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Aliases for RAI2 Gene

Aliases for RAI2 Gene

  • Retinoic Acid Induced 2 2 3 5
  • Retinoic Acid-Induced Protein 2 3

External Ids for RAI2 Gene

Previous GeneCards Identifiers for RAI2 Gene

  • GC0XM017362
  • GC0XM016484
  • GC0XM017020
  • GC0XM017179
  • GC0XM017578
  • GC0XM017728
  • GC0XM015576

Summaries for RAI2 Gene

Entrez Gene Summary for RAI2 Gene

  • Retinoic acid plays a critical role in development, cellular growth, and differentiation. The specific function of this retinoic acid-induced gene has not yet been determined but it may play a role in development. The chromosomal location of this gene designates it to be a candidate for diseases such as Nance-Horan syndrome, sensorineural deafness, non-specific X-linked cognitive disability, oral-facial-digital syndrome, and Fried syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

GeneCards Summary for RAI2 Gene

RAI2 (Retinoic Acid Induced 2) is a Protein Coding gene. Diseases associated with RAI2 include Nance-Horan Syndrome. Among its related pathways are Neuroscience.

Gene Wiki entry for RAI2 Gene

Additional gene information for RAI2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAI2 Gene

Genomics for RAI2 Gene

GeneHancer (GH) Regulatory Elements for RAI2 Gene

Promoters and enhancers for RAI2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ017859 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 650.7 +0.6 618 2.1 CTCF ZSCAN4 FEZF1 HIC1 ZNF335 ZFHX2 GLIS2 POLR2A ZNF366 ZBTB48 RAI2 ENSG00000227873
GH0XJ017412 Enhancer 1.1 Ensembl ENCODE 20.9 +446.9 446864 4.5 FEZF1 ATF7 FOS KLF13 ZNF662 TSHZ1 ZNF518A MYNN AEBP2 STAT3 RAI2 NHS CTPS2 TXLNG SCML1 RBBP7 MIR4768
GH0XJ017827 Enhancer 0.4 ENCODE 0.3 +34.3 34270 0.2 GFI1B SETDB1 RAI2 ENSG00000227873
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RAI2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RAI2 gene promoter:
  • Sox5
  • C/EBPbeta
  • Lmo2
  • HNF-1A
  • HNF-1
  • RORalpha1
  • E2F-1
  • FOXI1
  • HFH-3
  • CUTL1

Genomic Locations for RAI2 Gene

Genomic Locations for RAI2 Gene
61,298 bases
Minus strand
61,289 bases
Minus strand

Genomic View for RAI2 Gene

Genes around RAI2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAI2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAI2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAI2 Gene

Proteins for RAI2 Gene

  • Protein details for RAI2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Retinoic acid-induced protein 2
    Protein Accession:
    Secondary Accessions:
    • B1B1K2
    • B4DQM9
    • E7EMN4
    • Q8N6X7

    Protein attributes for RAI2 Gene

    530 amino acids
    Molecular mass:
    57180 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RAI2 Gene


neXtProt entry for RAI2 Gene

Post-translational modifications for RAI2 Gene

  • Ubiquitination at Lys266
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RAI2 Gene

Domains & Families for RAI2 Gene

Gene Families for RAI2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RAI2 Gene


Suggested Antigen Peptide Sequences for RAI2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RAI2: view

No data available for UniProtKB/Swiss-Prot for RAI2 Gene

Function for RAI2 Gene

Molecular function for RAI2 Gene

GENATLAS Biochemistry:
retinoic acid induced 2,expressed in heart,brain,placenta,lung,skeletal muscle,kidney,pancreas and retina,excluded as causing-disease gene in Nance-Horan syndrome

Phenotypes From GWAS Catalog for RAI2 Gene

Gene Ontology (GO) - Molecular Function for RAI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with RAI2: view
genes like me logo Genes that share phenotypes with RAI2: view

Animal Model Products

miRNA for RAI2 Gene

miRTarBase miRNAs that target RAI2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAI2 Gene

Localization for RAI2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAI2 gene
Compartment Confidence
nucleus 2
cytosol 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RAI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with RAI2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RAI2 Gene

Pathways & Interactions for RAI2 Gene

SuperPathway Contained pathways
1 Neuroscience
genes like me logo Genes that share pathways with RAI2: view

Pathways by source for RAI2 Gene

1 Cell Signaling Technology pathway for RAI2 Gene

Gene Ontology (GO) - Biological Process for RAI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009792 embryo development ending in birth or egg hatching NAS 10049581
genes like me logo Genes that share ontologies with RAI2: view

No data available for SIGNOR curated interactions for RAI2 Gene

Drugs & Compounds for RAI2 Gene

No Compound Related Data Available

Transcripts for RAI2 Gene

Unigene Clusters for RAI2 Gene

Retinoic acid induced 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAI2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b
SP1: - - - - -
SP2: - - -
SP3: - - -
SP4: - -
SP5: -
SP6: - - - -

Relevant External Links for RAI2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RAI2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAI2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RAI2 Gene

NURSA nuclear receptor signaling pathways regulating expression of RAI2 Gene:


SOURCE GeneReport for Unigene cluster for RAI2 Gene:


Evidence on tissue expression from TISSUES for RAI2 Gene

  • Lung(4.2)
genes like me logo Genes that share expression patterns with RAI2: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAI2 Gene

Orthologs for RAI2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RAI2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RAI2 34 33
  • 98.07 (n)
(Canis familiaris)
Mammalia RAI2 34 33
  • 87.81 (n)
(Mus musculus)
Mammalia Rai2 16 34 33
  • 87.65 (n)
(Rattus norvegicus)
Mammalia Rai2 33
  • 87.4 (n)
(Bos Taurus)
Mammalia RAI2 34 33
  • 86.11 (n)
(Monodelphis domestica)
Mammalia RAI2 34
  • 71 (a)
(Gallus gallus)
Aves RAI2 34 33
  • 68.91 (n)
(Anolis carolinensis)
Reptilia RAI2 34
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rai2 33
  • 60.08 (n)
(Danio rerio)
Actinopterygii LOC101885820 33
  • 50.32 (n)
RAI2 34
  • 37 (a)
Species where no ortholog for RAI2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAI2 Gene

Gene Tree for RAI2 (if available)
Gene Tree for RAI2 (if available)
Evolutionary constrained regions (ECRs) for RAI2: view image

Paralogs for RAI2 Gene

No data available for Paralogs for RAI2 Gene

Variants for RAI2 Gene

Sequence variations from dbSNP and Humsavar for RAI2 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000008884 -- 17,808,213(-) C/A intron_variant
rs1000053265 -- 17,811,360(-) C/T intron_variant
rs1000061171 -- 17,823,538(-) G/A intron_variant
rs1000148792 -- 17,824,763(-) TTT/TT intron_variant
rs1000277819 -- 17,832,296(-) C/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RAI2 Gene

Variant ID Type Subtype PubMed ID
nsv1144318 CNV deletion 24896259

Variation tolerance for RAI2 Gene

Residual Variation Intolerance Score: 76% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.96; 19.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RAI2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAI2 Gene

Disorders for RAI2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RAI2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
nance-horan syndrome
  • nhs
- elite association - COSMIC cancer census association via MalaCards
Search RAI2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RAI2

genes like me logo Genes that share disorders with RAI2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RAI2 Gene

Publications for RAI2 Gene

  1. Exclusion of RAI2 as the causative gene for Nance-Horan syndrome. (PMID: 10394933) Walpole SM … Toutain A (Human genetics 1999) 2 3 22 58
  2. Identification and characterization of the human homologue (RAI2) of a mouse retinoic acid-induced gene in Xp22. (PMID: 10049581) Walpole SM … Trump D (Genomics 1999) 2 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A … Stelzl U (Molecular systems biology 2015) 3 58

Products for RAI2 Gene

Sources for RAI2 Gene

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