This gene encodes a GTP-binding protein that belongs to the small GTPase superfamily and Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. [provided by RefSeq, Jul 2008] See more...

Aliases for RALB Gene

Aliases for RALB Gene

  • RAS Like Proto-Oncogene B 2 3 5
  • Ras Related GTP Binding Protein B 2 3
  • Ras-Related Protein Ral-B 3 4
  • V-Ral Simian Leukemia Viral Oncogene Homolog B (Ras Related; GTP Binding Protein) 3
  • V-Ral Simian Leukemia Viral Oncogene Homolog B 2
  • RALB Ras Like Proto-Oncogene B 3
  • RAS-Like Protein B 3
  • EC 3.6.5.2 4
  • RALB 5

External Ids for RALB Gene

Previous GeneCards Identifiers for RALB Gene

  • GC02P118215
  • GC02P118931
  • GC02P120917
  • GC02P121105
  • GC02P120726
  • GC02P120997
  • GC02P113335

Summaries for RALB Gene

Entrez Gene Summary for RALB Gene

  • This gene encodes a GTP-binding protein that belongs to the small GTPase superfamily and Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. [provided by RefSeq, Jul 2008]

GeneCards Summary for RALB Gene

RALB (RAS Like Proto-Oncogene B) is a Protein Coding gene. Diseases associated with RALB include Pancreatic Cancer and Glutathionuria. Among its related pathways are Ras signaling pathway and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include GTP binding and ubiquitin protein ligase binding. An important paralog of this gene is RALA.

UniProtKB/Swiss-Prot Summary for RALB Gene

  • Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles (By similarity). Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells (By similarity). Required for suppression of apoptosis (PubMed:17875936). In late stages of cytokinesis, upon completion of the bridge formation between dividing cells, mediates exocyst recruitment to the midbody to drive abscission (PubMed:18756269).

Gene Wiki entry for RALB Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RALB Gene

Genomics for RALB Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RALB Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RALB on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RALB

Top Transcription factor binding sites by QIAGEN in the RALB gene promoter:
  • FOXO4
  • GCNF
  • GCNF-1
  • GCNF-2
  • HEN1
  • LCR-F1
  • MZF-1
  • NRF-2
  • RFX1
  • SEF-1 (1)

Genomic Locations for RALB Gene

Latest Assembly
chr2:120,240,064-120,294,711
(GRCh38/hg38)
Size:
54,648 bases
Orientation:
Plus strand

Previous Assembly
chr2:121,010,428-121,052,286
(GRCh37/hg19 by Entrez Gene)
Size:
41,859 bases
Orientation:
Plus strand

chr2:120,997,640-121,052,289
(GRCh37/hg19 by Ensembl)
Size:
54,650 bases
Orientation:
Plus strand

Genomic View for RALB Gene

Genes around RALB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RALB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RALB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RALB Gene

Proteins for RALB Gene

  • Protein details for RALB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11234-RALB_HUMAN
    Recommended name:
    Ras-related protein Ral-B
    Protein Accession:
    P11234
    Secondary Accessions:
    • B4E040
    • Q53T32
    • Q6ZS74

    Protein attributes for RALB Gene

    Size:
    206 amino acids
    Molecular mass:
    23409 Da
    Quaternary structure:
    • Interacts with EXOC2/Sec5 and EXOC8/Exo84 (PubMed:14525976, PubMed:18756269, PubMed:19166349). Interacts (via effector domain) with RALBP1 (PubMed:7673236, PubMed:20696399).

    Three dimensional structures from OCA and Proteopedia for RALB Gene

    Alternative splice isoforms for RALB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RALB Gene

Post-translational modifications for RALB Gene

  • Prenylation is essential for membrane localization. The geranylgeranylated form and the farnesylated mutant does not undergo alternative prenylation in response to geranylgeranyltransferase I inhibitors (GGTIs) and farnesyltransferase I inhibitors (FTIs).
  • The farnesylated form confers resistance to the proapoptotic and anti-anchorage-dependent growth effects of geranylgeranyltransferase I inhibitors, including GGTI-2417.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RALB Gene

Domains & Families for RALB Gene

Gene Families for RALB Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RALB Gene

InterPro:
Blocks:
  • Transforming protein P21 RAS signature
  • Ras small GTPase, Ras type

Suggested Antigen Peptide Sequences for RALB Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ55177, highly similar to Ras-related protein Ral-B (B4E040_HUMAN)
  • cDNA, FLJ92808, Homo sapiens v-ral simian leukemia viral oncogene homolog B (rasrelated (Q53T32_HUMAN)
  • cDNA FLJ45773 fis, clone NETRP2003448, highly similar to Ras-related protein RAL-B (Q6ZS74_HUMAN)
  • Ras-related protein Ral-B (RALB_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P11234

UniProtKB/Swiss-Prot:

RALB_HUMAN :
  • Belongs to the small GTPase superfamily. Ras family.
Family:
  • Belongs to the small GTPase superfamily. Ras family.
genes like me logo Genes that share domains with RALB: view

Function for RALB Gene

Molecular function for RALB Gene

UniProtKB/Swiss-Prot Function:
Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles (By similarity). Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells (By similarity). Required for suppression of apoptosis (PubMed:17875936). In late stages of cytokinesis, upon completion of the bridge formation between dividing cells, mediates exocyst recruitment to the midbody to drive abscission (PubMed:18756269).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2; Evidence={ECO:0000305};.
UniProtKB/Swiss-Prot EnzymeRegulation:
Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).
GENATLAS Biochemistry:
simian leukemia viral (v-ral) oncogene homolog B,Ras oncogene superfamily member

Enzyme Numbers (IUBMB) for RALB Gene

Phenotypes From GWAS Catalog for RALB Gene

Gene Ontology (GO) - Molecular Function for RALB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003924 GTPase activity IEA,IDA 19166349
GO:0005515 protein binding IPI 7673236
GO:0005525 GTP binding IEA,IMP 24056301
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with RALB: view
genes like me logo Genes that share phenotypes with RALB: view

Animal Models for RALB Gene

MGI Knock Outs for RALB:
  • Ralb Ralb<tm1.1Cjm>
  • Ralb Ralb<tm1a(EUCOMM)Wtsi>

miRNA for RALB Gene

miRTarBase miRNAs that target RALB

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RALB

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RALB Gene

Localization for RALB Gene

Subcellular locations from UniProtKB/Swiss-Prot for RALB Gene

Cell membrane. Lipid-anchor. Cytoplasmic side. Midbody. Note=During late cytokinesis, enriched at the midbody. {ECO:0000269 PubMed:18756269}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RALB gene
Compartment Confidence
plasma membrane 5
extracellular 4
cytosol 3
cytoskeleton 2
nucleus 2
endosome 2
lysosome 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for RALB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,IDA 17875936
GO:0016020 membrane IEA --
GO:0030496 midbody IEA,IDA 18756269
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with RALB: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RALB Gene

Pathways & Interactions for RALB Gene

genes like me logo Genes that share pathways with RALB: view

Pathways by source for RALB Gene

2 BioSystems pathways for RALB Gene
1 GeneGo (Thomson Reuters) pathway for RALB Gene
  • Cytoskeleton remodeling_RalB regulation pathway
5 Qiagen pathways for RALB Gene
  • FGF Pathway
  • Molecular Mechanisms of Cancer
  • p38 Signaling
  • Phospholipase-C Pathway
  • Ras Pathway
1 Cell Signaling Technology pathway for RALB Gene
1 GeneTex pathway for RALB Gene

SIGNOR curated interactions for RALB Gene

Other effect:

Gene Ontology (GO) - Biological Process for RALB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001928 regulation of exocyst assembly ISS --
GO:0001934 positive regulation of protein phosphorylation IMP 24056301
GO:0006915 apoptotic process IEA --
GO:0007049 cell cycle IEA --
GO:0007165 signal transduction IEA,TAS 2120779
genes like me logo Genes that share ontologies with RALB: view

Drugs & Compounds for RALB Gene

(1) Additional Compounds for RALB Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RALB: view

Transcripts for RALB Gene

mRNA/cDNA for RALB Gene

2 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RALB

Alternative Splicing Database (ASD) splice patterns (SP) for RALB Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - -
SP5: -
SP6: - - - - -
SP7: - - - - -
SP8: - - - - - -
SP9: -
SP10: -

Relevant External Links for RALB Gene

GeneLoc Exon Structure for
RALB

Expression for RALB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RALB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RALB Gene

This gene is overexpressed in Whole Blood (x7.7).

Protein differential expression in normal tissues from HIPED for RALB Gene

This gene is overexpressed in Uterus (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RALB Gene



Protein tissue co-expression partners for RALB Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RALB

SOURCE GeneReport for Unigene cluster for RALB Gene:

Hs.469820

Evidence on tissue expression from TISSUES for RALB Gene

  • Nervous system(4.9)
  • Lung(4.5)
  • Eye(4.3)
  • Skin(2.6)
  • Kidney(2.5)
  • Intestine(2.5)
  • Blood(2.5)
  • Heart(2.2)
  • Spleen(2.2)
  • Adrenal gland(2.2)
  • Muscle(2.1)
  • Liver(2.1)
  • Lymph node(2)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with RALB: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RALB Gene

Orthologs for RALB Gene

This gene was present in the common ancestor of animals.

Orthologs for RALB Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RALB 29 30
  • 100 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia RALB 30
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia RALB 29 30
  • 91.59 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia RALB 29 30
  • 89.32 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ralb 29 16 30
  • 85.28 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia RALB 30
  • 85 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ralb 29
  • 84.14 (n)
Chicken
(Gallus gallus)
Aves RALB 29 30
  • 83.98 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia RALB 30
  • 96 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.5659 29
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia Str.7039 29
Zebrafish
(Danio rerio)
Actinopterygii ralba 29 30
  • 77.83 (n)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9969 29
Fruit Fly
(Drosophila melanogaster)
Insecta Rala 30 31
  • 73 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea Y53G8AR.3 31
  • 68 (a)
ral-1 30
  • 52 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.10753 30
  • 65 (a)
OneToMany
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.12282 29
Species where no ortholog for RALB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for RALB Gene

ENSEMBL:
Gene Tree for RALB (if available)
TreeFam:
Gene Tree for RALB (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RALB: view image
Alliance of Genome Resources:
Additional Orthologs for RALB

Paralogs for RALB Gene

genes like me logo Genes that share paralogs with RALB: view

Variants for RALB Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RALB Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
994009 Uncertain Significance: none provided 120,278,671(+) G/A
NM_002881.3(RALB):c.7G>A (p.Ala3Thr)
MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for RALB Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for RALB Gene

Variant ID Type Subtype PubMed ID
dgv2226e59 CNV duplication 20981092
nsv1000477 CNV gain 25217958
nsv1109282 CNV deletion 24896259
nsv2894 CNV deletion 18451855
nsv508164 CNV deletion 20534489
nsv834346 CNV gain 17160897

Variation tolerance for RALB Gene

Residual Variation Intolerance Score: 37.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.55; 11.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RALB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RALB
Leiden Open Variation Database (LOVD)
RALB

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RALB Gene

Disorders for RALB Gene

MalaCards: The human disease database

(3) MalaCards diseases for RALB Gene - From: COP and GCD

Disorder Aliases PubMed IDs
pancreatic cancer
  • pancreatic carcinoma
glutathionuria
  • gamma-glutamyltranspeptidase deficiency
colorectal cancer
  • crc
- elite association - COSMIC cancer census association via MalaCards
Search RALB in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RALB

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with RALB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RALB Gene

Publications for RALB Gene

  1. Solution structure and dynamics of the small GTPase RalB in its active conformation: significance for effector protein binding. (PMID: 19166349) Fenwick RB … Owen D (Biochemistry 2009) 3 4 22
  2. Distinct roles of RalA and RalB in the progression of cytokinesis are supported by distinct RalGEFs. (PMID: 18756269) Cascone I … Camonis J (The EMBO journal 2008) 3 4 22
  3. Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth. (PMID: 17875936) Falsetti SC … Sebti SM (Molecular and cellular biology 2007) 3 4 22
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 40
  5. The small GTPase Ral mediates SDF-1-induced migration of B cells and multiple myeloma cells. (PMID: 18227351) de Gorter DJ … Spaargaren M (Blood 2008) 3 22

Products for RALB Gene

Sources for RALB Gene