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RALBP1 plays a role in receptor-mediated endocytosis and is a downstream effector of the small GTP-binding protein RAL (see RALA; MIM 179550). Small G proteins, such as RAL, have GDP-bound inactive and GTP-bound active forms, which shift from the inactive to the active state through the action of RALGDS (MIM 601619), which in turn is activated by RAS (see HRAS; MIM 190020) (sum... See more...
Aliases for RALBP1 Gene
Aliases for RALBP1 Gene
External Ids for RALBP1 Gene
- HGNC: 9841
- NCBI Entrez Gene: 10928
- Ensembl: ENSG00000017797
- OMIM®: 605801
- UniProtKB/Swiss-Prot: Q15311
Previous GeneCards Identifiers for RALBP1 Gene
- GC18P009629
Summaries for RALBP1 Gene
-
RALBP1 plays a role in receptor-mediated endocytosis and is a downstream effector of the small GTP-binding protein RAL (see RALA; MIM 179550). Small G proteins, such as RAL, have GDP-bound inactive and GTP-bound active forms, which shift from the inactive to the active state through the action of RALGDS (MIM 601619), which in turn is activated by RAS (see HRAS; MIM 190020) (summary by Feig, 2003 [PubMed 12888294]).[supplied by OMIM, Nov 2010]
GeneCards Summary for RALBP1 Gene
RALBP1 (RalA Binding Protein 1) is a Protein Coding gene. Diseases associated with RALBP1 include Lung Cancer. Among its related pathways are p75 NTR receptor-mediated signalling and Ras signaling pathway. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and Rac GTPase binding.
UniProtKB/Swiss-Prot Summary for RALBP1 Gene
-
Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin.
Additional gene information for RALBP1 Gene
- HGNC (9841)
- NCBI Entrez Gene (10928)
- Ensembl (ENSG00000017797)
- OMIM® (605801)
- UniProtKB/Swiss-Prot (Q15311)
- Open Targets Platform(ENSG00000017797)
- Monarch Initiative
- Alliance of Genome Resources
- Search for RALBP1 at DataMed
- Search for RALBP1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RALBP1 Gene
Genomics for RALBP1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for RALBP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around RALBP1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RALBP1
- Top Transcription factor binding sites by QIAGEN in the RALBP1 gene promoter:
-
- AP-2alpha
- AP-2alphaA
- AP-2beta
- AP-2gamma
- AREB6
- p53
- Pax-4a
- Sp1
Genomic Locations for RALBP1 Gene
Latest Assembly
- chr18:9,475,009-9,538,114
- (GRCh38/hg38)
- Size:
- 63,106 bases
- Orientation:
- Plus strand
Previous Assembly
- chr18:9,475,511-9,538,112
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 62,602 bases
- Orientation:
- Plus strand
Genomic View for RALBP1 Gene
Genes around RALBP1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 18p11.22 by HGNC
- 18p11.22 by Entrez Gene
- 18p11.22 by Ensembl
RALBP1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RALBP1 Gene
Proteins for RALBP1 Gene
-
Protein details for RALBP1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q15311-RBP1_HUMAN
- Recommended name:
- RalA-binding protein 1
- Protein Accession:
- Q15311
- D3DUI0
Protein attributes for RALBP1 Gene
- Size:
- 655 amino acids
- Molecular mass:
- 76063 Da
- Quaternary structure:
-
- Interacts with the GTP-bound form of RALA, RALB, CDC42 and RAC1. Interacts with REPS1 and REPS2 and this does not affect the Ral-binding activity. Interacts with DAB2IP. Interacts with catalytically active CCNB1 and CDK1 during mitosis. Interacts with EPN1, NUMB and TFAP2A during interphase and mitosis.
Protein Expression for RALBP1 Gene
Post-translational modifications for RALBP1 Gene
Other Protein References for RALBP1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences RIP1 / RALBP1 Antibody and RIP1 / RALBP1 Monoclonal Antibody
- G Biosciences Immunotag™ RALBP1 Antibody
-
Custom Antibody ServicesOriGene Antibodies for RALBP1
- Novus Biologicals Antibodies for RALBP1
-
Abcam antibodies for RALBP1
- Invitrogen Antibodies for RALBP1 (AFLGC-RALBP1)
-
Boster Bio Antibodies for RALBP1
-
Custom Antibody ServicesProSci Antibodies for RALBP1
-
Santa Cruz Biotechnology (SCBT) Antibodies for RALBP1
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for RALBP1
- Origene Custom Protein Services for RALBP1
- antibodies-online: Show 14 available RALBP1 Proteins ranked by validation data
- Compare Top RALBP1 Proteins
-
Quality Products:
Assay products for research
- antibodies-online: Show 11 available RALBP1 Elisa Kits ranked by validation data
- Compare Top RALBP1 Elisa Kits
-
Quality Products:
-
Abcam assays for RALBP1
No data available for DME Specific Peptides for RALBP1 Gene
Domains & Families for RALBP1 Gene
Gene Families for RALBP1 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transporters
Protein Domains for RALBP1 Gene
- InterPro:
- Blocks:
-
- RhoGAP domain
Suggested Antigen Peptide Sequences for RALBP1 Gene
- GenScript: Design optimal peptide antigens:
-
- Ral-interacting protein 1 (RBP1_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for RALBP1 Gene
Function for RALBP1 Gene
Molecular function for RALBP1 Gene
- UniProtKB/Swiss-Prot Function:
- Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin.
Phenotypes From GWAS Catalog for RALBP1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005096 | GTPase activator activity | IEA,IDA | 7673236 |
| GO:0005515 | protein binding | IPI | 9422736 |
| GO:0017160 | Ral GTPase binding | IEA | -- |
| GO:0022857 | transmembrane transporter activity | IDA | 10924126 |
| GO:0031267 | small GTPase binding | IEA,IPI | 7673236 |
Phenotypes for RALBP1 Gene
- MGI mutant phenotypes for RALBP1:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for RALBP1:
Animal Models for research
-
Taconic Biosciences Mouse Models for RALBP1
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for RALBP1 - Starting at $85 >
- * RALBP1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for RALBP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RALBP1
-
Santa Cruz Biotechnology (SCBT) CRISPR for RALBP1
miRNA for RALBP1 Gene
- miRTarBase miRNAs that target RALBP1
-
- mmu-miR-301b-3p (MIRT007889)
- mmu-miR-19b-3p (MIRT012340)
- hsa-miR-1914-5p (MIRT035794)
- hsa-miR-615-3p (MIRT040266)
- hsa-miR-125a-5p (MIRT045735)
- hsa-miR-10b-5p (MIRT047496)
- hsa-miR-10a-5p (MIRT047750)
- hsa-miR-185-5p (MIRT738261)
- hsa-miR-298 (MIRT739544)
- hsa-miR-3150b-3p (MIRT740327)
- hsa-miR-3158-5p (MIRT740481)
- hsa-miR-4306 (MIRT743918)
- hsa-miR-4418 (MIRT744159)
- hsa-miR-4428 (MIRT744312)
- hsa-miR-4481 (MIRT745118)
- hsa-miR-4640-5p (MIRT746337)
- hsa-miR-4644 (MIRT746390)
- hsa-miR-4693-3p (MIRT747150)
- hsa-miR-4726-5p (MIRT747766)
- hsa-miR-4745-5p (MIRT748189)
- hsa-miR-4784 (MIRT748844)
- hsa-miR-509-3-5p (MIRT749676)
- hsa-miR-509-5p (MIRT749712)
- hsa-miR-5192 (MIRT749952)
- hsa-miR-6508-3p (MIRT752975)
- hsa-miR-6758-5p (MIRT754885)
- hsa-miR-6856-5p (MIRT757731)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RALBP1
- Browse OriGene Inhibitory RNA Products For RALBP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RALBP1
Clone products for research
- Applied Biological Materials (abm): Clones for RALBP1 - Starting at $45 >
- * RALBP1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for RALBP1
- Addgene plasmids for RALBP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RALBP1
Cell Lines for research
-
Horizon Cell Lines for RALBP1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RALBP1 Gene
Localization for RALBP1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for RALBP1 Gene
- Membrane. Peripheral membrane protein.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| nucleus | 3 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| endosome | 2 |
| extracellular | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytosol (2)
- Nuclear membrane (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | -- |
| GO:0016020 | membrane | IBA,IDA | 10924126 |
Pathways & Interactions for RALBP1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Doxorubicin Pathway, Pharmacokinetics | ||
| 2 | Cytoskeletal Signaling | ||
| 3 | Endometrial cancer | ||
| 4 | Pathways in cancer | ||
| 5 | Ras signaling pathway | ||
Pathways by source for RALBP1 Gene
4 BioSystems pathways for RALBP1 Gene
3 Reactome pathways for RALBP1 Gene
4 PharmGKB pathways for RALBP1 Gene
3 KEGG pathways for RALBP1 Gene
5 GeneGo (Thomson Reuters) pathways for RALBP1 Gene
- Cytoskeleton remodeling_RalA regulation pathway
- Cytoskeleton remodeling_RalB regulation pathway
- G-protein signaling_Cross-talk between Ras-family GTPases
- G-protein signaling_Regulation of CDC42 activity
- G-protein signaling_Regulation of RAC1 activity
3 Qiagen pathways for RALBP1 Gene
- FGF Pathway
- Molecular Mechanisms of Cancer
- Ras Pathway
1 Cell Signaling Technology pathway for RALBP1 Gene
2 GeneTex pathways for RALBP1 Gene
Interacting Proteins for RALBP1 Gene
Selected Interacting proteins:
Q15311-RBP1_HUMAN
ENSP00000019317
for RALBP1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for RALBP1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006897 | endocytosis | IBA | 21873635 |
| GO:0006935 | chemotaxis | TAS | 10848592 |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007264 | small GTPase mediated signal transduction | IEA,IPI | 7673236 |
| GO:0043087 | regulation of GTPase activity | IDA | 7673236 |
Drugs & Compounds for RALBP1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Doxorubicin | Approved, Investigational | Pharma | Transporter, substrate | Topo II inhibitor,immunosuppresive antineoplastic antibiotic | 2106 | |
| Carbamazepine | Approved, Investigational | Pharma | Transporter, substrate | Inhibitor of neuronal voltage-gated Na+ channels; anticonvulsant | 109 | |
| Sorafenib | Approved, Investigational | Pharma | Transporter, substrate | Raf kinases and tyrosine kinases inhibitor, RAF, VEGFR2, and PDGFR-beta inhibitors, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors | 801 | |
| Vincristine | Approved, Investigational | Pharma | Transporter, substrate | Microtubule disrupter,antitumor agent | 1112 | |
| Glutathione | Approved, Investigational | Nutra | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for RALBP1 Gene
mRNA/cDNA for RALBP1 Gene
- 1 REFSEQ mRNAs :
- 9 NCBI additional mRNA sequence :
- 6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000019317 4368 nts (view in UCSC)
- ENST00000383432 4379 nts (view in UCSC)
- ENST00000458039 836 nts (view in UCSC)
- ENST00000577221 503 nts (view in UCSC)
- ENST00000585015 945 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for RALBP1 - Starting at $85 >
- * RALBP1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for RALBP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RALBP1
-
Santa Cruz Biotechnology (SCBT) CRISPR for RALBP1
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RALBP1
- Browse OriGene Inhibitory RNA Products For RALBP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RALBP1
Clone products for research
- Applied Biological Materials (abm): Clones for RALBP1 - Starting at $45 >
- * RALBP1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for RALBP1
- Addgene plasmids for RALBP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RALBP1
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||
| SP4: | - | - |
Relevant External Links for RALBP1 Gene
- GeneLoc Exon Structure for
- RALBP1
Expression for RALBP1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
This gene is overexpressed in Peripheral blood mononuclear cells (11.8) and Retina (6.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RALBP1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RALBP1
SOURCE GeneReport for Unigene cluster for RALBP1 Gene:
Hs.528993mRNA Expression by UniProt/SwissProt for RALBP1 Gene:
Q15311-RBP1_HUMAN
Tissue specificity:
Expressed ubiquitously but at low levels. Shows a strong expression in the erythrocytes.
Evidence on tissue expression from TISSUES for RALBP1 Gene
- Nervous system(4.5)
- Liver(4.5)
- Blood(4.4)
- Bone marrow(4.3)
- Kidney(2.7)
- Muscle(2.7)
- Heart(2.5)
- Intestine(2.4)
- Pancreas(2.2)
- Skin(2.2)
- Lung(2.1)
- Stomach(2)
Primer products for research
-
OriGene qPCR primer pairs for RALBP1
-
OriGene qPCR primer pairs and template standards for RALBP1
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RALBP1 Gene
Orthologs for RALBP1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | RALBP1 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | RALBP1 29 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 30 |
|
OneToMany | |
| -- 30 |
|
OneToMany | |||
| Oppossum (Monodelphis domestica) |
Mammalia | RALBP1 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Ralbp1 29 16 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Ralbp1 29 |
|
||
| Cow (Bos Taurus) |
Mammalia | RALBP1 29 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | RALBP1 29 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | RALBP1 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ralbp1 29 |
|
||
| Str.11420 29 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | rlip1-A-prov 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | ralbp1 29 30 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | Rlip 30 31 |
|
OneToOne | |
| Worm (Caenorhabditis elegans) |
Secernentea | rlbp-1 30 |
|
OneToOne | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RGD1 30 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 30 |
|
OneToOne |
- Species where no ortholog for RALBP1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for RALBP1 Gene
- ENSEMBL:
- Gene Tree for RALBP1 (if available)
- TreeFam:
- Gene Tree for RALBP1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for RALBP1: view image
- Alliance of Genome Resources:
- Additional Orthologs for RALBP1
Paralogs for RALBP1 Gene
(1) SIMAP similar genes for RALBP1 Gene using alignment to 3 proteins:
- RBP1_HUMAN
- E7ENF8_HUMAN
- J3QLT3_HUMAN
Pseudogenes.org Pseudogenes for RALBP1 Gene
No data available for Paralogs for RALBP1 Gene
Variants for RALBP1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RALBP1 Gene
| SNP ID | Clinical significance and condition | Chr 18 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1447868828 | Likely Benign: not provided | 9,535,868(+) |
G/A NM_006788.4(RALBP1):c.1899G>A (p.Glu633=) |
SYNONYMOUS | |
| rs1598868030 | Likely Benign: not provided | 9,516,858(+) |
A/G NM_006788.4(RALBP1):c.258A>G (p.Ala86=) |
SYNONYMOUS | |
| rs28552921 | Benign: not provided | 9,517,223(+) |
G/A NM_006788.4(RALBP1):c.623G>A (p.Arg208Gln) |
MISSENSE | |
| rs528466267 | Benign: not provided | 9,522,340(+) |
C/T NM_006788.4(RALBP1):c.884C>T (p.Thr295Met) |
MISSENSE | |
| rs748697781 | Likely Benign: not provided | 9,535,892(+) |
G/A NM_006788.4(RALBP1):c.1923G>A (p.Pro641=) |
SYNONYMOUS |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
14.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.88;
35.08% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RALBP1 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RALBP1 Gene
Disorders for RALBP1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| lung cancer |
|
|
Search RALBP1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for RALBP1
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for RALBP1 Gene
Publications for RALBP1 Gene
- Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity. (PMID: 7673236) Jullien-Flores V … Camonis JH (The Journal of biological chemistry 1995) 2 3 4 22
- The association between polymorphisms in RLIP76 and drug response in epilepsy. (PMID: 18086001) Leschziner GD … Pirmohamed M (Pharmacogenomics 2007) 3 22 40
- AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation. (PMID: 15310755) Zhang H … Min W (The Journal of biological chemistry 2004) 3 4 22
- RLIP76 is the major ATP-dependent transporter of glutathione-conjugates and doxorubicin in human erythrocytes. (PMID: 11437348) Sharma R … Awasthi YC (Archives of biochemistry and biophysics 2001) 3 4 22
- Novel function of human RLIP76: ATP-dependent transport of glutathione conjugates and doxorubicin. (PMID: 10924126) Awasthi S … Awasthi YC (Biochemistry 2000) 3 4 22
ExternalLinks
Products for RALBP1 Gene
- Custom Antibody ServicesOriGene Antibodies for RALBP1
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for RALBP1
- Origene Custom Protein Services for RALBP1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RALBP1
- Browse OriGene Inhibitory RNA Products For RALBP1
- OriGene qPCR primer pairs for RALBP1
- OriGene qPCR primer pairs and template standards for RALBP1
- OriGene CRISPR knockouts for RALBP1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For RALBP1
- Sino Biological Human cDNA Clone for RALBP1
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
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- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for RALBP1
- Novus Biologicals proteins and lysates for RALBP1
- Browse Antibodies
- Browse Peptides and Proteins
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- Abcam antibodies for RALBP1
- Abcam assays for RALBP1
- Find your target
- Browse Primary Antibodies
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- Search Knockout (KO) Validated Antibodies
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- Taconic Biosciences Mouse Models for RALBP1
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for RALBP1 (AFLGC-RALBP1)
- VectorBuilder Custom and pre-made DNA vectors for RALBP1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for RALBP1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for RALBP1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for RALBP1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for RALBP1
- Addgene plasmids for RALBP1
- antibodies-online: Show 59 available RALBP1 Antibodies ranked by validation data
- Compare Top RALBP1 Antibodies
- antibodies-online: Show 11 available RALBP1 Elisa Kits ranked by validation data
- Compare Top RALBP1 Elisa Kits
- Quality Products:
- antibodies-online: Show 14 available RALBP1 Proteins ranked by validation data
- Compare Top RALBP1 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for RALBP1
- Search Santa Cruz Biotechnology (SCBT) for RALBP1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for RALBP1
- Custom Antibody ServicesProSci Antibodies for RALBP1
- Search for RALBP1 Proteins at ProSci
- Horizon Cell Lines for RALBP1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RALBP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RALBP1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for RALBP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RALBP1
- Boster Bio Antibodies for RALBP1
- Browse Boster Bio ELISA Kits
Sources for RALBP1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc
- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
- (165) PDBe
- (166) Rfam
- (167) SILVA
- (168) snOPY
- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
- (173) 5SRRNADB
- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources