Aliases for RAET1G Gene
External Ids for RAET1G Gene
Previous GeneCards Identifiers for RAET1G Gene
This gene encodes a member of the major histocompatibility complex (MHC) class I family of proteins. Although the encoded protein includes C-terminal transmembrane and cytoplasmic domains, proteolytic processing results in the removal of these domains and subsequent tethering to the plasma membrane by a glycosylphosphatidylinositol (GPI)-anchor. The encoded protein is one of several related ligands of the natural killer group 2, member D (NKG2D) receptor, which functions as an activating receptor in innate and adaptive immunity. This gene is present in a gene cluster on chromosome 6. [provided by RefSeq, Jul 2015]
GeneCards Summary for RAET1G Gene
RAET1G (Retinoic Acid Early Transcript 1G) is a Protein Coding gene. Diseases associated with RAET1G include Ovary Serous Adenocarcinoma and Good Syndrome. Among its related pathways are Metabolism of proteins and Post-translational modification- synthesis of GPI-anchored proteins. Gene Ontology (GO) annotations related to this gene include peptide antigen binding and natural killer cell lectin-like receptor binding. An important paralog of this gene is ULBP2.
UniProtKB/Swiss-Prot Summary for RAET1G Gene
[Isoform 1]: Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.
[Isoform 3]: Down-regulates the expression of KLRK1 and stimulates natural killer cells to secrete IFNG.
[Isoform 2]: Stimulates natural killer cells to secrete IFNG.