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RALGAPB (Ral GTPase Activating Protein Non-Catalytic Subunit Beta) is a Protein Coding gene. Among its related pathways are Translocation of GLUT4 to the plasma membrane and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and GTPase activator activity.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005096 | GTPase activator activity | IEA,ISS | -- |
GO:0046982 | protein heterodimerization activity | ISS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Vesicle-mediated transport | ||
2 | Translocation of GLUT4 to the plasma membrane |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0043547 | positive regulation of GTPase activity | IEA | -- |
GO:0051056 | regulation of small GTPase mediated signal transduction | IEA | -- |
GO:0090630 | activation of GTPase activity | ISS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
RBC8 | Pharma | 0 |
Compound | Action | Cas Number |
---|---|---|
RBC8 | 361185-42-4 |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 | ^ | 19a | · | 19b | ^ | 20 | ^ | 21 | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP5: |
ExUns: | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27a | · | 27b | ^ | 28 | ^ | 29 | ^ | 30a | · | 30b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||
SP2: | - | ||||||||||||||||||||
SP3: | - | ||||||||||||||||||||
SP4: | |||||||||||||||||||||
SP5: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | RALGAPB 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | RALGAPB 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | RALGAPB 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Ralgapb 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Ralgapb 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | RALGAPB 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | RALGAPB 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | RALGAPB 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | RALGAPB 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ralgapb 30 |
|
||
Str.20424 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.16058 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | ralgapb 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | CG34408 30 31 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007925 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | D2085.5 30 31 |
|
OneToMany | |
C34C6.2 31 |
|
OneToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.1742 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 20 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
689661 | Uncertain Significance: Marfanoid habitus and intellectual disability | 38,497,420(+) | C/T | MISSENSE_VARIANT | |
788838 | Benign: not provided | 38,570,800(+) | G/A | SYNONYMOUS_VARIANT | |
rs1225426795 | Uncertain Significance: Severe Myopia | 38,517,841(+) | T/C | MISSENSE_VARIANT | |
rs758022116 | Likely Pathogenic: Septo-optic dysplasia sequence | 38,535,152(+) | G/T | MISSENSE_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2359941 | CNV | deletion | 18987734 |
esv2581563 | CNV | deletion | 19546169 |
esv2624452 | CNV | deletion | 19546169 |
esv2722399 | CNV | deletion | 23290073 |
esv2758794 | CNV | gain | 17122850 |
esv3557054 | CNV | deletion | 23714750 |
nsv1058457 | CNV | loss | 25217958 |
nsv1114214 | CNV | deletion | 24896259 |
nsv1127836 | CNV | deletion | 24896259 |
nsv179180 | CNV | deletion | 16902084 |
nsv509769 | CNV | insertion | 20534489 |
No disorders were found for RALGAPB Gene.