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This gene encodes a member of the heterogeneous nuclear ribonucleoprotein (hnRNP) gene family. This protein may play a role in pre-mRNA splicing and in embryonic development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011] See more...
Aliases for RALY Gene
Aliases for RALY Gene
- HnRNP Core Protein C-Like 2 3 4
- RNA-Binding Protein Raly 3 4
- Autoantigen P542 3 4
- RNA Binding Protein, Autoantigenic (HnRNP-Associated With Lethal Yellow Homolog (Mouse)) 2
- RNA Binding Protein, Autoantigenic (HnRNP-Associated With Lethal Yellow Homolog) 3
- RNA-Binding Protein (Autoantigenic) 3
- RALY 5
External Ids for RALY Gene
- HGNC: 15921
- NCBI Entrez Gene: 22913
- Ensembl: ENSG00000125970
- OMIM®: 614663
- UniProtKB/Swiss-Prot: Q9UKM9
Previous GeneCards Identifiers for RALY Gene
- GC20P032340
- GC20P033250
- GC20P033297
- GC20P032045
- GC20P032581
- GC20P029366
Summaries for RALY Gene
-
This gene encodes a member of the heterogeneous nuclear ribonucleoprotein (hnRNP) gene family. This protein may play a role in pre-mRNA splicing and in embryonic development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
GeneCards Summary for RALY Gene
RALY (RALY Heterogeneous Nuclear Ribonucleoprotein) is a Protein Coding gene. Diseases associated with RALY include Skin Carcinoma In Situ and Dermatosis Papulosa Nigra. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is RALYL.
UniProtKB/Swiss-Prot Summary for RALY Gene
-
RNA-binding protein that acts as a transcriptional cofactor for cholesterol biosynthetic genes in the liver. Binds the lipid-responsive non-coding RNA LeXis and is required for LeXis-mediated effect on cholesterogenesis (By similarity). May be a heterogeneous nuclear ribonucleoprotein (hnRNP) (PubMed:9376072).
Additional gene information for RALY Gene
- HGNC (15921)
- NCBI Entrez Gene (22913)
- Ensembl (ENSG00000125970)
- OMIM® (614663)
- UniProtKB/Swiss-Prot (Q9UKM9)
- Open Targets Platform(ENSG00000125970)
- Monarch Initiative
- Search for RALY at DataMed
- Search for RALY at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RALY Gene
Genomics for RALY Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for RALY Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around RALY on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RALY
- Top Transcription factor binding sites by QIAGEN in the RALY gene promoter:
-
- Nkx2-5
- POU2F1a
- Spz1
- STAT3
Genomic Locations for RALY Gene
Latest Assembly
- chr20:33,993,646-34,108,308
- (GRCh38/hg38)
- Size:
- 114,663 bases
- Orientation:
- Plus strand
Previous Assembly
- chr20:32,581,717-32,672,690
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 90,974 bases
- Orientation:
- Plus strand
- chr20:32,581,452-32,696,114
- (GRCh37/hg19 by Ensembl)
- Size:
- 114,663 bases
- Orientation:
- Plus strand
Genomic View for RALY Gene
Genes around RALY on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20q11.22 by HGNC
- 20q11.22 by Entrez Gene
- 20q11.22 by Ensembl
RALY Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RALY Gene
Proteins for RALY Gene
-
Protein details for RALY Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UKM9-RALY_HUMAN
- Recommended name:
- RNA-binding protein Raly
- Protein Accession:
- Q9UKM9
- Q14621
- Q2M365
- Q5QPL8
- Q9BQX6
- Q9UJE3
Protein attributes for RALY Gene
- Size:
- 306 amino acids
- Molecular mass:
- 32463 Da
- Quaternary structure:
-
- Identified in the spliceosome C complex (PubMed:11991638). Interacts (through its RNA-binding domain) with FUS (through its RNA-binding domain); both are components of the same RNPs (PubMed:30354839).
- Miscellaneous:
-
- Autoantigen found in infectious mononucleosis caused by Epstein-Barr virus. An epitope recognized by B-cells, which cross-react with the BKRF1 protein (EBNA-1 nuclear protein) of Epstein-Barr virus has been identified.
Protein Expression for RALY Gene
Post-translational modifications for RALY Gene
Other Protein References for RALY Gene
Antibodies for research
- LifeSpan BioSciences RALY Antibody (LS-B11433) and RALY Antibody (LS-B14428)
- G Biosciences Immunotag™ RALY Antibody
- GeneTex Anti-RALY antibody
- Novus Biologicals Antibodies for RALY
-
Abcam antibodies for RALY
- Invitrogen Antibodies for RALY (AFLGC-RALY)
-
Biorbyt antibodies for RALY
- Sino Biological Antibodies for RALY
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for RALY
- Origene Custom Protein Services for RALY
- ProSpec Recombinant Proteins for RALY
- antibodies-online: Show 7 available RALY Proteins ranked by validation data
- Compare Top RALY Proteins
-
Quality Products:
-
Abcam proteins for RALY
Assay products for research
- antibodies-online: Search results for available RALY related products ranked by validation data
No data available for DME Specific Peptides for RALY Gene
Domains & Families for RALY Gene
Gene Families for RALY Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for RALY Gene
- InterPro:
- Blocks:
-
- RNA-binding region RNP-1 (RNA recognition motif)
- ProtoNet:
Suggested Antigen Peptide Sequences for RALY Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ77422, highly similar to Homo sapiens RNA binding protein, autoantigenic (hnRNP-associated with lethal yellow homolog (mouse)), transcript variant 1, mRNA (Q53GL6_HUMAN)
- hnRNP associated with lethal yellow protein homolog (RALY_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9UKM9- Family:
-
- Belongs to the RRM HNRPC family. RALY subfamily.
Function for RALY Gene
Molecular function for RALY Gene
- UniProtKB/Swiss-Prot Function:
- RNA-binding protein that acts as a transcriptional cofactor for cholesterol biosynthetic genes in the liver. Binds the lipid-responsive non-coding RNA LeXis and is required for LeXis-mediated effect on cholesterogenesis (By similarity). May be a heterogeneous nuclear ribonucleoprotein (hnRNP) (PubMed:9376072).
Phenotypes From GWAS Catalog for RALY Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003712 | transcription coregulator activity | IEA,ISS | -- |
| GO:0003723 | RNA binding | IEA,IBA | 21873635 |
| GO:0005515 | protein binding | IPI | 22365833 |
Phenotypes for RALY Gene
- MGI mutant phenotypes for RALY:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for RALY:
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for RALY - Starting at $85 >
- * RALY CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for RALY
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RALY
-
Santa Cruz Biotechnology (SCBT) CRISPR for RALY
miRNA for RALY Gene
- miRTarBase miRNAs that target RALY
-
- hsa-miR-320a (MIRT044575)
- hsa-miR-486-3p (MIRT497388)
- hsa-miR-885-3p (MIRT497389)
- hsa-miR-6886-3p (MIRT497390)
- hsa-miR-938 (MIRT497391)
- hsa-miR-6754-3p (MIRT497392)
- hsa-miR-412-3p (MIRT497393)
- hsa-miR-6765-3p (MIRT497394)
- hsa-miR-3622b-3p (MIRT497395)
- hsa-miR-3622a-3p (MIRT497396)
- hsa-miR-127-5p (MIRT666728)
- hsa-miR-7843-3p (MIRT666729)
- hsa-miR-6881-3p (MIRT666730)
- hsa-miR-6780a-3p (MIRT666731)
- hsa-miR-7111-3p (MIRT666732)
- hsa-miR-5581-5p (MIRT666733)
- hsa-miR-4297 (MIRT666734)
- hsa-miR-4786-3p (MIRT666735)
- hsa-miR-4635 (MIRT666736)
- hsa-miR-6719-3p (MIRT666737)
- hsa-miR-4526 (MIRT666738)
- hsa-miR-3660 (MIRT666739)
- hsa-miR-6730-3p (MIRT666740)
- hsa-miR-7110-3p (MIRT666741)
- hsa-miR-3667-3p (MIRT666742)
- hsa-miR-6769b-3p (MIRT666743)
- hsa-miR-3183 (MIRT666744)
- hsa-miR-4723-3p (MIRT666745)
- hsa-miR-3614-3p (MIRT666746)
- hsa-miR-654-3p (MIRT666747)
- hsa-miR-1273h-3p (MIRT736843)
- hsa-miR-1285-3p (MIRT737034)
- hsa-miR-1321 (MIRT737359)
- hsa-miR-1324 (MIRT737399)
- hsa-miR-148a-3p (MIRT737672)
- hsa-miR-148b-3p (MIRT737687)
- hsa-miR-149-3p (MIRT737781)
- hsa-miR-152-3p (MIRT737876)
- hsa-miR-15a-3p (MIRT737928)
- hsa-miR-2110 (MIRT738910)
- hsa-miR-3166 (MIRT740581)
- hsa-miR-3187-5p (MIRT740929)
- hsa-miR-34a-5p (MIRT741443)
- hsa-miR-34c-5p (MIRT741486)
- hsa-miR-4270 (MIRT743591)
- hsa-miR-4271 (MIRT743634)
- hsa-miR-4437 (MIRT744498)
- hsa-miR-4441 (MIRT744558)
- hsa-miR-449a (MIRT745410)
- hsa-miR-449b-5p (MIRT745442)
- hsa-miR-4524b-3p (MIRT745890)
- hsa-miR-4533 (MIRT746029)
- hsa-miR-4717-5p (MIRT747525)
- hsa-miR-4721 (MIRT747560)
- hsa-miR-4725-3p (MIRT747715)
- hsa-miR-4728-5p (MIRT747877)
- hsa-miR-4739 (MIRT748076)
- hsa-miR-4747-5p (MIRT748268)
- hsa-miR-4756-5p (MIRT748448)
- hsa-miR-4764-3p (MIRT748584)
- hsa-miR-4771 (MIRT748684)
- hsa-miR-5088-5p (MIRT749639)
- hsa-miR-5189-5p (MIRT749890)
- hsa-miR-5196-5p (MIRT750052)
- hsa-miR-5704 (MIRT751383)
- hsa-miR-612 (MIRT752232)
- hsa-miR-6721-5p (MIRT753829)
- hsa-miR-6754-5p (MIRT754733)
- hsa-miR-6780b-5p (MIRT755646)
- hsa-miR-6785-5p (MIRT755872)
- hsa-miR-6847-3p (MIRT757456)
- hsa-miR-6860 (MIRT757863)
- hsa-miR-6883-5p (MIRT758457)
- hsa-miR-7845-5p (MIRT759810)
- hsa-miR-802 (MIRT760008)
- hsa-miR-939-3p (MIRT760726)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RALY
- Browse OriGene Inhibitory RNA Products For RALY
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RALY
Clone products for research
- Applied Biological Materials (abm): Clones for RALY - Starting at $45 >
- * RALY as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG204103
- MG216731
- MG218198
- MG218213
- MR204103
- MR204103L3
- MR204103L4
- MR216731
- MR216731L3
- MR216731L4
- MR218198
- MR218198L3
- MR218198L4
- MR218213
- MR218213L3
- MR218213L4
- RC210723
- RC210723L1
- RC210723L2
- RC210723L3
- RC210723L4
- RC223333
- RC223333L3
- RC223333L4
- RG210723
- RG223333
- RR208747
- RR208747L3
- RR208747L4
- MR204103L3V
- MR204103L4V
- MR216731L3V
- MR216731L4V
- MR218198L3V
- MR218198L4V
- MR218213L3V
- MR218213L4V
- RC210723L1V
- RC210723L2V
- RC210723L3V
- RC210723L4V
- RC223333L3V
- RC223333L4V
- RR208747L3V
- RR208747L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for RALY
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RALY
Cell Lines for research
-
Horizon Cell Lines for RALY
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RALY Gene
Localization for RALY Gene
Subcellular locations from UniProtKB/Swiss-Prot for RALY Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
- Nucleoplasm (4)
- Vesicles (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | TAS,IDA | 22720776 |
| GO:0005681 | spliceosomal complex | IEA | -- |
| GO:0071013 | catalytic step 2 spliceosome | IDA | 11991638 |
Pathways & Interactions for RALY Gene
Interacting Proteins for RALY Gene
Selected Interacting proteins:
Q9UKM9-RALY_HUMAN
ENSP00000246194
for RALY Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for RALY
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000398 | mRNA splicing, via spliceosome | IC | 11991638 |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006397 | mRNA processing | IEA | -- |
| GO:0008380 | RNA splicing | IEA | -- |
| GO:0042632 | cholesterol homeostasis | IEA,ISS | -- |
No data available for Pathways by source for RALY Gene
Transcripts for RALY Gene
mRNA/cDNA for RALY Gene
- 2 REFSEQ mRNAs :
- 12 NCBI additional mRNA sequence :
- 10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000246194 6213 nts (view in UCSC)
- ENST00000333552 786 nts (view in UCSC)
- ENST00000375114 6430 nts (view in UCSC)
- ENST00000413297 766 nts (view in UCSC)
- ENST00000442805 871 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for RALY - Starting at $85 >
- * RALY CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for RALY
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RALY
-
Santa Cruz Biotechnology (SCBT) CRISPR for RALY
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RALY
- Browse OriGene Inhibitory RNA Products For RALY
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RALY
Clone products for research
- Applied Biological Materials (abm): Clones for RALY - Starting at $45 >
- * RALY as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG204103
- MG216731
- MG218198
- MG218213
- MR204103
- MR204103L3
- MR204103L4
- MR216731
- MR216731L3
- MR216731L4
- MR218198
- MR218198L3
- MR218198L4
- MR218213
- MR218213L3
- MR218213L4
- RC210723
- RC210723L1
- RC210723L2
- RC210723L3
- RC210723L4
- RC223333
- RC223333L3
- RC223333L4
- RG210723
- RG223333
- RR208747
- RR208747L3
- RR208747L4
- MR204103L3V
- MR204103L4V
- MR216731L3V
- MR216731L4V
- MR218198L3V
- MR218198L4V
- MR218213L3V
- MR218213L4V
- RC210723L1V
- RC210723L2V
- RC210723L3V
- RC210723L4V
- RC223333L3V
- RC223333L4V
- RR208747L3V
- RR208747L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for RALY
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RALY
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · | 11b | · | 11c | · | 11d | · | 11e | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: |
| ExUns: | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 |
|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||
| SP2: | |||||||||
| SP3: | |||||||||
| SP4: | |||||||||
| SP5: | |||||||||
| SP6: | |||||||||
| SP7: | |||||||||
| SP8: | |||||||||
| SP9: | |||||||||
| SP10: | |||||||||
| SP11: | |||||||||
| SP12: | |||||||||
| SP13: | |||||||||
| SP14: |
Relevant External Links for RALY Gene
- GeneLoc Exon Structure for
- RALY
Expression for RALY Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RALY Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RALY
SOURCE GeneReport for Unigene cluster for RALY Gene:
Hs.136947mRNA Expression by UniProt/SwissProt for RALY Gene:
Q9UKM9-RALY_HUMAN
Tissue specificity:
Expressed in heart, brain, lung, liver, skeletal muscle, kidney and pancreas. Weakly expressed in placenta.
Evidence on tissue expression from TISSUES for RALY Gene
- Nervous system(4.8)
- Liver(4.4)
- Blood(4.4)
- Skin(3)
- Lung(2.8)
- Intestine(2.5)
- Muscle(2.4)
- Eye(2.3)
- Lymph node(2.2)
- Heart(2.2)
- Kidney(2.1)
Primer products for research
-
OriGene qPCR primer pairs for RALY
-
OriGene qPCR primer pairs and template standards for RALY
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RALY Gene
Orthologs for RALY Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | RALY 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | RALY 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | RALY 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Raly 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Raly 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
| Chicken (Gallus gallus) |
Aves | RALY 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | RALY 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | raly 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.20815 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | raly 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG42458 31 |
|
OneToMany |
- Species where no ortholog for RALY was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for RALY Gene
- ENSEMBL:
- Gene Tree for RALY (if available)
- TreeFam:
- Gene Tree for RALY (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for RALY: view image
Paralogs for RALY Gene
(16) SIMAP similar genes for RALY Gene using alignment to 7 proteins:
- RALY_HUMAN
- L8E7Y8_HUMAN
- Q53GL6_HUMAN
- Q5QPL9_HUMAN
- Q5QPM0_HUMAN
- Q5QPM1_HUMAN
- Q5QPM2_HUMAN
Variants for RALY Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RALY Gene
| SNP ID | Clinical significance and condition | Chr 20 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs35191085 | -. Benign: not provided | 34,075,911(+) |
p.Val139MetG/A |
MISSENSE | |
| rs761012335 | Benign: not provided | 34,077,074(+) |
T/C NM_016732.3(RALY):c.705T>C (p.Gly235=) |
SYNONYMOUS | |
| rs2281209 | - |
p.Gly251Ser |
|||
| rs3180568 | - |
p.Gln215Arg |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
76.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.17;
69.57% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RALY Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- RALY
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RALY Gene
Disorders for RALY Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| skin carcinoma in situ |
|
|
| dermatosis papulosa nigra |
|
|
| fanconi anemia, complementation group a |
|
|
Search RALY in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for RALY
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for RALY Gene
Publications for RALY Gene
- Alternative processing of the human and mouse raly genes(1). (PMID: 10500250) Khrebtukova I … Michaud EJ (Biochimica et biophysica acta 1999) 2 3 4
- The p542 gene encodes an autoantigen that cross-reacts with EBNA-1 of the Epstein Barr virus and which may be a heterogeneous nuclear ribonucleoprotein. (PMID: 9376072) Rhodes GH … Vaughan JH (Journal of autoimmunity 1997) 3 4 23
- The hnRNP RALY regulates PRMT1 expression and interacts with the ALS-linked protein FUS: implication for reciprocal cellular localization. (PMID: 30354839) Gasperini L … Macchi P (Molecular biology of the cell 2018) 3 4
- Proteome-wide characterization of the RNA-binding protein RALY-interactome using the in vivo-biotinylation-pulldown-quant (iBioPQ) approach. (PMID: 23614458) Tenzer S … Macchi P (Journal of proteome research 2013) 2 3
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
ExternalLinks
Products for RALY Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
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- OriGene qPCR primer pairs and template standards for RALY
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- MG204103
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- MR204103
- MR204103L3
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- RC210723
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- RC223333
- RC223333L3
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- RR208747
- RR208747L3
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- MR204103L3V
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- MR218198L3V
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- MR218213L3V
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- RC210723L1V
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- RC210723L3V
- RC210723L4V
- RC223333L3V
- RC223333L4V
- RR208747L3V
- RR208747L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Sino Biological Antibodies for RALY
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- High-throughput Antibody Production Service
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- Novus Biologicals proteins and lysates for RALY
- Browse Antibodies
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- Abcam proteins for RALY
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- VectorBuilder Custom and pre-made DNA vectors for RALY (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for RALY (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for RALY (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for RALY CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for RALY
- antibodies-online: Show 33 available RALY Antibodies ranked by validation data
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- antibodies-online: Search results for available RALY related products ranked by validation data
- antibodies-online: Show 7 available RALY Proteins ranked by validation data
- Compare Top RALY Proteins
- Quality Products:
- Horizon Cell Lines for RALY
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RALY
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RALY
- Search GeneCopoeia for miRNA 3'UTR Target clone products for RALY
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RALY
- Biorbyt antibodies for RALY
Sources for RALY Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
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- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
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- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB