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The product of this gene belongs to the small GTPase superfamily, Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. This gene encodes a low molecular mass ras-like GTP-binding protein that shares about 50% similarity with other ras proteins. [provided by RefSeq, Jul 2008]
RALA (RAS Like Proto-Oncogene A) is a Protein Coding gene. Diseases associated with RALA include Subendocardial Myocardial Infarction and Pancreatic Cancer. Among its related pathways are Signaling by GPCR and Ras signaling pathway. Gene Ontology (GO) annotations related to this gene include GTP binding and ubiquitin protein ligase binding. An important paralog of this gene is RALB.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0003924 | GTPase activity | IEA,IBA | 21873635 |
GO:0005515 | protein binding | IPI | 7673236 |
GO:0005525 | GTP binding | IEA,IDA | 24056301 |
GO:0017022 | myosin binding | IPI | 24056301 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | IEA,IDA | 17875936 |
GO:0005925 | focal adhesion | IDA | -- |
GO:0009986 | cell surface | IDA | 19306925 |
GO:0016020 | membrane | IEA | -- |
GO:0030139 | colocalizes_with endocytic vesicle | IDA | 19306925 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | RET signaling | ||
2 | Endometrial cancer | ||
3 | Ras signaling pathway | ||
4 | Vesicle-mediated transport | ||
5 | Cytoskeletal Signaling |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001843 | neural tube closure | IEA | -- |
GO:0006887 | exocytosis | IEA | -- |
GO:0006935 | chemotaxis | TAS | 10848592 |
GO:0007049 | cell cycle | IEA | -- |
GO:0007165 | signal transduction | IEA,TAS | 2550440 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Guanosine diphosphate | Experimental | Pharma | Target | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | RALA 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | RALA 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Rala 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Rala 30 17 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | RALA 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | RALA 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | RALA 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | RALA 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | RALA 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | rala 30 |
|
||
Str.15001 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.663 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | ralab 31 |
|
OneToMany | |
ralaa 30 31 |
|
OneToMany | |||
zgc64038 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | Rala 30 31 32 |
|
OneToMany | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP012108 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | Y53G8AR.3 32 |
|
|
|
ral-1 30 31 |
|
OneToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.10753 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 07 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
872219 | Likely Pathogenic: not provided | 39,696,751(+) | T/A | MISSENSE_VARIANT | |
rs1204820978 | Uncertain Significance: not specified | 39,706,150(+) | C/T | NONSENSE | |
rs1554297905 | Pathogenic/Likely Pathogenic: Inborn genetic diseases; not provided | 39,686,740(+) | G/A | MISSENSE_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
subendocardial myocardial infarction |
|
|
pancreatic cancer |
|
|
laryngeal tuberculosis |
|
|
anisakiasis |
|
|
bladder cancer |
|