Aliases for RALBP1 Gene
External Ids for RALBP1 Gene
Previous GeneCards Identifiers for RALBP1 Gene
RALBP1 plays a role in receptor-mediated endocytosis and is a downstream effector of the small GTP-binding protein RAL (see RALA; MIM 179550). Small G proteins, such as RAL, have GDP-bound inactive and GTP-bound active forms, which shift from the inactive to the active state through the action of RALGDS (MIM 601619), which in turn is activated by RAS (see HRAS; MIM 190020) (summary by Feig, 2003 [PubMed 12888294]).[supplied by OMIM, Nov 2010]
GeneCards Summary for RALBP1 Gene
RALBP1 (RalA Binding Protein 1) is a Protein Coding gene. Diseases associated with RALBP1 include Lung Cancer. Among its related pathways are p75 NTR receptor-mediated signalling and Ras signaling pathway. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and Rac GTPase binding.
UniProtKB/Swiss-Prot Summary for RALBP1 Gene
Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin.