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RALBP1 plays a role in receptor-mediated endocytosis and is a downstream effector of the small GTP-binding protein RAL (see RALA; MIM 179550). Small G proteins, such as RAL, have GDP-bound inactive and GTP-bound active forms, which shift from the inactive to the active state through the action of RALGDS (MIM 601619), which in turn is activated by RAS (see HRAS; MIM 190020) (summary by Feig, 2003 [PubMed 12888294]).[supplied by OMIM, Nov 2010]
RALBP1 (RalA Binding Protein 1) is a Protein Coding gene. Diseases associated with RALBP1 include Lung Cancer. Among its related pathways are Signaling by GPCR and Regulation of CDC42 activity. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and Rac GTPase binding.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005096 | GTPase activator activity | IEA,IDA | 7673236 |
GO:0005515 | protein binding | IPI | 9422736 |
GO:0017160 | Ral GTPase binding | IEA,IPI | 7673236 |
GO:0022857 | transmembrane transporter activity | IDA | 10924126 |
GO:0042626 | ATPase activity, coupled to transmembrane movement of substances | TAS | 11437348 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005829 | cytosol | TAS | -- |
GO:0016020 | membrane | IBA,IDA | 10924126 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Doxorubicin Pathway, Pharmacokinetics | ||
2 | Cytoskeletal Signaling | ||
3 | Endometrial cancer | ||
4 | Pathways in cancer | ||
5 | Ras signaling pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006897 | endocytosis | IBA | 21873635 |
GO:0006935 | chemotaxis | TAS | 10848592 |
GO:0007165 | signal transduction | IEA | -- |
GO:0007264 | small GTPase mediated signal transduction | IEA,IPI | 7673236 |
GO:0043087 | regulation of GTPase activity | IDA | 7673236 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Doxorubicin | Approved, Investigational | Pharma | Transporter, substrate | Topo II inhibitor,immunosuppresive antineoplastic antibiotic | 2029 | |
Carbamazepine | Approved, Investigational | Pharma | Transporter, substrate | Inhibitor of neuronal voltage-gated Na+ channels; anticonvulsant | 104 | |
Sorafenib | Approved, Investigational | Pharma | Transporter, substrate | Raf kinases and tyrosine kinases inhibitor, RAF, VEGFR2, and PDGFR-beta inhibitors, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors | 779 | |
Vincristine | Approved, Investigational | Pharma | Transporter, substrate | Microtubule disrupter,antitumor agent | 1073 | |
Glutathione | Approved, Investigational | Nutra | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||||||
SP4: | - | - |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | RALBP1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | RALBP1 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Oppossum (Monodelphis domestica) |
Mammalia | RALBP1 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Ralbp1 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Ralbp1 30 |
|
||
Cow (Bos Taurus) |
Mammalia | RALBP1 30 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | RALBP1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | RALBP1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ralbp1 30 |
|
||
Str.11420 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | rlip1-A-prov 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | ralbp1 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | Rlip 31 32 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | rlbp-1 31 |
|
OneToOne | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RGD1 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 18 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
716581 | Likely Benign: not provided | 9,522,350(+) | G/A | SYNONYMOUS_VARIANT | |
747831 | Benign: not provided | 9,522,340(+) | C/T | MISSENSE_VARIANT | |
748072 | Likely Benign: not provided | 9,516,858(+) | A/G | SYNONYMOUS_VARIANT | |
748073 | Likely Benign: not provided | 9,535,892(+) | G/A | SYNONYMOUS_VARIANT | |
756087 | Likely Benign: not provided | 9,535,868(+) | G/A | SYNONYMOUS_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
lung cancer |
|