This gene encodes a member of the major histocompatibility complex (MHC) class I family of proteins. Although the encoded protein includes C-terminal transmembrane and cytoplasmic domains, proteolytic processing results in the removal of these domains and subsequent tethering to the plasma membrane by a glycosylphosphatidylinositol (GPI)-anchor. The encoded protein is one of se... See more...

Aliases for RAET1G Gene

Aliases for RAET1G Gene

  • Retinoic Acid Early Transcript 1G 2 3 5
  • Retinoic Acid Early Transcript 1G Protein 3 4
  • UL-16 Binding Protein 5 3 4
  • ULBP5 3 4
  • Retinoic Acid Early Transcript 1G Pseudogene 2

External Ids for RAET1G Gene

Previous GeneCards Identifiers for RAET1G Gene

  • GC06U900331
  • GC06M150323
  • GC06M150279
  • GC06M150238
  • GC06M147803

Summaries for RAET1G Gene

Entrez Gene Summary for RAET1G Gene

  • This gene encodes a member of the major histocompatibility complex (MHC) class I family of proteins. Although the encoded protein includes C-terminal transmembrane and cytoplasmic domains, proteolytic processing results in the removal of these domains and subsequent tethering to the plasma membrane by a glycosylphosphatidylinositol (GPI)-anchor. The encoded protein is one of several related ligands of the natural killer group 2, member D (NKG2D) receptor, which functions as an activating receptor in innate and adaptive immunity. This gene is present in a gene cluster on chromosome 6. [provided by RefSeq, Jul 2015]

GeneCards Summary for RAET1G Gene

RAET1G (Retinoic Acid Early Transcript 1G) is a Protein Coding gene. Diseases associated with RAET1G include Ovary Serous Adenocarcinoma and Good Syndrome. Among its related pathways are Metabolism of proteins and Post-translational modification- synthesis of GPI-anchored proteins. Gene Ontology (GO) annotations related to this gene include peptide antigen binding and natural killer cell lectin-like receptor binding. An important paralog of this gene is ULBP2.

UniProtKB/Swiss-Prot Summary for RAET1G Gene

  • [Isoform 1]: Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.
  • [Isoform 3]: Down-regulates the expression of KLRK1 and stimulates natural killer cells to secrete IFNG.
  • [Isoform 2]: Stimulates natural killer cells to secrete IFNG.

Additional gene information for RAET1G Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RAET1G Gene

Genomics for RAET1G Gene

GeneHancer (GH) Regulatory Elements for RAET1G Gene

Promoters and enhancers for RAET1G Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RAET1G on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RAET1G

Genomic Locations for RAET1G Gene

Genomic Locations for RAET1G Gene
chr6:149,916,878-149,923,152
(GRCh38/hg38)
Size:
6,275 bases
Orientation:
Minus strand
chr6:150,238,014-150,244,257
(GRCh37/hg19)
Size:
6,244 bases
Orientation:
Minus strand

Genomic View for RAET1G Gene

Genes around RAET1G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAET1G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAET1G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAET1G Gene

Proteins for RAET1G Gene

  • Protein details for RAET1G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6H3X3-ULBP5_HUMAN
    Recommended name:
    UL-16 binding protein 5
    Protein Accession:
    Q6H3X3
    Secondary Accessions:
    • Q6H3X2

    Protein attributes for RAET1G Gene

    Size:
    334 amino acids
    Molecular mass:
    37106 Da
    Quaternary structure:
    • Interacts with KLRK1/NKG2D.
    • (Microbial infection) In CMV-infected cells, interacts with the viral glycoprotein UL16; this interaction causes RAET1G retention in the endoplasmic reticulum and cis-Golgi and prevents binding to and activation of KLRK1/NKG2D, providing CMV with an immune evasion mechanism.
    Miscellaneous:
    • UL16-binding proteins (ULBPs) are unusual members of the extended MHC class I superfamily. They do not contain the alpha 3 domain and lack a transmembrane domain.

    Alternative splice isoforms for RAET1G Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAET1G Gene

Post-translational modifications for RAET1G Gene

  • The functional form is cleaved C-terminally of the GPI-anchor and yields a 28 kDa protein.
  • Glycosylation at Asn82
  • Modification sites at PhosphoSitePlus

Other Protein References for RAET1G Gene

Antibody Products

No data available for DME Specific Peptides for RAET1G Gene

Domains & Families for RAET1G Gene

Gene Families for RAET1G Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for RAET1G Gene

Blocks:
  • MHC class I signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RAET1G Gene

GenScript: Design optimal peptide antigens:
  • Retinoic acid early transcript 1G (Q4V753_HUMAN)
  • Retinoic acid early transcript 1G (Q4V9S8_HUMAN)
  • Retinoic acid early transcript 1G protein (RET1G_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6H3X3

UniProtKB/Swiss-Prot:

ULBP5_HUMAN :
  • Belongs to the MHC class I family.
Family:
  • Belongs to the MHC class I family.
genes like me logo Genes that share domains with RAET1G: view

Function for RAET1G Gene

Molecular function for RAET1G Gene

UniProtKB/Swiss-Prot Function:
[Isoform 1]: Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.
UniProtKB/Swiss-Prot Function:
[Isoform 3]: Down-regulates the expression of KLRK1 and stimulates natural killer cells to secrete IFNG.
UniProtKB/Swiss-Prot Function:
[Isoform 2]: Stimulates natural killer cells to secrete IFNG.

Phenotypes From GWAS Catalog for RAET1G Gene

Gene Ontology (GO) - Molecular Function for RAET1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15240696
GO:0046703 natural killer cell lectin-like receptor binding IPI 15240696
genes like me logo Genes that share ontologies with RAET1G: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAET1G

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RAET1G Gene

Localization for RAET1G Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAET1G Gene

[Isoform 1]: Cell membrane; Lipid-anchor, GPI-anchor. Endoplasmic reticulum. Note=Mainly found intracellularly. {ECO:0000269 PubMed:15240696, ECO:0000269 PubMed:19223974, ECO:0000269 PubMed:20304922}.
[Isoform 2]: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAET1G gene
Compartment Confidence
plasma membrane 4
extracellular 4
endoplasmic reticulum 3
nucleus 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RAET1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA 21873635
GO:0005783 endoplasmic reticulum IEA --
GO:0005886 plasma membrane TAS,NAS --
GO:0009897 external side of plasma membrane IBA 21873635
genes like me logo Genes that share ontologies with RAET1G: view

Pathways & Interactions for RAET1G Gene

genes like me logo Genes that share pathways with RAET1G: view

Gene Ontology (GO) - Biological Process for RAET1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002729 positive regulation of natural killer cell cytokine production IDA 18544572
GO:0006955 immune response IBA 21873635
GO:0016032 viral process IEA --
GO:0042267 natural killer cell mediated cytotoxicity IDA 15240696
genes like me logo Genes that share ontologies with RAET1G: view

No data available for SIGNOR curated interactions for RAET1G Gene

Drugs & Compounds for RAET1G Gene

No Compound Related Data Available

Transcripts for RAET1G Gene

mRNA/cDNA for RAET1G Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAET1G

Alternative Splicing Database (ASD) splice patterns (SP) for RAET1G Gene

No ASD Table

Relevant External Links for RAET1G Gene

GeneLoc Exon Structure for
RAET1G

Expression for RAET1G Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RAET1G Gene

mRNA differential expression in normal tissues according to GTEx for RAET1G Gene

This gene is overexpressed in Esophagus - Mucosa (x10.9) and Adrenal Gland (x9.5).

Protein differential expression in normal tissues from HIPED for RAET1G Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RAET1G Gene



Protein tissue co-expression partners for RAET1G Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RAET1G

SOURCE GeneReport for Unigene cluster for RAET1G Gene:

Hs.558792

mRNA Expression by UniProt/SwissProt for RAET1G Gene:

Q6H3X3-ULBP5_HUMAN
Tissue specificity: Isoform 1 is highly expressed in colon and in a number of tumor cell lines and highly restricted in normal tissues. Both isoforms are frequently expressed in cell lines derived from epithelial cancers, and in primary breast cancers.
genes like me logo Genes that share expression patterns with RAET1G: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAET1G Gene

Orthologs for RAET1G Gene

This gene was present in the common ancestor of mammals.

Orthologs for RAET1G Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAET1G 30
  • 97.21 (n)
-- 31
  • 86 (a)
ManyToMany
-- 31
  • 84 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 31
  • 33 (a)
OneToMany
cow
(Bos Taurus)
Mammalia RAET1G 31
  • 33 (a)
ManyToMany
Species where no ortholog for RAET1G was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RAET1G Gene

ENSEMBL:
Gene Tree for RAET1G (if available)
TreeFam:
Gene Tree for RAET1G (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RAET1G: view image

Paralogs for RAET1G Gene

(11) SIMAP similar genes for RAET1G Gene using alignment to 7 proteins:

  • RET1G_HUMAN
  • C9JAK3_HUMAN
  • J7HBB6_HUMAN
  • J7HEM2_HUMAN
  • J7HHG3_HUMAN
  • Q4V753_HUMAN
  • Q4V9S8_HUMAN
genes like me logo Genes that share paralogs with RAET1G: view

Variants for RAET1G Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RAET1G Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs9397449 - p.Thr70Arg

Additional dbSNP identifiers (rs#s) for RAET1G Gene

Structural Variations from Database of Genomic Variants (DGV) for RAET1G Gene

Variant ID Type Subtype PubMed ID
esv2732866 CNV deletion 23290073
esv3890963 CNV loss 25118596
nsv517022 CNV gain+loss 19592680
nsv970172 CNV duplication 23825009

Variation tolerance for RAET1G Gene

Residual Variation Intolerance Score: 95.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.69; 32.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RAET1G Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAET1G

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAET1G Gene

Disorders for RAET1G Gene

MalaCards: The human disease database

(2) MalaCards diseases for RAET1G Gene - From: DISEASES

Disorder Aliases PubMed IDs
ovary serous adenocarcinoma
  • malignant ovarian serous tumor
good syndrome
  • thymoma with hypogammaglobulinemia
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for RAET1G

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with RAET1G: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RAET1G Gene

Publications for RAET1G Gene

  1. Two human ULBP/RAET1 molecules with transmembrane regions are ligands for NKG2D. (PMID: 15240696) Bacon L … Trowsdale J (Journal of immunology (Baltimore, Md. : 1950) 2004) 2 3 4 23 54
  2. Single nucleotide polymorphism analysis of the NKG2D ligand cluster on the long arm of chromosome 6: Extensive polymorphisms and evidence of diversity between human populations. (PMID: 20219610) Antoun A … Briggs DC (Human immunology 2010) 3 23 41 54
  3. Post-translational modification of the NKG2D ligand RAET1G leads to cell surface expression of a glycosylphosphatidylinositol-linked isoform. (PMID: 20304922) Ohashi M … Trowsdale J (The Journal of biological chemistry 2010) 3 4 23 54
  4. Polymorphisms of NKG2D ligands: diverse RAET1/ULBP genes in northeastern Thais. (PMID: 19688209) Romphruk AV … Leelayuwat C (Immunogenetics 2009) 3 23 41 54
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54

Products for RAET1G Gene

Sources for RAET1G Gene