Aliases for RALB Gene
External Ids for RALB Gene
Previous GeneCards Identifiers for RALB Gene
This gene encodes a GTP-binding protein that belongs to the small GTPase superfamily and Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. [provided by RefSeq, Jul 2008]
GeneCards Summary for RALB Gene
RALB (RAS Like Proto-Oncogene B) is a Protein Coding gene. Diseases associated with RALB include Pancreatic Cancer and Epileptic Encephalopathy, Early Infantile, 4. Among its related pathways are ERK Signaling and Ras signaling pathway. Gene Ontology (GO) annotations related to this gene include GTP binding and ubiquitin protein ligase binding. An important paralog of this gene is RALA.
UniProtKB/Swiss-Prot Summary for RALB Gene
Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles (By similarity). Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells (By similarity). Required for suppression of apoptosis (PubMed:17875936). In late stages of cytokinesis, upon completion of the bridge formation between dividing cells, mediates exocyst recruitment to the midbody to drive abscission (PubMed:18756269).