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RALGPS2 (Ral GEF With PH Domain And SH3 Binding Motif 2) is a Protein Coding gene. Diseases associated with RALGPS2 include Alzheimer Disease. Gene Ontology (GO) annotations related to this gene include guanyl-nucleotide exchange factor activity. An important paralog of this gene is RALGPS1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005085 | guanyl-nucleotide exchange factor activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA | -- |
GO:0005886 | plasma membrane | IEA | -- |
GO:0016020 | membrane | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007264 | small GTPase mediated signal transduction | IEA | -- |
GO:0032485 | regulation of Ral protein signal transduction | IEA | -- |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | RALGPS2 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | RALGPS2 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | RALGPS2 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | RALGPS2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | RALGPS2 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Ralgps2 30 17 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | RALGPS1 31 |
|
OneToOne | |
RALGPS2 30 |
|
||||
Lizard (Anolis carolinensis) |
Reptilia | RALGPS2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ralgps2 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | ralgps2 30 31 |
|
OneToOne | |
zgc63650 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.7645 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG5522 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CDC25 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.5548 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
784965 | Benign: not provided | 178,852,705(+) | G/A | SYNONYMOUS_VARIANT,INTRON_VARIANT | |
rs35161510 | - | p.Asn225Ser |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1005359 | CNV | loss | 25217958 |
nsv1014249 | CNV | gain | 25217958 |
nsv1124600 | CNV | duplication | 24896259 |
nsv3710 | CNV | insertion | 18451855 |
nsv466206 | CNV | gain | 19166990 |
nsv470748 | CNV | gain | 18288195 |
nsv525444 | CNV | loss | 19592680 |
nsv548265 | CNV | gain | 21841781 |
nsv825498 | CNV | loss | 20364138 |
nsv946519 | CNV | duplication | 23825009 |
nsv947455 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
alzheimer disease |
|
|