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RALBP1 plays a role in receptor-mediated endocytosis and is a downstream effector of the small GTP-binding protein RAL (see RALA; MIM 179550). Small G proteins, such as RAL, have GDP-bound inactive and GTP-bound active forms, which shift from the inactive to the active state through the action of RALGDS (MIM 601619), which in turn is activated by RAS (see HRAS; MIM 190020) (sum... See more...
Aliases for RALBP1 Gene
Aliases for RALBP1 Gene
External Ids for RALBP1 Gene
- HGNC: 9841
- Entrez Gene: 10928
- Ensembl: ENSG00000017797
- OMIM: 605801
- UniProtKB: Q15311
Previous GeneCards Identifiers for RALBP1 Gene
- GC18P009629
Summaries for RALBP1 Gene
-
RALBP1 plays a role in receptor-mediated endocytosis and is a downstream effector of the small GTP-binding protein RAL (see RALA; MIM 179550). Small G proteins, such as RAL, have GDP-bound inactive and GTP-bound active forms, which shift from the inactive to the active state through the action of RALGDS (MIM 601619), which in turn is activated by RAS (see HRAS; MIM 190020) (summary by Feig, 2003 [PubMed 12888294]).[supplied by OMIM, Nov 2010]
GeneCards Summary for RALBP1 Gene
RALBP1 (RalA Binding Protein 1) is a Protein Coding gene. Diseases associated with RALBP1 include Lung Cancer. Among its related pathways are Phenytoin Pathway, Pharmacokinetics and G-protein signaling_Cross-talk between Ras-family GTPases. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and Rac GTPase binding.
UniProtKB/Swiss-Prot Summary for RALBP1 Gene
-
Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin.
Additional gene information for RALBP1 Gene
- Monarch Initiative
- Search for RALBP1 at DataMed
- Search for RALBP1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RALBP1 Gene
Genomics for RALBP1 Gene
GeneHancer (GH) Regulatory Elements for RALBP1 Gene
Promoters and enhancers for RALBP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around RALBP1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the RALBP1 gene promoter:
-
- AP-2alpha
- AP-2alphaA
- AP-2beta
- AP-2gamma
- AREB6
- p53
- Pax-4a
- Sp1
Genomic Locations for RALBP1 Gene
Genomic Locations for RALBP1 Gene
- chr18:9,475,009-9,538,114
- (GRCh38/hg38)
- Size:
- 63,106 bases
- Orientation:
- Plus strand
- chr18:9,475,007-9,538,114
- (GRCh37/hg19)
- Size:
- 63,108 bases
- Orientation:
- Plus strand
Genomic View for RALBP1 Gene
Genes around RALBP1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 18p11.22 by HGNC
- 18p11.22 by Entrez Gene
- 18p11.22 by Ensembl
RALBP1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RALBP1 Gene
Proteins for RALBP1 Gene
-
Protein details for RALBP1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q15311-RBP1_HUMAN
- Recommended name:
- RalA-binding protein 1
- Protein Accession:
- Q15311
- D3DUI0
Protein attributes for RALBP1 Gene
- Size:
- 655 amino acids
- Molecular mass:
- 76063 Da
- Quaternary structure:
-
- Interacts with the GTP-bound form of RALA, RALB, CDC42 and RAC1. Interacts with REPS1 and REPS2 and this does not affect the Ral-binding activity. Interacts with DAB2IP. Interacts with catalytically active CCNB1 and CDK1 during mitosis. Interacts with EPN1, NUMB and TFAP2A during interphase and mitosis.
Protein Expression for RALBP1 Gene
Post-translational modifications for RALBP1 Gene
Other Protein References for RALBP1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ RALBP1 Antibody
- Atlas Antibodies Anti-RALBP1 Antibody
-
Creative Biolabs
- Recombinant Anti-Human RALBP1 Antibody Fab Fragment
- Recombinant Anti-Human RALBP1 Antibody
- Mouse Anti-RALBP1 Recombinant Antibody (1C2-A10)
- Rabbit Anti-RALBP1 Recombinant Antibody (11C1064)
- Recombinant Mouse Anti-Human RALBP1 Antibody
- rabbit Anti-RALBP1 Recombinant Antibody (11C1064'D87H8)
- Hi-Affi™ Recombinant Rabbit Anti-RALBP1 Monoclonal Antibody (DS2988AB)
- Mouse Anti-RALBP1 Recombinant Antibody (2A1)
- Novus Biologicals Antibodies for RALBP1
-
Abcam antibodies for RALBP1
- Invitrogen Antibodies for RALBP1 (AFLGC-RALBP1)
-
Boster Bio Antibodies for RALBP1
-
Santa Cruz Biotechnology (SCBT) Antibodies for RALBP1
Protein Products
- Creative Biomart Recombinant Human RALBP1 293 Cell Lysate and Recombinant Human RALBP1 Protein, His-tagged
- Search Origene for MassSpec and Protein Over-expression Lysates for RALBP1
- Origene Custom Protein Services for RALBP1
- antibodies-online: Show 14 available RALBP1 Proteins ranked by validation data
- Compare Top RALBP1 Proteins
-
Quality Products:
Assay Products
- Creative Diagnostics Human RALBP1 ELISA Matched Antibody Pair
- Aviva Systems Biology RALBP1 ELISA Kit (Human) (OKDD00501) and RALBP1 ELISA Kit (Human) (OKCD00529)
- antibodies-online: Show 11 available RALBP1 Elisa Kits ranked by validation data
- Compare Top RALBP1 Elisa Kits
-
Quality Products:
-
Abcam assays for RALBP1
No data available for DME Specific Peptides for RALBP1 Gene
Domains & Families for RALBP1 Gene
Gene Families for RALBP1 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transporters
Protein Domains for RALBP1 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for RALBP1 Gene
- GenScript: Design optimal peptide antigens:
-
- Ral-interacting protein 1 (RBP1_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for RALBP1 Gene
Function for RALBP1 Gene
Molecular function for RALBP1 Gene
- UniProtKB/Swiss-Prot Function:
- Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin.
Phenotypes From GWAS Catalog for RALBP1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005096 | GTPase activator activity | IDA | 7673236 |
| GO:0005515 | protein binding | IPI | 9422736 |
| GO:0017160 | Ral GTPase binding | IEA,IPI | 7673236 |
| GO:0022857 | transmembrane transporter activity | IDA | 10924126 |
| GO:0042626 | ATPase activity, coupled to transmembrane movement of substances | TAS | 11437348 |
Phenotypes for RALBP1 Gene
- MGI mutant phenotypes for RALBP1:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for RALBP1:
Animal Model Products
-
Taconic Biosciences Mouse Models for RALBP1
CRISPR Products
-
OriGene CRISPR knockouts for RALBP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RALBP1
- genomics-online: gRNA clones - Search for available RALBP1 gRNA products
- Overview of 130 available RALBP1 gene related products
- Applied Biological Materials (abm): CRISPR Clones for RALBP1 - Select products 50% OFF >
- * RALBP1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * RALBP1 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for RALBP1
miRNA for RALBP1 Gene
- miRTarBase miRNAs that target RALBP1
-
- hsa-mir-1914-5p (MIRT035794)
- hsa-mir-615-3p (MIRT040266)
- hsa-mir-125a-5p (MIRT045735)
- hsa-mir-10b-5p (MIRT047496)
- hsa-mir-10a-5p (MIRT047750)
- hsa-mir-185-5p (MIRT738261)
- hsa-mir-298 (MIRT739544)
- hsa-mir-3150b-3p (MIRT740327)
- hsa-mir-3158-5p (MIRT740481)
- hsa-mir-4306 (MIRT743918)
- hsa-mir-4418 (MIRT744159)
- hsa-mir-4428 (MIRT744312)
- hsa-mir-4481 (MIRT745118)
- hsa-mir-4640-5p (MIRT746337)
- hsa-mir-4644 (MIRT746390)
- hsa-mir-4693-3p (MIRT747150)
- hsa-mir-4726-5p (MIRT747766)
- hsa-mir-4745-5p (MIRT748189)
- hsa-mir-4784 (MIRT748844)
- hsa-mir-509-3-5p (MIRT749676)
- hsa-mir-509-5p (MIRT749712)
- hsa-mir-5192 (MIRT749952)
- hsa-mir-6508-3p (MIRT752975)
- hsa-mir-6758-5p (MIRT754885)
- hsa-mir-6856-5p (MIRT757731)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for RALBP1
- Browse OriGene Inhibitory RNA Products For RALBP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RALBP1
- genomics-online: shRNA clones - Search for available RALBP1 shRNA products
- Overview of 130 available RALBP1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for RALBP1
- Addgene plasmids for RALBP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RALBP1
- Applied Biological Materials (abm): Clones for RALBP1 - Select products 50% OFF >
- * RALBP1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * RALBP1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Cell Line Products
-
Horizon Cell Lines for RALBP1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RALBP1 Gene
Localization for RALBP1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for RALBP1 Gene
- Membrane; Peripheral membrane protein.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| nucleus | 3 |
| endosome | 2 |
| cytoskeleton | 1 |
- Cytosol (2)
- Nuclear membrane (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | -- |
| GO:0016020 | membrane | IBA,IDA | 10924126 |
Pathways & Interactions for RALBP1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Doxorubicin Pathway, Pharmacokinetics | ||
| 2 | Cytoskeletal Signaling | ||
| 3 | Endometrial cancer | ||
| 4 | Pathways in cancer | ||
| 5 | Ras signaling pathway | ||
Pathways by source for RALBP1 Gene
4 BioSystems pathways for RALBP1 Gene
3 Reactome pathways for RALBP1 Gene
4 PharmGKB pathways for RALBP1 Gene
3 KEGG pathways for RALBP1 Gene
5 GeneGo (Thomson Reuters) pathways for RALBP1 Gene
3 Qiagen pathways for RALBP1 Gene
- FGF Pathway
- Molecular Mechanisms of Cancer
- Ras Pathway
1 Cell Signaling Technology pathway for RALBP1 Gene
2 GeneTex pathways for RALBP1 Gene
Interacting Proteins for RALBP1 Gene
Selected Interacting proteins:
Q15311-RBP1_HUMAN
ENSP00000019317
for RALBP1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for RALBP1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006897 | endocytosis | IBA | 21873635 |
| GO:0006935 | chemotaxis | TAS | 10848592 |
| GO:0007165 | signal transduction | TAS | -- |
| GO:0007264 | small GTPase mediated signal transduction | IPI,IEA | 7673236 |
| GO:0034220 | ion transmembrane transport | IEA | -- |
No data available for SIGNOR curated interactions for RALBP1 Gene
Drugs & Compounds for RALBP1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Doxorubicin | Approved, Investigational | Pharma | Transporter, substrate | Topo II inhibitor,immunosuppresive antineoplastic antibiotic | 2016 | |
| Carbamazepine | Approved, Investigational | Pharma | Transporter, substrate | Inhibitor of neuronal voltage-gated Na+ channels; anticonvulsant | 103 | |
| Sorafenib | Approved, Investigational | Pharma | Transporter, substrate | Raf kinases and tyrosine kinases inhibitor, RAF, VEGFR2, and PDGFR-beta inhibitors, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors | 762 | |
| Vincristine | Approved, Investigational | Pharma | Transporter, substrate | Microtubule disrupter,antitumor agent | 1046 | |
| Guanosine triphosphate | Experimental | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug Products
- Creative Biomart Recombinant Human RALBP1 293 Cell Lysate and Recombinant Human RALBP1 Protein, His-tagged
Transcripts for RALBP1 Gene
mRNA/cDNA for RALBP1 Gene
- (1) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (300) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000019317 4368 bps (ENST00000019317.8)
- ENST00000383432 4379 bps (ENST00000383432.7)
- ENST00000458039 836 bps (ENST00000458039.3)
- ENST00000577221 503 bps (ENST00000577221.1)
- ENST00000585015 945 bps (ENST00000585015.6)
CRISPR Products
-
OriGene CRISPR knockouts for RALBP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RALBP1
- genomics-online: gRNA clones - Search for available RALBP1 gRNA products
- Overview of 130 available RALBP1 gene related products
- Applied Biological Materials (abm): CRISPR Clones for RALBP1 - Select products 50% OFF >
- * RALBP1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * RALBP1 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for RALBP1
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for RALBP1
- Browse OriGene Inhibitory RNA Products For RALBP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RALBP1
- genomics-online: shRNA clones - Search for available RALBP1 shRNA products
- Overview of 130 available RALBP1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for RALBP1
- Addgene plasmids for RALBP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RALBP1
- Applied Biological Materials (abm): Clones for RALBP1 - Select products 50% OFF >
- * RALBP1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * RALBP1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||
| SP4: | - | - |
Expression for RALBP1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
This gene is overexpressed in Peripheral blood mononuclear cells (11.8) and Retina (6.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RALBP1 Gene
NURSA nuclear receptor signaling pathways regulating expression of RALBP1 Gene:
RALBP1SOURCE GeneReport for Unigene cluster for RALBP1 Gene:
Hs.528993mRNA Expression by UniProt/SwissProt for RALBP1 Gene:
Q15311-RBP1_HUMAN
Tissue specificity:
Expressed ubiquitously but at low levels. Shows a strong expression in the erythrocytes.
Evidence on tissue expression from TISSUES for RALBP1 Gene
- Liver(4.4)
- Nervous system(4.4)
- Blood(4.3)
- Bone marrow(4.2)
- Kidney(2.2)
- Lung(2.1)
- Heart(2)
- Intestine(2)
- Muscle(2)
Primer Products
-
OriGene qPCR primer pairs for RALBP1
-
OriGene qPCR primer pairs and template standards for RALBP1
- genomics-online: primer clones - Search for available RALBP1 Primer products
- Overview of 130 available RALBP1 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RALBP1 Gene
Orthologs for RALBP1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | RALBP1 33 32 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | RALBP1 33 32 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | RALBP1 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 33 |
|
OneToMany | |
| -- 33 |
|
OneToMany | |||
| mouse (Mus musculus) |
Mammalia | Ralbp1 17 33 32 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ralbp1 32 |
|
||
| cow (Bos Taurus) |
Mammalia | RALBP1 33 32 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | RALBP1 33 32 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | RALBP1 33 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ralbp1 32 |
|
||
| Str.11420 32 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | rlip1-A-prov 32 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ralbp1 33 32 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | Rlip 33 34 |
|
OneToOne | |
| worm (Caenorhabditis elegans) |
Secernentea | rlbp-1 33 |
|
OneToOne | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RGD1 33 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 33 |
|
OneToOne |
- Species where no ortholog for RALBP1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for RALBP1 Gene
- ENSEMBL:
- Gene Tree for RALBP1 (if available)
- TreeFam:
- Gene Tree for RALBP1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for RALBP1: view image
Paralogs for RALBP1 Gene
(1) SIMAP similar genes for RALBP1 Gene using alignment to 3 proteins:
- RBP1_HUMAN
- E7ENF8_HUMAN
- J3QLT3_HUMAN
Pseudogenes.org Pseudogenes for RALBP1 Gene
No data available for Paralogs for RALBP1 Gene
Variants for RALBP1 Gene
| SNP ID | Clin | Chr 18 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000089842 | -- | 9,512,804(+) | G/A/C/T | intron_variant | |
| rs1000091799 | -- | 9,498,484(+) | C/T | intron_variant | |
| rs1000115058 | -- | 9,487,584(+) | A/G | intron_variant | |
| rs1000146629 | -- | 9,529,070(+) | A/C/G | intron_variant | |
| rs1000229096 | -- | 9,509,604(+) | C/A/T | intron_variant |
Residual Variation Intolerance Score:
14.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.88;
35.08% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RALBP1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- RALBP1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RALBP1 Gene
Disorders for RALBP1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| lung cancer |
|
Search RALBP1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for RALBP1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for RALBP1 Gene
Publications for RALBP1 Gene
- Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity. (PMID: 7673236) Jullien-Flores V … Camonis JH (The Journal of biological chemistry 1995) 2 3 4 23 56
- The association between polymorphisms in RLIP76 and drug response in epilepsy. (PMID: 18086001) Leschziner GD … Pirmohamed M (Pharmacogenomics 2007) 3 23 43 56
- RLIP76 is the major ATP-dependent transporter of glutathione-conjugates and doxorubicin in human erythrocytes. (PMID: 11437348) Sharma R … Awasthi YC (Archives of biochemistry and biophysics 2001) 3 4 23 56
- Novel function of human RLIP76: ATP-dependent transport of glutathione conjugates and doxorubicin. (PMID: 10924126) Awasthi S … Awasthi YC (Biochemistry 2000) 3 4 23 56
- Rlip76 transports sunitinib and sorafenib and mediates drug resistance in kidney cancer. (PMID: 19626587) Singhal SS … Awasthi S (International journal of cancer 2010) 3 23 56
ExternalLinks
Products for RALBP1 Gene
- Custom Antibody ServicesOriGene Antibodies for RALBP1
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- Custom Assay Services
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- Origene Custom Protein Services for RALBP1
- Origene sirna, shrna, and RNAi products in human, mouse, rat for RALBP1
- Browse OriGene Inhibitory RNA Products For RALBP1
- OriGene qPCR primer pairs for RALBP1
- OriGene qPCR primer pairs and template standards for RALBP1
- OriGene CRISPR knockouts for RALBP1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For RALBP1
- Sino Biological Human cDNA Clone for RALBP1
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- High-throughput Antibody Production Service
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- Lentiviral ORF Clones
- Novus Biologicals Antibodies for RALBP1
- Novus Biologicals proteins and lysates for RALBP1
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- Abcam antibodies for RALBP1
- Abcam assays for RALBP1
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- Search Knockout (KO) Validated Antibodies
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- Taconic Biosciences Mouse Models for RALBP1
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for RALBP1 (AFLGC-RALBP1)
- Addgene plasmids for RALBP1
- antibodies-online: Show 59 available RALBP1 Antibodies ranked by validation data
- Compare Top RALBP1 Antibodies
- antibodies-online: Show 11 available RALBP1 Elisa Kits ranked by validation data
- Compare Top RALBP1 Elisa Kits
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- antibodies-online: Show 14 available RALBP1 Proteins ranked by validation data
- Compare Top RALBP1 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for RALBP1
- Search Santa Cruz Biotechnology (SCBT) for RALBP1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for RALBP1
- Horizon Cell Lines for RALBP1
- genomics-online: cdna clones - Search for available RALBP1 CDNA products
- Overview of 130 available RALBP1 gene related products
- orf clones - Search for available RALBP1 ORF products
- Overview of 130 available RALBP1 gene related products
- genomics-online: gRNA clones - Search for available RALBP1 gRNA products
- Overview of 130 available RALBP1 gene related products
- genomics-online: primer clones - Search for available RALBP1 Primer products
- Overview of 130 available RALBP1 gene related products
- genomics-online: shRNA clones - Search for available RALBP1 shRNA products
- Overview of 130 available RALBP1 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RALBP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RALBP1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for RALBP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RALBP1
- Boster Bio Antibodies for RALBP1
- Browse Boster Bio ELISA Kits
Sources for RALBP1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) CGAP SAGE
- (31) SOURCE
- (32) HomoloGene
- (33) PanEnsembl
- (34) euGenes
- (35) SGD
- (36) FlyBase
- (37) WormBase
- (38) Pseudogene
- (39) DGV
- (40) dbSNP
- (41) GenAtlas
- (42) HGMD
- (43) GAD
- (44) BGMUT
- (45) HuGE
- (46) Atlas
- (47) GenBank
- (48) H-invDB
- (49) HORDE
- (50) HUGE
- (51) IMGT
- (52) Leiden
- (53) miRBase
- (54) DME
- (55) OriGene
- (56) PubMed
- (57) R&D Systems
- (58) TGDB
- (59) Tocris
- (60) Abcam
- (61) Novus Biologicals
- (62) ProSpec
- (63) Sino Biological
- (64) GenScript
- (65) Qiagen
- (66) OCA
- (67) Proteopedia
- (68) MOPED
- (69) neXtProt
- (70) Reactome
- (71) GeneGo (Thomson Reuters)
- (72) DISEASES
- (73) SIMAP
- (74) GenomeRNAi
- (75) LifeMap
- (76) miRTarBase
- (77) MalaCards
- (78) Invitrogen
- (79) BitterDB
- (80) ESI-BIO
- (81) RefSeq
- (82) BioSystems
- (83) MaxQB
- (84) IUPHAR
- (85) BioGPS
- (86) Illumina
- (87) COMPARTMENTS
- (88) HOMER
- (89) PaxDb
- (90) ApexBio
- (91) Addgene
- (92) antibodies-online
- (93) CYP
- (94) NONCODE
- (95) TreeFam
- (96) PathCards
- (97) GeneReviews
- (98) GeneTex
- (99) Taconic Biosciences
- (100) GTEx
- (101) ProteomicsDB
- (102) SCBT
- (103) DGIdb
- (104) ClinicalTrials
- (105) RVIS
- (106) SIGNOR
- (107) diseasecard
- (108) NIH Rare Diseases
- (109) Orphanet
- (110) UMLS
- (111) GTR
- (112) Disease Ontology
- (113) Genetics Home Reference
- (114) MeSH
- (115) MedlinePlus
- (116) CDC
- (117) NINDS
- (118) NCBI Bookshelf
- (119) ClinVar
- (120) Gene Damage Index
- (121) HPO
- (122) UDN
- (123) VISTA
- (124) FANTOM5
- (125) ENCODE
- (126) ProSci
- (127) Horizon
- (128) NURSA
- (129) IID
- (130) VectorBuilder
- (131) SNPedia
- (132) BRCA Exchange
- (133) CIViC
- (134) ProteoGenix
- (135) dbSUPER
- (136) TISSUES
- (137) Gene ORGANizer
- (138) abm
- (139) Human Protein Atlas
- (140) GWAS Catalog
- (141) Monarch Initiative
- (142) DataMed
- (143) HumanCyc
- (144) genomics-online
- (145) UCNEbase
- (146) EPDnew
- (147) Applied Biosystems
- (148) GlyConnect
- (149) Aminode
- (150) GeneCopoeia
- (151) GPS-Prot
- (152) RNACentral
- (153) LncRNADisease
- (154) LOVD
- (155) miR2Disease
- (156) DiseaseEnhancer
- (157) Boster Bio
- (158) Biorbyt
- (159) Biocompare
- (160) Mastermind
- (161) CTD^2 Dashboard
- (162) CraniofacialAtlas
- (163) GeneImprint
- (164) Synthego
- (165) Bio Basic
- (166) ENA
- (167) GtRNAdb
- (168) LncBase
- (169) LncBook
- (170) LNCipedia
- (171) LncRNAdb
- (172) Modomics
- (173) PDBe
- (174) Rfam
- (175) SILVA
- (176) snOPY
- (177) SRPDB
- (178) GENCODE
- (179) TarBase
- (180) MyBioSource