -- |
GO:0008380 | RNA splicing | IEA | -- |
GO:0042632 | cholesterol homeostasis | IEA,ISS | -- |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · | 11b | · | 11c | · | 11d | · | 11e | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP9: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP11: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP14: |
ExUns: | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 |
---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||
SP2: | |||||||||
SP3: | |||||||||
SP4: | |||||||||
SP5: | |||||||||
SP6: | |||||||||
SP7: | |||||||||
SP8: | |||||||||
SP9: | |||||||||
SP10: | |||||||||
SP11: | |||||||||
SP12: | |||||||||
SP13: | |||||||||
SP14: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | RALY 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | RALY 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | RALY 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Raly 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Raly 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
Chicken (Gallus gallus) |
Aves | RALY 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | RALY 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | raly 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.20815 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | raly 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | CG42458 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 20 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs35191085 | -. Benign: not provided | 34,075,911(+) |
p.Val139MetG/A |
MISSENSE | |
rs761012335 | Benign: not provided | 34,077,074(+) |
T/C NM_016732.3(RALY):c.705T>C (p.Gly235=) |
SYNONYMOUS | |
rs2281209 | - |
p.Gly251Ser |
|||
rs3180568 | - |
p.Gln215Arg |
Disorder | Aliases | PubMed IDs |
---|---|---|
skin carcinoma in situ |
|
|
dermatosis papulosa nigra |
|
|
fanconi anemia, complementation group a |
|
|