Aliases for RALBP1 Gene
External Ids for RALBP1 Gene
Previous GeneCards Identifiers for RALBP1 Gene
RALBP1 plays a role in receptor-mediated endocytosis and is a downstream effector of the small GTP-binding protein RAL (see RALA; MIM 179550). Small G proteins, such as RAL, have GDP-bound inactive and GTP-bound active forms, which shift from the inactive to the active state through the action of RALGDS (MIM 601619), which in turn is activated by RAS (see HRAS; MIM 190020) (summary by Feig, 2003 [PubMed 12888294]).[supplied by OMIM, Nov 2010]
GeneCards Summary for RALBP1 Gene
RALBP1 (RalA Binding Protein 1) is a Protein Coding gene. Diseases associated with RALBP1 include Lung Cancer. Among its related pathways are Signaling by GPCR and Regulation of CDC42 activity. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and Rac GTPase binding.
UniProtKB/Swiss-Prot Summary for RALBP1 Gene
Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin.