Aliases for RAET1G Gene
External Ids for RAET1G Gene
Previous GeneCards Identifiers for RAET1G Gene
This gene encodes a member of the major histocompatibility complex (MHC) class I family of proteins. Although the encoded protein includes C-terminal transmembrane and cytoplasmic domains, proteolytic processing results in the removal of these domains and subsequent tethering to the plasma membrane by a glycosylphosphatidylinositol (GPI)-anchor. The encoded protein is one of several related ligands of the natural killer group 2, member D (NKG2D) receptor, which functions as an activating receptor in innate and adaptive immunity. This gene is present in a gene cluster on chromosome 6. [provided by RefSeq, Jul 2015]
GeneCards Summary for RAET1G Gene
RAET1G (Retinoic Acid Early Transcript 1G) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Immune response Role of DAP12 receptors in NK cells. Gene Ontology (GO) annotations related to this gene include peptide antigen binding and natural killer cell lectin-like receptor binding. An important paralog of this gene is ULBP2.
UniProtKB/Swiss-Prot for RAET1G Gene
Isoform 1: Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.
Isoform 3: Down-regulates the expression of KLRK1 and stimulates natural killer cells to secrete IFNG.
Isoform 2: Stimulates natural killer cells to secrete IFNG.